From: Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin
Parameters | Controls | One phase of head and neck irradiation | |
---|---|---|---|
0Â Gy | 0.5Â Gy | 2Â Gy | |
AUC (min μg/mL) | 262 ± 52 | 542 ± 192* | 611 ± 66* |
t1/2 (min) | 32 ± 15 | 27 ± 5.1 | 28 ± 7.8 |
Cmax (μg/mL) | 12 ± 1.0 | 19 ± 10 | 18 ± 2.8 |
MRT (min) | 28 ± 9.4 | 33 ± 8.3 | 32 ± 11.6 |
CL (mL/kg/min) | 19 ± 3.4 | 10 ± 2.9* | 8.2 ± 0.9* |
Vss (mL/kg) | 544 ± 202 | 337 ± 150 | 257 ± 94 |