Figure 4
From: Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70
HO-1 immunohistochemistry staining on renal tissue from living (A,C) and brain dead rats (B,D) showed a significant increase in HO-1 protein in renal cortical tubules of the 4 h brain dead group (B, 100x) compared to the living group (A 100x). At a magnification of 400x (C,D) it is apparent that there is an increase in HO-1 protein in a number of singular tubular cells of brain dead rats. Also, several positive cells can be observed in the glomerulus (D, Arrowheads) which could be CD68+ macrophages.