Table 5 Mutation patterns in discrepant cases
From: Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma
Tissue types | Discrepancy secondary/primary melanomas (%) | Primary tumour | Metastasis | ||
|---|---|---|---|---|---|
BRAF | NRAS | BRAF | NRAS | ||
Lymph node metastasis | 11/120 | V600K | wt | wt | wt |
wt | wt | L597R | wt | ||
wt | wt | V600E | wt | ||
wt | wt | V600E | wt | ||
wt | wt | V600E | wt | ||
(9.2%) | V600E | wt | wt | wt | |
wt | wt | V600E | wt | ||
V600E | wt | wt | wt | ||
V600E | wt | wt | wt | ||
wt | wt | V600E | wt | ||
V600E | not tested | wt | not tested | ||
Visceral metastasis | 3/40 | V600E | wt | wt | wt |
wt | wt | V600E | wt | ||
(7.5%) | |||||
wt | wt | V600E | wt | ||
Brain metastasis | 5/24 | V600E | wt | wt | wt |
wt | wt | V600E | wt | ||
wt | wt | wt | Q61L | ||
(20.8%) | |||||
wt | wt | wt | Q61L | ||
wt | wt | wt | Q61R | ||
Skin | 15/52 | wt | wt | wt | Q61L |
V600E | wt | wt | wt | ||
V600E | wt | wt | wt | ||
wt | Q61R | wt | wt | ||
wt | Q61R | V600E | wt | ||
wt | Q61R | V600E | wt | ||
metastasis | (28.8%) | ||||
wt | wt | V600E | wt | ||
wt | wt | V600E | wt | ||
V600E | wt | V600E | wt | ||
wt | wt | V600E | wt | ||
wt | wt | V600E | wt | ||
V600E | wt | wt | wt | ||
wt | wt | V600E | wt | ||
V600E | not tested | wt | not tested | ||
| Â | Â | V600E | not tested | wt | not tested |