Figure 6

The combination of Src and JAK inhibition decreases in vivo proliferation compared to single agents. Nude mice bearing HOSC1 PDX tumors were treated with Dasatinib (20 mg/kg), BMS911543 (10 mg/kg), both, or vehicle for 16 days as indicated. (A) Tumor size was measured twice a week. (B) Tumors were stained for PCNA at the end of treatment and nuclear staining intensity scored and graphed. Representative IHC fields are shown. *p < 0.05 compared to control (vehicle treated).