ABC item | Group | Baseline | 4w | 8w | 16w | 24w |
---|---|---|---|---|---|---|
Irritability | CBMNC | 16.36 ± 9.61 | 14.00 ± 8.66 | 9.50 ± 8.81 | 10.21 ± 9.58 | 8.14 ± 8.37 |
Combination | 15.00 ± 7.81 | 11.22 ± 5.76 | 9.78 ± 4.32 | 5.67 ± 3.24 | 4.22 ± 3.19 | |
Control | 9.15 ± 5.58 | 8.31 ± 5.41 | 8.46 ± 5.41 | 8.69 ± 5.56 | 6.92 ± 4.96 | |
Lethargy/Social withdrawal | CBMNC | 30.71 ± 6.08 | 26.86 ± 5.26a | 24.07 ± 7.08a | 23.86 ± 8.62a | 24.14 ± 9.65a |
Combination | 31.00 ± 6.98 | 25.78 ± 6.50a | 22.67 ± 5.27a | 21.11 ± 5.82a | *16.00 ± 7.92ab | |
Control | 35.08 ± 4.96 | 34.31 ± 5.14 | 33.92 ± 4.73 | 32.46 ± 5.55 | *30.54 ± 5.03 | |
Stereotypic behavior | CBMNC | 29.43 ± 9.77 | *22.43 ± 8.98 | *18.86 ± 10.52 | *18.00 ± 10.86 | *17.07 ± 9.93 |
Combination | 28.33 ± 8.47 | 20.78 ± 8.81 | 17.22 ± 7.12 | 13.22 ± 6.78 | *9.33 ± 5.81ab | |
Control | 22.77 ± 6.86 | 20.85 ± 6.63 | 21.08 ± 4.82 | 18.38 ± 5.58 | 17.31 ± 4.05 | |
Hyperactivity | CBMNC | 11.86 ± 4.55a | 10.07 ± 4.63 | 7.57 ± 4.83 | 7.29 ± 5.27 | 6.86 ± 5.26 |
Combination | 11.89 ± 6.88a | 9.33 ± 5.87 | 7.22 ± 5.19 | 5.89 ± 3.37 | 4.67 ± 3.74 | |
Control | 6.08 ± 3.15 | 6.31 ± 2.81 | 6.46 ± 3.38 | 6.15 ± 3.39 | 5.08 ± 2.40 | |
Inappropriate speech | CBMNC | 5.71 ± 4.30a | 3.79 ± 3.29 | 3.43 ± 3.34 | 2.93 ± 2.87 | 2.14 ± 2.32 |
Combination | 5.56 ± 2.83a | 4.56 ± 2.92 | 3.11 ± 1.62 | 3.22 ± 2.44 | 2.56 ± 2.19 | |
Control | 2.38 ± 2.10 | 2.69 ± 2.21 | 3.00 ± 2.27 | 2.92 ± 2.56 | 2.46 ± 2.63 | |
Total score | CBMNC | 94.07 ± 21.98 | 77.14 ± 22.4 | *63.43 ± 29.93 | *62.29 ± 33.98 | *58.36 ± 31.73a |
Combination | 91.78 ± 25.92 | 71.67 ± 22.57 | 60.00 ± 18.94 | 49.11 ± 14.61 | *36.78 ± 16.95ab | |
Control | 75.46 ± 12.05 | 72.46 ± 12.95 | 72.92 ± 11.43 | 68.62 ± 12.58 | *62.31 ± 11.3 |