Combined features based on MT1-MMP expression, CD11b + immunocytes density and LNR predict clinical outcomes of gastric cancer

Table 3 Analyses of factors regarding OS

Variables	N	N of death (%)	Median OS (Range)	5-year survival rate (%)	Log-rank test χ²value	P
Age (yrs)
<60	99	52 (52.5)	30.1 (1.5-99.5)	45.1	3.584	0.058
≥60	85	56 (65.9)	24.8 (0.8-102.3)	28.6		0.058
Gender
Male	132	74 (56.1)	30.3 (0.8-102.3)	40.0	2.114	0.146
Female	52	34 (65.4)	25.1 (1.3-94.8)	30.3		0.146
Tumor size (cm²) ^a
<16	73	35 (47.9)	41.6 (1.1-99.5)	52.9	7.882	0.005
≥16	88	57 (64.8)	24.2 (0.8-102.3)	29.2		0.005
Histological grade ^b
1/2	55	88 (56.1)	30.1 (1.1-102.3)	54.2	13.412	<0.001
3/4	124	20 (74.1)	16.8 (0.8-74.9)	30.1		<0.001
Lymph nodes metastasis
Yes	131	83 (63.4)	24.8 (0.8-102.3)	52.9	5.895	0.015
No	53	25 (47.2)	34.1 (6.1-99.5)	30.5		0.015
Serosa invasion (T stage)
T1-2	27	7 (25.9)	58.9 (20.2-99.5)	74.9	14.742	<0.001
T3-4	157	101 (64.3)	24.8 (0.8-102.3)	30.8		<0.001
TNM
Early (I, II)	58	26 (44.8)	35.8 (6.1-99.5)	54.0	9.823	0.002
Advanced	126	82 (65.1)	22.8 (0.8-102.3)	29.2
(III, IV)
Surgery
SR	159	89 (56.0)	30.0 (0.8-102.3)	39.8	5.902	0.015
TR/CR	25	19 (76.0)	18.0 (3.8-89.9)	21.8		0.015
Chemotherapy
Yes	149	87 (49.7)	33.5 (5.3-99.5)	35.9	0.016	0.900
No	35	21 (60.0)	28.4 (0.8-102.3)	40.0		0.900
LNR ^c
≤0.33	94	41 (43.6)	38.8 (1.1-102.3)	55.1	24.881	<0.001
>0.33	90	67 (74.4)	20.1 (0.8-99.1)	18.3		<0.001
MT1-MMP
Negative	46	18 (39.1)	35.7 (3.8-79.3)	54.0	5.869	0.015
Positive	138	90 (65.2)	25.4 (0.8-102.3)	32.2		0.015
CD11b + immunocytes density
Low	92	62 (67.4)	25.1 (0.8-99.1)	27.6	4.655	0.031
High	92	46 (50.0)	30.7 (1.3-102.3)	46.7		0.031
Combined features (MT1-MMP density, CD11b + immunocytes density and LNR)
Group I	73	26 (35.6)	38.7 (6.1-94.1)	61.4	28.173	<0.001
Group II	111	82 (73.9)	18.1 (0.8-90.9)	21.1

^a Analysis was performed based on 161 patients with complete data of tumor size. ^b Analysis was performed based on 179 patients with gastric adenocarcinoma. ^c The median of LNR was 0.33 (6 cases), and GC cases were different in distinct subgroups.OS: overall survival; SR: subtotal resection; TR: total resection; CR: combined resection; LNR: lymph node ratio.

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