Figure 1

Immunohistological findings in TMAs. (A-D) Representative example of MT1-MMP (A), CD11b + immunocytes (C) staining of a GC tissue microarray, and the corresponding digital image analyzed with the image software, with MT1-MMP (B) and CD11b + immunocytes (D) represented in red. (E,G) MT1-MMP staining was mainly in the cytoplasm or on the cell membrane of tumor cells (Blue arrow), and most of the stroma cells had negative staining, although sporadic positive staining on these cells was also observed (F,H). CD11b staining showed that CD11b + immunocytes mainly infiltrated into the juncture of cancer nest and stroma, especially at the invasive front (Red and Green arrows).