Table 3 Criteria for haploidentical PBSC donation

Inclusion criteria

Biological family members

3/6 HLA match (using loci A, B, DR)

18 years of age

No malignancy in the past 5 years except for non-melanoma skin cancers

Normal CBC

β-HCG urine or serum negative if donor is of childbearing age

Adequate venous access so leukapheresis can be performed via standard peripheral IV

Exclusion criteria

HIV-1 or 2, syphilis, hepatitis B or C, HTLV 1 or 2, CMV, Chagas, and West Nile Virus positive

Symptomatic congestive heart failure (CHF)

Oxygen dependant chronic obstructive lung disease (COPD)

Cirrhosis or active liver disease

History of any lymphoid, myeloid or other non-solid malignancy

History of transplantation