Table 1 Peptides targeting tumor blood vessels
From: Peptides as targeting probes against tumor vasculature for diagnosis and drug delivery
Sequence (no. of amino acids, name) | Tumor types tested | Receptors | Applications | References |
|---|---|---|---|---|
CDCRGDCFC(9, RGD) | Various tumor types | αvβ3 and αvβ5 integrins | Targeted diagnosis and therapy(TD and TT) | |
CNGRCVSGCAGRC(13, NGR) CNGRC(5, NGR-2C) | Various tumor types | CD13 | TD and TT | |
CTPSPFSHC(9, TCP-1) | Orthotopic colorectal cancer and gastric cancer | ND* | TD and TT | [19] |
IFLLWQR(7, IF7) | Melanoma Colorectal cancer | Anxa1 | TT | [60] |
CTTHWGFTLC(10) | MDA-MB-435-derived breast carcinomas KS1767-derived Kaposi’s sarcomas | MMP-2 MMP-9 | TT | [95] |
KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (31, F3) | HL-60 human leukemia tumor MDA-MB-435 tumors | Nucleolin | ND | |
CSRPRRSEC(9) | HPV16-induced dysplastic skin | Â | Â | Â |
CGKRK(5) and CDTRL(5) | HPV16-induced skin carcinoma Breast carcinomas | ND | ND | [58] |
CKAAKNK(7, KAA) and CKGAKAR(7, KAR) | Pancreatic tumors | ND | ND | [59] |
CRGRRST(7,RGR) | Pancreatic tumors Angiogenic islets | PDGF-β | ND | [59] |
CRGDK/R GPD/E C (9, iRGD) | Various tumor types | αv integrins and neuropilin-1 | TD and TT | |
CPRECESIC(9) | EF43-fgf4-derived breast tumor MDA-MB-435-derived breast tumor | Aminopeptidase A | TT | [96] |
CGNSNPKSC(9, GX1) | Gastric cancer | ND | TD and TT | [97] |
SVSVGMKPSPRP (12, SP5-52) | Several cancers | ND | TT | [56] |