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Table 6 Percentage change of lipids according to SLCO1B1 c.388A > G, SLCO1B1 c.521T > C and SLCO1B3 int7A > G genotypes after 12 months of raloxifene treatment in 53 postmenopausal women

From: Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

 

Genotype

SLCO1B1 c.388A > G

SLCO1B1 c.521T > C

SLCO1B3 int7 T → G

AA

AG

GG

p value (ANOVA)

TT

TC

p value (t-test)

CC

non CC

p value (t-test)

Δ HOL (%)

0.08 (±2.41)

−3.8 (±2.8)

−6.9 (±2.0)

0.368

−4.0 (±1.9)

−2.7 (±3.5)

0.725

−2.3 (±2.1)

−6.1 (±2.7)

0.291

Δ HDL (%)

−1.3 (±2.7)

3.0 (±3.2)

−3.9 (±4.0)

0.379

0.7 (±2.5)

0.06 (±3.7)

0.890

1.7 (±2.4)

−2.0 (±3.8)

0.393

Δ LDL (%)

2.7 (±3.8)

−6.1 (±3.5)

−10.3 (±3.4)

0.132

−4.9 (±2.5)

−4.9 (±4.7)

0.994

−4.4 (±3.1)

−5.8 (±3.2)

0.781

Δ TG (%)

12.9 (±12.8)

−6.7 (±4.2)

21.3 (±12.1)

0.041 a

−1.2 (±6.8)

14.6 (±7.2)

0.124

6.8 (±6.4)

−0.9 (±7.1)

0.455

  1. The values are presented as means (standard errors).
  2. aBonferoni test (ANOVA), no differences.