Secreted protein acidic and rich in cysteine (SPARC) is associated with nasopharyngeal carcinoma metastasis and poor prognosis

Table 3 Cox Regression analysis of the SPARC expression, clinicopathological variables for overall survival in NPC patients

Variable	Univariate Crude HR (95% CI)	P value	*Multivariate adjusted HR (95% CI)	P value
SPARC expression
High versus Low	1.785 (1.455-2.190)	< 0.001	1.741 (1.414-2.144)	< 0.001
Agec (years)
> 47 versus ≤ 47	1.554 (1.265-1.910)	< 0.001	1.551 (1.259-1.910)	< 0.001
Sex
Female versus Male	0.780 (0.616-0.987)	0.039	0.854 (0.673-1.083)	0.193
Clinical Stage
III + IV versus I + II	4.692 (3.325-6.620)	< 0.001	4.766 (3.361-6.758)	< 0.001
WHO histological classification
NKDC versus NKUC	0.935 (0.716-1.222)	0.625	0.919 (0.701-1.205)	0.54
KSCC versus NKUC	1.988 (1.183-3.342)	0.01	1.804 (1.069-3.047)	0.027

*Adjusted for SPARC expression, sex, WHO histological classification, age, and clinical stage. SPARC secreted protein acidic and rich in cysteine; WHO World health organization; NPC nasopharyngeal carcinoma; NKUC, non-keratinizing undifferentiated carcinoma; NKDC non-keratinizing differentiated carcinoma; KSCC keratinizing squamous cell carcinoma; HR hazard ratio; CI confidence interval

ISSN: 1479-5876