From: Nerve growth factor: from the early discoveries to the potential clinical use
Disease | Study type | NGF type and dosage | Delivery route | Outcome | Side effects | References |
---|---|---|---|---|---|---|
Neurotrophic keratitis | Twelve patients case report. | Mouse NGF. Several daily applications of a 200 μg/ml solution for 6 weeks. | Topical (eye). | Healing of all of the ulcers, improved corneal sensitivity and integrity and improved visual acuity. | Not reported. | [172] |
 | Prospective, noncomparative, interventional case series; 43 patients. | Mouse NGF. Several daily applications of a 200 μg/ml solution until ulcer healing. | Topical (eye). | Complete resolution of the epithelial defect between 12 days and 6 weeks of treatment. Improvement of corneal sensitivity and visual acuity. | Hyperemia and ocular and periocular pain. | [176] |
 | Observational study on 11 patients. | Mouse NGF. Several daily applications of a 200 μg/ml solution until ulcer healing. | Topical (eye). | Ulcer healing between 9 and 43 days after initiation of treatment. No development of systemic anti-NGF antibodies in a follow-up time of 72 months. | Mild and transient conjunctival hyperemia and photophobia. | [177] |
Glaucoma | Three patients case report. | Mouse NGF. Four daily applications of a 200 μg/ml solution for 3 months. | Topical (eye). | Progressive improvement in the functionality of the inner retinal layer and in the parameters of the post-retinal neural conduction and visual acuity, maintained for 3 months after discontinuation of treatment. | Local burning during the first week of treatment in a single patient. | [178] |
Bilateral age-related macular degeneration (retinopathy) | Single case study. | Mouse NGF. Three times daily applications of 200 μg/ml solution for 2 separate periods of 1 year and 5 years in the right eye. | Topical (eye). | Improvement in visual acuity and in the amplitude of the ERG. | Slight burning at the time of application of eye drops during the first month of treatment. | [179] |