Figure 1

Focal ischemia models in divergent substrains of spontaneously hypertensive rats (SHR). SHR were sent to National Institute of Health (NIH) at the F13 generation in 1966 (SHR/N), and then from NIH to Charles River, Taconic Farms, and Harlan. In France, Iffa-Credo received their original breeding stocks of SHR from NIH in 1976, and Janvier started breedings in 1978 with SHR derived from the Delalande Research Center, which in turn received their original breeding stocks from Kyoto University in 1974. Two colonies of SHRSP (SHRSP/A3N [NIH] and SHRSP/Bbb [Heidelberg]) were separated at F35, 36 in 1975. CNRS, Centre National de la Recherche Scientifique; SHRSP or SP, stroke prone SHR: NIH, National Institute of Health; MCAO, middle cerebral artery occlusion; d, distal; p, proximal; CCAO, common carotid artery occlusion; YAG, yttrium-aluminium-garnet (laser).