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Table 2 Effect of NG-methyl-L-arginine on inhibition of arginase activity by rIFN-γ

From: rIFN-γ-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition

Cell line

Arginase activity (μg urea/mg protein)

 

Control

NMMA (1 mM)

rIFN-γ (500 U/ml)

rIFN-γ + NMMA

2774

1.8

1.7

1.0

0.7

CAOV3

2.1

1.5

0.8

0.6

NMP-1

0.5

0.5

0.1

0.1

2008

1.2

1.3

2.1

2.4

2008.C13

1.6

1.6

2.6

3.4

  1. The cells were incubated with control medium, rIFN-γ, and/or NMMA for 72 hours and processed as described in Materials and Methods.
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Journal of Translational Medicine

ISSN: 1479-5876

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