Fig. 3From: The potential and promise for clinical application of adoptive T cell therapy in cancerSummary of major barriers of Adoptive cell therapy (ACT) in solid tumors. Some of the most difficult barriers to the development of ACT in solid tumors included tumor heterogeneity, antigen loss, hard trafficking and infiltration, an immunosuppressive tumor microenvironment, and T cell exhaustion. By FigdrawBack to article page