%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
2016-11-11T15:46:22+05:30
Springer
2016-11-15T13:22:28+01:00
2016-11-15T13:22:28+01:00
Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
Ceftriaxone,Sepsis,Pharmacokinetics/pharmacodynamics,Glomerular filtration barrier,Glycocalyx,Sialic acids,Monte Carlo simulation
application/pdf
doi:10.1186/s12967-016-1072-9
BioMed Central
Journal of Translational Medicine, doi:10.1186/s12967-016-1072-9
Ceftriaxone
Sepsis
Pharmacokinetics/pharmacodynamics
Glomerular filtration barrier
Glycocalyx
Sialic acids
Monte Carlo simulation
Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat
Valentina Selmi
Beatrice Loriga
Luca Vitali
Martina Carlucci
Alessandro Filippo
Giulio Carta
Eleonora Sgambati
Lorenzo Tofani
Angelo Raffaele Gaudio
Andrea Novelli
Chiara Adembri
10.1186/s12967-016-1072-9
2010-04-23
true
springer.com
springerlink.com
"http://dx.doi.org/10.1186/s12967-016-1072-9
10.1186/s12967-016-1072-9
1479-5876
journal
Journal of Translational Medicine
The Author(s)
2010-04-23
true
10.1186/s12967-016-1072-9
noindex
springer.com
springerlink.com
VoR
uuid:5d2c9d23-6eaf-4ea9-b3b9-553cba1d8bf4
uuid:e4518ba6-6c3a-462c-9417-9caaeb1d98fe
default
1
converted
uuid:e98794dd-ccf1-4dda-b4bd-c7b76973f22d
converted to PDF/A-2b
pdfToolbox
2016-11-11T15:39:43+05:30
converted
uuid:0a2fc12b-e4ee-4322-bcc0-1cb41cf55e2d
converted to PDF/A-2b
pdfToolbox
2016-11-11T15:40:30+05:30
2
B
Beatrice Loriga
http://orcid.org/0000-0002-4890-0898
http://ns.adobe.com/pdfx/1.3/
pdfx
PDF/X ID Schema
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Mirrors crossmark:DOI
doi
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
seq Text
internal
A name object indicating whether the document has been modified to include trapping information
robots
Text
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://crossref.org/crossmark/1.0/
crossmark
Crossmark Schema
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was publishe.
MajorVersionDate
Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
CrossMarkDomains
CrossMarkDomains
seq Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism Schema
external
This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
URI
external
The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.
issn
Text
internal
Volume number
volume
Text
internal
Issue number
number
Text
internal
Starting page
startingPage
Text
internal
Ending page
endingPage
Text
external
The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
Copyright
copyright
Text
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
Springer Nature ORCID Schema
http://springernature.com/ns/xmpExtensions/2.0/
sn
authorInfo
seq AuthorInformation
external
Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
AuthorInformation
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
3 0 obj
<>/XObject<>/ProcSet[/PDF/Text]/Font<>>>/Thumb 13 0 R/MediaBox[0.0 0.0 595.276 790.866]/Annots 14 0 R/Rotate 0>>
endobj
14 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R]
endobj
15 0 obj
<>/Rect[189.895 667.868 194.815 655.702]/H/N/AP<>>>
endobj
16 0 obj
<>/Rect[125.522 631.868 130.442 619.702]/H/N/AP<>>>
endobj
17 0 obj
<>/Rect[136.371 631.868 141.29 619.702]/H/N/AP<>>>
endobj
18 0 obj
<>/Rect[105.223 559.868 110.143 547.702]/H/N/AP<>>>
endobj
19 0 obj
<>/Rect[254.32 451.868 259.24 439.702]/H/N/AP<>>>
endobj
20 0 obj
<>/Rect[172.803 415.868 177.722 403.702]/H/N/AP<>>>
endobj
21 0 obj
<>/Rect[280.203 355.868 285.122 343.702]/H/N/AP<>>>
endobj
22 0 obj
<>/Rect[89.5845 307.868 94.5041 295.702]/H/N/AP<>>>
endobj
23 0 obj
<>/Rect[153.958 259.868 158.878 247.702]/H/N/AP<>>>
endobj
24 0 obj
<>/Rect[149.576 223.868 154.495 211.702]/H/N/AP<>>>
endobj
25 0 obj
<>/Rect[159.033 223.868 168.872 211.702]/H/N/AP<>>>
endobj
26 0 obj
<>/Rect[59.8876 175.868 69.7268 163.702]/H/N/AP<>>>
endobj
27 0 obj
<>/Rect[454.994 404.391 459.913 392.224]/H/N/AP<>>>
endobj
28 0 obj
<>/Rect[344.341 380.391 354.18 368.224]/H/N/AP<>>>
endobj
29 0 obj
<>/Rect[360.109 380.391 369.948 368.224]/H/N/AP<>>>
endobj
5 0 obj
<>stream
x\nFvWu\ u[I3{ X,`-ar_$k_cy$&ɪh.$BFkq66BD)&2Lw$n+_\}J?/`.yqǢuZEY,Y-?~eݯʮs
b/E-/y~r_UlEOq9Oj'j#sF<,M
b۸Z\dz*Z-?ưOxK7i)h]NLm+`!lEroc/`WY$dhJaRK߯~xvYq
/s5d%9_l2>"ϬA_῭\;"IO6
Dx/B, pڎ*\8G(z#~R`A;E$q{CsFyh[Zd:nہAKJL454ڥ66k6nhv
P+pҕ]2\ٵU(Vʈ/>ζ켜RN,/$V-ZrÛ@A.\@o"J2x_
kzX$^i
3vZ4jˁ46w߮"-Qv~+eBe,w`cǁM+7Zv3\bM:^ڮ⸰~Ѭ) wILc.Ewzjkk4Kݣ`OK?2/&`m~:3D`|,z*:7/Ѽ?>,pU3
Iβ
.ׯUo YE߃4'e
Rn-3hOJKrl8у/)j2kN"`xNYTW:zIqlGl]p% B6;x3<Ѿ#!֠w GHZٱwc)qJi$SURpOT_F%Ò$__DՉ~ l>FiDV%.dҿcC+:n;ͪ*mM|)6
aIiaw5ǵ(uFlvbݹF.#a_IiWbܒbU݄JzԖW_o_WnW"$l{;< hޝ
9Y}aEěQ٥ hxtЈHz\@'pAթ<_T pB(6>Ѯf_a8/0U~BW8J>Sd@WmR}C0"(@E8~A),ʅޣ,fp&ZPjdH %g` %$a%:$7.UΞ.)v
F.&WbY;4#_B B-~TJQo#Bڗ%@b=Pbs$OD&'{I^b_R$ɑ̌%WyUOr?wȦ0C"4JȽ ({d)M5@ o\
gt,sS%uE.1>_+5rՒ,C=Mu-;$#Y0嘕hR6J܀nrZ(06z6{D KF:B)hcգ{I5S|4ba;;.ԋIINeq vSe]TZ;{#nXAc'R8% =%I7i|F'kT B
EJfo4(x/e} ~1f4]I?Nqz=u1͠4mjٮ
Mg*Tit:SdfS,
>ҫvG
;`0.g
YF 675j`CT]kCdaA9.F
nBQ&c]d%ۡbୋ<>,>>S9r˓uZZǨq?d,u\B2)Z$? ~v*Xjjd
{x'/sM!"\e"}6I&;x28¢}vbb7ְ"iSacc\~4k91,3҈1ͳ,d8oʕ[Zm_1"/EVg<2,S3KGA;VRcN1Oek/NWCG`?ɍmE(zqAh,XULDoZ2F`+xӶ*?﹜=[J*
O܆juPQPD%P.x
%)0Hg+ЩSBіP?>M4o= AMћ*J<I%c
{=6@bܡ*~/w)s29B8 TT+Y2}G1.okPm|g2Pq }R.bB:VZ[Nnk @
n\`\D]`ӂA ÎdXې-J{vi:F7tL Hi(nVYelHv}Nw%E} º)e&z Kt٣[ΠzQgS|qI,JlػUO鹵VZά*x^O2tdT+TDz=%tb̭>!0S*&Cs8A
Qh[mju|indC13Ή0&JaCK?8>A[ZF#E)Xa
٩p#6H^p:A<np'O;JE^hJajd遼'i}XSXXxO#VvU?aK_&- .֢"]CSN63"
b=L1`pf7|W{?'2ۆ d7:%PAiU\E=ORH@pb4am8-"x˛"@뷊rqzy
33`h=G^N7ѷqż3j1wq*]ED)IBTxgdi9ˈ+k+ ziȗ i07i9ݹ^hEa*ӤL@YI4F,Р,}0cX|cZufBNA|3-`:WG!ߑ)ɕflC7L9,҈շ&t/.'Ya%(Ѭ4s@X?-<^1j4
.T$g *
#)k\]ǀ&1MܹdVTm^ĪBNirg8j~Bai8rl/S49ߛ{0HΝ5 *p*ʤz"~B-M"^-f15j2(=㑀~ݤJ{b]4 r7@^hiEǬ{
>)a"אhZۭQ*a{j&1\<6ْe:{.Kr} 2zaK{
H&FQ[
1:)53`
YRB٭ L7.O9|K
X)i_#YQ8F㘜6ʦIB~JܠK )[jRX0[HS(UP!Ia͢o,p6kb5aAK@A)&l1qq?Q|HO$Yլ˓M0Gġ3q=bix71,,q0nq7&:C@ ԆxEՈ[RݡFE8˲pŲ+;9"3m$5acSt>)dKrIdC7k<S$1bI^A"%Gge-qZϨ7Bۺbx?
É:0Yv_9YZ
1-k.qCqTp7ѽm{*HkX[SsXۜYp;}4 F7Pch6K0`sQ8|NqӼR^sO0GN=䐱M 5wF.t/|=6֛, ½?D/q #FχغAF`oPQT=fGXLyh픂a r^(&_ݪ#%Kp̒t{F΅LH闵?/x^`
ũS{ƻw vn%G0a*|9sy2029 {Y^/Uu{urqfY!GW88t4XwѼKBz?8[%IcNiJT,%M
%sYǺ}NQjwSsTW[㓭V^폅>)T77O"ٳF\5GD} ;O53є,Ä ΜI
SGi쥇"%K_tRDI"խàz2xNyq08rq)mwwoщoQqj}f+D
ngI?"J/6ܡtN^cp