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  1. Therapeutic idiotypic (Id) vaccination is an experimental treatment for selected B cell malignancies. A broader use of Id-based vaccination, however, is hampered by the complexity and costs due to the individu...

    Authors: Pier Adelchi Ruffini, Audun Os, Riccardo Dolcetti, Geir E Tjønnfjord, Ludvig A Munthe and Bjarne Bogen
    Citation: Journal of Translational Medicine 2014 12:207
  2. New approaches to generate effective anticancer responses by either inducing immune responses or inhibiting immunosuppression are under development to improve efficacy in patients. On March 4-5th, 2014, a symposi...

    Authors: M Ángela Aznar, Ignacio Melero and José I Quetglas
    Citation: Journal of Translational Medicine 2014 12:202
  3. Vaccination with dendritic cells (DC) loaded with tumor antigens elicits tumor-specific immune responses capable of killing cancer cells without inducing meaningful side-effects. Patients with advanced melanom...

    Authors: Francesco de Rosa, Laura Ridolfi, Ruggero Ridolfi, Giorgia Gentili, Linda Valmorri, Oriana Nanni, Massimiliano Petrini, Laura Fiammenghi, Anna Maria Granato, Valentina Ancarani, Elena Pancisi, Valentina Soldati, Serena Cassan, Angela Riccobon, Elisabetta Parisi, Antonino Romeo…
    Citation: Journal of Translational Medicine 2014 12:209
  4. Tumor metabolism is a crucial factor for the carcinogenesis of oral squamous cell carcinoma (OSCC).

    Authors: Martin Grimm, Marcel Cetindis, Max Lehmann, Thorsten Biegner, Adelheid Munz, Peter Teriete, Wiebke Kraut and Siegmar Reinert
    Citation: Journal of Translational Medicine 2014 12:208
  5. Treatment with interferon-alpha (IFN-α) and ribavirin successfully clears hepatitis C virus (HCV) infection in 50% of patients infected with genotype 1. Addition of NS3-4A protease inhibitors (PIs) increases r...

    Authors: Nollaig M Bourke, Mary-Teresa O’Neill, Shahzad Sarwar, Suzanne Norris, Stephen Stewart, John E Hegarty, Nigel J Stevenson and Cliona O’Farrelly
    Citation: Journal of Translational Medicine 2014 12:206
  6. The capacity of the recombinant Vaccinia virus GLV-1h68 as a single agent to efficiently treat different human or canine cancers has been shown in several preclinical studies. Currently, its human safety and e...

    Authors: Elisabeth Hofmann, Stephanie Weibel and Aladar A Szalay
    Citation: Journal of Translational Medicine 2014 12:197
  7. Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancer in developing countries. The prognosis and survival rate of ESCC are very poor. Recently, microRNAs (miRNAs) have e...

    Authors: Heping Li, Dayong Zheng, Bing Zhang, Liangshuai Liu, Junwei Ou, Wei Chen, Shiqiu Xiong, Yong Gu and Jianyong Yang
    Citation: Journal of Translational Medicine 2014 12:196
  8. Primary IgA nephropathy (IgAN) is the most common form of idiopathic glomerulonephritis worldwide. Although most patients are able to achieve remission with the current therapy, a large number of patients will...

    Authors: Zhaohui Ni, Yanhong Yuan, Qin Wang, Liou Cao, Xiajing Che, Minfang Zhang, Yuanyuan Xie, Chaojun Qi and Shan Mou
    Citation: Journal of Translational Medicine 2014 12:194
  9. Inflammatory factors play a vital role in the progression of liver cancer, although exact factors and related mechanisms still remain unclear. The present study aimed at screening inflammatory factors related ...

    Authors: Xiaojing Xu, Peixin Huang, Biwei Yang, Xiangdong Wang and Jinglin Xia
    Citation: Journal of Translational Medicine 2014 12:193
  10. BAG3 gene mutations have been recently implicated as a novel cause of dilated cardiomyopathy (DCM). Our aim was to evaluate the prevalence of BAG3 mutations in Polish patients with DCM and to search for genotype...

    Authors: Maria Franaszczyk, Zofia T Bilinska, Małgorzata Sobieszczańska-Małek, Ewa Michalak, Justyna Sleszycka, Agnieszka Sioma, Łukasz A Małek, Dorota Kaczmarska, Ewa Walczak, Paweł Włodarski, Łukasz Hutnik, Blanka Milanowska, Zofia Dzielinska, Grzegorz Religa, Jacek Grzybowski, Tomasz Zieliński…
    Citation: Journal of Translational Medicine 2014 12:192
  11. Ipilimumab is an antagonistic monoclonal antibody against cytotoxic T-lymphocyte antigen-4 (CTLA-4) that enhances antitumor immunity by inhibiting immunosuppressive activity of regulatory T cells (Treg). In th...

    Authors: Hiroshi Yano, Archana Thakur, Elyse N Tomaszewski, Minsig Choi, Abhinav Deol and Lawrence G Lum
    Citation: Journal of Translational Medicine 2014 12:191
  12. As a surface glycoprotein, CD147 is capable of stimulating the production of matrix metalloproteinases (MMPs) from neighboring fibroblasts. The aim of the present study is to explore the role of soluble CD147 ...

    Authors: Jiao Wu, Zhi-Wei Hao, You-Xu Zhao, Xiang-Min Yang, Hao Tang, Xin Zhang, Fei Song, Xiu-Xuan Sun, Bin Wang, Gang Nan, Zhi-Nan Chen and Huijie Bian
    Citation: Journal of Translational Medicine 2014 12:190
  13. As it remains unclear whether hypoxia of cardiomyocytes could trigger the release of brain natriuretic peptide (BNP) in humans, we investigated whether breathing normobaric hypoxic gas mixture increases the ci...

    Authors: Ilkka Heinonen, Matti Luotolahti, Olli Vuolteenaho, Mikko Nikinmaa, Antti Saraste, Jaakko Hartiala, Juha Koskenvuo, Juhani Knuuti and Olli Arjamaa
    Citation: Journal of Translational Medicine 2014 12:189
  14. Experimental and human studies have demonstrated that innate immune mechanisms and consequent inflammatory reaction play a critical role in cardiac response to ischemic injury. Thus, the detection of immuno-in...

    Authors: Emanuela Turillazzi, Marco Di Paolo, Margherita Neri, Irene Riezzo and Vittorio Fineschi
    Citation: Journal of Translational Medicine 2014 12:188
  15. Non-traditional CD4+CD25–CD69+ T cells were found to be involved in disease progression in tumor-bearing mouse models and cancer patients recently. We attempted to define whether this subset of T cells were re...

    Authors: Xiao-su Zhao, Xu-hua Wang, Xiang-yu Zhao, Ying-jun Chang, Lan-ping Xu, Xiao-hui Zhang and Xiao-jun Huang
    Citation: Journal of Translational Medicine 2014 12:187
  16. Kruppel-like-factor (KLF) 10 is identified as transforming growth factor (TGF) β inducible early gene and is reported to suppress lipogenic genes. Although previous studies report that TGFβ plays an important ...

    Authors: Ja Kyung Kim, Kwan Sik Lee, Hye Young Chang, Woon Kyu Lee and Jung Il Lee
    Citation: Journal of Translational Medicine 2014 12:186
  17. Numerous inflammation-related pathways have been shown to play important roles in atherogenesis. Rapid and efficient assessment of the relative influence of each of those pathways is a challenge in the era of ...

    Authors: Héctor De León, Stéphanie Boué, Walter K Schlage, Natalia Boukharov, Jurjen W Westra, Stephan Gebel, Aaron VanHooser, Marja Talikka, R Brett Fields, Emilija Veljkovic, Michael J Peck, Carole Mathis, Vy Hoang, Carine Poussin, Renee Deehan, Katrin Stolle…
    Citation: Journal of Translational Medicine 2014 12:185
  18. Homologous recombination repair (HRR) pathway deficiencies have significant implications for cancer predisposition and treatment strategies. Improved quantitative methods for functionally characterizing these ...

    Authors: David B Rosen, Ling Y Leung, Brent Louie, James A Cordeiro, Andrew Conroy, Iuliana Shapira, Scott Z Fields, Alessandra Cesano and Rachael E Hawtin
    Citation: Journal of Translational Medicine 2014 12:184
  19. Serum quantitative hepatitis B surface antigen (HBsAg) levels may be an important predictor of hepatitis B e antigen (HBeAg) seroconversion (SC) in HBeAg-positive chronic hepatitis B (CHB) patients during anti...

    Authors: Jiezuan Yang, Jiajia Chen, Ping Ye, Linfeng Jin, Wei Wu, Guoping Sheng and Lan-Juan Li
    Citation: Journal of Translational Medicine 2014 12:183
  20. Acute myeloid leukemia (AML) is the second most common form of leukemia in children. Aberrant DNA methylation patterns are a characteristic feature in various tumors, including AML. Metallothionein III (MT3) i...

    Authors: Yan-Fang Tao, Li-Xiao Xu, Jun Lu, Lan Cao, Zhi-Heng Li, Shao-Yan Hu, Na-Na Wang, Xiao-Juan Du, Li-Chao Sun, Wen-Li Zhao, Pei-Fang Xiao, Fang Fang, Yan-Hong Li, Gang Li, He Zhao, Yi-Ping Li…
    Citation: Journal of Translational Medicine 2014 12:182
  21. Therapeutic hypothermia is a treatment modality that is increasingly used to improve clinical neurological outcomes for ischemia-reperfusion injury-mediated diseases. Antibody-initiated classical complement pa...

    Authors: Tushar A Shah, Clifford T Mauriello, Pamela S Hair, Amandeep Sandhu, Michael P Stolz, William Thomas Bass, Neel K Krishna and Kenji M Cunnion
    Citation: Journal of Translational Medicine 2014 12:181
  22. BID functions as a bridge molecule between death-receptor and mitochondrial related apoptotic pathways to amplify apoptotic signaling. Our previous studies have demonstrated a substantial increase in BID expre...

    Authors: Su He Wang, Yongyi Fan and James R Baker Jr
    Citation: Journal of Translational Medicine 2014 12:180
  23. The inflammatory marker, C reactive protein has been proposed to also be a biomarker for adaptive immune responses in cancer patients with a possible application in time based chemotherapy. Fluxes in serum CRP...

    Authors: Mutsa T Madondo, Sandra Tuyaerts, Brit B Turnbull, Anke Vanderstraeten, Holbrook Kohrt, Balasubramanian Narasimhan, Frederic Amant, Michael Quinn and Magdalena Plebanski
    Citation: Journal of Translational Medicine 2014 12:179
  24. Single-cell network profiling (SCNP) is a multiparametric flow cytometry-based approach that simultaneously measures evoked signaling in multiple cell subsets. Previously, using the SCNP approach, age-associat...

    Authors: Diane M Longo, Brent Louie, Jason Ptacek, Greg Friedland, Erik Evensen, Santosh Putta, Michelle Atallah, David Spellmeyer, Ena Wang, Zoltan Pos, Francesco M Marincola, Andrea Schaeffer, Suzanne Lukac, Radha Railkar, Chan R Beals, Alessandra Cesano…
    Citation: Journal of Translational Medicine 2014 12:178
  25. Toll-like receptor 4 (TLR4), a lipopolysaccharide (LPS) receptor complex signal-transducing molecule, plays a crucial role in sensing LPS from gram-negative bacteria. TLR4 signaling pathway activation by LPS p...

    Authors: Ashham Mansur, Luisa von Gruben, Aron F Popov, Maximilian Steinau, Ingo Bergmann, Daniel Ross, Michael Ghadimi, Tim Beissbarth, Martin Bauer and José Hinz
    Citation: Journal of Translational Medicine 2014 12:177
  26. The biologic heterogeneity of soft tissue sarcomas (STS), even within histological subtypes, complicates treatment. In earlier studies, gene expression patterns that distinguish two subsets of clear cell renal...

    Authors: Keith M Skubitz, Amy PN Skubitz, Wayne W Xu, Xianghua Luo, Pauline Lagarde, Jean-Michel Coindre and Frédéric Chibon
    Citation: Journal of Translational Medicine 2014 12:176
  27. We previously reported the clinical efficacy of adoptive immunotherapy (AIT) with dendritic cells (DCs) pulsed with mucin 1 (MUC1) peptide and cytotoxic T lymphocytes (CTLs). We also reported that gemcitabine ...

    Authors: Yoshitaro Shindo, Shoichi Hazama, Yoshinari Maeda, Hiroto Matsui, Michihisa Iida, Nobuaki Suzuki, Kiyoshi Yoshimura, Tomio Ueno, Shigefumi Yoshino, Kohei Sakai, Yutaka Suehiro, Takahiro Yamasaki, Yuji Hinoda and Masaaki Oka
    Citation: Journal of Translational Medicine 2014 12:175
  28. Our goal was to test whether short-term intermittent hypobaric hypoxia (IHH) at a level well tolerated by healthy humans could, in combination with muscle electro-stimulation (ME), mobilize circulating progeni...

    Authors: Luisa Corral, Casimiro Javierre, Juan Blasi, Ginés Viscor, Antoni Ricart and Josep Lluis Ventura
    Citation: Journal of Translational Medicine 2014 12:174
  29. Rapidly determining the complex genetic basis of Hypertrophic cardiomyopathy (HCM) is vital to better understanding and optimally managing this common polygenetic cardiovascular disease.

    Authors: Zongzhe Li, Jin Huang, Jinzhao Zhao, Chen Chen, Hong Wang, Hu Ding, Dao Wu Wang and Dao Wen Wang
    Citation: Journal of Translational Medicine 2014 12:173
  30. Cardiac gene therapy for heart disease is a major translational research area with potential, yet problems with safe and efficient gene transfer into cardiac muscle remain unresolved. Existing methodology to i...

    Authors: Anthony S Fargnoli, Anbin Mu, Michael G Katz, Richard D Williams, Kenneth B Margulies, David B Weiner, Shu Yang and Charles R Bridges
    Citation: Journal of Translational Medicine 2014 12:171
  31. Circulating endothelial progenitor cells (EPCs) may be a biomarker for vascular function and cardiovascular risk in patients with coronary artery disease (CAD). Dimethylarginine dimethylaminohydrolase 2 (DDAH2...

    Authors: Pan-Pan Niu, Yu Cao, Ting Gong, Jin-Hui Guo, Bi-Kui Zhang and Su-Jie Jia
    Citation: Journal of Translational Medicine 2014 12:170
  32. Kaposi’s sarcoma (KS) is the most frequently occurring cancer in Mozambique among men and the second most frequently occurring cancer among women. Effective therapeutic treatments for KS are poorly understood ...

    Authors: Saharnaz Baghdadchi, Kimberly Liu, Jacquelyn Knapp, Gabriel Prager, Susannah Graves, Kevan Akrami, Rolanda Manuel, Rui Bastos, Erin Reid, Dennis Carson, Sadik Esener, Joseph Carson and Yu-Tsueng Liu
    Citation: Journal of Translational Medicine 2014 12:169
  33. Human bone marrow mesenchymal stem cells (hBMSCs) are multipotent cells that can differentiate into a variety of cell types. Elevated expression of peroxisome proliferator-activated receptor-γ (PPARγ) promotes...

    Authors: Junkui Sun, Yisheng Wang, Yuebai Li and Guoqiang Zhao
    Citation: Journal of Translational Medicine 2014 12:168
  34. The methylation inhibitor 5-Aza-2′-deoxycytidine (decitabine, DAC) has a great therapeutic value for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). But decitabine monotherapy was associated ...

    Authors: Kongfei Li, Chao Hu, Chen Mei, Zhigang Ren, Juan Carlos Vera, Zhengping Zhuang, Jie Jin and Hongyan Tong
    Citation: Journal of Translational Medicine 2014 12:167
  35. Overall cure rates in acute myeloid leukemia (AML) continue to range between 60-65% with disease relapse being a major cause of mortality. The PI3K-Akt-mTOR kinase pathway plays a vital role in pro-survival si...

    Authors: Himalee Sabnis, Heath L Bradley, Silvia T Bunting, Todd M Cooper and Kevin D Bunting
    Citation: Journal of Translational Medicine 2014 12:166
  36. Co-infections of HBV and HIV are frequent due to similar routes of transmission. In that transmission through blood is an important route for both HBV and HIV, evaluation of the prevalence of HBV in HIV infect...

    Authors: Yu Liu, Peibin Zeng, Jingxing Wang, Gui Liu, Min Xu, Ling Ke, Miao He and Zhong Liu
    Citation: Journal of Translational Medicine 2014 12:164
  37. Disulfiram (DS), an anti-alcoholism drug, demonstrates strong antitumor activity in a copper (Cu)-dependent manner. This study investigates the cytotoxicity of DS/Cu complex in lymphoid malignant cell lines in vi...

    Authors: Jie Zha, Feili Chen, Huijuan Dong, Pengcheng Shi, Yao Yao, Yanyan Zhang, Rongwei Li, Shiyun Wang, Peng Li, Weiguang Wang and Bing Xu
    Citation: Journal of Translational Medicine 2014 12:163
  38. High-throughput screening techniques that analyze the metabolic endpoints of biological processes can identify the contributions of genetic predisposition and environmental factors to the development of common...

    Authors: Sweety Mathew, Susanne Krug, Thomas Skurk, Anna Halama, Antonia Stank, Anna Artati, Cornelia Prehn, Joel A Malek, Gabi Kastenmüller, Werner Römisch-Margl, Jerzy Adamski, Hans Hauner and Karsten Suhre
    Citation: Journal of Translational Medicine 2014 12:161
  39. HER2 status assessment is a prerequisite for the establishment of an appropriate treatment strategy in gastric cancer. Gastric cancers are very heterogeneous and separate evaluations of gene amplification and ...

    Authors: Dominique Werner, Achim Battmann, Kristina Steinmetz, Tobin Jones, Tiffany Lamb, Michele Martinez, Hans-Michael Altmannsberger and Salah-Eddin Al-Batran
    Citation: Journal of Translational Medicine 2014 12:160
  40. Lung adenocarcinoma is a heterogernous disease that creates challenges for classification and management. The purpose of this study is to identify specific miRNA markers closely associated with the survival of...

    Authors: Xuelian Li, Yunrui Shi, Zhihua Yin, Xiaoxia Xue and Baosen Zhou
    Citation: Journal of Translational Medicine 2014 12:159
  41. Resveratrol is a polyphenolic compound found in several plants. In the last decades, the interest in this compound has enormously increased after benefits on metabolism and increased lifespan of various organi...

    Authors: Valentina Ponzo, Laura Soldati and Simona Bo
    Citation: Journal of Translational Medicine 2014 12:158
  42. Rheumatoid arthritis (RA) is a debilitating and painful disease leading to increased morbidity and mortality and novel therapeutic approaches are needed. The purpose of this study was to elucidate if mesenchym...

    Authors: Oksana Kehoe, Alison Cartwright, Ayman Askari, Alicia J El Haj and Jim Middleton
    Citation: Journal of Translational Medicine 2014 12:157
  43. Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology...

    Authors: Peter D Caie, Arran K Turnbull, Susan M Farrington, Anca Oniscu and David J Harrison
    Citation: Journal of Translational Medicine 2014 12:156
  44. Nuclear factor-κB (NF-κB) induces a variety of biological processes through transcriptional gene control whose products are components in various signaling pathways. MicroRNAs are a small endogenous non-coding...

    Authors: Jian Zhang, Haidong Wu, Pu Li, Yanzheng Zhao, Min Liu and Hua Tang
    Citation: Journal of Translational Medicine 2014 12:155
  45. Drug-induced gene expression dataset (for example Connectivity Map, CMap) represent a valuable resource for drug-repurposing, a class of methods for identifying novel indications for approved drugs. Recently, ...

    Authors: Ling Jin, Jian Tu, Jianwei Jia, Wenbin An, Huanran Tan, Qinghua Cui and Zhixin Li
    Citation: Journal of Translational Medicine 2014 12:153

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