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  1. Dendritic cells (DC) pulsed with tumor-derived antigenic material have widely been used in antitumor vaccination protocols. However, the optimal strategy of DC loading has not yet been established. Our aim was...

    Authors: Christian Adam, Josef Mysliwietz and Ralph Mocikat

    Citation: Journal of Translational Medicine 2007 5:16

    Content type: Research

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  2. Treatment records and follow-up data on 40 patients with primary and metastatic liver malignancies who underwent a single whole-liver treatment with Y-90 resin microspheres (SIR-Spheres® Sirtex Medical, Lake Fore...

    Authors: Seza A Gulec, Geraldine Mesoloras, William A Dezarn, Patrick McNeillie and Andrew S Kennedy

    Citation: Journal of Translational Medicine 2007 5:15

    Content type: Research

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  3. Previously, we reported that adoptively transferred perforin k/o (PKO), and IFN-γ k/o (GKO), or perforin/IFN-γ double k/o (PKO/GKO) effector T cells mediated regression of B16BL6-D5 (D5) pulmonary metastases a...

    Authors: Hauke Winter, Natasja K van den Engel, Christian H Poehlein, Rudolf A Hatz, Bernard A Fox and Hong-Ming Hu

    Citation: Journal of Translational Medicine 2007 5:14

    Content type: Research

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  4. With the present study we introduce a novel and simple biomaterial able to induce regeneration of bone. We theorized that nourishing a bone defect with calcium and with a large amount of activated platelets ma...

    Authors: Giuseppe Intini, Sebastiano Andreana, Francesco E Intini, Robert J Buhite and Libuse A Bobek

    Citation: Journal of Translational Medicine 2007 5:13

    Content type: Research

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  5. Telomerase, a reverse transcriptase primarily devoted to the elongation of telomeres in mammalian cells, is also the first bona fide common tumor antigen. In fact, telomerase is over-expressed in > 85% of tumo...

    Authors: Xochtil Cortez-Gonzalez and Maurizio Zanetti

    Citation: Journal of Translational Medicine 2007 5:12

    Content type: Review

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  6. Although the sequence of events leading to wound repair has been described at the cellular and, to a limited extent, at the protein level this process has yet to be fully elucidated. Genome wide transcriptiona...

    Authors: Kavita Deonarine, Monica C Panelli, Mitchell E Stashower, Ping Jin, Kina Smith, Herbert B Slade, Christopher Norwood, Ena Wang, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2007 5:11

    Content type: Research

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  7. Toll-like receptor (TLR)3 ligands serve as natural inducers of pro-inflammatory cytokines capable of promoting Type-1 adaptive immunity, and TLR3 is abundantly expressed by cells within the central nervous sys...

    Authors: Xinmei Zhu, Fumihiko Nishimura, Kotaro Sasaki, Mitsugu Fujita, Jill E Dusak, Junichi Eguchi, Wendy Fellows-Mayle, Walter J Storkus, Paul R Walker, Andres M Salazar and Hideho Okada

    Citation: Journal of Translational Medicine 2007 5:10

    Content type: Research

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  8. As part of the Houston Vanguard study, a subset of 10 patients randomized to receive IL-2 therapy were compared to 4 patients randomized to not receive IL-2, for markers of T cell activation and death during t...

    Authors: Dorothy E Lewis, Kimber L Gross, Martine M Diez, Maria L Martinez, Helen N Lukefahr, Claudia A Kozinetz and Roberto C Arduino

    Citation: Journal of Translational Medicine 2007 5:9

    Content type: Research

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  9. Cord blood is currently used as an alternative to bone marrow as a source of stem cells for hematopoietic reconstitution after ablation. It is also under intense preclinical investigation for a variety of indi...

    Authors: Neil H Riordan, Kyle Chan, Annette M Marleau and Thomas E Ichim

    Citation: Journal of Translational Medicine 2007 5:8

    Content type: Review

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  10. The objective of this study was to identify the molecular processes responsible for the anti-lesional activity of imiquimod in subjects with actinic keratosis using global gene expression profiling.

    Authors: Abel Torres, Leslie Storey, Makala Anders, Richard L Miller, Barbara J Bulbulian, Jizhong Jin, Shalini Raghavan, James Lee, Herbert B Slade and Woubalem Birmachu

    Citation: Journal of Translational Medicine 2007 5:7

    Content type: Research

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  11. XIAP up-regulation is associated with chemotherapy resistance. Phenoxodiol causes XIAP degradation and chemotherapy sensitization in ovarian cancer. Here we assessed XIAP expression in melanomas, using tissue ...

    Authors: Harriet M Kluger, Mary M McCarthy, Ayesha B Alvero, Mario Sznol, Stephan Ariyan, Robert L Camp, David L Rimm and Gil Mor

    Citation: Journal of Translational Medicine 2007 5:6

    Content type: Research

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  12. Previously, we have successfully targeted the mannose receptor (MR) expressed on monocyte-derived dendritic cells (DCs) using a fully human MR-specific antibody, B11, as a vehicle to deliver whole protein tumo...

    Authors: Venky Ramakrishna, John P Vasilakos, Joseph D Tario Jr, Marc A Berger, Paul K Wallace and Tibor Keler

    Citation: Journal of Translational Medicine 2007 5:5

    Content type: Research

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  13. The potent clinical responses seen in patients with chronic myeloid leukemia (CML) after administration of donor-specific lymphocytes, as well as the correlation between the presence of antigen specific T cell...

    Authors: Annette M Marleau, Jeffrey H Lipton, Neil H Riordan and Thomas E Ichim

    Citation: Journal of Translational Medicine 2007 5:4

    Content type: Review

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  14. Despite advances in our cellular and molecular knowledge, hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. It is now known to be highly heterogeneous: it enc...

    Authors: Fabio Grizzi, Barbara Franceschini, Cody Hamrick, Eldo E Frezza, Everardo Cobos and Maurizio Chiriva-Internati

    Citation: Journal of Translational Medicine 2007 5:3

    Content type: Review

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  15. Overexpression of Neutral Endopeptidase (NEP) has been reported in metastatic carcinomas, implicating NEP in tumor progression and suggesting a role for NEP inhibitors in its treatment. We investigated the rol...

    Authors: Elsa F Velazquez, Molly Yancovitz, Anna Pavlick, Russell Berman, Richard Shapiro, Dusan Bogunovic, David O'Neill, Yi-Lo Yu, Joanna Spira, Paul J Christos, Xi Kathy Zhou, Madhu Mazumdar, David M Nanus, Leonard Liebes, Nina Bhardwaj, David Polsky…

    Citation: Journal of Translational Medicine 2007 5:2

    Content type: Research

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  16. While insulin replacement remains the cornerstone treatment for type I diabetes mellitus (T1DM), the transplantation of pancreatic islets of Langerhans has the potential to become an important alternative. And...

    Authors: Jiaqiang Ren, Ping Jin, Ena Wang, Eric Liu, David M Harlan, Xin Li and David F Stroncek

    Citation: Journal of Translational Medicine 2007 5:1

    Content type: Review

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  17. DNA hypermethylation and histone deacetylation are epigenetic events that contribute to the absence or downregulated expression of different components of the tumor recognition complex. These events affect the...

    Authors: María de Lourdes Mora-García, Alfonso Duenas-González, Jorge Hernández-Montes, Erick De la Cruz-Hernández, Enrique Pérez-Cárdenas, Benny Weiss-Steider, Edelmiro Santiago-Osorio, Vianney Francisco Ortíz-Navarrete, Víctor Hugo Rosales, David Cantú, Marcela Lizano-Soberón, Martha Patricia Rojo-Aguilar and Alberto Monroy-García

    Citation: Journal of Translational Medicine 2006 4:55

    Content type: Research

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  18. This study explores the psychological, socio-cultural and economic consequences of infertility on couples' life. The purpose of this research is to improve knowledge about the potentially serious implications ...

    Authors: Nicole J Wiersema, Anouck J Drukker, Mai Ba Tien Dung, Giang Huynh Nhu, Nguyen Thanh Nhu and Cornelis B Lambalk

    Citation: Journal of Translational Medicine 2006 4:54

    Content type: Research

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  19. Limb-girdle muscular dystrophy (LGMD) is a group of heterogeneous muscular disorders with autosomal dominant and recessive inheritance, in which the pelvic or shoulder girdle musculature is predominantly or pr...

    Authors: Yong Zhang, Jianwei Ye, Dazhi Chen, Xinyi Zhao, Xingjun Xiao, Sheng Tai, Wei Yang and Dahai Zhu

    Citation: Journal of Translational Medicine 2006 4:53

    Content type: Research

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  20. The immune system spontaneously responds to tumor-associated antigens in peripheral blood of colorectal cancer (CRC) patients. Regulatory T cells (Treg) are suspected of influencing the interaction between the...

    Authors: Christoph Loddenkemper, Martin Schernus, Michel Noutsias, Harald Stein, Eckhard Thiel and Dirk Nagorsen

    Citation: Journal of Translational Medicine 2006 4:52

    Content type: Research

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  21. Current clinical and histopathological criteria used to define the prognosis of melanoma patients are inadequate for accurate prediction of clinical outcome. We investigated whether genome screening by means o...

    Authors: Susanna Mandruzzato, Andrea Callegaro, Gianluca Turcatel, Samuela Francescato, Maria C Montesco, Vanna Chiarion-Sileni, Simone Mocellin, Carlo R Rossi, Silvio Bicciato, Ena Wang, Francesco M Marincola and Paola Zanovello

    Citation: Journal of Translational Medicine 2006 4:50

    Content type: Research

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  22. Besides being the effectors of native anti-tumor cytotoxicity, NK cells participate in T-lymphocyte responses by promoting the maturation of dendritic cells (DC). Adherent NK (A-NK) cells constitute a subset o...

    Authors: Lina Matera, Alessandra Galetto, Marilena Bello, Cinzia Baiocco, Isabella Chiappino, Giancarlo Castellano, Alessandra Stacchini, Maria A Satolli, Michele Mele, Sergio Sandrucci, Antonio Mussa, Gianni Bisi and Theresa L Whiteside

    Citation: Journal of Translational Medicine 2006 4:49

    Content type: Research

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  23. The tumor microenvironment consists of tumor, immune, stromal, and inflammatory cells which produce cytokines, growth factors, and adhesion molecules that promote tumor progression and metastasis. Of particula...

    Authors: Anne M Lewis, Sheelu Varghese, Hui Xu and H Richard Alexander

    Citation: Journal of Translational Medicine 2006 4:48

    Content type: Review

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  24. Human polyomavirus BK (BKV) has been implicated in oncogenic transformation. Its ability to replicate is determined by the binding of its large tumor antigen (LTag) to products of tumor-suppressor genes regula...

    Authors: Maurizio Provenzano, Laura Bracci, Stephen Wyler, Tvrtko Hudolin, Giovanni Sais, Rainer Gosert, Paul Zajac, Giorgio Palu', Michael Heberer, Hans H Hirsch and Giulio C Spagnoli

    Citation: Journal of Translational Medicine 2006 4:47

    Content type: Research

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  25. Candida albicans is a dimorphic fungus that can grow in yeast morphology or hyphal form depending on the surrounding environment. This ubiquitous fungus is present in skin and mucus membranes as a potential patho...

    Authors: Viachaslau M Barodka, Edward Acheampong, Garry Powell, Ludmila Lobach, David A Logan, Zahida Parveen, Valerie Armstead and Muhammad Mukhtar

    Citation: Journal of Translational Medicine 2006 4:46

    Content type: Research

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  26. Very little is known of the regulation of the function of human osteoclasts, largely due to the virtual impossibility of obtaining human osteoclasts ex vivo. It has recently become possible to generate human oste...

    Authors: Barrie Kirstein, Urszula Grabowska, Bertil Samuelsson, Masahiro Shiroo, Timothy J Chambers and Karen Fuller

    Citation: Journal of Translational Medicine 2006 4:45

    Content type: Methodology

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  27. Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activatory receptors that are expressed by most natural killer (NK) cells. The KIR gene family is polymorphic: genomic diversity ...

    Authors: A Bontadini, M Testi, MC Cuccia, M Martinetti, C Carcassi, A Chiesa, E Cosentini, E Dametto, S Frison, AM Iannone, C Lombardo, A Malagoli, M Mariani, L Mariotti, L Mascaretti, L Mele…

    Citation: Journal of Translational Medicine 2006 4:44

    Content type: Research

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  28. Although described by Hippocrates in 400 B.C., pemphigus disease still needs a safe therapeutical approach, given that the currently used therapies (i.e. corticosteroids and immunosuppressive drugs) often prov...

    Authors: Giovanni Angelini, Domenico Bonamonte, Alberta Lucchese, Gianfranco Favia, Rosario Serpico, Abraham Mittelman, Simone Simone, Animesh A Sinha and Darja Kanduc

    Citation: Journal of Translational Medicine 2006 4:43

    Content type: Research

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  29. Incomplete Freund's adjuvant (IFA) serves as a carrier for water-in-oil emulsion (W/O) vaccines. The stability of such emulsions greatly affects vaccine safety and efficacy since continued presence of antigen ...

    Authors: Yi T Koh, Sean A Higgins, Jeffrey S Weber and W Martin Kast

    Citation: Journal of Translational Medicine 2006 4:42

    Content type: Research

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  30. The culture and expansion of human cells for clinical use requires the presence of human serum or plasma in culture media. Although these supplements have been extensively characterized in their chemical compo...

    Authors: Saleh Ayache, Monica C Panelli, Karen M Byrne, Stefanie Slezak, Susan F Leitman, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2006 4:40

    Content type: Research

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  31. Aberrant signaling by ErbB-2 (HER 2, Neu), a member of the human Epidermal Growth Factor (EGF) receptor family, is associated with an aggressive clinical behaviour of carcinomas, particularly breast tumors. An...

    Authors: Patrizia Galeffi, Alessio Lombardi, Immacolata Pietraforte, Flavia Novelli, Monica Di Donato, Maria Sperandei, Andrea Tornambé, Rocco Fraioli, Aline Martayan, Pier Giorgio Natali, Maria Benevolo, Marcella Mottolese, Francisco Ylera, Cristina Cantale and Patrizio Giacomini

    Citation: Journal of Translational Medicine 2006 4:39

    Content type: Research

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  32. Recently, it was described that an HLA-A24 restricted peptide derived from the survivin splice variant survivin-2B can be recognized by CD8(+) cytotoxic T-cells. The identification of an HLA-A24 epitope is cri...

    Authors: Mads Hald Andersen, Rikke B Soerensen, Jürgen C Becker and Per thor Straten

    Citation: Journal of Translational Medicine 2006 4:38

    Content type: Commentary

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  33. A number of autoimmune diseases have been clinically and pathologically characterized. In contrast, target antigens have been identified only in a few cases and, in these few cases, the knowledge of the exact ...

    Authors: Alberta Lucchese, Abraham Mittelman, Luciana Tessitore, Rosario Serpico, Animesh A Sinha and Darja Kanduc

    Citation: Journal of Translational Medicine 2006 4:37

    Content type: Research

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  34. We present our experience of therapeutic vaccination using dendritic cells (DC) pulsed with autologous tumor antigens in patients with advanced melanoma.

    Authors: Ruggero Ridolfi, Massimiliano Petrini, Laura Fiammenghi, Monica Stefanelli, Laura Ridolfi, Michela Ballardini, Giuseppe Migliori and Angela Riccobon

    Citation: Journal of Translational Medicine 2006 4:36

    Content type: Research

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  35. Dendritic cells (DCs) have been used as vaccines in clinical trials of immunotherapy of cancer and other diseases. Nonetheless, progress towards the use of DCs in the clinic has been slow due in part to the ab...

    Authors: Svetomir N Markovic, Allan B Dietz, Carl W Greiner, Mary L Maas, Greg W Butler, Douglas J Padley, Peggy A Bulur, Jacob B Allred, Edward T Creagan, James N Ingle, Dennis A Gastineau and Stanimir Vuk-Pavlovic

    Citation: Journal of Translational Medicine 2006 4:35

    Content type: Methodology

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  36. The World Health Organization (WHO)'s "3 × 5 program" has spurred efforts to place 3 million people on combination antiretroviral therapy (ART) for treatment of AIDS in resource-limited countries. Paradoxicall...

    Authors: Lynn S Zijenah, Gerard Kadzirange, Simon Madzime, Margaret Borok, Chiedza Mudiwa, Ocean Tobaiwa, Mary Mucheche, Simbarashe Rusakaniko and David A Katzenstein

    Citation: Journal of Translational Medicine 2006 4:33

    Content type: Research

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  37. The development of resistance to cytotoxic chemotherapy continues to be a major obstacle for successful anticancer therapy. It has been shown that cells exposed to toxic concentrations of commonly used cancer ...

    Authors: Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Alma Chavez-Blanco, Alma Revilla-Vazquez, Luis Benitez-Bribiesca and Alfonso Duenas-González

    Citation: Journal of Translational Medicine 2006 4:32

    Content type: Research

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  38. It is well known that the use of the α-adrenergic receptor antagonists in the BPH therapy may induce ejaculatory disorder. A review of clinical literature shows a greater incidence of ejaculatory disorder duri...

    Authors: Marco Grasso, Flavio Fortuna, Caterina Lania and Salvatore Blanco

    Citation: Journal of Translational Medicine 2006 4:31

    Content type: Research

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  39. We previously showed that tumor-free peritoneum of patients with epithelial ovarian cancer (EOC) exhibited enhanced expression of several inflammatory response genes compared to peritoneum of benign disease. H...

    Authors: Xipeng Wang, Michael Deavers, Rebecca Patenia, Roland L Bassett Jr, Peter Mueller, Qing Ma, Ena Wang and Ralph S Freedman

    Citation: Journal of Translational Medicine 2006 4:30

    Content type: Research

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  40. We compared gene expression profiles in acutely dissected aorta with those in normal control aorta.

    Authors: Barbara Theresia Weis-Müller, Olga Modlich, Irina Drobinskaya, Derya Unay, Rita Huber, Hans Bojar, Jochen D Schipke, Peter Feindt, Emmeran Gams, Wolfram Müller, Timm Goecke and Wilhelm Sandmann

    Citation: Journal of Translational Medicine 2006 4:29

    Content type: Research

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  41. Thyroid papillary microcarcinoma (TPM) is defined according to WHO criteria as a thyroid tumor smaller than 1–1.5 cm. TPMs are encountered in 0.5–35.6 % of autopsies or surgical specimens where carcinoma had b...

    Authors: Demet Corapcioglu, Serpil D Sak, Tuncay Delibasi, Vedia Tonyukuk, Nuri Kamel, Ali R Uysal, Savas Kocak, Semih Aydintug and Gurbuz Erdogan

    Citation: Journal of Translational Medicine 2006 4:28

    Content type: Research

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  42. Experimentally, interleukin-2 (IL-2) exerts complex immunological functions promoting the proliferation, survival and activation of T cells on one hand and inducing immune regulatory mechanisms on the other. T...

    Authors: Ping Jin, Ena Wang, Maurizio Provenzano, Sara Deola, Silvia Selleri, Jiaqiang Ren, Sonia Voiculescu, David Stroncek, Monica C Panelli and Francesco M Marincola

    Citation: Journal of Translational Medicine 2006 4:26

    Content type: Research

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  43. Oxidative stress could play a role in pathogenesis of hepatitis C virus (HCV) infection. The aim of our study is to determine oxidant/antioxidant status of patients with chronic hepatitis C (CHC), and the effe...

    Authors: Görenek Levent, Acar Ali, Aydın Ahmet, Eyigun Can Polat, Çetinkaya Aytaç, Eken Ayşe and Sayal Ahmet

    Citation: Journal of Translational Medicine 2006 4:25

    Content type: Research

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  44. In vivo studies have recently demonstrated that interleukin 21 (IL-21) enhances the anti-tumor function of T-cells and NK cells in murine tumor models, and the combined use of IL-21 and IL-15 has resulted in p...

    Authors: Hong He, Preya Wisner, Guojun Yang, Hong-Ming Hu, Dan Haley, William Miller, Aisling O'Hara, W Gregory Alvord, Christopher H Clegg, Bernard A Fox, Walter J Urba and Edwin B Walker

    Citation: Journal of Translational Medicine 2006 4:24

    Content type: Research

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  45. Nasopharyngeal carcinoma (NPC) is common among Southern Chinese and the main histology is the undifferentiated carcinoma associated with Epstein-Barr virus (EBV) infection. p63 is a recently proved member of t...

    Authors: Can Guo, Zhi-Gang Pan, Da-Jiang Li, Jing-Ping Yun, Mei-Zhen Zheng, Zhe-Yu Hu, Li-Zhen Cheng and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2006 4:23

    Content type: Research

    Published on:

  46. Historically cancer vaccines have yielded suboptimal clinical results. We have developed a novel strategy for eliciting antitumor immunity based upon homology between neoplastic tissue and the developing place...

    Authors: Zhaohui Zhong, Kornel P Kusznieruk, Igor A Popov, Neil H Riordan, Hamid Izadi, Li Yijian, Salman Sher, Orest M Szczurko, Michael G Agadjanyan, Richard H Tullis, Amir Harandi, Boris N Reznik, Grigor V Mamikonyan and Thomas E Ichim

    Citation: Journal of Translational Medicine 2006 4:22

    Content type: Research

    Published on:

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