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  1. We previously demonstrated that vascular endothelial growth factor receptor type 2 (VEGF-R2)-positive cells induced from mouse embryonic stem (ES) cells can differentiate into both endothelial cells (ECs) and ...

    Authors: Naofumi Oyamada, Hiroshi Itoh, Masakatsu Sone, Kenichi Yamahara, Kazutoshi Miyashita, Kwijun Park, Daisuke Taura, Megumi Inuzuka, Takuhiro Sonoyama, Hirokazu Tsujimoto, Yasutomo Fukunaga, Naohisa Tamura and Kazuwa Nakao

    Citation: Journal of Translational Medicine 2008 6:54

    Content type: Research

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  2. Metastatic melanoma is a highly chemotherapy resistant tumour. The use of newer targeted therapies alone and in combination with chemotherapy may offer new hope of improving response to treatment. Dasatinib, a...

    Authors: Alex J Eustace, John Crown, Martin Clynes and Norma O'Donovan

    Citation: Journal of Translational Medicine 2008 6:53

    Content type: Research

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  3. Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic monitoring. However, currently available cancer biomarkers have the disadvantage of lacking specificity and/or sensitivity. Dev...

    Authors: Hua Xue, Bingjian Lu and Maode Lai

    Citation: Journal of Translational Medicine 2008 6:52

    Content type: Review

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  4. Human hepatocellular carcinoma (HCC) cells express WT1 and/or carcinoembryonic antigen (CEA) as potential targets for the induction of antitumor immunity. In this study, generation of cytotoxic T lymphocytes (...

    Authors: Shigeo Koido, Sadamu Homma, Eiichi Hara, Makoto Mitsunaga, Yoshihisa Namiki, Akitaka Takahara, Eijiro Nagasaki, Hideo Komita, Yukiko Sagawa, Toshifumi Ohkusa, Kiyotaka Fujise, Jianlin Gong and Hisao Tajiri

    Citation: Journal of Translational Medicine 2008 6:51

    Content type: Research

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  5. Pharmaceutical doses of ascorbic acid (AA, vitamin C, or its salts) have been reported to exert anticancer activity in vitro and in vivo. One proposed mechanism involves direct cytotoxicity mediated by accumulati...

    Authors: Nina A Mikirova, Thomas E Ichim and Neil H Riordan

    Citation: Journal of Translational Medicine 2008 6:50

    Content type: Research

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  6. To determine the role of interferon-alpha in controlling HIV infection we phenotypically and functionally analyzed circulating plasmacytoid dendritic cells (pDC), which are known to be the highest interferon-a...

    Authors: Raffaele Badolato, Claudia Ghidini, Fabio Facchetti, Federico Serana, Alessandra Sottini, Marco Chiarini, Elena Spinelli, Silvia Lonardi, Alessandro Plebani, Luigi Caimi and Luisa Imberti

    Citation: Journal of Translational Medicine 2008 6:49

    Content type: Research

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  7. Ayurveda is an ancient system of personalized medicine documented and practiced in India since 1500 B.C. According to this system an individual's basic constitution to a large extent determines predisposition ...

    Authors: Bhavana Prasher, Sapna Negi, Shilpi Aggarwal, Amit K Mandal, Tav P Sethi, Shailaja R Deshmukh, Sudha G Purohit, Shantanu Sengupta, Sangeeta Khanna, Farhan Mohammad, Gaurav Garg, Samir K Brahmachari and Mitali Mukerji

    Citation: Journal of Translational Medicine 2008 6:48

    Content type: Research

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  8. Our previous publication showed that 9% of patients with a history of myocardial infarction MI. could be labeled as aspirin resistant; all of these patients were aspirin resistant because of non-compliance. Th...

    Authors: Kenneth A Schwartz, Dianne E Schwartz, Kimberly Barber, Mathew Reeves and Anthony C De Franco

    Citation: Journal of Translational Medicine 2008 6:46

    Content type: Research

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  9. Critical limb ischemia (CLI) is an advanced form of peripheral artery disease which is responsible for approximately 100,000 amputations per year in the US. Trials to date have reported clinical improvement an...

    Authors: Michael P Murphy, Hao Wang, Amit N Patel, Suman Kambhampati, Niren Angle, Kyle Chan, Annette M Marleau, Andrew Pyszniak, Ewa Carrier, Thomas E Ichim and Neil H Riordan

    Citation: Journal of Translational Medicine 2008 6:45

    Content type: Research

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  10. The status of a disease can be reflected by specific transcriptional profiles resulting from the induction or repression activity of a number of genes. Here, we proposed a time-dependent diagnostic model to pr...

    Authors: Tao Huang, Kang Tu, Yu Shyr, Chao-Chun Wei, Lu Xie and Yi-Xue Li

    Citation: Journal of Translational Medicine 2008 6:44

    Content type: Methodology

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  11. In prostate cancer, the identification of drug combinations that could reduce the tumor cell population and rapidly eradicate hormone-resistant cells potentially present would be a remarkable breakthrough in t...

    Authors: Francesco Fabbri, Giovanni Brigliadori, Silvia Carloni, Paola Ulivi, Ivan Vannini, Anna Tesei, Rosella Silvestrini, Dino Amadori and Wainer Zoli

    Citation: Journal of Translational Medicine 2008 6:43

    Content type: Research

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  12. This study was aimed to investigate the short- and long-term outcomes of percutaneous coronary intervention (PCI) between single bare metal stent (BMS) and single drug eluting stent (DES) in nondiabetic patien...

    Authors: Yue-jin Yang, Sheng Kang, Bo Xu, Ji-lin Chen, Shu-bin Qiao, Xue-wen Qin, Min Yao, Jue Chen, Yong-jian Wu, Hai-bo Liu, Jin-qing Yuan, Shi-jie You, Jian-jun Li, Jun Dai and Run-lin Gao

    Citation: Journal of Translational Medicine 2008 6:42

    Content type: Research

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  13. Strategies to discover circulating protein markers of ovarian cancer are urgently needed. We developed a novel technology that permits us to isolate recombinant antibodies directed against the potential serum ...

    Authors: Nathalie Scholler, Jennifer A Gross, Barbara Garvik, Lance Wells, Yan Liu, Christian M Loch, Arturo B Ramirez, Martin W McIntosh, Paul D Lampe and Nicole Urban

    Citation: Journal of Translational Medicine 2008 6:41

    Content type: Research

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  14. Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HSC mobilization include G-CSF and the CX...

    Authors: Ping Jin, Ena Wang, Jiaqiang Ren, Richard Childs, Jeong Won Shin, Hanh Khuu, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2008 6:39

    Content type: Research

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  15. Our previous studies have demonstrated that transduction of human dendritic cells (DC) with adenovirus encoding secondary lymphoid chemokine, CCL21, led to secretion of biologically active CCL21 without alteri...

    Authors: Felicita Baratelli, Hiroko Takedatsu, Saswati Hazra, Katherine Peebles, Jie Luo, Pam S Kurimoto, Gang Zeng, Raj K Batra, Sherven Sharma, Steven M Dubinett and Jay M Lee

    Citation: Journal of Translational Medicine 2008 6:38

    Content type: Research

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  16. Advances in cancer therapy have been substantial in terms of molecular understanding of disease mechanisms, however these advances have not translated into increased survival in the majority of cancer types. O...

    Authors: Thomas E Ichim, Zhaohui Zhong, Shalesh Kaushal, Xiufen Zheng, Xiubao Ren, Xishan Hao, James A Joyce, Harold H Hanley, Neil H Riordan, James Koropatnick, Vladimir Bogin, Boris R Minev, Wei-Ping Min and Richard H Tullis

    Citation: Journal of Translational Medicine 2008 6:37

    Content type: Research

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  17. Prothrombin G20210A gene variant (FII G20210A) is a risk factor for venous thrombotic disease while conflicting results have been reported for the risk of arterial thrombotic events. However, vascular episodes...

    Authors: Pierpaolo Di Micco, Rosanna Di Fiore, Alferio Niglio, Sandro Quaranta, Antonella Angiolillo, Giuseppe Cardillo and Giuseppe Castaldo

    Citation: Journal of Translational Medicine 2008 6:36

    Content type: Research

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  18. The golden retriever muscular dystrophy (GRMD) dogs represent the best available animal model for therapeutic trials aiming at the future treatment of human Duchenne muscular dystrophy (DMD). We have obtained ...

    Authors: Irina Kerkis, Carlos E Ambrosio, Alexandre Kerkis, Daniele S Martins, Eder Zucconi, Simone AS Fonseca, Rosa M Cabral, Carlos MC Maranduba, Thais P Gaiad, Adriana C Morini, Natassia M Vieira, Marina P Brolio, Osvaldo A Sant'Anna, Maria A Miglino and Mayana Zatz

    Citation: Journal of Translational Medicine 2008 6:35

    Content type: Research

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  19. Quantification of T-cell receptor (TCR) chain families can be utilized for detection of clonal T-cell populations. Besides southern blotting and antibody-based approaches, quantitative real time PCR (qRT PCR) ...

    Authors: Sebastian Ochsenreither, Alberto Fusi, Antonia Busse, Dirk Nagorsen, David Schrama, Jürgen Becker, Eckhard Thiel and Ulrich Keilholz

    Citation: Journal of Translational Medicine 2008 6:34

    Content type: Methodology

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  20. The pathogenesis of nasopharyngeal carcinoma (NPC) is a complicated process involving genetic predisposition, Epstein-Bar Virus infection, and genetic alterations. Although some oncogenes and tumor suppressor ...

    Authors: Weiyi Fang, Xin Li, Qingping Jiang, Zhen Liu, Huiling Yang, Shuang Wang, Siming Xie, Qiuzhen Liu, Tengfei Liu, Jing Huang, Weibing Xie, Zuguo Li, Yingdong Zhao, Ena Wang, Francesco M Marincola and Kaitai Yao

    Citation: Journal of Translational Medicine 2008 6:32

    Content type: Research

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  21. "Translational medicine" as a fashionable term is being increasingly used to describe the wish of biomedical researchers to ultimately help patients. Despite increased efforts and investments into R&D, the out...

    Authors: Martin Wehling

    Citation: Journal of Translational Medicine 2008 6:31

    Content type: Commentary

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  22. Bone Marrow (BM) progenitor cells can target the site of myocardial injury, contributing to tissue repair by neovascolarization and/or by a possible direct paracrine effect on the inflammatory cascade. Angiote...

    Authors: Michele M Ciulla, Elisa Montelatici, Stefano Ferrero, Paola Braidotti, Roberta Paliotti, Giuseppe Annoni, Elisa De Camilli, Giuseppe Busca, Luisa Chiappa, Paolo Rebulla, Fabio Magrini and Lorenza Lazzari

    Citation: Journal of Translational Medicine 2008 6:30

    Content type: Research

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  23. Cytomegalovirus (CMV) seronegative recipients (R-) of kidney transplants (KT) from seropositive donors (D+) are at higher risk for CMV replication and ganciclovir(GCV)-resistance than CMV R(+). We hypothesized...

    Authors: Adrian Egli, Isabelle Binet, Simone Binggeli, Clemens Jäger, Alexis Dumoulin, Stefan Schaub, Juerg Steiger, Urban Sester, Martina Sester and Hans H Hirsch

    Citation: Journal of Translational Medicine 2008 6:29

    Content type: Research

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  24. Esophageal tumors generally bear a poor prognosis. Radical surgery is generally the only curative method available but is not feasible in the majority of patients; palliative therapy with stent placement is ge...

    Authors: David Melodelima, Frederic Prat, Jacques Fritsch, Yves Theillere and Dominique Cathignol

    Citation: Journal of Translational Medicine 2008 6:28

    Content type: Research

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  25. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been proposed for prevention and treatment of a variety of human cancers. Piroxicam, in particular, has been recently shown to exert significant anti-tumoral ...

    Authors: Alessandra Verdina, Irene Cardillo, Angela Nebbioso, Rossella Galati, Simona Menegozzo, Lucia Altucci, Ada Sacchi and Alfonso Baldi

    Citation: Journal of Translational Medicine 2008 6:27

    Content type: Research

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  26. Interleukin-12 (IL-12) is a cytokine well known for its role in immunity. A lesser known function of IL-12 is its role in hematopoiesis. The promising data obtained in the preclinical models of antitumor immun...

    Authors: Lena A Basile, Timothy K Gallaher, Darryl Shibata, Joseph D Miller and Dan Douer

    Citation: Journal of Translational Medicine 2008 6:26

    Content type: Research

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  27. Trastuzumab is a monoclonal antibody selectively directed against Her2 and approved for the treatment of Her2 overexpressing breast cancer patients. Its proposed mechanisms of action include mediation of antib...

    Authors: Alessandra Beano, Elena Signorino, Andrea Evangelista, Davide Brusa, Marinella Mistrangelo, Maria Antonia Polimeni, Rosella Spadi, Michela Donadio, Libero Ciuffreda and Lina Matera

    Citation: Journal of Translational Medicine 2008 6:25

    Content type: Commentary

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  28. We previously reported that survivin-2B, a splicing variant of survivin, was expressed in various types of tumors and that survivin-2B peptide might serve as a potent immunogenic cancer vaccine. The objective ...

    Authors: Tetsuhiro Tsuruma, Yuji Iwayama, Tosei Ohmura, Tadashi Katsuramaki, Fumitake Hata, Tomohisa Furuhata, Koji Yamaguchi, Yasutoshi Kimura, Toshihiko Torigoe, Nobuhiko Toyota, Atsuhito Yagihashi, Yoshihiko Hirohashi, Hiroko Asanuma, Kumiko Shimozawa, Minoru Okazaki, Yasuhiro Mizushima…

    Citation: Journal of Translational Medicine 2008 6:24

    Content type: Research

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  29. The heterogeneity that soft tissue sarcomas (STS) exhibit in their clinical behavior, even within histological subtypes, complicates patient care. Histological appearance is determined by gene expression. Morp...

    Authors: Keith M Skubitz, Stefan Pambuccian, J Carlos Manivel and Amy PN Skubitz

    Citation: Journal of Translational Medicine 2008 6:23

    Content type: Research

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  30. CTLA4-blocking antibodies induce tumor regression in a subset of patients with melanoma. Analysis of immune parameters in peripheral blood may help define how responses are mediated.

    Authors: Begoña Comin-Anduix, Yohan Lee, Jason Jalil, Alain Algazi, Pilar de la Rocha, Luis H Camacho, Viviana A Bozon, Cecile A Bulanhagui, Elisabeth Seja, Arturo Villanueva, Bradley R Straatsma, Antonio Gualberto, James S Economou, John A Glaspy, Jesus Gomez-Navarro and Antoni Ribas

    Citation: Journal of Translational Medicine 2008 6:22

    Content type: Research

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  31. Because of the lack of full characterization of tumor associated antigens for solid tumors, whole antigen use is a convenient approach to tumor vaccination. Tumor RNA and apoptotic tumor cells have been used a...

    Authors: Fabian Benencia, Maria C Courrèges and George Coukos

    Citation: Journal of Translational Medicine 2008 6:21

    Content type: Research

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  32. Transcription factor forkhead box protein 3 (Foxp3) specifically characterizes the thymically derived naturally occurring regulatory T cells (Tregs). Limited evidence indicates that it is also expressed, albei...

    Authors: Vaios Karanikas, Matthaios Speletas, Maria Zamanakou, Fani Kalala, Gedeon Loules, Theodora Kerenidi, Angeliki K Barda, Konstantinos I Gourgoulianis and Anastasios E Germenis

    Citation: Journal of Translational Medicine 2008 6:19

    Content type: Research

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  33. Management considerations in hypokalemic periodic paralysis include accurate diagnosis, potassium dosage for acute attacks, choice of diuretic for prophylaxis, identification of triggers, creating a safe physi...

    Authors: Jacob O Levitt

    Citation: Journal of Translational Medicine 2008 6:18

    Content type: Commentary

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    The Erratum to this article has been published in Journal of Translational Medicine 2014 12:198

  34. Upon Ag-activation cytotoxic T cells (CTLs) produce IFN-γ GM-CSF and TNF-α, which deliver simultaneously pro-apoptotic and pro-inflammatory signals to the surrounding microenvironment. Whether this secretion a...

    Authors: Silvia Selleri, Sara Deola, Zoltan Pos, Ping Jin, Andrea Worschech, Stefanie L Slezak, Cristiano Rumio, Monica C Panelli, Dragan Maric, David F Stroncek, Ena Wang and Francesco M Marincola

    Citation: Journal of Translational Medicine 2008 6:17

    Content type: Research

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  35. Idiopathic pulmonary fibrosis (IPF) is a treatment resistant disease with poor prognosis. Numerous compounds have been demonstrated to efficiently prevent pulmonary fibrosis (PF) in animal models but only a fe...

    Authors: Kjetil Ask, Renee Labiris, Laszlo Farkas, Antje Moeller, Aaron Froese, Troy Farncombe, Grant B McClelland, Mark Inman, Jack Gauldie and Martin RJ Kolb

    Citation: Journal of Translational Medicine 2008 6:16

    Content type: Research

    Published on:

  36. Multiple Myeloma is a cancer of B plasma cells, which produce non-specific antibodies and proliferate uncontrolled. Due to the potential relapse and non-specificity of current treatments, immunotherapy promise...

    Authors: Maurizio Chiriva-Internati, Raffaele Ferrari, Madhavi Prabhakar, Yuefei Yu, Luigi Baglioni, Jorge Moreno, Nicoletta Gagliano, Nicola Portinaro, Marjorie R Jenkins, Eldo E Frezza, Fred Hardwicke, Nicholas D'Cunha, W Martin Kast and Everardo Cobos

    Citation: Journal of Translational Medicine 2008 6:15

    Content type: Research

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  37. Ayurveda is one of the ancient systems of health care of Indian origin. Roughly translated into "Knowledge of life", it is based on the use of natural herbs and herb products for therapeutic measures to boost ...

    Authors: Custer C Deocaris, Nashi Widodo, Renu Wadhwa and Sunil C Kaul

    Citation: Journal of Translational Medicine 2008 6:14

    Content type: Review

    Published on:

  38. Tumor-derived aberrantly methylated DNA might serve as diagnostic biomarkers for cancer, but so far, few such markers have been identified. The aim of the present study was to investigate the potential of the MAL

    Authors: Guro E Lind, Terje Ahlquist, Matthias Kolberg, Marianne Berg, Mette Eknæs, Miguel A Alonso, Anne Kallioniemi, Gunn I Meling, Rolf I Skotheim, Torleiv O Rognum, Espen Thiis-Evensen and Ragnhild A Lothe

    Citation: Journal of Translational Medicine 2008 6:13

    Content type: Research

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  39. Cognate immunity against neoplastic cells depends on a balance between effector T cells and regulatory T (Treg) cells. Treg cells prevent immune attack against normal and neoplastic cells by directly suppressi...

    Authors: Mary Ann Rasku, Amy L Clem, Sucheta Telang, Beverly Taft, Kelly Gettings, Hana Gragg, Daniel Cramer, Sheron C Lear, Kelly M McMasters, Donald M Miller and Jason Chesney

    Citation: Journal of Translational Medicine 2008 6:12

    Content type: Research

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  40. Adrenergic gene polymorphisms are associated with cardiovascular and metabolic phenotypes. We investigated the influence of adrenergic gene polymorphisms on cardiovascular risk in women with suspected myocardi...

    Authors: Michael A Pacanowski, Issam Zineh, Haihong Li, B Delia Johnson, Rhonda M Cooper-DeHoff, Vera Bittner, Dennis M McNamara, Barry L Sharaf, C Noel Bairey Merz, Carl J Pepine and Julie A Johnson

    Citation: Journal of Translational Medicine 2008 6:11

    Content type: Research

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  41. The mouse is an important and widely utilized animal model for bone marrow transplant (BMT) translational studies. Here, we document the course of an unexpected increase in mortality of congenic mice that unde...

    Authors: Raimon Duran-Struuck, Adam Hartigan, Shawn G Clouthier, Melissa C Dyson, Kathi Lowler, Erin Gatza, Isao Tawara, Tomomi Toubai, Elisabeth Weisiger, Kelly Hugunin, Pavan Reddy and John E Wilkinson

    Citation: Journal of Translational Medicine 2008 6:10

    Content type: Research

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  42. Ovarian carcinoma is the leading cause of mortality among gynecological cancers in the world. The high mortality rate is associated with lack of early diagnosis and development of drug resistance. The antitumo...

    Authors: Anna Bratasz, Karuppaiyah Selvendiran, Tomasz Wasowicz, Andrey Bobko, Valery V Khramtsov, Louis J Ignarro and Periannan Kuppusamy

    Citation: Journal of Translational Medicine 2008 6:9

    Content type: Research

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  43. As for a consolidated tradition, the 5th annual meeting of the Italian Network for Cancer Biotherapy took place in the Certosa of Pontignano, a Tuscan monastery, on September 20–22, 2007. The congress gathered mo...

    Authors: Michele Maio, Hugues JM Nicolay, Paolo Ascierto, Filippo Belardelli, Roberto Camerini, Mario P Colombo, Paola Queirolo, Ruggero Ridolfi, Vincenzo Russo, Lucia Anzalone, Ester Fonsatti and Giorgio Parmiani

    Citation: Journal of Translational Medicine 2008 6:8

    Content type: Commentary

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  44. Human embryonic stem cells (hESCs) have been extensively discussed in public and scientific communities for their potential in treating diseases and injuries. However, not much has been achieved in turning the...

    Authors: Kaushik Dilip Deb and Kanchan Sarda

    Citation: Journal of Translational Medicine 2008 6:7

    Content type: Review

    Published on:

  45. Sixteen melanoma patients (1 stage IIC, 8 stage III, and 7 stage IV) were treated in a Phase I study with a vaccine (DC/Apo-Nec) composed of autologous dendritic cells (DCs) loaded with a mixture of apoptotic/...

    Authors: Erika M von Euw, María M Barrio, David Furman, Estrella M Levy, Michele Bianchini, Isabelle Peguillet, Olivier Lantz, Alejandra Vellice, Abraham Kohan, Matías Chacón, Cassian Yee, Rosa Wainstok and José Mordoh

    Citation: Journal of Translational Medicine 2008 6:6

    Content type: Research

    Published on:

  46. Among the challenges facing translational medicine today is the need for greater productivity and safety during the drug development process. To meet this need, practitioners of translational medicine are deve...

    Authors: C Gerald Curtis, Kevin Bilyard and Hugo Stephenson

    Citation: Journal of Translational Medicine 2008 6:5

    Content type: Commentary

    Published on:

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