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  1. Denervation-induced muscle atrophy is complex disease involving multiple biological processes with unknown mechanisms. N6-methyladenosine (m6A) participates in skeletal muscle physiology by regulating multiple...

    Authors: Junjie Sun, Hai Zhou, Zehao Chen, Han Zhang, Yanzhe Cao, Xinlei Yao, Xin Chen, Boya Liu, Zihui Gao, Yuntian Shen, Lei Qi and Hualin Sun
    Citation: Journal of Translational Medicine 2023 21:845
  2. Oncolytic viruses (OVs) for cancer treatment are in a rapid stage of development, and the direct tumor lysis and activation of a comprehensive host immune response are irreplaceable advantages of cancer immuno...

    Authors: Zhen Shen, Xiyu Liu, Guixiang Fan, Jintong Na, Qiaoqiao Liu, Faquan Lin, Zhikun Zhang and Liping Zhong
    Citation: Journal of Translational Medicine 2023 21:842
  3. To develop and validate a conventional MRI-based radiomic model for predicting prognosis in patients with IDH wild-type glioblastoma (GBM) and reveal the biological underpinning of the radiomic phenotypes.

    Authors: Fangzhan Guan, Zilong Wang, Yuning Qiu, Yu Guo, Dongling Pei, Minkai Wang, Aoqi Xing, Zhongyi Liu, Bin Yu, Jingliang Cheng, Xianzhi Liu, Yuchen Ji, Dongming Yan, Jing Yan and Zhenyu Zhang
    Citation: Journal of Translational Medicine 2023 21:841
  4. Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB. Aberrant expression of FGFR1 due ...

    Authors: Ruyue Wang, Jinjing Zhong, Xiuyi Pan, Zhengzheng Su, Yunyi Xu, Mengni Zhang, Xueqin Chen, Ni Chen, Ting Yu and Qiao Zhou
    Citation: Journal of Translational Medicine 2023 21:840
  5. Activated osteoclasts cause excessive bone resorption, and disrupt bone homeostasis, leading to osteoporosis. The extracellular signal-regulated kinase (ERK) signaling is the classical pathway related to osteo...

    Authors: Tao Yang, Weiwei Chen, Kai Gan, Chaofeng Wang, Xiaoxiao Xie, Yuangang Su, Haoyu Lian, Jiake Xu, Jinmin Zhao and Qian Liu
    Citation: Journal of Translational Medicine 2023 21:839
  6. LIPH, a membrane-associated phosphatidic acid-selective phospholipase A1a, can produce LPA (Lysophosphatidic acid) from PA (Phosphatidic acid) on the outer leaflet of the plasma membrane. It is well known that...

    Authors: Lijie Han, Yongsheng Jiang, Minmin Shi, Lina Gan, Zhichong Wu, Meilin Xue, Youwei Zhu, Cheng Xiong, Ting Wang, Xiaozhu Lin, Baiyong Shen, Lingxi Jiang and Hao Chen
    Citation: Journal of Translational Medicine 2023 21:838
  7. Patients with steroid-refractory acute graft-versus-host disease (aGvHD) not tolerating/responding to ruxolitinib (RR-aGvHD) have a dismal prognosis.

    Authors: Halvard Bonig, Mareike Verbeek, Peter Herhaus, Krischan Braitssch, Gernot Beutel, Christoph Schmid, Nadine Müller, Gesine Bug, Michaela Döring, Arend von Stackelberg, Johanna Tischer, Francis Ayuk, Gerald Wulf, Udo Holtick, Lisa-Marie Pfeffermann, Bernd Jahrsdörfer…
    Citation: Journal of Translational Medicine 2023 21:837
  8. Machine learning (ML) represents a powerful tool to capture relationships between molecular alterations and cancer types and to extract biological information. Here, we developed a plain ML model aimed at dist...

    Authors: Veronica Zelli, Andrea Manno, Chiara Compagnoni, Rasheed Oyewole Ibraheem, Francesca Zazzeroni, Edoardo Alesse, Fabrizio Rossi, Claudio Arbib and Alessandra Tessitore
    Citation: Journal of Translational Medicine 2023 21:836
  9. The Neutrophil-to-lymphocyte ratio (NLR) is a marker of poor prognosis in hospitalized older patients with different diseases, but there is still no consensus on the optimal cut-off value to identify older pat...

    Authors: Mirko Di Rosa, Jacopo Sabbatinelli, Luca Soraci, Andrea Corsonello, Anna Rita Bonfigli, Antonio Cherubini, Riccardo Sarzani, Roberto Antonicelli, Giuseppe Pelliccioni, Roberta Galeazzi, Francesca Marchegiani, Salvatore Iuorio, Daniele Colombo, Maurizio Burattini, Fabrizia Lattanzio and Fabiola Olivieri
    Citation: Journal of Translational Medicine 2023 21:835
  10. Psoriasis is a chronic inflammatory skin disease with metabolic abnormalities serving as important contributors for pathogenesis and progression. Polyunsaturated fatty acids (PUFAs) have been found to be assoc...

    Authors: Xin Wang, Rui Ma, Rongcan Shi, Hui Qin, Wenjuan Chen, Zengyang Yu, Yangfeng Ding, Chen Peng and Yuling Shi
    Citation: Journal of Translational Medicine 2023 21:834
  11. Glycolytic metabolic reprogramming is a phenomenon in which cells undergo altered metabolic patterns during malignant transformation, mainly involving various aspects of glycolysis, electron transport chain, o...

    Authors: Hongying Zhao, Rongke Jiang, Zhijing Feng, Xue Wang and Chunmei Zhang
    Citation: Journal of Translational Medicine 2023 21:833
  12. The use of umbilical cord mesenchymal stem cells (UC-MSCs) is a burgeoning method for the treatment of liver cirrhosis. However, the secretory phenotype and regulatory ability of UC-MSCs are easily affected by...

    Authors: Ye Xie, Jia Yao, Mengchao Yan, Yan Lin, Jiayun Wei, Haiping Wang, Yongcui Mao, Pinyan Liu and Xun Li
    Citation: Journal of Translational Medicine 2023 21:832
  13. Microbiota alterations are linked with gastric cancer (GC). However, the relationship between the oral microbiota (especially oral fungi) and GC is not known. In this study, we aimed to apply 2b-RAD sequencing...

    Authors: Shengfu He, Yating Sun, Weijie Sun, Mingyang Tang, Bao Meng, Yanyan Liu, Qinxiang Kong, Yongxiang Li, Jiawen Yu and Jiabin Li
    Citation: Journal of Translational Medicine 2023 21:831
  14. Advancing personalized medicine in brain cancer relies on innovative strategies, with mRNA vaccines emerging as a promising avenue. While the initial use of mRNA vaccines was in oncology, their stunning succes...

    Authors: Feng Lin, Emma Z. Lin, Misa Anekoji, Thomas E. Ichim, Joyce Hu, Francesco M. Marincola, Lawrence D. Jones, Santosh Kesari and Shashaanka Ashili
    Citation: Journal of Translational Medicine 2023 21:830
  15. Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the start of the pandemic, olfactory dysfunction (OD) has been rep...

    Authors: Bian Hu, Mengdan Gong, Yizhen Xiang, Siyuan Qu, Hai Zhu and Dong Ye
    Citation: Journal of Translational Medicine 2023 21:829
  16. The tumor microenvironment plays a key role in non-small cell lung cancer (NSCLC) development and also influences the effective response to immunotherapy. The pro-inflammatory factor interleukin-17A mediates i...

    Authors: Hua Liao, Xiaodan Chang, Lin Gao, Cuiping Ye, Yujie Qiao, Lingyan Xie, Jie Lin, Shaoxi Cai and Hangming Dong
    Citation: Journal of Translational Medicine 2023 21:828
  17. Cancer-associated fibroblasts (CAFs) are the most abundant stromal cell population in breast tumors. A functionally diverse population of CAFs increases the dynamic complexity of the tumor microenvironment (TM...

    Authors: Wenfeng Zhang, Jia Wang, Cun Liu, Ye Li, Changgang Sun, Jibiao Wu and Qibiao Wu
    Citation: Journal of Translational Medicine 2023 21:827
  18. Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoyla...

    Authors: Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang and Qiang Zhang
    Citation: Journal of Translational Medicine 2023 21:826
  19. Causative genetic variants cannot yet be found for many disorders with a clear heritable component, including chronic fatigue disorders like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). These c...

    Authors: Julia Oakley, Martin Hill, Adam Giess, Mélanie Tanguy and Greg Elgar
    Citation: Journal of Translational Medicine 2023 21:825
  20. The morbidity of cancer keeps growing worldwide, and among that, the colorectal cancer (CRC) has jumped to third. Existing early screening tests for CRC are limited. The aim of this study was to develop a diag...

    Authors: Yang Yang, Zhipeng Wang, Xinxing Li, Jianfeng Lv, Renqian Zhong, Shouhong Gao, Feng Zhang and Wansheng Chen
    Citation: Journal of Translational Medicine 2023 21:824
  21. Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic e...

    Authors: Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He…
    Citation: Journal of Translational Medicine 2023 21:823
  22. Stroke is a common neurological disorder that disproportionately affects middle-aged and elderly individuals, leading to significant disability and mortality. Recently, human blood metabolites have been discov...

    Authors: Tianlong Zhang, Yina Cao, Jianqiang Zhao, Jiali Yao and Gang Liu
    Citation: Journal of Translational Medicine 2023 21:822
  23. Pulmonary hypertension (PH), an infrequent disease, is characterized by excessive pulmonary vascular remodeling and proliferation of pulmonary artery smooth muscle cells (PASMCs). However, its underlying molec...

    Authors: Yingli Liu, Li Zhu, Yue Ming, Zhuhua Wu, Lili Zhang, Qi Chen and Yong Qi
    Citation: Journal of Translational Medicine 2023 21:821
  24. UV-induced cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers. The constant alterations of the lymphatic-centered immune microenvironment are essential in transforming from photoag...

    Authors: Yuling L. Yang, Chu Zhou, Qi Chen, Shuzhan Z. Shen, Jiandan D. Li, Xiuli L. Wang and Peiru R. Wang
    Citation: Journal of Translational Medicine 2023 21:820
  25. The protein tyrosine phosphatase H receptor (PTPRH) is known to regulate the occurrence and development of pancreatic and colorectal cancer. However, its association with glycolysis in non-small cell lung canc...

    Authors: Shu Wang, Zhiming Cheng, Yan Cui, Shuoyan Xu, Qiu Luan, Shan Jing, Bulin Du, Xuena Li and Yaming Li
    Citation: Journal of Translational Medicine 2023 21:819
  26. Anaplastic thyroid carcinoma (ATC) is a deadly disease with a poor prognosis. Thus, there is a pressing need to determine the mechanism of ATC progression. The homeobox D9 (HOXD9) transcription factor has been...

    Authors: Yong Zhong, Fan Yu, Ling Yang, Yu Wang, Lin Liu, Chengyou Jia, Haidong Cai, Jianshe Yang, Shiyang Sheng, Zhongwei Lv, Li Weng, Bo Wu and Xiaoping Zhang
    Citation: Journal of Translational Medicine 2023 21:817
  27. Precancerous lesions of cervical cancer exhibit characteristics indicative of natural progression. To prevent overtreatment of patients whose cervical intraepithelial neoplasia (CIN) in regression and to predi...

    Authors: Yiran Liu, Shuzhen Wang, Jun Liu, Mingrui Su, Xiaoli Diao, Xiaolong Liang, Jianxin Zhang, Qiuxi Wang and Yuxin Zhan
    Citation: Journal of Translational Medicine 2023 21:816
  28. The pivotal role of the tumor microenvironment (TME) in the initiation and advancement of hepatocellular carcinoma (HCC) is widely acknowledged, as it fosters the proliferation and metastasis of HCC cells. Wit...

    Authors: Jingquan Huang, Qiulin Wu, David A. Geller and Yihe Yan
    Citation: Journal of Translational Medicine 2023 21:815
  29. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic and neuropathic symptoms.

    Authors: N. Azcue, R. Del Pino, M. Acera, T. Fernández-Valle, N. Ayo-Mentxakatorre, T. Pérez-Concha, A. Murueta-Goyena, J. V. Lafuente, A. Prada, A. López de Munain, G. Ruiz Irastorza, D. Martín-Iglesias, L. Ribacoba, I. Gabilondo, J. C. Gómez-Esteban and B. Tijero-Merino
    Citation: Journal of Translational Medicine 2023 21:814
  30. Extramedullary disease usually implies a dismal outcome in relapsed/refractory multiple myeloma patients, and requires novel treatment approaches. We designed a trial using Selinexor, a nuclear export protein ...

    Authors: Di Wang, Haiying Fu, Yimei Que, Haitao Ruan, Menglei Xu, Xiaolu Long, Qiuxia Yu, Chunhui Li, Zhe Li, Songbai Cai, Wei Chen, Cong Sun, Guang Hu, Shuai Wang, Donggou He, Jianming Mei…
    Citation: Journal of Translational Medicine 2023 21:812
  31. While the efficacy of neoadjuvant chemotherapy (NACT) in treating triple-negative breast cancer (TNBC) is generally accepted, not all patients derive benefit from this preoperative treatment. Presently, there ...

    Authors: Mohamed Omar, Pier Vitale Nuzzo, Francesco Ravera, Sara Bleve, Giuseppe Nicolò Fanelli, Claudio Zanettini, Itzel Valencia and Luigi Marchionni
    Citation: Journal of Translational Medicine 2023 21:811
  32. Epitranscriptomic abnormalities, which are highly prevalent in primary central nervous system malignancies, have been identified as crucial contributors to the development and progression of gliomas. RNA epitr...

    Authors: Shengrong Long, Yu Yan, Hongyu Xu, Lesheng Wang, Jiazhi Jiang, Ziyue Xu, Runming Liu, Qiangqiang Zhou, Xiaopeng Huang, Jincao Chen, Zhiqiang Li, Wei Wei and Xiang Li
    Citation: Journal of Translational Medicine 2023 21:810
  33. In recent decades, using circulating tumor cell (CTC), circulating tumor DNA (ctDNA), circulating tumor RNA (ctRNA), exosomes and etc. as liquid biomarkers has received enormous attention in various tumors, in...

    Authors: You Shuai, Zhonghua Ma, Jie Ju, Tong Wei, Songlin Gao, Yikun Kang, Zixuan Yang, Xue Wang, Jian Yue and Peng Yuan
    Citation: Journal of Translational Medicine 2023 21:809
  34. Sirtuin 7 (SIRT7) is an oncogene that promotes tumor progression in various malignancies, however, its role and regulatory mechanism in cervical squamous cell carcinoma (CSCC) is unknown. Herein, we attempted ...

    Authors: Juanpeng Yu, Shuai Yuan, Jinglin Song and Shengsheng Yu
    Citation: Journal of Translational Medicine 2023 21:807
  35. Cardiovascular disease (CVD) is a major complication in type 1 diabetes mellitus (T1D) patients. Previous studies have suggested that statins may be helpful for prevention of CVD in T1D, but there are limited ...

    Authors: Joonsang Yoo, Jimin Jeon, Minyoul Baek, Sun Ok Song and Jinkwon Kim
    Citation: Journal of Translational Medicine 2023 21:806
  36. Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial lung disease. Clinical models to accurately evaluate the prognosis of IPF are currently lacking. This study aimed to construct an ...

    Authors: Xiaoyun Cheng, Zhichao Feng, Boyu Pan, Qingxiang Liu, Yuanyuan Han, Lijun Zou, Pengfei Rong and Jie Meng
    Citation: Journal of Translational Medicine 2023 21:805
  37. Previous serological studies have indicated an association between viruses and atypical pathogens and Chronic Fatigue Syndrome (CFS). This study aims to investigate the correlation between infections from comm...

    Authors: Hsun Chang, Chien-Feng Kuo, Teng-Shun Yu, Liang-Yin Ke, Chung-Lieh Hung and Shin-Yi Tsai
    Citation: Journal of Translational Medicine 2023 21:804
  38. Tregs are key drivers of immunosuppression in solid tumors. As an important chemokine receptor on Tregs, the regulatory effect of CCR8 on tumor immunity has received more and more attention. However, the curre...

    Authors: Shuna Liu, Ziqi Tao, Jianfang Lou, Rong Li, Xin Fu, Juan Xu, Ting Wang, Lei Zhang, Wenwen Shang, Yepeng Mao and Fang Wang
    Citation: Journal of Translational Medicine 2023 21:803
  39. Wharton’s Jelly (WJ) Mesenchymal Stromal Cells (MSC) have emerged as an attractive allogeneic therapy for a number of indications, except for bone-related conditions requiring new tissue formation. This may be...

    Authors: Raquel Cabrera-Pérez, Alexis Ràfols-Mitjans, Ángela Roig-Molina, Silvia Beltramone, Joaquim Vives and Laura Batlle-Morera
    Citation: Journal of Translational Medicine 2023 21:802
  40. Skin cutaneous melanoma (SKCM) is the most aggressive skin cancer, accounting for more than 75% mortality rate of skin-related cancers. As a newly identified programmed cell death, pyroptosis has been found to...

    Authors: Shixin Zhao, Yongkang Zhu, Hengdeng Liu, Xuefeng He and Julin Xie
    Citation: Journal of Translational Medicine 2023 21:801
  41. Accumulating evidence supports the significant role of human microbiome in development and therapeutic response of tumors. Circulating microbial DNA is non-invasive and could show a general view of the microbi...

    Authors: Xiaohan Zhou, Liting You, Zhaodan Xin, Huiting Su, Juan Zhou and Ying Ma
    Citation: Journal of Translational Medicine 2023 21:800
  42. Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the...

    Authors: Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó and Sevil Korkmaz-Icöz
    Citation: Journal of Translational Medicine 2023 21:799
  43. The 70-gene signature (70-GS, MammaPrint) test has been recommended by the main guidelines to evaluate prognosis and chemotherapy benefit of hormonal receptor positive human epidermal receptor 2 negative (HR +...

    Authors: Bo Pan, Ying Xu, Ru Yao, Xi Cao, Xingtong Zhou, Zhixin Hao, Yanna Zhang, Changjun Wang, Songjie Shen, Yanwen Luo, Qingli Zhu, Xinyu Ren, Lingyan Kong, Yidong Zhou and Qiang Sun
    Citation: Journal of Translational Medicine 2023 21:798
  44. Epilepsy affects over 65 million people worldwide and significantly burdens patients, caregivers, and society. Drug-resistant epilepsy occurs in approximately 30% of patients and growing evidence indicates tha...

    Authors: Sereen Sandouka, Prince Kumar Singh, Aseel Saadi, Rhoda Olowe Taiwo, Yara Sheeni, Taige Zhang, Larin Deeb, Michelle Guignet, Steve H. White and Tawfeeq Shekh-Ahmad
    Citation: Journal of Translational Medicine 2023 21:796
  45. With the development of organic germanium and nanotechnology, germanium serves multiple biological functions, and its potential value in biochemistry and medicine has increasingly captured the attention of res...

    Authors: Xiao Luo, Jiaxue Sun, Deshenyue Kong, Yi Lei, Fangyou Gong, Tong Zhang, Zongwen Shen, Kunhua Wang, Huayou Luo and Yu Xu
    Citation: Journal of Translational Medicine 2023 21:795
  46. The occurrence and progression of tumors can be established through a complex interplay among tumor cells undergoing epithelial-mesenchymal transition (EMT), invasive factors and immune cells. In this study, w...

    Authors: Muhong Wang, Chunyu Deng, Cheng Yang, Mingze Yan, Haibo Lu, Yan Zhang, Honghao Liu, Zhekuan Tong, Jiaao Ma, Jiaming Wang, Yan Zhang, Jiahao Wang, Yuhong Xuan, Haiyue Cheng, Kai Zhao, Jiaqi Zhang…
    Citation: Journal of Translational Medicine 2023 21:794

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