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  1. Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor. E3 ligases play important functions in glioma pathogenesis. CRISPR system offers a powerful platform for genome manipulation,...

    Authors: Kun Lin, Shang-Hang Shen, Feng Lu, Pengfeng Zheng, Shizhong Wu, Jingwei Liao, Xiaohang Jiang, Guangming Zeng and De Wei
    Citation: Journal of Translational Medicine 2022 20:96
  2. Orthostatic intolerance-OI is common in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-ME/CFS. We used a 10-min passive vertical lean test as orthostatic challenge-OC and measured changes in vitals and end...

    Authors: Benjamin H. Natelson, Jin-Mann S. Lin, Michelle Blate, Sarah Khan, Yang Chen and Elizabeth R. Unger
    Citation: Journal of Translational Medicine 2022 20:95
  3. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS remains elusive, reduced natural killer (NK) cell cytotoxic function i...

    Authors: Natalie Eaton-Fitch, Stanley Du Preez, Hélène Cabanas, Katsuhiko Muraki, Donald Staines and Sonya Marshall-Gradisnik
    Citation: Journal of Translational Medicine 2022 20:94
  4. This study aimed to use bioinformatics methods to characterize epigenetic changes in terms of micro-RNA(miRNA) expression and DNA methylation during adipogenesis. The mRNA and miRNA expression microarray and D...

    Authors: Yong Zhang, Fancheng Chen, Fangxue Zhang and Xiaowei Huang
    Citation: Journal of Translational Medicine 2022 20:93
  5. Chemoresistance gradually develops during treatment of epithelial ovarian cancer (EOC). Metabolic alterations, especially in vivo easily detectable metabolites in paclitaxel (PTX)-resistant EOC remain unclear.

    Authors: Jing Lu, Ying Li, Yong Ai Li, Li Wang, An Rong Zeng, Xiao Liang Ma and Jin Wei Qiang
    Citation: Journal of Translational Medicine 2022 20:92
  6. Prostate cancer is the second most common cancer in men, and some new target genes are needed to predict the risk of prostate cancer progression and the treatment.

    Authors: Xing-cheng Wu, Yu-zhong Yu, Yu-zhi Zuo, Xian-Lu Song, Zhi-en Zhou, Yu Xiao, Dao-sheng Luo, Wei-gang Yan and Shan-Chao Zhao
    Citation: Journal of Translational Medicine 2022 20:91
  7. The number of elderly patients with early renal cell carcinoma (RCC) is on the rise. However, there is still a lack of accurate prediction models for the prognosis of early RCC in elderly patients. It is neces...

    Authors: Jinkui Wang, Jie Tang, Tiaoyao Chen, Song Yue, Wanting Fu, Zulong Xie and Xiaozhu Liu
    Citation: Journal of Translational Medicine 2022 20:90
  8. Adiponectin is an adipocyte-secreted cytokine that enhances insulin sensitivity and attenuates inflammation. Although circulating adiponectin level is often inversely associated with several malignancies, its...

    Authors: Zongmeng Zhang, Jinlin Du, Hui Shi, Shuai Wang, Yunjing Yan, Qihua Xu, Sujin Zhou, Zhenggang Zhao, Yunping Mu, Chaonan Qian, Allan Zijian Zhao, Sumei Cao and Fanghong Li
    Citation: Journal of Translational Medicine 2022 20:89
  9. The effect of the cytochrome P450 oxidoreductase (POR) rs10954732 (G > A) polymorphism on hepatocellular carcinoma (HCC) susceptibility is unknown. Here we found that A allele carriers showed a 69% decrease in su...

    Authors: Yan Fang, Hongming Yang, Guiming Hu, Jiakun Lu, Jun Zhou, Na Gao, Yuhan Gu, Cunzhen Zhang, Jinhuan Qiu, Yuanyuan Guo, Yunfei Zhang, Qiang Wen and Hailing Qiao
    Citation: Journal of Translational Medicine 2022 20:88
  10. Type 2 diabetes mellitus (T2DM) is caused by a combination of environmental, genetic, and epigenetic factors including, fasting blood glucose (FBG), genetic variant rs841853, and cg19693031 methylation. We eva...

    Authors: Hao-Hung Tsai, Chao-Yu Shen, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Oswald Ndi Nfor, Shin-Lin Chiu, Ying-Hsiang Chou and Yung-Po Liaw
    Citation: Journal of Translational Medicine 2022 20:87
  11. Peroxisome proliferator-activated receptor-beta/delta (PPARδ) was considered as the key regulator involved in the evolution of various tumors. Given that PPARδ potential role in hepatocellular carcinoma (HCC) ...

    Authors: Wei Han, Nan Wang, Rui Kong, Wen Bao and Jie Lu
    Citation: Journal of Translational Medicine 2022 20:86
  12. Rheumatoid arthritis (RA) is a progressive systemic autoimmune disease that is characterized by infiltration of inflammatory cells into the hyperplastic synovial tissue, resulting in subsequent destruction of ...

    Authors: Jin-Sil Park, Donghyun Lee, SeungCheon Yang, Ha Yeon Jeong, Hyun Sik Na, Keun-Hyung Cho, JeongWon Choi, Heebeom Koo, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2022 20:85
  13. Epithelial–mesenchymal transition (EMT) is a dynamic and complex cellular process that is known to be hijacked by cancer cells to facilitate invasion, metastasis and therapeutic resistance. Several quantitativ...

    Authors: Ankit P. Jain, Janani Sambath, Gajanan Sathe, Irene A. George, Akhilesh Pandey, Erik W. Thompson and Prashant Kumar
    Citation: Journal of Translational Medicine 2022 20:84
  14. Significant links between the microbiota and human health have emerged in the last 20 years. A correlation has recently been demonstrated between changes in the gut microbiota and the development of cancer. Th...

    Authors: Sa’ed H. Zyoud, Samah W. Al-Jabi, Riad Amer, Muna Shakhshir, Moyad Shahwan, Ammar A. Jairoun, Maha Akkawi and Adham Abu Taha
    Citation: Journal of Translational Medicine 2022 20:83
  15. B cell maturation antigen (BCMA), a transmembrane glycoprotein member of the tumor necrosis factor receptor superfamily 17 (TNFRSF17), highly expressed on the plasma cells of Multiple myeloma (MM) patients, as...

    Authors: Shirin Teymouri Nobari, Jafar Nouri Nojadeh and Mehdi Talebi
    Citation: Journal of Translational Medicine 2022 20:82
  16. Abnormal maternal lipid concentrations are associated with increased risk of preeclampsia. However, previous studies mainly focused on fasting lipid concentrations, scarce data have been published on the relat...

    Authors: Qing Liu, Zhihong Zhu, Wen Cai, Liu Yang, ShuangDi Li and Jiarong Zhang
    Citation: Journal of Translational Medicine 2022 20:81
  17. Papillary thyroid carcinoma (PTC) is one of most prevalent malignant endocrine neoplasms, and it is associated with a high frequency of BRAF gene mutations, which lead to lymphatic metastasis and distant metas...

    Authors: Xing Chen, Shan Lin, Ying Lin, Songsong Wu, Minling Zhuo, Ailong Zhang, Junjie Zheng and Zhenhui You
    Citation: Journal of Translational Medicine 2022 20:79
  18. Adrenocortical carcinoma (ACC) is an aggressive and rare malignant tumor and is prone to local invasion and metastasis. And, overexpressed Centromere Protein F (CENPF) is closely related to the oncogenesis of ...

    Authors: Yu-gang Huang, Dan Li, Li Wang, Xiao-min Su and Xian-bin Tang
    Citation: Journal of Translational Medicine 2022 20:78
  19. Cardiovascular impairment contributes to increased mortality in preterm infants with chronic lung disease. Macitentan, an endothelin-1 receptor antagonist, has the potential to attenuate pulmonary and cardiova...

    Authors: Philipp Baumann, Francesco Greco, Susanne Wiegert, Sven Wellmann, Giovanni Pellegrini and Vincenzo Cannizzaro
    Citation: Journal of Translational Medicine 2022 20:77
  20. Chronic obstructive pulmonary disease (COPD) is a prevalent, progressive respiratory disease, and acute exacerbations of COPD (AECOPD) can accelerate the deterioration of the disease. Increasing evidence sugge...

    Authors: Linfan Su, Yixian Qiao, Jinmei Luo, Rong Huang, Zhiwei Li, Hongbing Zhang, Hongmei Zhao, Jing Wang and Yi Xiao
    Citation: Journal of Translational Medicine 2022 20:76
  21. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play important roles in the metastasis and recurrence of hepatocellular carcinoma (HCC). A kinds of lncRNAs were found to be involved in regulatin...

    Authors: Zhanjun Chen, Leyang Xiang, Longhai Li, Huohui Ou, Yinghao Fang, Yuyan Xu, Qin Liu, Zhigang Hu, Yu Huang, Xianghong Li and Dinghua Yang
    Citation: Journal of Translational Medicine 2022 20:75
  22. Free circular RNAs(circRNAs) escaping from primary lesion of cancer to brain are strictly regulated by blood–brain barrier and therefore cerebrospinal fluid (CSF) circRNAs have potential advantage in exploring...

    Authors: Zhen Wang, Ruoying Yu, Xiaoxi Chen, Hua Bao, Ran Cao, An-Na Li, Qiuxiang Ou, Hai-Yan Tu, Qing Zhou, Xue Wu, Zhi-Bo Lin and Yi-Long Wu
    Citation: Journal of Translational Medicine 2022 20:74
  23. Nearly 250,000 veterans from the 1990–1991 Gulf War have Gulf War Illness (GWI), a condition with heterogeneous pathobiology that remains difficult to diagnose. As such, availability of blood biomarkers that r...

    Authors: Sarah Oberlin, Aurore Nkiliza, Megan Parks, James E. Evans, Nancy Klimas, Andrew P. Keegan, Kimberly Sullivan, Maxine H. Krengel, Michael Mullan, Fiona Crawford and Laila Abdullah
    Citation: Journal of Translational Medicine 2022 20:73
  24. Lung cancer remains a huge challenge to public health because of its high incidence and mortality, and lung adenocarcinoma (LUAD) is the main subtype of lung cancer. Hypoxia-induced vascular endothelial growth...

    Authors: Zhi Xia, Jian Xiao, Ziyu Dai and Qiong Chen
    Citation: Journal of Translational Medicine 2022 20:72
  25. Cancer screening provides the opportunity to detect cancer early, ideally before symptom onset and metastasis, and offers an increased opportunity for a better prognosis. The ideal biomarkers for cancer screen...

    Authors: Yue Yin, Ruilan Jiang, Mingwang Shen, Zhaofang Li, Ni Yan, Junqiao Feng, Hong Jiang, Jiaxin Lv, Lijuan Shi, Lina Wang, Xi Liu, Kaiyun Zhang and Di Chen
    Citation: Journal of Translational Medicine 2022 20:71
  26. Glioblastoma is currently an incurable cancer. Genome-wide association studies have demonstrated that 41 genetic variants are associated with glioblastoma and may provide an option for drug development.

    Authors: Wei-Zhi Lin, Yen-Chun Liu, Meng-Chang Lee, Chi-Tun Tang, Gwo-Jang Wu, Yu-Tien Chang, Chi-Ming Chu and Chia-Yang Shiau
    Citation: Journal of Translational Medicine 2022 20:70
  27. The treatment of sepsis remains a major challenge worldwide. Aminophylline has been shown to have anti-inflammatory effects; however, the role of aminophylline in sepsis, a disease characterized by immune dysr...

    Authors: Yuanzhe Li, Huayan Zhao, Guiying Sun, Yongtao Duan, Yanjun Guo, Lina Xie and Xianfei Ding
    Citation: Journal of Translational Medicine 2022 20:69
  28. Chinese herbal medicine is made up of hundreds of natural drug molecules and has played a major role in traditional Chinese medicine (TCM) for several thousand years. Therefore, it is of great significance to ...

    Authors: Pengcheng Zhao, Lin Lin, Mozheng Wu, Lili Wang, Qi Geng, Li Li, Ning Zhao, Jianyu Shi and Cheng Lu
    Citation: Journal of Translational Medicine 2022 20:67
  29. To develop and validate a survival model with clinico-biological features and 18F- FDG PET/CT radiomic features via machine learning, and for predicting the prognosis from the primary tumor of colorectal cancer.

    Authors: Lilang Lv, Bowen Xin, Yichao Hao, Ziyi Yang, Junyan Xu, Lisheng Wang, Xiuying Wang, Shaoli Song and Xiaomao Guo
    Citation: Journal of Translational Medicine 2022 20:66
  30. Revealing the impacts of endogenous and exogenous mutagenesis processes is essential for understanding the etiology of somatic genomic alterations and designing precise prognostication and treatment strategies...

    Authors: Amir Farmanbar, Sanaz Firouzi, Robert Kneller and Hossein Khiabanian
    Citation: Journal of Translational Medicine 2022 20:65
  31. Diffuse hemispheric glioma H3 G34-mutant (G34-DHG) is a new type of pediatric-type diffuse high-grade glioma in the fifth edition of the WHO Classification of Tumors of the Central Nervous System. The current ...

    Authors: Wanming Hu, Hao Duan, Sheng Zhong, Jing Zeng and Yonggao Mou
    Citation: Journal of Translational Medicine 2022 20:64
  32. The study investigated the predictive value of tumor angiogenesis observed by 18F-ALF-NOTA-PRGD2 II (denoted as 18F-Alfatide II) positron emission tomography (PET)/computed tomography (CT) before concurrent chemo...

    Authors: Yuchun Wei, Xueting Qin, Xiaoli Liu, Jinsong Zheng, Xiaohui Luan, Yue Zhou, Jinming Yu and Shuanghu Yuan
    Citation: Journal of Translational Medicine 2022 20:63
  33. Cutaneous melanoma exhibits heterogeneous metastatic patterns and prognosis. In this regard, liver metastasis, which is detected in ~ 10–20% of stage 4 patients, came to the fore of melanoma research, as it re...

    Authors: Sebastian A. Wohlfeil, Verena Häfele, Bianca Dietsch, Céline Weller, Carsten Sticht, Anna Sophia Jauch, Manuel Winkler, Christian David Schmid, Anna Lena Irkens, Ana Olsavszky, Kai Schledzewski, Philipp-Sebastian Reiners-Koch, Sergij Goerdt and Cyrill Géraud
    Citation: Journal of Translational Medicine 2022 20:62
  34. The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) have been used to predict therapeutic response in ...

    Authors: Xinke Zhang, A. Gari, Mei Li, Jierong Chen, Chunhua Qu, Lihong Zhang and Jiewei Chen
    Citation: Journal of Translational Medicine 2022 20:61
  35. High intensity interval training (HIIT) has been reported to exert better effects on cardiovascular fitness in obesity, but little known about the arterial stiffness (AS) in female university students with nor...

    Authors: Jingyun Hu, Min Liu, Ruoyu Yang, Liyan Wang, Leichao Liang, Yuanyuan Yang, Shihao Jia, Ruiyi Chen, Qianle Liu, Yu Ren, Lei Zhu and Ming Cai
    Citation: Journal of Translational Medicine 2022 20:60
  36. Colon cancer is a common malignant tumor of the digestive tract, and its incidence is ranked third among gastrointestinal tumors. The present study aims to investigate the role of a novel circular RNA (circCSP...

    Authors: Jin Wang, Lei Zhou, Bingxin Chen, Zhuwen Yu, Jianglei Zhang, Zhe Zhang, Chenrui Hu, Yanjin Bai, Xiaokang Ruan, Shengjia Wang, Jun Ouyang, Airong Wu and Xin Zhao
    Citation: Journal of Translational Medicine 2022 20:58
  37. Long non-coding RNAs (lncRNAs) are involved in the development of hepatocellular carcinoma (HCC). We aimed to investigate the function of LINC01146 in HCC.

    Authors: Xiaoyun Ma, Meile Mo, Chao Tan, Jennifer Hui Juan Tan, Huishen Huang, Bihu Liu, Dongping Huang, Shun Liu, Xiaoyun Zeng and Xiaoqiang Qiu
    Citation: Journal of Translational Medicine 2022 20:57
  38. Chronic tinnitus affects millions of people globally and constitutes the most commonly compensated disability among military service members in the United States. Existing treatment options largely surround he...

    Authors: John P. Marinelli, C. Lane Anzalone, Christoph M. Prummer, Gayla L. Poling, Jeffrey P. Staab, Nicole M. Tombers, Christine M. Lohse and Matthew L. Carlson
    Citation: Journal of Translational Medicine 2022 20:56
  39. Emerging evidences have indicated that the aberrant liquid–liquid phase separation (LLPS) leads to the dysfunction of biomolecular condensates, thereby contributing to the tumorigenesis and progression. Nevert...

    Authors: Jianglin Zheng, Zhipeng Wu, Yue Qiu, Xuan Wang and Xiaobing Jiang
    Citation: Journal of Translational Medicine 2022 20:55
  40. Chronic kidney disease (CKD) is characterized by high morbidity and mortality and is difficult to cure. Renal interstitial fibrosis (RIF) is a major determinant of, and commonly occurs within, CKD progression....

    Authors: Jieqing Zhou, Hong Jiang, Hongkun Jiang, Yan Fan, Jing Zhang, Xiaoxue Ma, Xuewei Yang, Yu Sun and Xing Zhao
    Citation: Journal of Translational Medicine 2022 20:54
  41. The transformation of hepatic stellate cell (HSC) to myofibroblast is a key event during liver fibrogenesis. However, the differentiation trajectory of HSC-to-myofibroblast transition and the switching genes d...

    Authors: Hua Wang, Shaoping Zheng, Hongbo Jiang, Xuejia Wang, Fengqin Zhou and Zhihong Weng
    Citation: Journal of Translational Medicine 2022 20:53
  42. It is widely acknowledged that gastric cancer seriously affects the quality of life and survival of patients. The correlation between the microbiota and gastric cancer has attracted extensive attention in rece...

    Authors: Yan Yang, Yingying Huang, Wu Lin, Jin Liu, Xiangliu Chen, Chuanzhi Chen, Xiongfei Yu and Lisong Teng
    Citation: Journal of Translational Medicine 2022 20:52
  43. Cervical cancer (CC) is one of the most common gynecological tumors that threatens women's health and lives. Aberrant expression of PIWI-interacting RNA (piRNA) is closely related with a range of cancers and c...

    Authors: Qi Xie, Zhen Li, Xiao Luo, Dan Wang, Yao Zhou, Jingge Zhao, Suhua Gao, Yongguang Yang, Wanying Fu, Lingfei Kong and Tingyi Sun
    Citation: Journal of Translational Medicine 2022 20:51
  44. Gastric cancer (GC) is the fifth leading cause of cancer-related death worldwide and is accompanied by low diagnosis and survival rates. The molecular mechanism of GC must be elucidated to improve treatment st...

    Authors: Zhijun Geng, Jing Li, Sandang Li, Yueyue Wang, Lele Zhang, Qiuzi Hu, Xinru Wang, Lugen Zuo, Xue Song, Xiaofeng Zhang, Sitang Ge and Jianguo Hu
    Citation: Journal of Translational Medicine 2022 20:50
  45. Identification of novel biomarker is important for development of molecular-targeted therapy agents for patients with hepatocellular carcinoma (HCC). This study aims to identify potential prognostic biomarkers...

    Authors: Zengwei Tang, Yuan Yang, Wen Chen, Enliang Li and Tingbo Liang
    Citation: Journal of Translational Medicine 2022 20:49

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