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  1. Breast cancer remains one of the most dreadful female malignancies globally, in which cancer stem cells (CSCs) play crucial functions. Circular RNAs have drawn great attention in cancer research area and propo...

    Authors: Yi-Ping Liu, Jin-Yu Heng, Xin-Yu Zhao and En-You Li

    Citation: Journal of Translational Medicine 2021 19:467

    Content type: Research

    Published on:

  2. Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts of selected patients with cardiac arrest (CA), extracorporeal membrane oxygenation (ECMO) includes an artificial oxygenati...

    Authors: Tai Yin, Lance B. Becker, Rishabh C. Choudhary, Ryosuke Takegawa, Muhammad Shoaib, Koichiro Shinozaki, Yusuke Endo, Koichiro Homma, Daniel M. Rolston, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Tomoaki Aoki, Santiago J. Miyara…

    Citation: Journal of Translational Medicine 2021 19:462

    Content type: Research

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  3. Abdominal aortic aneurysm (AAA), an irreversible cardiovascular disease prevalent in the artery, causes the increase of the aneurysm diameter over time, and is a fatal phenomenon inducing sidewall rupture. Lon...

    Authors: Tianming Le, Xin He, Jianhua Huang, Shuai Liu, Yang Bai and Kemin Wu

    Citation: Journal of Translational Medicine 2021 19:466

    Content type: Research

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  4. Despite much evidence supporting the monitoring of the divergence of transcutaneous partial pressure of carbon dioxide (tcPCO2) from arterial partial pressure carbon dioxide (artPCO2) as an indicator of the shock...

    Authors: Yusuke Endo, Taku Hirokawa, Taku Miyasho, Ryosuke Takegawa, Koichiro Shinozaki, Daniel M. Rolston, Lance B. Becker and Kei Hayashida

    Citation: Journal of Translational Medicine 2021 19:390

    Content type: Research

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  5. Toll-like receptors (TLRs) on neutrophils play a crucial role in detecting pathogens and organ/tissue injury in acute-on-chronic liver failure (ACLF). However, little is known about the exact mechanisms and po...

    Authors: Yi Zhang, Wei Wu, Yijie Wang, Lingjia Tong, Meng Hong, Qi Xia and Zhi Chen

    Citation: Journal of Translational Medicine 2021 19:465

    Content type: Research

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  6. Intestinal ischemia/reperfusion (I/R) injury commonly occurs during perioperative periods, resulting in high morbidity and mortality on a global scale. Dexmedetomidine (Dex) is a selective α2-agonist that is f...

    Authors: Qin Zhang, Xiao-Ming Liu, Qian Hu, Zheng-Ren Liu, Zhi-Yi Liu, Huai-Gen Zhang, Yuan-Lu Huang, Qiu-Hong Chen, Wen-Xiang Wang and Xue-Kang Zhang

    Citation: Journal of Translational Medicine 2021 19:463

    Content type: Research

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  7. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease which involves multiple body systems (e.g., immune, nervous, digestive, circulatory) and research domains (e.g., immunology...

    Authors: Ravi Mathur, Megan U. Carnes, Alexander Harding, Amy Moore, Ian Thomas, Alex Giarrocco, Michael Long, Marcia Underwood, Christopher Townsend, Roman Ruiz-Esparza, Quinn Barnette, Linda Morris Brown and Matthew Schu

    Citation: Journal of Translational Medicine 2021 19:461

    Content type: Research

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  8. Sarcoidosis is an inflammatory disease characterized by the formation of granulomas, which involve the heart in up to 25% of patients. Cardiac sarcoidosis can lead to life threatening arrhythmias and heart fai...

    Authors: Jordana Kron, Thomas Crawford, Virginia Mihalick, Frank Bogun, Jennifer H. Jordan, Todd Koelling, Huzaefah Syed, Aamer Syed, Thomas Iden, Kelly Polly, Emily Federmann, Kirsta Bray, Sangeeta Lathkar-Pradhan, Shilpa Jasti, Lynda Rosenfeld, David Birnie…

    Citation: Journal of Translational Medicine 2021 19:460

    Content type: Protocol

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  9. Adoptive transfer of chimeric antigen receptor (CAR)-engineered T cells combined with checkpoint inhibition may prevent T cell exhaustion and improve clinical outcomes. However, the approach is limited by cumu...

    Authors: Zhifen Yang, Lingyu Li, Ahu Turkoz, Pohan Chen, Rona Harari-Steinfeld, Maggie Bobbin, Ofir Stefanson, Hana Choi, Violena Pietrobon, Bennett Alphson, Angshumala Goswami, Vitaly Balan, Alper Kearney, Dharmesh Patel, Jin Yang, Damla Inel…

    Citation: Journal of Translational Medicine 2021 19:459

    Content type: Research

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  10. Induction of long-term synaptic depression (LTD) is proposed as a treatment mechanism for chronic pain but remains untested in clinical populations. Two interlinked studies; (1) A patient-assessor blinded, ran...

    Authors: Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl and Andreas Goebel

    Citation: Journal of Translational Medicine 2021 19:458

    Content type: Research

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  11. Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and hard periodontal tissues. Complete periodontal regeneration in clinics using the currently available treatment app...

    Authors: Hongbing Lin, Huishan Chen, Xuetao Zhao, Zhen Chen, Peipei Zhang, Yue Tian, Yawei Wang, Tong Ding, Lijing Wang and Yuqin Shen

    Citation: Journal of Translational Medicine 2021 19:456

    Content type: Review

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  12. Circular RNAs (circRNAs) are pivotal regulators of various human cancers and circ-ERBB2 is abnormally expressed in breast cancer cells. However, the role and mechanism of circ-ERBB2 in HER2-positive breast can...

    Authors: Jin-xiu Zhong, Yun-yuan Kong, Rong-guang Luo, Guo-jin Xia, Wen-xing He, Xue-zhong Chen, Wei-wei Tan, Qing-jie Chen, Yu-yin Huang and Yan-xing Guan

    Citation: Journal of Translational Medicine 2021 19:455

    Content type: Research

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  13. Ovarian cancer was one of the leading causes of female deaths. Patients with OC were essentially incurable and portends a poor prognosis, presumably because of profound genetic heterogeneity limiting reproduci...

    Authors: Hongyu Zhao, Yu Teng, Wende Hao, Jie Li, Zhefeng Li, Qi Chen, Chenghong Yin and Wentao Yue

    Citation: Journal of Translational Medicine 2021 19:454

    Content type: Research

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  14. HIV-1 reservoirs persist in the presence of combined antiretroviral therapy (cART). However, cART has transformed HIV-1 infection into a chronic disease marked by control of HIV-1 viral load and mortality redu...

    Authors: Matthew Weichseldorfer, Yvonne Affram, Alonso Heredia, Zahra Rikhtegaran-Tehrani, Mohammad M. Sajadi, Sumiko P. Williams, Yutaka Tagaya, Francesca Benedetti, Habib O. Ramadhani, Frank Denaro, Arshi Munawwar, Joseph Bryant, Davide Zella, Marvin Reitz, Fabio Romerio and Olga S. Latinovic

    Citation: Journal of Translational Medicine 2021 19:453

    Content type: Research

    Published on:

  15. The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible progress in treating the disease such that the mean survival age of individuals living with CF is now ~58 years in Canada...

    Authors: Jin-A Lee, Alex Cho, Elena N. Huang, Yiming Xu, Henry Quach, Jim Hu and Amy P. Wong

    Citation: Journal of Translational Medicine 2021 19:452

    Content type: Review

    Published on:

  16. Hypertrophic scar (HTS) is a fibrotic disorder of skins and may have repercussions on the appearance as well as functions of patients. Recent studies related have shown that competitive endogenous RNA (ceRNA) ...

    Authors: Zewei Zhang, Xin Huang, Jiahao Yang, Shuchen Gu, Yixuan Zhao, Yunhan Liu, Yimin Khoong, Shuqi Wang, Shenying Luo, Tao Zan and Guangshuai Li

    Citation: Journal of Translational Medicine 2021 19:451

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2022 20:35

  17. Osteosarcoma (OS) is the most frequent primary bone cancer, affecting mostly children and adolescents. Although much progress has been made throughout the years towards treating primary OS, the 5-year survival...

    Authors: Taiana Campos Leite, Rebecca Jean Watters, Kurt Richard Weiss and Giuseppe Intini

    Citation: Journal of Translational Medicine 2021 19:450

    Content type: Review

    Published on:

  18. Cancer is one of the most serious diseases threatening human health. Cancer immunotherapy represents the most promising treatment strategy due to its high efficacy and selectivity and lower side effects compar...

    Authors: Shihu Jiao, Quan Zou, Huannan Guo and Lei Shi

    Citation: Journal of Translational Medicine 2021 19:449

    Content type: Research

    Published on:

  19. Established clinical assessments for detecting dementia risk often require time, cost, and face-to-face meetings. We aimed to develop a Simplified Telephone Assessment for Dementia risk (STAD) (a new screening...

    Authors: Keitaro Makino, Sangyoon Lee, Seongryu Bae, Ippei Chiba, Kenji Harada, Osamu Katayama, Yohei Shinkai and Hiroyuki Shimada

    Citation: Journal of Translational Medicine 2021 19:448

    Content type: Research

    Published on:

  20. Ovarian cancer, a highly metastatic malignancy, has benefited tremendously from advances in modern human genomics. However, the genomic variations related to the metastasis remains unclear.

    Authors: Mengyao Xu, Shan Huang, Jiahui Chen, Wanxue Xu, Rong Xiang, Yongjun Piao and Shuangtao Zhao

    Citation: Journal of Translational Medicine 2021 19:447

    Content type: Research

    Published on:

  21. Young patients with colorectal cancer (CRC) exhibit poor prognoses compared to older patients due to the difficulty in early diagnosis and treatment. However, the underlying molecular characteristics are still...

    Authors: Tae Won Kim, Hye Kyung Hong, Chung Lee, Sunmin Kim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Jung Wook Huh, Yoon Ah Park, Je-Gun Joung, Woong-Yang Park and Yong Beom Cho

    Citation: Journal of Translational Medicine 2021 19:446

    Content type: Research

    Published on:

  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hongyu Zhang, Fenzan Wu, Xiaoxia Kong, Jie Yang, Huijun Chen, Liancheng Deng, Yi Cheng, Libing Ye, Sipin Zhu, Xie Zhang, Zhouguang Wang, Hongxue Shi, Xiaobing Fu, Xiaokun Li, Huazi Xu, Li Lin…

    Citation: Journal of Translational Medicine 2021 19:445

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2014 12:130

  23. High-grade glioma has a poor prognosis, and GSCs can have pivotal roles in glioma pathology. This study investigated GSC exosome-containing circRNA mechanisms affecting the malignant progression of glioma.

    Authors: Guowei Li and Qing Lan

    Citation: Journal of Translational Medicine 2021 19:444

    Content type: Research

    Published on:

  24. This study aimed to evaluate the utility of radiomics-based machine learning analysis with multiparametric DWI and to compare the diagnostic performance of radiomics features and mean diffusion metrics in the ...

    Authors: Kun Sun, Zhicheng Jiao, Hong Zhu, Weimin Chai, Xu Yan, Caixia Fu, Jie-Zhi Cheng, Fuhua Yan and Dinggang Shen

    Citation: Journal of Translational Medicine 2021 19:443

    Content type: Research

    Published on:

  25. Authors: Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner…

    Citation: Journal of Translational Medicine 2021 19:442

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2020 18:405

  26. Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of bitterness. Although in the fir...

    Authors: Kamila Tuzim and Agnieszka Korolczuk

    Citation: Journal of Translational Medicine 2021 19:440

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:478

  27. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yuan Chi, Zheng Gong, He Xin, Ziwen Wang and Zhaoyu Liu

    Citation: Journal of Translational Medicine 2021 19:438

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2020 18:126

  28. Radiotherapy (RT) still represents a mainstay of treatment in clinical oncology. Traditionally, the effectiveness of radiotherapy has been attributed to the killing potential of ionizing radiation (IR) over ma...

    Authors: Turid Hellevik, Rodrigo Berzaghi, Kristin Lode, Ashraful Islam and Inigo Martinez-Zubiaurre

    Citation: Journal of Translational Medicine 2021 19:437

    Content type: Review

    Published on:

  29. The number of older people is estimated to increase from 524 million in 2010 to 1.5 billion in 2050. The factors and models of human longevity and successful aging are questions that have intrigued individuals...

    Authors: Shihui Fu, Ping Ping, Yulong Li, Bo Li, Yali Zhao, Yao Yao and Pei Zhang

    Citation: Journal of Translational Medicine 2021 19:436

    Content type: Research

    Published on:

  30. Authors: Dan Wang, Weitang Yuan, Yaping Wang, Qian Wu, Li Yang, Feng Li, Xinfeng Chen, Zhen Zhang, Weina Yu, Nomathamsanqa Resegofetse Maimela, Ling Cao, Dong Wang, Junxia Wang, Zhenqiang Sun, Jinbo Liu and Yi Zhang

    Citation: Journal of Translational Medicine 2021 19:435

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2019 17:253

  31. Authors: Qilu Wei, Ning Kong, Xiaohui Liu, Run Tian, Ming Jiao, Yiyang Li, Huanshuai Guan, Kunzheng Wang and Pei Yang

    Citation: Journal of Translational Medicine 2021 19:434

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2021 19:157

  32. Colorectal carcinoma (CRC) harboring oncogenic fusions has been reported to be highly enriched in mismatch repair deficient (dMMR) tumors with MLH1 hypermethylation (MLH1me+) and wild-type BRAF and RAS. In this s...

    Authors: Jing Wang, Ruiyu Li, Junjie Li, Yuting Yi, Xiaoding Liu, Jingci Chen, Hui Zhang, Junliang Lu, Cami Li, Huanwen Wu and Zhiyong Liang

    Citation: Journal of Translational Medicine 2021 19:433

    Content type: Research

    Published on:

  33. Gastric cancer (GC) is the fifth most commonly diagnosed cancer worldwide. Due to the dismal prognosis, identifying novel therapeutic targets in GC is urgently needed. Evidences have shown that miRNAs played c...

    Authors: Yixun Lu, Benlong Zhang, Baohua Wang, Di Wu, Chuang Wang, Yunhe Gao, Wenquan Liang, Hongqing Xi, Xinxin Wang and Lin Chen

    Citation: Journal of Translational Medicine 2021 19:432

    Content type: Research

    Published on:

  34. High morbidity and mortality due to carbapenem-resistant Gram-negative bacilli (CR-GNB) has led to the resurgence of polymyxin B (PMB) use in the last decade. The aim of our multicenter, real-world study was t...

    Authors: Xiaojuan Zhang, Shaoyan Qi, Xiaoguang Duan, Bing Han, Shuguang Zhang, Shaohua Liu, Haixu Wang, Haibo Zhang and Tongwen Sun

    Citation: Journal of Translational Medicine 2021 19:431

    Content type: Research

    Published on:

  35. Central itch syndrome has been previously described in conditions such as stroke. The neurophysiology of central itch syndrome has been investigated in non-human primates but remains incompletely understood.

    Authors: Luciano Furlanetti, Harutomo Hasegawa, Natasha Hulse, Rachael Morris-Jones and Keyoumars Ashkan

    Citation: Journal of Translational Medicine 2021 19:430

    Content type: Research

    Published on:

  36. Colorectal cancer is one of the most common malignancy in the world. It has been reported that cancer stem cells (CSCs) serve as the primary drivers of tumorigenesis and tumor progression. There is an urgent n...

    Authors: Yifan Li, Jing Xun, Botao Wang, Yuan Ma, Lanqiu Zhang, Lei Yang, Ruifang Gao, Jun Guan, Tianyu Liu, Hejun Gao, Ximo Wang and Qi Zhang

    Citation: Journal of Translational Medicine 2021 19:429

    Content type: Research

    Published on:

  37. In the ovarian follicle, the Theca Cells (TCs) have two main functions: preserving morphological integrity and, importantly, secreting steroid androgen hormones. TCs express the essential enzyme 17α-hydroxylas...

    Authors: Christian Secchi, Martina Belli, Tracy N. H. Harrison, Joseph Swift, CheMyong Ko, Antoni J. Duleba, Dwayne Stupack, R. Jeffrey Chang and Shunichi Shimasaki

    Citation: Journal of Translational Medicine 2021 19:428

    Content type: Research

    Published on:

  38. The association between exposure to air pollution and sudden sensorineural hearing loss (SSNHL) has not been extensively discussed in the literature. Therefore, we conducted this nationwide study to evaluate t...

    Authors: Stella Chin-Shaw Tsai, Yi-Chao Hsu, Jung-Nien Lai, Ruey-Hwang Chou, Hueng-Chuen Fan, Frank Cheau-Feng Lin, Ruihong Zhang, Cheng-Li Lin and Kuang-Hsi Chang

    Citation: Journal of Translational Medicine 2021 19:424

    Content type: Research

    Published on:

  39. This research aimed to investigate the expression and function of FAM83A in the proliferation and metastasis in head and neck squamous cell carcinoma (HNSCC). FAM83A mRNA and protein expressions in HNSCC were ...

    Authors: Huan Ji, Haiyang Song, Zeyu Wang, Pengfei Jiao, Jiani Xu, Xuan Li, Hongming Du, Heming Wu and Yi Zhong

    Citation: Journal of Translational Medicine 2021 19:423

    Content type: Research

    Published on:

  40. The present study aimed to compare the efficacy and safety profiles of microspheres versus (vs.) polyvinyl alcohol (PVA) for bronchial artery embolization (BAE) treatment in patients with hemoptysis.

    Authors: Zhigang Fu, Xun Li, Fei Cai, Yinpeng Yuan, Xiaolin Zhang, Jingxia Qin and Yonghui Liang

    Citation: Journal of Translational Medicine 2021 19:422

    Content type: Research

    Published on:

  41. Integrating functional annotations into SNP-set association studies has been proven a powerful analysis strategy. Statistical methods for such integration have been developed for continuous and binary phenotyp...

    Authors: Haojie Lu, Yongyue Wei, Zhou Jiang, Jinhui Zhang, Ting Wang, Shuiping Huang and Ping Zeng

    Citation: Journal of Translational Medicine 2021 19:418

    Content type: Research

    Published on:

  42. In vitro oocyte maturation (IVM) is being increasingly approached in assisted reproductive technology (ART). This study aimed to evaluate the quality of embryos generated by in-vitro matured immature follicles...

    Authors: Jianhua Li, Jing Chen, Tiecheng Sun, Shuiwen Zhang, Tingting Jiao, Ri-Cheng Chian, Youzhu Li and Ye Xu

    Citation: Journal of Translational Medicine 2021 19:416

    Content type: Research

    Published on:

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