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  1. Serine/arginine-rich splicing factor 9 (SRSF9) is a classical RNA-binding protein that is essential for regulating gene expression programs through its interaction with target RNA. Whether SRSF9 plays an essen...

    Authors: Xiaoyu Wang, Xiansheng Lu, Ping Wang, Qiaoyu Chen, Le Xiong, Minshan Tang, Chang Hong, Xiaowen Lin, Kaixi Shi, Li Liang and Jie Lin
    Citation: Journal of Translational Medicine 2022 20:198
  2. Metagenomic next-generation sequencing (mNGS) is an important supplement to conventional tests for pathogen detections of pneumonia. However, mNGS pipelines were limited by irregularities, high proportion of h...

    Authors: Yukun He, Kechi Fang, Xing Shi, Donghong Yang, Lili Zhao, Wenyi Yu, Yali Zheng, Yu Xu, Xinqian Ma, Li Chen, Yu Xie, Yan Yu, Jing Wang and Zhancheng Gao
    Citation: Journal of Translational Medicine 2022 20:195
  3. Knowledge of the role of CYP2E1 in hepatocarcinogenesis is largely based on epidemiological and animal studies, with a primary focus on the role of CYP2E1 in metabolic activation of procarcinogens. Few studies...

    Authors: Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin and Haifeng Zhang
    Citation: Journal of Translational Medicine 2022 20:194
  4. We develop a new risk score to predict patients with stroke-associated pneumonia (SAP) who have an acute intracranial hemorrhage (ICH).

    Authors: Jing Yan, Weiqi Zhai, Zhaoxia Li, LingLing Ding, Jia You, Jiayi Zeng, Xin Yang, Chunjuan Wang, Xia Meng, Yong Jiang, Xiaodi Huang, Shouyan Wang, Yilong Wang, Zixiao Li, Shanfeng Zhu, Yongjun Wang…
    Citation: Journal of Translational Medicine 2022 20:193
  5. Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. However, expression profile and regulatory mechanism of TPI1 in breast cancer (BRCA) remain mysterious.

    Authors: Xiaoying Jin, Dandan Wang, Mengxia Lei, Yan Guo, Yuqing Cui, Fengzhi Chen, Weiling Sun and Xuesong Chen
    Citation: Journal of Translational Medicine 2022 20:191
  6. The circadian system is responsible for regulating various physiological activities and behaviors and has been gaining recognition. The circadian rhythm is adjusted in a 24-h cycle and has transcriptional–tran...

    Authors: Nai-Wei Hsu, Kai-Chen Chou, Yu-Ting Tina Wang, Chung-Lieh Hung, Chien-Feng Kuo and Shin-Yi Tsai
    Citation: Journal of Translational Medicine 2022 20:190
  7. Radiotherapy is among the routine treatment options for malignant tumors. And it damages DNA and other cellular organelles in target cells by using ionizing radiation produced by various rays, killing the cell...

    Authors: Huihui Sun, Rui Sun, Xing Song, Wendong Gu and Yingjie Shao
    Citation: Journal of Translational Medicine 2022 20:189
  8. Recent studies exploring the roles of invasion-metastasis associated miRNAs in gallbladder cancer (GBC) are limited. In the study, we aimed to identify the invasion-metastasis associated miRNAs in GBC by bioin...

    Authors: Jiasheng Cao, Huijiang Shao, Jiahao Hu, Renan Jin, Anyun Feng, Bin Zhang, Shijie Li, Tianen Chen, Sarun Jeungpanich, Win Topatana, Yitong Tian, Ziyi Lu, Xiujun Cai and Mingyu Chen
    Citation: Journal of Translational Medicine 2022 20:188
  9. Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma in adults. Metabolic reprogramming in tumors is closely related to the immune microenvironment. This study aimed to explore the interactions be...

    Authors: Jing He, Ziwei Chen, Qingfeng Xue, Pingping Sun, Yuan Wang, Cindy Zhu and Wenyu Shi
    Citation: Journal of Translational Medicine 2022 20:186
  10. Microlbuminuria is the earliest clinical evidence of diabetic kidney disease (DKD) and contributes to the induction and/or progression of DKD. Previous studies have shown that increased expression of angiopoie...

    Authors: Jing Liu, Junxia Yao, Yi Zhao, Jinxuan Su, Jiajia Ye and Yumei Wang
    Citation: Journal of Translational Medicine 2022 20:185
  11. Cellular therapies have become an important part of clinical care. The treatment of patients with cell therapies often involves the collection of autologous cells at the medical center treating the patient, th...

    Authors: David Stroncek, Anh Dinh, Herleen Rai, Nan Zhang, Rob Somerville and Sandhya Panch
    Citation: Journal of Translational Medicine 2022 20:184
  12. In this study we aimed to investigate signaling pathways that drive therapy resistance in esophageal adenocarcinoma (EAC). Paraffin-embedded material was analyzed in two patient cohorts: (i) 236 EAC patients w...

    Authors: A. Creemers, A. P. van der Zalm, A. van de Stolpe, L. Holtzer, M. Stoffels, G. K. J. Hooijer, E. A. Ebbing, H. van Ooijen, A. G. C. van Brussel, E. M. G. Aussems-Custers, M. I. van Berge Henegouwen, M. C. C. M. Hulshof, J. J. G. H. M. Bergman, S. L. Meijer, M. F. Bijlsma and H. W. M. van Laarhoven
    Citation: Journal of Translational Medicine 2022 20:183
  13. Pemphigus is an autoimmune skin disease. Ectopic lymphoid-like structures (ELSs) were found to be commonly present in the pemphigus lesions, presumably supporting in situ desmoglein (Dsg)-specific antibody pro...

    Authors: Zi-xuan Huang, Peng Qu, Kan-kan Wang, Jie Zheng, Meng Pan and Hai-qin Zhu
    Citation: Journal of Translational Medicine 2022 20:182
  14. Genome-wide association studies (GWAS) have revealed numerous loci associated with stroke. However, the underlying mechanisms at these loci in the pathogenesis of stroke and effective stroke drug targets are e...

    Authors: Bang-Sheng Wu, Shu-Fen Chen, Shu-Yi Huang, Ya-Nan Ou, Yue-Ting Deng, Shi-Dong Chen, Qiang Dong and Jin-Tai Yu
    Citation: Journal of Translational Medicine 2022 20:181
  15. Insulin resistance (IR) during gestational diabetes mellitus (GDM) has been linked to dysregulated insulin-PI3K/Akt pathway. A defective insulin-PI3K/Akt pathway and dysregulated circular RNA (circRNA) levels ...

    Authors: Runyu Du, Na Wu, Yu Bai, Lei Tang and Ling Li
    Citation: Journal of Translational Medicine 2022 20:180
  16. As part of the 2021 Immunotherapy Bridge virtual congress (December 1–2, Naples, Italy), the Great Debate sessions featured experts who were assigned counter opposing views on four important questions in immun...

    Authors: Paolo A. Ascierto, Lisa H. Butterfield, Olivera J. Finn, Andrew Futreal, Omid Hamid, Theresa LaVallee, Michael A. Postow, Igor Puzanov, Jeffrey Sosman, Bernard A. Fox and Patrick Hwu
    Citation: Journal of Translational Medicine 2022 20:179
  17. For a long time, breast cancer has been a leading cancer diagnosed in women worldwide, and approximately 90% of cancer-related deaths are caused by metastasis. For this reason, finding new biomarkers related t...

    Authors: Qingqing Li, Hui Yang, Peipei Wang, Xiaocen Liu, Kun Lv and Mingquan Ye
    Citation: Journal of Translational Medicine 2022 20:177
  18. Antibody response to SARS-CoV-2 is a valuable biomarker for the assessment of the spread of the virus in a population and evaluation of the vaccine candidates. Recent data suggest that antibody levels also may...

    Authors: Jānis Plūme, Artis Galvanovskis, Sindija Šmite, Nadezhda Romanchikova, Pawel Zayakin and Aija Linē
    Citation: Journal of Translational Medicine 2022 20:176
  19. Oropharyngeal dysphagia (OD) refers to any abnormality in the physiology of swallowing in the upper gastrointestinal tract, which leads to the related clinical complications, such as malnutrition, dehydration,...

    Authors: Fatemeh Rajati, Nassim Ahmadi, Zahra Al-sadat Naghibzadeh and Mohsen Kazeminia
    Citation: Journal of Translational Medicine 2022 20:175
  20. Cerebral venous sinus thrombosis (CVST) is a rare neurovascular disorder with highly variable manifestations and clinical courses. Animal models properly matched to the clinical form of CVST are necessary for ...

    Authors: Shuwen Mu, Yinghong Lin, Yongjun Xu, Xianqing Wei, Zihuan Zeng, Kunzhe Lin, Linghua Zhu, Qinghong Liu, Xingfeng Qi, Liangfeng Wei, Shengxiang Liang and Shousen Wang
    Citation: Journal of Translational Medicine 2022 20:174
  21. The human microbiome has been linked to several diseases. Gastrointestinal diseases are still one of the most prominent area of study in host-microbiome interactions however the underlying microbial mechanisms...

    Authors: Pouyan Ghaffari, Saeed Shoaie and Lars K. Nielsen
    Citation: Journal of Translational Medicine 2022 20:173
  22. Platinum-based chemotherapies are currently the first-line treatment of non-small cell lung cancer. This study will improve our understanding of the causes of resistance to cisplatin, especially in lung adeno...

    Authors: Qihai Sui, Zhencong Chen, Zhengyang Hu, Yiwei Huang, Jiaqi Liang, Guoshu Bi, Yunyi Bian, Mengnan Zhao, Cheng Zhan, Zongwu Lin, Qun Wang and Lijie Tan
    Citation: Journal of Translational Medicine 2022 20:171
  23. Studies have revealed an important role of activating transcription factor 1 (ATF1) and phosphorylated ATF1 at Ser63 in tumors. Our previous study identified Thr184 as a novel phosphorylation site of ATF1. How...

    Authors: Tong Li, Huiyuan Cao, Sa Wu, Peimin Zhong, Jie Ding, Jing Wang, Fangfang Wang, Zhiwei He and Guo-Liang Huang
    Citation: Journal of Translational Medicine 2022 20:169
  24. The etiology of fetal growth restriction (FGR) is complex and currently, there is a paucity of research about the genetic etiology of fetal growth restriction. We investigated the genetic associations and preg...

    Authors: Meiying Cai, Na Lin, Linjuan Su, Xiaoqing Wu, Xiaorui Xie, Shiyi Xu, Xianguo Fu, Liangpu Xu and Hailong Huang
    Citation: Journal of Translational Medicine 2022 20:168
  25. Calcific aortic valve disease (CAVD) is the most commonly valvular disease in the western countries initiated by inflammation and abnormal calcium deposition. Currently, there is no clinical drug for CAVD. Neu...

    Authors: Yan Liu, Peng Jiang, Liqin An, Mengying Zhu, Jin Li, Yue Wang, Qin Huang, Yi Xiang, Xiaorong Li, Qiong Shi and Yaguang Weng
    Citation: Journal of Translational Medicine 2022 20:167
  26. Acute kidney injury (AKI) is a major complication following cardiac surgery that substantially increases morbidity and mortality. Current diagnostic guidelines based on elevated serum creatinine and/or the pre...

    Authors: Hang Zhang, Zhongtian Wang, Yingdan Tang, Xin Chen, Dongfang You, Yaqian Wu, Min Yu, Wen Chen, Yang Zhao and Xin Chen
    Citation: Journal of Translational Medicine 2022 20:166
  27. Metabolic syndrome (MetS) is a prevalent multifactorial disorder that can increase the risk of developing diabetes, cardiovascular diseases, and cancer. We aimed to compare different machine learning classific...

    Authors: Mahdi Akbarzadeh, Nadia Alipour, Hamed Moheimani, Asieh Sadat Zahedi, Firoozeh Hosseini-Esfahani, Hossein Lanjanian, Fereidoun Azizi and Maryam S. Daneshpour
    Citation: Journal of Translational Medicine 2022 20:164
  28. Diabetes mellitus (DM), currently affecting 463 million people worldwide is a chronic disease characterized by impaired glucose metabolism resulting from the loss or dysfunction of pancreatic β-cells with the ...

    Authors: Abdoulaye Diane, Noora Ali Al-Shukri, Razik Bin Abdul Mu-u-min and Heba H. Al-Siddiqi
    Citation: Journal of Translational Medicine 2022 20:163
  29. Exosomes are microvesicles secreted by cells. They contain a variety of bioactive substances with important roles in intercellular communication. Circular RNA (circRNA), a type of nucleic acid molecule found i...

    Authors: Dong Ye, Mengdan Gong, Yongqin Deng, Shuai Fang, Yujie Cao, Yizhen Xiang and Zhisen Shen
    Citation: Journal of Translational Medicine 2022 20:161
  30. To evaluate the capability of basal and one-month differed white blood cells (WBC), neutrophil, lymphocyte and platelet values and their ratios (neutrophils-to-lymphocytes ratio, NLR, and platelets-to-lymphocy...

    Authors: Michele Guida, Nicola Bartolomeo, Davide Quaresmini, Pietro Quaglino, Gabriele Madonna, Jacopo Pigozzo, Anna Maria Di Giacomo, Alessandro Marco Minisini, Marco Tucci, Francesco Spagnolo, Marcella Occelli, Laura Ridolfi, Paola Queirolo, Ivana De Risi, Monica Valente, Angela Monica Sciacovelli…
    Citation: Journal of Translational Medicine 2022 20:159
  31. Determining the tissue of origin (TOO) is essential for managing cancer of unknown primary (CUP). In this study, we evaluated the concordance between genome profiling and DNA methylation analysis in determinin...

    Authors: Kaiyan Chen, Fanrong Zhang, Xiaoqing Yu, Zhiyu Huang, Lei Gong, Yanjun Xu, Hui Li, Sizhe Yu and Yun Fan
    Citation: Journal of Translational Medicine 2022 20:158
  32. JAK1 and JAK2 have been implicated in fibrosis and cancer as a fibroblast-related marker; however, their role in liver fibrosis has not been elucidated. Here, we aim to determine the effect and underlying mech...

    Authors: Zhenghui Song, Xinhui Liu, Wan Zhang, Yue Luo, Hua Xiao, Yun Liu, Guanqi Dai, Jian Hong and Aimin Li
    Citation: Journal of Translational Medicine 2022 20:157
  33. Dementia indicates a significant disease burden worldwide with increased population aging. This study aimed to investigate the impact of alcohol consumption on the risk of cognitive impairment in older adults.

    Authors: Fu-Shun Yen, Shiow-Ing Wang, Shih-Yi Lin, Yung-Hsiang Chao and James Cheng-Chung Wei
    Citation: Journal of Translational Medicine 2022 20:155
  34. Hepatocellular carcinoma (HCC), as the most common type of liver cancer, is characterized by high recurrence and metastasis. Circular RNA (circRNA) circ_0036412 was selected for studying the underlying mechani...

    Authors: Liyan Wang, Bin Li, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng and Lei Ma
    Citation: Journal of Translational Medicine 2022 20:154
  35. Authors: Malte Simon, Sadaf S. Mughal, Peter Horak, Sebastian Uhrig, Jonas Buchloh, Bogac Aybey, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Benedikt Brors and Charles D. Imbusch
    Citation: Journal of Translational Medicine 2022 20:152

    The original article was published in Journal of Translational Medicine 2021 19:204

  36. The NK cell line NK-92 and its genetically modified variants are receiving attention as immunotherapies to treat a range of malignancies. However, since NK-92 cells are themselves tumors, they require irradiat...

    Authors: Lydia Navarrete-Galvan, Michael Guglielmo, Judith Cruz Amaya, Julie Smith-Gagen, Vincent C. Lombardi, Rebecca Merica and Dorothy Hudig
    Citation: Journal of Translational Medicine 2022 20:151
  37. Oral squamous cell carcinoma (OSCC), as one of the commonest malignancies showing poor prognosis, has been increasingly suggested to be modulated by circular RNAs (circRNAs). Through GEO (Gene Expression Omnib...

    Authors: Liang Rong, Bo Chen, Ke Liu, Bingyao Liu, Xinyao He, Juan Liu, Junxia Li, Maodian He, Lei Zhu, Ke Liu, Xiaolei Shi, Yi Shuai and Lei Jin
    Citation: Journal of Translational Medicine 2022 20:148

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