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  1. The recurrence and metastasis of nasopharyngeal cancer (NPC) may be mainly attributed to the persistence of cancer stem cells (CSCs); however, the linkage mechanism has yet to be fully elucidated.

    Authors: Mengyang Zhao, Zibo Tang, Yijun Wang, Jiaojiao Ding, Ying Guo and Tianhui Gao

    Citation: Journal of Translational Medicine 2021 19:387

    Content type: Research

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  2. Little is known regarding the functional role of microRNA-193-3p (miR-193-3p) in sepsis. Hence, the aim of the present study was to investigate the effect of miR-193-3p on myocardial injury in mice with sepsis...

    Authors: Jianyuan Pan, Buse Alexan, Dorn Dennis, Chiristine Bettina, Laeuf Ilona Mariya Christoph and Yongqin Tang

    Citation: Journal of Translational Medicine 2021 19:386

    Content type: Research

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  3. Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses e...

    Authors: Kushtrim Kryeziu, Seyed H. Moosavi, Christian H. Bergsland, Marianne G. Guren, Peter W. Eide, Max Z. Totland, Kristoffer Lassen, Andreas Abildgaard, Arild Nesbakken, Anita Sveen and Ragnhild A. Lothe

    Citation: Journal of Translational Medicine 2021 19:384

    Content type: Research

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  4. Antiangiogenic therapy has increasingly become an important strategy for the treatment of colorectal cancer. Recent studies have shown that the tumour microenvironment (TME) promotes tumour angiogenesis. Bufal...

    Authors: Kai Fang, Yueping Zhan, Ruiqiu Zhu, Yuqian Wang, Chengqi Wu, Min Sun, Yanyan Qiu, Zeting Yuan, Xin Liang, Peihao Yin and Ke Xu

    Citation: Journal of Translational Medicine 2021 19:383

    Content type: Research

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  5. Glycolysis affects tumor growth, invasion, chemotherapy resistance, and the tumor microenvironment. In this study, we aimed to construct a glycolysis-related prognostic model for ovarian cancer and analyze its...

    Authors: Jianlei Bi, Fangfang Bi, Xue Pan and Qing Yang

    Citation: Journal of Translational Medicine 2021 19:382

    Content type: Research

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  6. Tumor-derived exosomes (TEXs) are involved in tumor progression and the immune modulation process and mediate intercellular communication in the tumor microenvironment. Although exosomes are considered promisi...

    Authors: Jiani Wu, Dongqiang Zeng, Shimeng Zhi, Zilan Ye, Wenjun Qiu, Na Huang, Li Sun, Chunlin Wang, Zhenzhen Wu, Jianping Bin, Yulin Liao, Min Shi and Wangjun Liao

    Citation: Journal of Translational Medicine 2021 19:381

    Content type: Research

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  7. The purpose of this study was to evaluate if HPV status serves as an independent predictor of early and late dysphagia outcomes when considered alongside standard patient characteristics and dose metrics for h...

    Authors: Xenia Ray, Whitney Sumner, Leisa Sutton, Parag Sanghvi, Ida Deichaite and Vitali Moiseenko

    Citation: Journal of Translational Medicine 2021 19:380

    Content type: Research

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  8. Since interferon regulatory factor (IRF) family functions in immune response to viral infection, its role in colorectal cancer (CRC) has not been inspected before. This study tries to investigate members of IR...

    Authors: Yan-Jie Chen, Shu-Neng Luo, Ling Dong, Tao-Tao Liu, Xi-Zhong Shen, Ning-Ping Zhang and Li Liang

    Citation: Journal of Translational Medicine 2021 19:379

    Content type: Research

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  9. Neuroinflammation has been proved to play a role in dopaminergic neuronal death in Parkinson’s disease (PD). This link highlights the relevance of the immune response in the progression of the disease. However...

    Authors: Diana D. Álvarez-Luquín, Adrián Guevara-Salinas, Asiel Arce-Sillas, Raquel Espinosa-Cárdenas, Jaquelín Leyva-Hernández, Esteban U. Montes-Moratilla and Laura Adalid-Peralta

    Citation: Journal of Translational Medicine 2021 19:378

    Content type: Research

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  10. Misdiagnosis of multiple sclerosis (MS) and neuromyelitis optica (NMO) may delay the treatment, resulting in poor prognosis. However, the precise identification of these two diseases is still challenging in cl...

    Authors: Jing Huang, Bowen Xin, Xiuying Wang, Zhigang Qi, Huiqing Dong, Kuncheng Li, Yun Zhou and Jie Lu

    Citation: Journal of Translational Medicine 2021 19:377

    Content type: Research

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  11. COVID-19 remains globally a highly infectious disease targeting multiple organs. Rehabilitation is increasingly valued among the supportive care fields to combat COVID-19 as currently definitive curative treat...

    Authors: Chaoran Yu and Ernest Johann Helwig

    Citation: Journal of Translational Medicine 2021 19:376

    Content type: Review

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  12. Systemic sclerosis is an autoimmune disease characterized by excessive dermal fibrosis with progression to internal organs, vascular impairment and immune dysregulation evidenced by the infiltration of inflamm...

    Authors: Pauline Beurier, Laure Ricard, Deborah Eshagh, Florent Malard, Lama Siblany, Olivier Fain, Mohamad Mohty, Béatrice Gaugler and Arsène Mekinian

    Citation: Journal of Translational Medicine 2021 19:375

    Content type: Research

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  13. Ubiquitin-conjugating enzyme E2T (UBE2T) acts as an oncogene in various types of cancer. However, the mechanisms behind its oncogenic role remain unclear in lung cancer. This study aims to explore the function...

    Authors: Jinhong Zhu, Haijiao Ao, Mingdong Liu, Kui Cao and Jianqun Ma

    Citation: Journal of Translational Medicine 2021 19:374

    Content type: Research

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  14. Pancreatic cancer is one of the most serious digestive malignancies. At present, there is an extreme lack of effective strategies in clinical treatment. The purpose of this study is to identify key genes and p...

    Authors: Yueqin Feng, Yuguan Jiang and Fengjin Hao

    Citation: Journal of Translational Medicine 2021 19:373

    Content type: Research

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  15. Epidermal growth factor receptor (EGFR) and lanthionine synthetase C-like 2 (LanCL2) genes locate in the same amplicon, and co-amplification of EGFR and LANCL2 is frequent in glioblastoma. However, the prognostic...

    Authors: Hua-fu Zhao, Xiu-ming Zhou, Jing Wang, Fan-fan Chen, Chang-peng Wu, Peng-yu Diao, Lin-rong Cai, Lei Chen, Yan-wen Xu, Jing Liu, Zong-yang Li, Wen-lan Liu, Zhong-ping Chen, Guo-dong Huang and Wei-ping Li

    Citation: Journal of Translational Medicine 2021 19:372

    Content type: Research

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  16. Immune cells in the tumor microenvironment have prognostic value. In preclinical models, recruitment and infiltration of these cells depends on immune cell homing (ICH) genes such as chemokines, cell adhesion ...

    Authors: Minyoung Kwak, Gulsun Erdag, Katie M. Leick, Stefan Bekiranov, Victor H. Engelhard and Craig L. Slingluff

    Citation: Journal of Translational Medicine 2021 19:371

    Content type: Research

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  17. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness which disproportionally affects females. This illness is associated with immune and metabolic perturbations that may be influenc...

    Authors: Aurore Nkiliza, Megan Parks, Adam Cseresznye, Sarah Oberlin, James E. Evans, Teresa Darcey, Kristina Aenlle, Daniel Niedospial, Michael Mullan, Fiona Crawford, Nancy Klimas and Laila Abdullah

    Citation: Journal of Translational Medicine 2021 19:370

    Content type: Research

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  18. To evaluate whether low coverage whole genome sequencing is suitable for the detection of malignant pelvic mass and compare its diagnostic value with traditional tumor markers. We enrolled 63 patients with a p...

    Authors: Ming Chen, Pengqiang Zhong, Mengzhi Hong, Jinfeng Tan, Xuegao Yu, Hao Huang, Juan Ouyang, Xiaoping Lin and Peisong Chen

    Citation: Journal of Translational Medicine 2021 19:369

    Content type: Research

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  19. Accumulative evidence shows that an organoid is a more practical and reliable tool in cancer biology research. This study aimed to identify and validate crucial genes involved in non-small cell lung cancer car...

    Authors: Xiao Ma, Su Yang, Hesheng Jiang, Yujie Wang and Zhen Xiang

    Citation: Journal of Translational Medicine 2021 19:368

    Content type: Research

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  20. Solute carrier family 7 member 11(SLC7A11) is a component of cysteine/glutamate transporter, which plays a key role in tumor growth; however, its underlying effect on radiosensitivity in esophageal squamous ce...

    Authors: Lei Feng, Kaikai Zhao, Liangchao Sun, Xiaoyang Yin, Junpeng Zhang, Conghe Liu and Baosheng Li

    Citation: Journal of Translational Medicine 2021 19:367

    Content type: Research

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  21. The causes of gestational diabetes mellitus (GDM) are still unclear. Recent studies have found that the imbalance of the gut microbiome could lead to disorders of human metabolism and immune system, resulting ...

    Authors: Yao Su, Hong-Kun Wang, Xu-Pei Gan, Li Chen, Yan-Nan Cao, De-Cui Cheng, Dong-Yao Zhang, Wen-Yu Liu, Fei-Fei Li and Xian-Ming Xu

    Citation: Journal of Translational Medicine 2021 19:366

    Content type: Research

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  22. Recently, convalescent plasma (CP) transfusion was employed for severe or critically ill patients with coronavirus disease-2019. However, the benefits of CP for patients with different conditions are still in ...

    Authors: Li Huang, Che Zhang, Xihui Zhou, Zhou Zhao, Weiping Wang, Weidong Leng, Xiao Su and Qizhou Lian

    Citation: Journal of Translational Medicine 2021 19:365

    Content type: Research

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  23. Luminal breast cancer (BC) is the most frequent subtype accounting for more than 70% of BC. LncRNAs, a class of non-coding RNAs with more than 200 nucleotides, are involved in a variety of cellular processes a...

    Authors: Sepideh Mehrpour Layeghi, Maedeh Arabpour, Abbas Shakoori, Mohammad Mehdi Naghizadeh, Yaser Mansoori, Javad Tavakkoly Bazzaz and Rezvan Esmaeili

    Citation: Journal of Translational Medicine 2021 19:364

    Content type: Research

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  24. Covid-19 became a global pandemic in 2019. Studies have shown that coronavirus can cause neurological symptoms, but clinical studies on its neurological symptoms are limited. In this meta-analysis, we aimed to...

    Authors: Yuanyuan He, Xiaojie Bai, Tiantian Zhu, Jialin Huang and Hong Zhang

    Citation: Journal of Translational Medicine 2021 19:363

    Content type: Research

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  25. Systemic lupus erythematosus (SLE) is an autoimmune disease with a complicated pathogenesis, and its aetiology has not been clearly unveiled. The lack of effective diagnosis and treatment methods makes it nece...

    Authors: Wencong Song, Jie Qiu, Lianghong Yin, Xiaoping Hong, Weier Dai, Donge Tang, Dongzhou Liu and Yong Dai

    Citation: Journal of Translational Medicine 2021 19:362

    Content type: Research

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  26. Angiogenesis is the process of capillary sprouting from pre-existing vessels and it plays a critical role in the carcinogenic process of lung adenocarcinoma (LUAD). However, the association of angiogenesis reg...

    Authors: Songhua Cai, Xiaotong Guo, Chujian Huang, Youjun Deng, Longde Du, Wenyi Liu, Chenglin Yang, Hongbo Zhao, Kai Ma, Lixu Wang, Jie He and Zhentao Yu

    Citation: Journal of Translational Medicine 2021 19:361

    Content type: Research

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  27. Gestational diabetes mellitus (GDM) is a serious public health issue affecting 9–15% of all pregnancies worldwide. Recently, it has been suggested that extracellular vesicles (EVs) play a role throughout gesta...

    Authors: Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacós, Fátima Crispi, Gregory Duncombe, Martha Lappas…

    Citation: Journal of Translational Medicine 2021 19:360

    Content type: Research

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  28. Although an association between the cytochrome P4502D6 (CYP2D6) *10 (100C>T) polymorphism and hepatocellular carcinoma (HCC) is known, the mechanism remains unclear. Here we aimed to explore mechanisms of CYP2...

    Authors: Guiming Hu, Fei Gao, Guanzhe Wang, Yan Fang, Yuanyuan Guo, Jun Zhou, Yuhan Gu, Cunzhen Zhang, Na Gao, Qiang Wen and Hailing Qiao

    Citation: Journal of Translational Medicine 2021 19:359

    Content type: Research

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  29. SARS-CoV-2, which has brought a huge negative impact on the world since the end of 2019, is reported to invade cells using the spike (S) protein to bind to angiotensin-converting enzyme II (ACE2) receptors on ...

    Authors: Jinfeng Peng, Jiwei Sun, Jiajia Zhao, Xuliang Deng, Fengyuan Guo and Lili Chen

    Citation: Journal of Translational Medicine 2021 19:358

    Content type: Research

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  30. The prevalence of chronic pain conditions is growing. Low back pain was the primary cause of disability worldwide out of 156 conditions assessed between 1990 and 2016, according to the Global Burden of Disease...

    Authors: Daniel I. Rhon, Julie M. Fritz, Tina A. Greenlee, Katie E. Dry, Rachel J. Mayhew, Mary C. Laugesen, Edita Dragusin and Deydre S. Teyhen

    Citation: Journal of Translational Medicine 2021 19:357

    Content type: Methodology

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  31. Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier funct...

    Authors: Juan Huang, Ziyan Yang, Yanyun Li, Xingxing Chai, Yanfang Liang, Bihua Lin, Ziyu Ye, Shaobing Zhang, Zhengping Che, Hailiang Zhang, Xueying Zhang, Zhao Zhang, Tao Chen, Weiqing Yang and Jincheng Zeng

    Citation: Journal of Translational Medicine 2021 19:356

    Content type: Research

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  32. Diabetic nephropathy (DN) is a leading cause of renal failure, whereas the effective and early diagnostic biomarkers are still lacking.

    Authors: Ye Feng, Xin Zhong, Hai-Feng Ni, Cui Wang, Tao-Tao Tang, Li-Ting Wang, Kai-Yun Song, Ri-Ning Tang, Hong Liu, Bi-Cheng Liu and Lin-Li Lv

    Citation: Journal of Translational Medicine 2021 19:355

    Content type: Research

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  33. A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms of migraineurs. Frequency is one of the key stimulation parameters. The aim of this study ...

    Authors: Jin Cao, Yue Zhang, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Sierra Hodges, Jian Kong and Bo Liu

    Citation: Journal of Translational Medicine 2021 19:354

    Content type: Research

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  34. Accumulating evidence highlights the critical roles of fibroblast growth factors (FGFs) in regulating the progression of multiple human cancers, including non-small cell lung cancer (NSCLC). In this study, we ...

    Authors: Xiaowei Wu, Minjie Li, Ying Li, Yu Deng, Shun Ke, Fan Li, Yujin Wang and Shuchang Zhou

    Citation: Journal of Translational Medicine 2021 19:353

    Content type: Research

    Published on:

  35. As an important part of tumor immunotherapy for adjunct, therapeutic tumor vaccines have been effective against multiple solid cancers, while their efficacy against lower grade glioma (LGG) remains undefined. ...

    Authors: Liguo Ye, Long Wang, Ji’an Yang, Ping Hu, Chunyu Zhang, Shi’ao Tong, Zhennan Liu and Daofeng Tian

    Citation: Journal of Translational Medicine 2021 19:352

    Content type: Research

    Published on:

  36. Given the clinical low efficient treatment based on mono-brain-target design in Alzheimer’s disease (AD) and an increasing emphasis on microbiome-gut-brain axis which was considered as a crucial pathway to aff...

    Authors: Jie Gao, Nian Zhou, Yongkang Wu, Mengna Lu, Qixue Wang, Chenyi Xia, Mingmei Zhou and Ying Xu

    Citation: Journal of Translational Medicine 2021 19:351

    Content type: Research

    Published on:

  37. The roles of FTO gene and the level of serum 25-OH-vitamin D in obesity are frequently reported. This study aimed to investigate the interactions of serum 25-OH-vitamin D level, FTO and IRX3 genes expression, ...

    Authors: Maryam Gholamalizadeh, Saeid Doaei, Zohreh Mokhtari, Vahideh Jalili, Fatemeh Bourbour, Saeed Omidi, Kamal Ebrahimi, Naser Kalantari, Sheyda Abdi, Ghasem Azizi Tabesh, Mohammad Naimi Joubani, Esmaeil Roohbakhsh and Seyed Alireza Mosavi Jarrahi

    Citation: Journal of Translational Medicine 2021 19:350

    Content type: Research

    Published on:

  38. Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent,...

    Authors: Demin Cheng, Qi Xu, Yue Wang, Guanru Li, Wenqing Sun, Dongyu Ma, Siyun Zhou, Yi Liu, Lei Han and Chunhui Ni

    Citation: Journal of Translational Medicine 2021 19:349

    Content type: Research

    Published on:

  39. Pathological complete response (pCR) is considered a surrogate endpoint for favorable survival in breast cancer patients treated with neoadjuvant chemotherapy (NAC). Predictive biomarkers of treatment response...

    Authors: Fengling Li, Yongquan Yang, Yani Wei, Ping He, Jie Chen, Zhongxi Zheng and Hong Bu

    Citation: Journal of Translational Medicine 2021 19:348

    Content type: Research

    Published on:

  40. Tumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role in regulating macrophage function. However, it is still elusive wheth...

    Authors: Jia-Lei Sun, Ning-Ping Zhang, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Weinire Abuduwaili, Fu Wang, Xiang-Nan Yu, Xuan Shi, Guang-Qi Song, Hao Wu, Tao-Tao Liu, Xi-Zhong Shen, Bin Deng, Shu-Qiang Weng, Ling Dong…

    Citation: Journal of Translational Medicine 2021 19:347

    Content type: Research

    Published on:

  41. Kidney transplantation is an optimal method for treatment of end-stage kidney failure. However, kidney transplant rejection (KTR) is commonly observed to have negative effects on allograft function. MicroRNAs ...

    Authors: Yuxin Lin, Liangliang Wang, Wenqing Ge, Yu Hui, Zheng Zhou, Linkun Hu, Hao Pan, Yuhua Huang and Bairong Shen

    Citation: Journal of Translational Medicine 2021 19:346

    Content type: Research

    Published on:

  42. Authors: Lin Shui, Xiaofen Li, Yang Peng, Jiangfang Tian, Shuangshuang Li, Du He, Ang Li, Bole Tian, Mao Li, Heli Gao, Ning An, Cheng Yi and Dan Cao

    Citation: Journal of Translational Medicine 2021 19:345

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2021 19:301

  43. Although reports implicate radioresistance as an important obstacle for the management of breast cancer, its molecular mechanism is elusive. Herein, we found that high HDGF levels are expressed significantly i...

    Authors: Lingyun Qiu, Yan Ma, Xiaohua Chen, Liheng Zhou, Haibo Zhang, Guansheng Zhong, Lei Zhang and Jianming Tang

    Citation: Journal of Translational Medicine 2021 19:344

    Content type: Research

    Published on:

  44. Mental disorders widely contribute to the modern global disease burden, creating a significant need for improvement of treatments. Scalp stimulation methods (such as scalp acupuncture and transcranial electric...

    Authors: Jin Cao, Thalia Celeste Chai-Zhang, Yiting Huang, Maya Nicole Eshel and Jian Kong

    Citation: Journal of Translational Medicine 2021 19:343

    Content type: Research

    Published on:

  45. To examine the effects of BI 1029539 (GS-248), a novel selective human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, in experimental models of acute lung injury (ALI) and sepsis in transgenic mice co...

    Authors: Malarvizhi Gurusamy, Saeed Nasseri, Dileep Reddy Rampa, Huiying Feng, Dongwon Lee, Anton Pekcec, Henri Doods and Dongmei Wu

    Citation: Journal of Translational Medicine 2021 19:340

    Content type: Research

    Published on:

  46. DNA damage response plays critical roles in tumor pathogenesis and radiotherapy resistance. Protein phosphorylation is a critical mechanism in regulation of DNA damage response; however, the key mediators for ...

    Authors: Jia Liu, Jingyi Li, Zhao Sun, Yangmiao Duan, Fengqin Wang, Guangwei Wei and Jing-Hua Yang

    Citation: Journal of Translational Medicine 2021 19:339

    Content type: Research

    Published on:

  47. Fine tuned balance of reactive oxygen species (ROS) is essential for tumor cells and tumor cells use immune checkpoints to evade attack form immunity system. However, it’s unclear whether there is any crosstal...

    Authors: Bangbao Tao, Juanhong Shi, Shuai Shuai, Haiyan Zhou, Hongxia Zhang, Bin Li, Xiaoqiang Wang, Guohui Li, Hua He and Jun Zhong

    Citation: Journal of Translational Medicine 2021 19:338

    Content type: Research

    Published on:

  48. Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe3O4 magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Here...

    Authors: Shuzhen Chen, Fushi Han, Dongdong Huang, Jinqian Meng, Jiapeng Chu, Meng Wang and Peijun Wang

    Citation: Journal of Translational Medicine 2021 19:337

    Content type: Research

    Published on:

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