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  1. Tumor-draining lymph nodes (TDLNs) are primary sites, where anti-tumor lymphocytes are primed to tumor-specific antigens and play pivotal roles in immune responses against tumors. Although adoptive cell therap...

    Authors: Kazumi Okamura, Satoshi Nagayama, Tomohiro Tate, Hiu Ting Chan, Kazuma Kiyotani and Yusuke Nakamura
    Citation: Journal of Translational Medicine 2022 20:241
  2. As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have recently gained attention as an important type of innate immune regulatory cell. NK cells can rapidly kill multipl...

    Authors: Junfeng Chu, Fengcai Gao, Meimei Yan, Shuang Zhao, Zheng Yan, Bian Shi and Yanyan Liu
    Citation: Journal of Translational Medicine 2022 20:240
  3. Chimeric antigen receptor (CAR) T cell therapy has attracted attention for its promising therapeutic effects on hematological malignancies. However, there are problems such as relapse during long-term follow-u...

    Authors: Taku Kouro, Hidetomo Himuro and Tetsuro Sasada
    Citation: Journal of Translational Medicine 2022 20:239
  4. Only a small number of patients survive an out-of-hospital cardiac arrest (CA) and can be discharged from hospital alive with a large percentage of these patients retaining neurological impairments. In recent ...

    Authors: Patrick Bernhard, Berit Amelie Bretthauer, Sam Joé Brixius, Hannah Bügener, Johannes Elias Groh, Christian Scherer, Domagoj Damjanovic, Jörg Haberstroh, Georg Trummer, Christoph Benk, Friedhelm Beyersdorf, Oliver Schilling and Jan-Steffen Pooth
    Citation: Journal of Translational Medicine 2022 20:238
  5. Physical activity (PA) may protect against infertility by modulating the hypothalamic-pituitary–gonadal axis, thereby reducing gonadotropin levels, elevating immune function, and inhibiting inflammation and ci...

    Authors: Fangfang Xie, Yanli You, Chong Guan, Yuanjia Gu, Fei Yao and Jiatuo Xu
    Citation: Journal of Translational Medicine 2022 20:237
  6. Harnessing the effector mechanisms of the immune system to combat brain tumors with antigen specificity and memory has been in research and clinical testing for many years. Government grant mechanisms and non-...

    Authors: Christine E. Brown, Samantha Bucktrout, Lisa H. Butterfield, Olga Futer, Evanthia Galanis, Adilia Hormigo, Michael Lim, Hideho Okada, Robert Prins, Sara Siebel Marr and Kirk Tanner
    Citation: Journal of Translational Medicine 2022 20:236
  7. Necroptosis is a new form of programmed cell death that is associated with cancer initiation, progression, immunity, and chemoresistance. However, the roles of necroptosis-related genes (NRGs) in colorectal ca...

    Authors: Wenqin Luo, Wenqiang Xiang, Lu Gan, Ji Che, Jing Li, Yichao Wang, Lingyu Han, Ruiqi Gu, Li Ye, Renjie Wang, Xiuping Zhang, Ye Xu, Weixing Dai, Shaobo Mo, Qingguo Li and Guoxiang Cai
    Citation: Journal of Translational Medicine 2022 20:235
  8. Cardiometabolic disease (CMD) increases the risk of mortality, but the extent to which this can be offset by adherence to a healthy lifestyle is unknown. We aimed to investigate whether and to what extent a co...

    Authors: Chenjie Xu and Zhi Cao
    Citation: Journal of Translational Medicine 2022 20:234
  9. Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary ...

    Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Chuan-Jue Cui and Jian-Jun Li
    Citation: Journal of Translational Medicine 2022 20:233
  10. In 2010, November 16th, the Mediterranean diet was given the recognition of UNESCO as an “Intangible Heritage of Humanity” as this dietary pattern is rooted in the preservation of tradition, land, and biodiver...

    Authors: Annamaria Colao, Claudia Vetrani, Giovanna Muscogiuri, Luigi Barrea, Antonia Tricopoulou, Laura Soldati and Prisco Piscitelli
    Citation: Journal of Translational Medicine 2022 20:232
  11. According to international guidelines, Human Papillomavirus (HPV) DNA tests represent a valid alternative to Pap Test for primary cervical cancer screening, provided that they guarantee balanced clinical sensi...

    Authors: Alice Avian, Nicolò Clemente, Elisabetta Mauro, Erica Isidoro, Michela Di Napoli, Sandra Dudine, Anna Del Fabro, Stefano Morini, Tiziana Perin, Fabiola Giudici, Tamara Cammisuli, Nicola Foschi, Marco Mocenigo, Michele Montrone, Chiara Modena, Martina Polenghi…
    Citation: Journal of Translational Medicine 2022 20:231
  12. Little is known about SARS-CoV-2 seroconversion in asymptomatic patients affected by solid cancer, and whether it is associated with specific transcriptomics changes in peripheral blood mononuclear cells (PBMC).

    Authors: Francesco Ravera, Roberto Borea, Gabriella Cirmena, Martina Dameri, Lorenzo Ferrando, Maurizio Gallo, Cecilia Casini, Neri Fallani, Mario Stabile, Valentina Barbero, Roberto Murialdo, Lucia Tixi, Margherita Cappuccio, Andrea Cuboni, Irene Sivieri, Giuseppe Fornarini…
    Citation: Journal of Translational Medicine 2022 20:230
  13. Molecular chaperones assist protein folding, facilitate degradation of misfolded polypeptides, and thereby maintain protein homeostasis. Impaired chaperone activity leads to defective protein quality control t...

    Authors: Manar Elkenani, Amal Z. Barakat, Torsten Held, Daniel Marques Rodrigues, Sherok Mobarak, Surabhi Swarnka, Ibrahim M. Adham and Belal A. Mohamed
    Citation: Journal of Translational Medicine 2022 20:229
  14. RNA adenosine modifications, which are primarily mediated by “writer” enzymes (RMWs), play a key role in epigenetic regulation in various biological processes, including tumorigenesis. However, the expression ...

    Authors: Shijie Chen, Jin Zeng, Liping Huang, Yi Peng, Zuyun Yan, Aiqian Zhang, Xingping Zhao, Jun Li, Ziting Zhou, Sidan Wang, Shengyu Jing, Minghua Hu, Yuezhan Li, Dong Wang, Weiguo Wang, Haiyang Yu…
    Citation: Journal of Translational Medicine 2022 20:228
  15. Previous studies demonstrated a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations also emerged, and the nature of such relationship ...

    Authors: Meng Zhang, Jiahao Qiao, Shuo Zhang and Ping Zeng
    Citation: Journal of Translational Medicine 2022 20:227
  16. In polyglutamine (polyQ) diseases, the identification of modifiers and the construction of prediction model for progression facilitate genetic counseling, clinical management and therapeutic interventions.

    Authors: Linliu Peng, Yun Peng, Zhao Chen, Chunrong Wang, Zhe Long, Huirong Peng, Yuting Shi, Lu Shen, Kun Xia, Vanessa B. Leotti, Laura Bannach Jardim, Beisha Tang, Rong Qiu and Hong Jiang
    Citation: Journal of Translational Medicine 2022 20:226
  17. Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed a...

    Authors: Åslaug Helland, Hege G. Russnes, Gro Live Fagereng, Khalid Al-Shibli, Yvonne Andersson, Thomas Berg, Line Bjørge, Egil Blix, Bodil Bjerkehagen, Sigmund Brabrand, Marte Grønlie Cameron, Astrid Dalhaug, Dalia Dietzel, Tom Dønnem, Espen Enerly, Åsmund Flobak…
    Citation: Journal of Translational Medicine 2022 20:225
  18. Extracellular vesicle (EV)-microRNAs (miRNAs) are potential biomarkers for various renal diseases. This study attempted to identify the circulating EV-miRNA signature not only for discriminating idiopathic mem...

    Authors: In O. Sun, Yun-Ui Bae, Haekyung Lee, Hyoungnae Kim, Jin Seok Jeon, Hyunjin Noh, Jong-Soo Choi, Kyung-Oh Doh and Soon Hyo Kwon
    Citation: Journal of Translational Medicine 2022 20:224
  19. While ondansetron (OND) is widespread availability, the contribution of OND to improve patient outcomes among intensive care unit (ICU) patients has not been examined. This study aimed to illustrate the associ...

    Authors: Yingying Fang, Chao Xiong and Xinghe Wang
    Citation: Journal of Translational Medicine 2022 20:223
  20. Cigarette smoking (CS) is a strong risk factor for idiopathic pulmonary fibrosis (IPF). It can activate lung fibroblasts (LF) by inducing redox imbalance. We previously showed that clearing mitochondrial react...

    Authors: Yue Zhang, Ting Li, Miaoxia Pan, Wei Wang, Wenhui Huang, Yafei Yuan, Zhanzhan Xie, Yixin Chen, Jun Peng, Xu Li and Ying Meng
    Citation: Journal of Translational Medicine 2022 20:222
  21. Sclerostin is the protein product of the SOST gene and is known for its inhibitory effects on bone formation. The monoclonal antibody against sclerostin has been approved as a novel treatment method for osteoporo...

    Authors: Chufang Liao, Shanshan Liang, Yining Wang, Ting Zhong and Xiangning Liu
    Citation: Journal of Translational Medicine 2022 20:221
  22. An increasing number of studies have demonstrated that long non-coding RNAs (lncRNAs) serve as key regulators in tumor development and progression. However, only a few lncRNAs have been functionally characteri...

    Authors: Jixu Wang, Futao Hou, Lusheng Tang, Ke Xiao, Tengfei Yang, Zhiqiang Wang and Gu Liu
    Citation: Journal of Translational Medicine 2022 20:220
  23. Diabetic retinopathy (DR), especially proliferative diabetic retinopathy (PDR) is a common cause of blindness and visual impairment. Early prediction of its occurrence and progression is important to improved ...

    Authors: Huan Wang, Zhen Guo and Yu Xu
    Citation: Journal of Translational Medicine 2022 20:219
  24. Early diagnosis and treatment of chronic pancreatitis (CP) are limited. In this study, St13, a co-chaperone protein, was investigated whether it constituted a novel regulatory target in CP. Meanwhile, we evalu...

    Authors: Rong-chang Cao, Wan-jun Yang, Wang Xiao, Lei Zhou, Jie-hui Tan, Meng Wang, Zhi-tao Zhou, Huo-ji Chen, Jia Xu, Xue-mei Chen, Yang-chen Jin, Jia-yu Lin, Jun-ling Zeng, Shu-ji Li, Min Luo, Guo-dong Hu…
    Citation: Journal of Translational Medicine 2022 20:218
  25. The two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), both downregulate immune surface molecules, such as MHC-I, ICAM-1, and B7-2, enabling them...

    Authors: Yiquan Wu, Prabha Shrestha, Natalie M. Heape and Robert Yarchoan
    Citation: Journal of Translational Medicine 2022 20:217
  26. The 2019 coronavirus disease pandemic (COVID-19) poses an enormous threat to public health worldwide, and the ensuing management of social isolation has greatly decreased opportunities for physical activity (P...

    Authors: Xiong Chen, Xiaosi Hong, Wenjing Gao, Shulu Luo, Jiahao Cai, Guochang Liu and Yinong Huang
    Citation: Journal of Translational Medicine 2022 20:216
  27. Acute kidney injury (AKI) is the most common and serious complication of sepsis, accompanied by high mortality and disease burden. The early prediction of AKI is critical for timely intervention and ultimately...

    Authors: Suru Yue, Shasha Li, Xueying Huang, Jie Liu, Xuefei Hou, Yumei Zhao, Dongdong Niu, Yufeng Wang, Wenkai Tan and Jiayuan Wu
    Citation: Journal of Translational Medicine 2022 20:215
  28. In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key player in regulating RNA metabolism and function through coding as well as non-coding RNAs. Accumulating evidence has shown that m5C m...

    Authors: Mingyang Li, Zijia Tao, Yiqiao Zhao, Lei Li, Jianyi Zheng, Zeyu Li and Xiaonan Chen
    Citation: Journal of Translational Medicine 2022 20:214
  29. This paper is a report of recommendations for addressing translational challenges in amyloid disease research. They were developed during and following an international online workshop organized by the LINXS I...

    Authors: Miriam Solomon, Vito Foderà, Annette Eva Langkilde, Perry Elliott, Fabrizio Tagliavini, Trevor Forsyth, Oxana Klementieva and Vittorio Bellotti
    Citation: Journal of Translational Medicine 2022 20:213
  30. Hepatocellular carcinoma (HCC) is the most common pathological type of liver cancer. Valosin-containing protein (VCP) is a member of the AAA-ATPase family associated with multiple molecular functions and invo...

    Authors: Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu and Xuegong Fan
    Citation: Journal of Translational Medicine 2022 20:212
  31. The correlations between circulating tumour DNA (ctDNA)-derived genomic markers and treatment response and survival outcome in Chinese patients with advanced breast cancer (ABC) have not been extensively chara...

    Authors: Hao Liao, Jiayang Zhang, Tiantian Zheng, Xiaoran Liu, Jianxin Zhong, Bin Shao, Xiaoxi Dong, Xiaohong Wang, Pan Du, Bonnie L. King, Shidong Jia, Jianjun Yu and Huiping Li
    Citation: Journal of Translational Medicine 2022 20:211
  32. Colorectal cancer is a commonly diagnosed cancer worldwide. Unfortunately, many patients do not respond to standard chemotherapy treatments and develop disease relapse and metastases. Besides cancer cell speci...

    Authors: Simona Salerno, Anders Ståhlberg, André Holdfeldt, Elinor Bexe Lindskog and Göran Landberg
    Citation: Journal of Translational Medicine 2022 20:209
  33. Extracellular vesicles (EVs) play a key role in constructing a microenvironment that favors the differentiation of stem cells. The present work aimed to determine the molecular mechanisms by which EV derived f...

    Authors: Chaoting Yan, Na Li, Tong Xiao, Xiaying Ye, Lin Fu, Yu Ye, Tao Xu and Jinhua Yu
    Citation: Journal of Translational Medicine 2022 20:208
  34. The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by t...

    Authors: Shahrokh Abdolahi, Zeinab Ghazvinian, Samad Muhammadnejad, Mahshid Saleh, Hamid Asadzadeh Aghdaei and Kaveh Baghaei
    Citation: Journal of Translational Medicine 2022 20:206
  35. NOS1 expression predicts poor prognosis in patients with melanoma. However, the molecular function of NOS1 in the type I IFN response and immune escape of melanoma is still unknown.

    Authors: Xi Chen, Zhiwei Zou, Qianli Wang, Wenwen Gao, Sisi Zeng, Shuangyan Ye, Pengfei Xu, Mengqiu Huang, Keyi Li, Jianping Chen, Zhuo Zhong, Qianbing Zhang, Bingtao Hao and Qiuzhen Liu
    Citation: Journal of Translational Medicine 2022 20:205
  36. Post-cardiac surgery acute kidney injury (AKI) is associated with increased mortality. A high-protein meal enhances the renal blood flow and glomerular filtration rate (GFR) and might protect the kidneys from ...

    Authors: Faeq Husain-Syed, David R. Emlet, Jochen Wilhelm, Tommaso Hinna Danesi, Fiorenza Ferrari, Pércia Bezerra, Salvador Lopez-Giacoman, Gianluca Villa, Khodr Tello, Horst-Walter Birk, Werner Seeger, Davide Giavarina, Loris Salvador, Dana Y. Fuhrman, John A. Kellum and Claudio Ronco
    Citation: Journal of Translational Medicine 2022 20:204
  37. Tanimilast is a novel and selective inhaled inhibitor of phosphodiesterase-4 in advanced clinical development for chronic obstructive pulmonary disease (COPD). Tanimilast is known to exert prominent anti-infla...

    Authors: Hoang Oanh Nguyen, Valentina Salvi, Laura Tiberio, Fabrizio Facchinetti, Mirco Govoni, Gino Villetti, Maurizio Civelli, Ilaria Barbazza, Carolina Gaudenzi, Mauro Passari, Tiziana Schioppa, Francesca Sozio, Annalisa Del Prete, Silvano Sozzani and Daniela Bosisio
    Citation: Journal of Translational Medicine 2022 20:203
  38. Prostatic cancer (PCa) is one of the most common malignant tumors in men worldwide. Emerging evidence indicates significance of hypoxia and immunity in PCa invasion and metastasis. This study aimed to develop ...

    Authors: Fang Lyu, Yunxue Li, Zhecheng Yan, Qingliu He, Lulin Cheng, Pu Zhang, Bing Liu, Chunyu Liu, Yarong Song and Yifei Xing
    Citation: Journal of Translational Medicine 2022 20:202
  39. As a common complication of epithelial ovarian cancer (EOC), malignant ascites contributes to the peritoneal metastasis of EOC. CircRNAs play essential roles in tumor metastasis. However, no circRNAs have been...

    Authors: Ning Luo, Zubaidan Sulaiman, Chunyan Wang, Jinye Ding, Yingying Chen, Biting Liu, Zhongping Cheng and Shupeng Liu
    Citation: Journal of Translational Medicine 2022 20:201
  40. The Great Debate session at the 2021 Melanoma Bridge virtual congress (December 2–4) featured counterpoint views from experts on seven important issues in melanoma. The debates considered the use of adoptive c...

    Authors: Paolo A. Ascierto, Allison Betof Warner, Christian Blank, Corrado Caracò, Sandra Demaria, Jeffrey E. Gershenwald, Nikhil I. Khushalani, Georgina V. Long, Jason J. Luke, Janice M. Mehnert, Caroline Robert, Piotr Rutkowski, Hussein A. Tawbi, Iman Osman and Igor Puzanov
    Citation: Journal of Translational Medicine 2022 20:200
  41. Urinary extracellular vesicles (EVs) are a source of biomarkers with broad potential applications across clinical research, including monitoring radiation exposure. A key limitation to their implementation is ...

    Authors: Charles P. Hinzman, Meth Jayatilake, Sunil Bansal, Brian L. Fish, Yaoxiang Li, Yubo Zhang, Shivani Bansal, Michael Girgis, Anton Iliuk, Xiao Xu, Jose A. Fernandez, John H. Griffin, Elizabeth A. Ballew, Keith Unger, Marjan Boerma, Meetha Medhora…
    Citation: Journal of Translational Medicine 2022 20:199
  42. Serine/arginine-rich splicing factor 9 (SRSF9) is a classical RNA-binding protein that is essential for regulating gene expression programs through its interaction with target RNA. Whether SRSF9 plays an essen...

    Authors: Xiaoyu Wang, Xiansheng Lu, Ping Wang, Qiaoyu Chen, Le Xiong, Minshan Tang, Chang Hong, Xiaowen Lin, Kaixi Shi, Li Liang and Jie Lin
    Citation: Journal of Translational Medicine 2022 20:198
  43. N6-methyladenosine (m6A) RNA methylation plays a critical role in key genetic events for various cancers; yet, how m6A functions within the tumor microenvironment (TME) remains to be elucidated.

    Authors: Yuzhen Gao, Hao Wang, Shipeng Chen, Rui An, Yadong Chu, Guoli Li, Yanzhong Wang, Xinyou Xie and Jun Zhang
    Citation: Journal of Translational Medicine 2022 20:197
  44. Spondyloarthritis (SpA) and rheumatoid arthritis (RA) are chronic autoimmune diseases, but they are usually difficult to distinguish in the early stage of the diseases. The purpose of this study is to explore ...

    Authors: Jiaqian Wang, Yuan Xue and Liang Zhou
    Citation: Journal of Translational Medicine 2022 20:196
  45. Knowledge of the role of CYP2E1 in hepatocarcinogenesis is largely based on epidemiological and animal studies, with a primary focus on the role of CYP2E1 in metabolic activation of procarcinogens. Few studies...

    Authors: Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin and Haifeng Zhang
    Citation: Journal of Translational Medicine 2022 20:194
  46. We develop a new risk score to predict patients with stroke-associated pneumonia (SAP) who have an acute intracranial hemorrhage (ICH).

    Authors: Jing Yan, Weiqi Zhai, Zhaoxia Li, LingLing Ding, Jia You, Jiayi Zeng, Xin Yang, Chunjuan Wang, Xia Meng, Yong Jiang, Xiaodi Huang, Shouyan Wang, Yilong Wang, Zixiao Li, Shanfeng Zhu, Yongjun Wang…
    Citation: Journal of Translational Medicine 2022 20:193
  47. Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. However, expression profile and regulatory mechanism of TPI1 in breast cancer (BRCA) remain mysterious.

    Authors: Xiaoying Jin, Dandan Wang, Mengxia Lei, Yan Guo, Yuqing Cui, Fengzhi Chen, Weiling Sun and Xuesong Chen
    Citation: Journal of Translational Medicine 2022 20:191

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