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  1. Adipose tissue normally contains immune cells that regulate adipocyte function and contribute to metabolic disorders including obesity and diabetes mellitus. Psoriasis is associated with increased risk for met...

    Authors: Shawn Rose, Elena Stansky, Pradeep K Dagur, Leigh Samsel, Elizabeth Weiner, Amir Jahanshad, Julia Doveikis, Haley B Naik, Martin P Playford, J Philip McCoy and Nehal N Mehta
    Citation: Journal of Translational Medicine 2014 12:258
  2. Psoriasis is a multifactorial, chronic disease of skin affecting 2-3% of the world’s population. Genetic studies of psoriasis have identified a number of susceptibility genes that are involved in anti-viral im...

    Authors: Rashmi Gupta, Henri-Alexandre Michaud, Xue Zeng, Maya Debbaneh, Sarah T Arron, R Brad Jones, Christopher E Ormsby, Douglas F Nixon and Wilson Liao
    Citation: Journal of Translational Medicine 2014 12:256
  3. Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA ...

    Authors: Maria Lina Tornesello, Clorinda Annunziata, Luigi Buonaguro, Simona Losito, Stefano Greggi and Franco M Buonaguro
    Citation: Journal of Translational Medicine 2014 12:255
  4. The clipping of an artery supplying one of the two kidneys (2K1C) activates the renin-angiotensin (Ang) system (RAS), resulting in hypertension and endothelial dysfunction. Recently, we demonstrated the intrar...

    Authors: Ananda T Dias, Amanda S Cintra, Jéssica C Frossard, Zaira Palomino, Dulce E Casarini, Isabele BS Gomes, Camille M Balarini, Agata L Gava, Bianca P Campagnaro, Thiago MC Pereira, Silvana S Meyrelles and Elisardo C Vasquez
    Citation: Journal of Translational Medicine 2014 12:250
  5. Umbilical cord mesenchymal stem cells (UCMSCs) have a considerable advantage and potential in treating for central nervous system diseases and have become a novel alternative treatment for spinal cord injury. ...

    Authors: Hongbin Cheng, Xuebin Liu, Rongrong Hua, Guanghui Dai, Xiaodong Wang, Jianhua Gao and Yihua An
    Citation: Journal of Translational Medicine 2014 12:253
  6. Human cystatin C (HCC) is a potential biomarker for tubular damage and impaired renal function. It is difficult to obtain efficient paired monoclonal antibodies against HCC with low molecular to meet the requi...

    Authors: Renren Jiang, Chao Xu, Xiaoli Zhou, Tianhao Wang and Gang Yao
    Citation: Journal of Translational Medicine 2014 12:205
  7. Angiogenesis plays a pivotal role in malignant tumour growth and the metastatic process. We analysed the prognostic value of two angiogenesis parameters, microRNA-126 (miRNA-126) and microvessel density (MVD),...

    Authors: Torben Frøstrup Hansen, Sanne Kjær-Frifeldt, Søren Morgenthaler, Thorarinn Blondal, Jan Lindebjerg, Anders Jakobsen and Flemming Brandt Sørensen
    Citation: Journal of Translational Medicine 2014 12:254
  8. Postural tachycardia syndrome (POTS) is a heterogeneous disorder that creates challenges for treatment. Beta-blocker was one of the most commonly used drugs, but it is inconsistently effective. The purpose of ...

    Authors: Qingyou Zhang, Xia Chen, Jiawei Li and Junbao Du
    Citation: Journal of Translational Medicine 2014 12:249
  9. Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by largely unsatisfactory responses to the currently available therapeutic strategies. In this study we evaluated th...

    Authors: Francesca Tavano, Andrea Fontana, Fabio Pellegrini, Francesca Paola Burbaci, Francesca Rappa, Francesco Cappello, Massimiliano Copetti, Evaristo Maiello, Lucia Lombardi, Paolo Graziano, Manlio Vinciguerra, Fabio Francesco di Mola, Pierluigi di Sebastiano, Angelo Andriulli and Valerio Pazienza
    Citation: Journal of Translational Medicine 2014 12:248
  10. Accurate estimation of a burned area is crucial to decisions about fluid resuscitation, surgical options, nutritional support, and prognosis. Widely used clinical methods to estimate a burn area are two-dimens...

    Authors: Wen-bo Sheng, Ding Zeng, Yan Wan, Li Yao, Hong-tai Tang and Zhao-fan Xia
    Citation: Journal of Translational Medicine 2014 12:242
  11. IL-10+ regulatory B (Bregs), CD4+Foxp3+ regulatory T (Tregs), and CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells regulate the progression of infection disease. This study aimed at examining how those cells ...

    Authors: Li Wang, Jinpeng Qiu, Lei Yu, Xiaoli Hu, Pingwei Zhao and Yanfang Jiang
    Citation: Journal of Translational Medicine 2014 12:251
  12. At present, no effective clinical treatment is available for the late effects of radiation myelopathy. The aim of the present study was to assess the therapeutic effects of human umbilical cord-derived mesench...

    Authors: Li Wei, Jing Zhang, Xiu-Bin Xiao, Hai-Xing Mai, Ke Zheng, Wan-Liang Sun, Lei Wang, Feng Liang, Zai-Liang Yang, Yuan Liu, Yan-Qing Wang, Zhi-Fang Li, Jia-Ning Wang, Wei-Jing Zhang and Hua You
    Citation: Journal of Translational Medicine 2014 12:246
  13. Aberrant expression of miR-1 has been implicated in various cancers. However, the mechanisms underlying the role of miR-1 in CRC progression still have not been clarified clearly. Here, we showed the decreased...

    Authors: Lijun Xu, Yue Zhang, Hui Wang, Guanhua Zhang, Yanqing Ding and Liang Zhao
    Citation: Journal of Translational Medicine 2014 12:244
  14. This study was conducted to determine if anti-tumor vaccination administered prior to partial debulking surgery could improve survival using a murine solid tumour model.

    Authors: Scott A Fisher, Amanda Cleaver, Devina D Lakhiani, Andrea Khong, Theresa Connor, Ben Wylie, W Joost Lesterhuis, Bruce WS Robinson and Richard A Lake
    Citation: Journal of Translational Medicine 2014 12:245
  15. The inadequacy of existing therapeutic tools together with the paucity of organ donors have always led medical researchers to innovate the current treatment methods or to discover new ways to cure disease. Eme...

    Authors: Thekkeparambil Chandrabose Srijaya, Thamil Selvee Ramasamy and Noor Hayaty Abu Kasim
    Citation: Journal of Translational Medicine 2014 12:243
  16. Advances in melanoma treatment through targeted inhibition of oncogenic BRAF are limited owing to the development of acquired resistance. The involvement of BRAFV600E in metabolic reprogramming of melanoma cells ...

    Authors: Cecilie Abildgaard, Christina Dahl, Astrid L Basse, Tao Ma and Per Guldberg
    Citation: Journal of Translational Medicine 2014 12:247
  17. We explored how the knowledge translation and innovation processes are structured when theyresult in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature n...

    Authors: David Fajardo-Ortiz, Luis Duran, Laura Moreno, Hector Ochoa and Victor M Castaño
    Citation: Journal of Translational Medicine 2014 12:227
  18. HLA-haploidentical hematopoietic stem cell transplantation (HSCT) is suitable for patients lacking related or unrelated HLA-matched donors. Herein, we investigated whether plerixafor (MZ), as an adjunct to G-C...

    Authors: Sergio Rutella, Perla Filippini, Valentina Bertaina, Giuseppina Li Pira, Lidia Altomare, Stefano Ceccarelli, Letizia P Brescia, Barbarella Lucarelli, Elia Girolami, Gianpiero Conflitti, Maria Giuseppina Cefalo, Alice Bertaina, Tiziana Corsetti, Lorenzo Moretta and Franco Locatelli
    Citation: Journal of Translational Medicine 2014 12:240
  19. The treatment of oral squamous cell carcinoma (OSCC) following early detection is associated with good outcomes. Therefore, the survival and prognosis of OSCC patients could be hugely improved by identifying r...

    Authors: Yi-Hui Lai, Ru-Yin He, Jian-Liang Chou, Michael W-Y Chan, Yu-Fen Li and Chien-Kuo Tai
    Citation: Journal of Translational Medicine 2014 12:237
  20. Coexpression of CD160 and PD-1 on HIV-specific CD8+ T-cells defines a highly exhausted T-cell subset. CD160 binds to Herpes Virus Entry Mediator (HVEM) and blocking this interaction with HVEM antibodies reverses ...

    Authors: Mohamed El-Far, Charles Pellerin, Louise Pilote, Jean-Francois Fortin, Ivan A D Lessard, Yoav Peretz, Elizabeth Wardrop, Patrick Salois, Richard C Bethell, Michael G Cordingley and George Kukolj
    Citation: Journal of Translational Medicine 2014 12:217
  21. Expression of the long non-coding RNA (lncRNA) LOC285194 was previously shown to be correlated with aggressive clinicopathological features and poor prognosis in several cancers. The aim of the present study w...

    Authors: Yu-suo Tong, Xi-lei Zhou, Xiao-wei Wang, Qing-quan Wu, Tong-xin Yang, Jin Lv, Jin-song Yang, Bin Zhu and Xiu-feng Cao
    Citation: Journal of Translational Medicine 2014 12:233
  22. Since first sequencing the human genome in 2003, emerging genetic/genomic technologies have ushered in a revolutionary era of medicine that purports to bridge molecular biology and clinical care. The field of ...

    Authors: Vasiliki Rahimzadeh and Gillian Bartlett
    Citation: Journal of Translational Medicine 2014 12:238
  23. Salvia-Nelumbinis naturalis (SNN), initially called Jiangzhi Granula as a formulae of Chinese medicinal decoction, has been used clinically to treat non-alcoholic fatty liver disease (NAFLD) and related syndro...

    Authors: Li Zhang, Jiaoya Xu, Haiyan Song, Zemin Yao and Guang Ji
    Citation: Journal of Translational Medicine 2014 12:236
  24. Peroxisome proliferator-activated receptor gamma-2 gene (PPARγ2) rs1801282 (Pro12Ala) polymorphism has been associated with lower risk of metabolic disturbance and atherosclerosis. The aim of this study was to an...

    Authors: Pilar García-Broncano, Juan Berenguer, Amanda Fernández-Rodríguez, Daniel Pineda-Tenor, María Ángeles Jiménez-Sousa, Mónica García–Alvarez, Pilar Miralles, Teresa Aldámiz-Echevarria, Juan Carlos López, Dariela Micheloud and Salvador Resino
    Citation: Journal of Translational Medicine 2014 12:235
  25. Remote ischemic preconditioning (RIPC) protects the heart from ischemia and reperfusion (I/R) injury. The underlying molecular mechanisms are unclear. It has been demonstrated that Connexin 43 (Cx43) is critic...

    Authors: Timo Brandenburger, Ragnar Huhn, Andreas Galas, Benedikt H Pannen, Verena Keitel, Franziska Barthel, Inge Bauer and André Heinen
    Citation: Journal of Translational Medicine 2014 12:228
  26. Relative hypovolemia is frequently found in early stages of severe sepsis and septic shock and prompt and aggressive fluid therapy has become standard of care improving tissue perfusion and patient outcome. Th...

    Authors: Nivaldo Ribeiro Villela, Ana Olimpia Maia Teixeira dos Santos, Marcos Lopes de Miranda and Eliete Bouskela
    Citation: Journal of Translational Medicine 2014 12:232
  27. Activation of the PI3K/AKT pathway, a common mechanism in all subtypes of endometrial cancers (endometrioid and non-endometrioid tumors), has important roles in contributing to epithelial-mesenchymal transitio...

    Authors: Peixin Dong, Yosuke Konno, Hidemichi Watari, Masayoshi Hosaka, Masayuki Noguchi and Noriaki Sakuragi
    Citation: Journal of Translational Medicine 2014 12:231
  28. The molecular mechanisms whereby hepatitis B virus (HBV) induces hepatocellular carcinoma (HCC) remain elusive. We used genomic and molecular techniques to investigate host-virus interactions by studying multi...

    Authors: Marta Melis, Giacomo Diaz, David E Kleiner, Fausto Zamboni, Juraj Kabat, Jinping Lai, Giulia Mogavero, Ashley Tice, Ronald E Engle, Steven Becker, Charles R Brown, Jeffrey C Hanson, Jaime Rodriguez-Canales, Michael Emmert-Buck, Sugantha Govindarajan, Michael Kew…
    Citation: Journal of Translational Medicine 2014 12:230
  29. Epithelial ovarian carcinoma is the most lethal gynecological cancer due to its silent onset and recurrence with resistance to chemotherapy. Overexpression of oncogene c-Myc is one of the most frequently encou...

    Authors: Jiandong Wang, Xiaoli Ma, Hannah M Jones, Leo Li-Ying Chan, Fang Song, Weiyuan Zhang, Victoria L Bae-Jump and Chunxiao Zhou
    Citation: Journal of Translational Medicine 2014 12:226
  30. The treatment of human cancer has been seriously hampered for decades by resistance to chemotherapeutic drugs. A very efficient mechanism of tumor resistance to drugs is the proton pumps-mediated acidification...

    Authors: Enrico P Spugnini, Sabrina Buglioni, Francesca Carocci, Menicagli Francesco, Bruno Vincenzi, Maurizio Fanciulli and Stefano Fais
    Citation: Journal of Translational Medicine 2014 12:225
  31. Clozapine is highly effective in treatment-resistant schizophrenia, although, there remains significant variability in the response to this drug. To better understand this variability, the objective of this st...

    Authors: Claire H Li, Robert E Stratford Jr, Nieves Velez de Mendizabal, Thomas IFH Cremers, Bruce G Pollock, Benoit H Mulsant, Gary Remington and Robert R Bies
    Citation: Journal of Translational Medicine 2014 12:203
  32. NKT cells play a protective role in ischemia reperfusion (IR) injury, of which the trafficking in the body and recruitment in injured organs can be influenced by immunosuppressive therapy. Therefore, we invest...

    Authors: Chao Zhang, Long Zheng, Long Li, Lingyan Wang, Liping Li, Shang Huang, Chenli Gu, Lexi Zhang, Cheng Yang, Tongyu Zhu and Ruiming Rong
    Citation: Journal of Translational Medicine 2014 12:224
  33. Breast cancer risk is partially determined by several hormone-related factors. Preclinical and clinical studies suggested that resveratrol may modulate these hormonal factors.

    Authors: H-H Sherry Chow, Linda L Garland, Brandy M Heckman-Stoddard, Chiu-Hsieh Hsu, Valerie D Butler, Catherine A Cordova, Wade M Chew and Terri L Cornelison
    Citation: Journal of Translational Medicine 2014 12:223
  34. High mobility group box protein 1 (HMGB1) acts as an endogenous danger molecule that is released from necrotic cells and activated macrophages. We have previously shown that peptide Hp91, whose sequence corres...

    Authors: Rebecca Saenz, Diahnn Futalan, Lien Leutenez, Fien Eekhout, Jessie F Fecteau, Simeon Sundelius, Stig Sundqvist, Marie Larsson, Tomoko Hayashi, Boris Minev, Dennis Carson, Sadik Esener, Bradley Messmer and Davorka Messmer
    Citation: Journal of Translational Medicine 2014 12:211
  35. The role of molecular analysis in the management of gastrointestinal stromal tumors (GIST) remains indisputable. To date, tumor tissue extracted from specimens obtained by surgical or biopsy procedures has bee...

    Authors: Margherita Nannini, Annalisa Astolfi, Milena Urbini, Guido Biasco and Maria A Pantaleo
    Citation: Journal of Translational Medicine 2014 12:210
  36. Concepts like coercion, vulnerability, and dignitary harm have acquired specialized meanings in the research ethics literature. Institutional Review Boards (IRBs), also called Research Ethics Committees (RECs)...

    Authors: Simon N Whitney
    Citation: Journal of Translational Medicine 2014 12:201
  37. Systemic mast cell activation disease (MCAD) is characterized by an enhanced release of mast cell-derived mediators, including eicosanoids, which induce a broad spectrum of clinical symptoms. Accordingly, the ...

    Authors: Dirk Schäfer, Peter Dreßen, Stefan Brettner, Norbert-Folke Rath, Gerhard J Molderings, Katrin Jensen and Christina Ziemann
    Citation: Journal of Translational Medicine 2014 12:213
  38. CIK cells therapy has been evaluated as an adoptive cell immunotherapy for cancer patients, but there still have not been any standardized systems for evaluating the antitumor efficacy yet. The WHO and RECIST ...

    Authors: Xiao-Dong Li, Mei Ji, Xiao Zheng, Zhong-Hua Ning, Jun Wu, Binfeng Lu, Chang-Ping Wu and Jing-Ting Jiang
    Citation: Journal of Translational Medicine 2014 12:215
  39. Single cell transcriptome defined as the entire RNA or polyadenylated products of RNA polymerase II on a cell can describe the gene regulation networks responsible for physiological functions, behaviours, and ...

    Authors: Zhitu Zhu, Diane C Wang, Laurenţiu M Popescu and Xiangdong Wang
    Citation: Journal of Translational Medicine 2014 12:212
  40. Human placenta releases specific nanovesicles (i.e. exosomes) into the maternal circulation during pregnancy, however, the presence of placenta-derived exosomes in maternal blood during early pregnancy remains to...

    Authors: Suchismita Sarker, Katherin Scholz-Romero, Alejandra Perez, Sebastian E Illanes, Murray D Mitchell, Gregory E Rice and Carlos Salomon
    Citation: Journal of Translational Medicine 2014 12:204
  41. Transcription factor Sp1 is multifaceted, with the ability to function as an oncogene or a tumor suppressor, depending on the cellular context. We previously reported that Sp1 is required for the transcription...

    Authors: Jing-Ping Zhang, Hua Zhang, Hong-Bo Wang, Yan-Xian Li, Gui-Hong Liu, Shan Xing, Man-Zhi Li and Mu-Sheng Zeng
    Citation: Journal of Translational Medicine 2014 12:222
  42. Orthorexia and muscle dysmorphia are disorders affecting above all young adults whose prevalence and social impact are still unclear. We aimed to evaluate the prevalence of the traits of orthorexia and muscle ...

    Authors: Simona Bo, Rossana Zoccali, Valentina Ponzo, Laura Soldati, Luca De Carli, Andrea Benso, Elisabetta Fea, Alberto Rainoldi, Marilena Durazzo, Secondo Fassino and Giovanni Abbate-Daga
    Citation: Journal of Translational Medicine 2014 12:221
  43. Recently, regulatory T (Treg) cells have gained interest in the fields of immunopathology, transplantation and oncoimmunology. Here, we investigated the microRNA expression profile of human natural CD8+CD25+ Treg...

    Authors: Fadi Jebbawi, Hussein Fayyad-Kazan, Makram Merimi, Philippe Lewalle, Jean-Christophe Verougstraete, Oberdan Leo, Pedro Romero, Arsene Burny, Bassam Badran, Philippe Martiat and Redouane Rouas
    Citation: Journal of Translational Medicine 2014 12:218
  44. Atherosclerosis is a chronic inflammatory process of the vessel walls, and CD4+ T-cells are peculiar to both human and murine atherosclerotic lesions. There is a recent line of research favoring hypothetic allerg...

    Authors: Giovanni Tarantino, Susan Costantini, Carmine Finelli, Francesca Capone, Eliana Guerriero, Nicolina La Sala, Saverio Gioia and Giuseppe Castello
    Citation: Journal of Translational Medicine 2014 12:214
  45. our objective was to examine the plasma levels of three biological markers involved in cerebral ischemia (IL-6, glutamate and TNF-alpha) in stroke patients and compare them with two different rat models of foc...

    Authors: Patricia Martínez-Sánchez, María Gutiérrez-Fernández, Blanca Fuentes, Jaime Masjuán, María Alonso de Leciñana Cases, Maria Elena Novillo-López and Exuperio Díez-Tejedor
    Citation: Journal of Translational Medicine 2014 12:220
  46. The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol,...

    Authors: Stefania Bulotta, Marilena Celano, Saverio Massimo Lepore, Tiziana Montalcini, Arturo Pujia and Diego Russo
    Citation: Journal of Translational Medicine 2014 12:219
  47. Aurora kinase A (AurkA) is over-expressed in melanoma and its inhibition has been observed to limit tumor growth, suggesting a potential role in melanoma treatment.

    Authors: Emilia Caputo, Roberta Miceli, Maria Letizia Motti, Rosarita Taté, Federica Fratangelo, Gerardo Botti, Nicola Mozzillo, Maria Vincenza Carriero, Ernesta Cavalcanti, Giuseppe Palmieri, Gennaro Ciliberto, Giuseppe Pirozzi and Paolo Antonio Ascierto
    Citation: Journal of Translational Medicine 2014 12:216
  48. Platinum-based chemotherapy improves survival among patients with non-small cell lung cancer (NSCLC), but the efficiency is limited due to resistance. In this study, we aimed to identify the expression of Auro...

    Authors: Jie Xu, Cai-feng Yue, Wei-hua Zhou, Yuan-min Qian, Yan Zhang, Shao-wu Wang, An-wen Liu and Quentin Liu
    Citation: Journal of Translational Medicine 2014 12:200

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