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  1. Fatty acid synthase (FASN) is crucial to de novo long-chain fatty acid synthesis, needed to meet cancer cells’ increased demands for membrane, energy, and protein production.

    Authors: Dirk O Bauerschlag, Nicolai Maass, Peter Leonhardt, Frederik A Verburg, Ulrich Pecks, Felix Zeppernick, Agnieszka Morgenroth, Felix M Mottaghy, Rene Tolba, Ivo Meinhold-Heerlein and Karen Bräutigam
    Citation: Journal of Translational Medicine 2015 13:146
  2. The invariant natural killer T (iNKT) cell has been shown to play a central role in early stages immune responses against Mycobacterium tuberculosis (Mtb) infection, which become nonresponsive (anergic) and fails...

    Authors: Zhen-Min Jiang, Wei Luo, Qian Wen, Su-Dong Liu, Pei-Pei Hao, Chao-Ying Zhou, Ming-Qian Zhou and Li Ma
    Citation: Journal of Translational Medicine 2015 13:141
  3. Advanced melanoma patients have an extremely poor long term prognosis and are in strong need of new therapies. The recently developed targeted therapies have resulted in a marked antitumor effect, but most res...

    Authors: Carmela Rozera, Giancarlo Antonini Cappellini, Giuseppina D’Agostino, Laura Santodonato, Luciano Castiello, Francesca Urbani, Iole Macchia, Eleonora Aricò, Ida Casorelli, Paola Sestili, Enrica Montefiore, Domenica Monque, Davide Carlei, Mariarosaria Napolitano, Paola Rizza, Federica Moschella…
    Citation: Journal of Translational Medicine 2015 13:139
  4. Inflammatory breast cancer (IBC) is the most rare and aggressive variant of breast cancer (BC); however, only a limited number of specific gene signatures with low generalization abilities are available and fe...

    Authors: Andrea Remo, Ines Simeone, Massimo Pancione, Pietro Parcesepe, Pascal Finetti, Luigi Cerulo, Halima Bensmail, Daniel Birnbaum, Steven J Van Laere, Vittorio Colantuoni, Franco Bonetti, François Bertucci, Erminia Manfrin and Michele Ceccarelli
    Citation: Journal of Translational Medicine 2015 13:138
  5. Pancreatic ductal adenocarcinoma (PDAC) is still a lethal malignancy. Long noncoding RNAs (lncRNAs) have been shown to play a critical role in cancer development and progression. Here we identified overexpress...

    Authors: Yibiao Ye, Jie Chen, Yu Zhou, Zhiqiang Fu, Quanbo Zhou, YingXue Wang, Wenchao Gao, ShangYou Zheng, Xiaohui Zhao, Tao Chen and Rufu Chen
    Citation: Journal of Translational Medicine 2015 13:137
  6. Osteosarcoma (OS) is the most common pediatric primary malignant bone tumor. As the prognosis for patients following standard treatment did not improve for almost three decades, functional preclinical models t...

    Authors: Claudia Blattmann, Markus Thiemann, Albrecht Stenzinger, Eva K Roth, Anne Dittmar, Hendrik Witt, Burkhard Lehner, Eva Renker, Manfred Jugold, Viktoria Eichwald, Wilko Weichert, Peter E Huber and Andreas E Kulozik
    Citation: Journal of Translational Medicine 2015 13:136
  7. Functional brown adipose tissue (BAT), involved in energy expenditure, has recently been detected in substantial amounts in adults. Formerly overlooked BAT has now become an attractive anti-obesity target.

    Authors: Andrea Guennoun, Melissa Kazantzis, Remy Thomas, Martin Wabitsch, Daniel Tews, Konduru Seetharama Sastry, Mouaadh Abdelkarim, Vladimir Zilberfarb, Arthur Donny Strosberg and Lotfi Chouchane
    Citation: Journal of Translational Medicine 2015 13:135
  8. Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate ...

    Authors: Khalid Hussain Janbaz, Tashfeen Akhtar, Fatima Saqib, Imran Imran, Muhammad Zia-Ul-Haq, Chaweeewan Jansakul, Vincenzo De Feo and Marius Moga
    Citation: Journal of Translational Medicine 2015 13:134
  9. Cholesterol lowering statins have been demonstrated to exert anti-tumoral effects on breast cancer by decreasing proliferation as measured by Ki67. The biological mechanisms behind the anti-proliferative effec...

    Authors: Maria Feldt, Olöf Bjarnadottir, Siker Kimbung, Karin Jirström, Pär-Ola Bendahl, Srinivas Veerla, Dorthe Grabau, Ingrid Hedenfalk and Signe Borgquist
    Citation: Journal of Translational Medicine 2015 13:133
  10. The emergence of drug resistance in cancer patients limits the success rate of clinical chemotherapy. MicroRNAs (miRNAs) may play a role in chemoresistance and may be involved in modulating of some drug resist...

    Authors: Chengguang Sui, Fandong Meng, Yan Li and Youhong Jiang
    Citation: Journal of Translational Medicine 2015 13:132
  11. Combination chemotherapy is very active in small cell lung cancer (SCLC), although no improvement in overall survival (OS) has been done in the last 25 years, with Cisplatin-Etoposide (PE) still considered the...

    Authors: Corrado Boni, Maria Pagano, Licia Baldi, Roberta Gnoni, Luca Braglia, Luisa Savoldi and Francesca Zanelli
    Citation: Journal of Translational Medicine 2015 13:130
  12. Recent clinical studies suggest that inflammatory mediators have huge potential in individualized therapy and in efficacy screening and can be utilized as biomarkers for a plethora of pathological conditions. ...

    Authors: Raffaele Altara, Marco Manca, Kevin CM Hermans, Evangelos P Daskalopoulos, Hans-Peter Brunner-La Rocca, Rob JJ Hermans, Harry AJ Struijker-Boudier and Matthijs W Blankesteijn
    Citation: Journal of Translational Medicine 2015 13:129
  13. The important role of food and nutrition in public health is being increasingly recognized as crucial for its potential impact on health-related quality of life and the economy, both at the societal and indivi...

    Authors: Laura Di Renzo, Carmen Colica, Alberto Carraro, Beniamino Cenci Goga, Luigi Tonino Marsella, Roberto Botta, Maria Laura Colombo, Santo Gratteri, Ting Fa Margherita Chang, Maurizio Droli, Francesca Sarlo and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2015 13:128
  14. Enumeration of circulating tumor cells (CTCs) obtained from minimally invasive blood samples has been well established as a valuable monitoring tool in metastatic and early breast cancer, as well as in several...

    Authors: Henrik Frithiof, Charlotte Welinder, Anna-Maria Larsson, Lisa Rydén and Kristina Aaltonen
    Citation: Journal of Translational Medicine 2015 13:126
  15. Recent advances in extracellular signaling suggest that extracellular protein phosphorylation is a regulatory mechanism outside the cell. The list of reported active extracellular protein kinases and phosphata...

    Authors: Garif Yalak and Bjorn R Olsen
    Citation: Journal of Translational Medicine 2015 13:125
  16. Ebola hemorrhagic fever (Ebola) is still a highly lethal infectious disease long affecting mainly neglected populations in sub-Saharan Africa. Moreover, this disease is now considered a potential worldwide thr...

    Authors: David Fajardo-Ortiz, José Ortega-Sánchez-de-Tagle and Victor M Castaño
    Citation: Journal of Translational Medicine 2015 13:124
  17. Adoptive transfer of minor histocompatibility antigen (MiHA)-specific T cells is a promising therapy for patients with hematological cancers. However, the efficacy of the transferred cells is hampered by the a...

    Authors: Valérie Janelle, Cédric Carli, Julie Taillefer, Julie Orio and Jean-Sébastien Delisle
    Citation: Journal of Translational Medicine 2015 13:123
  18. Malignant mesothelioma (MM) arises from mesothelial cells that line the pleural, peritoneal and pericardial surfaces. The majority of MMs are pleural and have been associated with asbestos exposure. Previously...

    Authors: Hakan Alakus, Shawn E Yost, Brian Woo, Randall French, Grace Y Lin, Kristen Jepsen, Kelly A Frazer, Andrew M Lowy and Olivier Harismendy
    Citation: Journal of Translational Medicine 2015 13:122
  19. The anaphylactoid reactions induced by andrographis injection have repeatedly been reported. The aim of our study was to evaluate the immuno-sensitizing potential of extracts from Andrographis paniculata Nees and...

    Authors: Xuguang Hu, Ya Wen, Shasha Liu, Jiabo Luo, Xiaomei Tan, Zhiheng Li, Xinhua Lu and Xiaoying Long
    Citation: Journal of Translational Medicine 2015 13:121
  20. As IL-12 and IL-18 have important immunostimulatory role the aim of this study was to investigate their in vitro effects on functional and receptor characteristics of NK cells and their subsets in healthy control...

    Authors: Katarina Mirjačić Martinović, Nada Babović, Radan Džodić, Vladimir Jurišić, Suzana Matković and Gordana Konjević
    Citation: Journal of Translational Medicine 2015 13:120
  21. In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-rela...

    Authors: Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A Rouh, Idil I Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif…
    Citation: Journal of Translational Medicine 2015 13:119
  22. Stroke is the second most common cause of death in people over 45 years of age in Colombia and is the leading cause of permanent disability worldwide. Cerebral ischemia is a stroke characterized by decreased b...

    Authors: Johanna Andrea Gutiérrez-Vargas, Angel Cespedes-Rubio and Gloria Patricia Cardona-Gómez
    Citation: Journal of Translational Medicine 2015 13:118
  23. The endothelial glycocalyx layer (EGL) is a key regulator of vascular permeability, cell adhesion, and inflammation. The EGL is primarily composed of syndecan-1, hyaluronic acid (HA), heparan sulfate (HS) and ...

    Authors: Elaheh Rahbar, Jessica C Cardenas, Gyulnar Baimukanova, Benjamin Usadi, Roberta Bruhn, Shibani Pati, Sisse R Ostrowski, Pär I Johansson, John B Holcomb and Charles E Wade
    Citation: Journal of Translational Medicine 2015 13:117
  24. Genetic amplification of HER2 drives tumorigenesis and cancer progression in a subset of patients with gastric cancer (GC), and treatment with trastuzumab, a humanized HER2-neutralizing antibody, improves the ove...

    Authors: De-Hua Yu, Lili Tang, Hua Dong, Zhengwei Dong, Lianhai Zhang, Jiangang Fu, Xinying Su, Tianwei Zhang, Haihua Fu, Lu Han, Liang Xie, Hao Chen, Ziliang Qian, Guanshan Zhu, Jia Wang, Qingqing Ye…
    Citation: Journal of Translational Medicine 2015 13:116
  25. The upper gastrointestinal tract is home to some of most notorious cancers like esophagogastric and pancreatic cancer. Several factors contribute to the lethality of these tumors, but one that stands out for b...

    Authors: Helene Damhofer, Eva A Ebbing, Anne Steins, Lieke Welling, Johanna A Tol, Kausilia K Krishnadath, Tom van Leusden, Marc J van de Vijver, Marc G Besselink, Olivier R Busch, Mark I van Berge Henegouwen, Otto van Delden, Sybren L Meijer, Frederike Dijk, Jan Paul Medema, Hanneke W van Laarhoven…
    Citation: Journal of Translational Medicine 2015 13:115
  26. Docetaxel is one of the most frequently used drugs to treat breast cancer. However, resistance or incomplete response to docetaxel is a major challenge. The aim of this study was to utilize MR metabolomics to ...

    Authors: Jack JA van Asten, Riyas Vettukattil, Tessa Buckle, Sven Rottenberg, Fijs van Leeuwen, Tone F Bathen and Arend Heerschap
    Citation: Journal of Translational Medicine 2015 13:114
  27. Since it was first described, the imprinted cluster 11p15.5 has been reported to be deregulated in a variety of pediatric and adult cancers including that of the lung. Both protein coding and non-coding genes ...

    Authors: Imad J Matouk, David Halle, Michal Gilon and Abraham Hochberg
    Citation: Journal of Translational Medicine 2015 13:113
  28. A considerable proportion of autoimmune hemolytic anemia (AIHA) are secondary to underlying autoimmune disorders, especially syetemic lupus erythematosus (SLE), and the clinical and laboratory index for early ...

    Authors: Boting Wu, Weiguang Wang, Yanxia Zhan, Feng Li, Shanhua Zou, Lihua Sun and Yunfeng Cheng
    Citation: Journal of Translational Medicine 2015 13:112
  29. Current methodology for the diagnosis of diseases in the urinary system includes patient symptomology, urine analysis and urine culture. Asymptomatic bacteriuria from urethral colonization or indwelling cathet...

    Authors: Yanbao Yu, Patricia Sikorski, Cynthia Bowman-Gholston, Nicolas Cacciabeve, Karen E Nelson and Rembert Pieper
    Citation: Journal of Translational Medicine 2015 13:111
  30. Osteosarcoma (OS) is the most common type of solid bone cancer, with latent metastasis being a typical mode of disease progression and a major contributor to poor prognosis. For this to occur, cells must resis...

    Authors: Jessica M Foley, Donald J Scholten II, Noel R Monks, David Cherba, David J Monsma, Paula Davidson, Dawna Dylewski, Karl Dykema, Mary E Winn and Matthew R Steensma
    Citation: Journal of Translational Medicine 2015 13:110
  31. Non-alcoholic fatty liver disease represents the most common chronic liver disease in obese children of industrialized countries. Nowadays the first line of treatment of pediatric non-alcoholic fatty liver dis...

    Authors: Elvira Verduci, Carlotta Lassandro, Giovanni Radaelli and Laura Soldati
    Citation: Journal of Translational Medicine 2015 13:109
  32. In order to provide personalized treatment to patients with breast cancer, an accurate, reliable and cost-efficient analytical technique is needed for drug screening and evaluation of tumor response to chemoth...

    Authors: Bi-Bo Wu, Yi-Ping Gong, Xin-Hong Wu, Yuan-Yuan Chen, Fang-Fang Chen, Li-Ting Jin, Bo-Ran Cheng, Fen Hu and Bin Xiong
    Citation: Journal of Translational Medicine 2015 13:108
  33. Combined antiretroviral therapy has drastically reduced mortality and morbidity of HIV-infected individuals. Nevertheless long-term toxicity and appearance of viral resistance hampers the prolonged effectivene...

    Authors: Francesca Sironi, Mauro Malnati, Nicola Mongelli, Paolo Cozzi, Christina Guzzo, Silvia Ghezzi, Carles Martínez-Romero, Adolfo García-Sastre, Paolo Lusso, Daniela Jabes and Priscilla Biswas
    Citation: Journal of Translational Medicine 2015 13:107
  34. The mammalian target of rapamycin (mTOR) signaling pathway plays a pivotal role in numerous cellular processes involving growth, proliferation and survival. The purpose of this study was to investigate the ant...

    Authors: Franziska Niehr, Wilko Weichert, Albrecht Stenzinger, Volker Budach and Ingeborg Tinhofer
    Citation: Journal of Translational Medicine 2015 13:106
  35. Let-7a has been shown to play important roles in nasopharyngeal carcinoma (NPC) cell proliferation and apoptosis, but little is known about the function and mechanism of let-7a in nasopharyngeal carcinoma meta...

    Authors: Aibing Wu, Kunpeng Wu, Jinmei Li, Yanli Mo, Yanming Lin, Yuzhou Wang, Xiang Shen, Shujun Li, Lixia Li and Zhixiong Yang
    Citation: Journal of Translational Medicine 2015 13:105
  36. Acquired radioresistance has significantly compromised the efficacy of radiotherapy for esophageal cancer. The purpose of this study is to investigate the roles of epithelial-mesenchymal transition (EMT) and t...

    Authors: Huafang Su, Xiance Jin, Xuebang Zhang, Lihao Zhao, Baochai Lin, Lili Li, Zhenghua Fei, Lanxiao Shen, Ya Fang, Huanle Pan and Congying Xie
    Citation: Journal of Translational Medicine 2015 13:104
  37. Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by numerous fluid-filled cysts that frequently result in end-stage renal disease. While promising treatment options are ...

    Authors: Nathalie Piazzon, Florian Bernet, Linda Guihard, Wouter N Leonhard, Séverine Urfer, Dmitri Firsov, Hassib Chehade, Bruno Vogt, Sophia Piergiovanni, Dorien JM Peters, Olivier Bonny and Daniel B Constam
    Citation: Journal of Translational Medicine 2015 13:103
  38. Recurrent platinum-resistant ovarian cancer has no curative options, necessitating the development of novel treatments, including immunotherapy.

    Authors: Mythili Koneru, Roisin O’Cearbhaill, Swati Pendharkar, David R Spriggs and Renier J Brentjens
    Citation: Journal of Translational Medicine 2015 13:102
  39. Tumor associated antigens are useful in colorectal cancer (CRC) management. The ribosomal P proteins (P0, P1, P2) play an important role in protein synthesis and tumor formation. The immunogenicity of the ribo...

    Authors: Monica Benvenuto, Pierpaolo Sileri, Piero Rossi, Laura Masuelli, Massimo Fantini, Monica Nanni, Luana Franceschilli, Giuseppe Sconocchia, Giulia Lanzilli, Roberto Arriga, Giovanni Faggioni, Florigio Lista, Augusto Orlandi, Vittorio Manzari, Achille Lucio Gaspari, Andrea Modesti…
    Citation: Journal of Translational Medicine 2015 13:101
  40. Ganoderma lucidum polysaccharides (GLPS) have been used as traditional Chinese medicine for their properties of cancer prevention and immunomodulation. However, it is unclear whether GLPS has t...

    Authors: Aimei Li, Xuanyu Shuai, Zhijun Jia, Hangyu Li, Xiubin Liang, Dongming Su and Wanhua Guo
    Citation: Journal of Translational Medicine 2015 13:100
  41. Vascular disease is promoted by systemic inflammation that can arise from sites distal to the affected vessels. We sought to characterize the net inflammatory potential of serum from patients with coronary art...

    Authors: Heidi Cung, Mario J Aragon, Katherine Zychowski, Joe R Anderson, James Nawarskas, Carlos Roldan, Akshay Sood, Clifford Qualls and Matthew J Campen
    Citation: Journal of Translational Medicine 2015 13:99
  42. Dormant leukemia stem cells (LSC) promote therapeutic resistance and leukemic progression as a result of unbridled activation of stem cell gene expression programs. Thus, we hypothesized that 1) deregulation o...

    Authors: Anil Sadarangani, Gabriel Pineda, Kathleen M Lennon, Hye-Jung Chun, Alice Shih, Annelie E Schairer, Angela C Court, Daniel J Goff, Sacha L Prashad, Ifat Geron, Russell Wall, John D McPherson, Richard A Moore, Minya Pu, Lei Bao, Amy Jackson-Fisher…
    Citation: Journal of Translational Medicine 2015 13:98
  43. Aquaporins (AQPs) are a family of water channel proteins distributed in various human tissues, responsible for the transport of small solutes such as glycerol, even gas and ions. The expression of AQPs has bee...

    Authors: Jian Wang, Li Feng, Zhitu Zhu, Minghuan Zheng, Diane Wang, Zhihong Chen and Hongzhi Sun
    Citation: Journal of Translational Medicine 2015 13:96
  44. Melatonin, a well-known antioxidant, has been shown to possess anti-invasive properties for glioma. However, little is known about the effect of melatonin on glioma cell migration and invasion under hypoxia, w...

    Authors: Cheng-Shi Xu, Ze-Fen Wang, Xiao-Dong Huang, Li-Ming Dai, Chang-Jun Cao and Zhi-Qiang Li
    Citation: Journal of Translational Medicine 2015 13:95
  45. Rare hematopoietic stem cell populations are responsible for the transplantation engraftment process. Umbilical cord blood (UCB) is usually processed to the total nucleated cell (TNC), but not to the mononucle...

    Authors: John Patterson, Cally H Moore, Emily Palser, Jason C Hearn, Daniela Dumitru, Holli A Harper and Ivan N Rich
    Citation: Journal of Translational Medicine 2015 13:94
  46. Interleukin-12 (IL-12) has long been considered to be effective in triggering an anticancer immune response, however, the dosage has been limited by potential systemic immunotoxicity. Since focused ultrasound ...

    Authors: Pin-Yuan Chen, Han-Yi Hsieh, Chiung-Yin Huang, Chun-Yen Lin, Kuo-Chen Wei and Hao-Li Liu
    Citation: Journal of Translational Medicine 2015 13:93
  47. Osteoclasts, bone-specialized multinucleated cells, are responsible for bone destructive diseases such as rheumatoid arthritis and osteoporosis. Natural plant-derived products have received substantial attenti...

    Authors: Xiangying Kong, Wenbin Wu, Yue Yang, Hongye Wan, Xiaomin Li, Michun Zhong, Hongyan Zhao, Xiaohui Su, Shiwei Jia, Dahong Ju and Na Lin
    Citation: Journal of Translational Medicine 2015 13:91

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:199

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