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  1. The endometrial regenerative cell (ERC) is a novel type of adult mesenchymal stem cell isolated from menstrual blood. Previous studies demonstrated that ERCs possess unique immunoregulatory properties in vitro...

    Authors: Shanzheng Lu, Ganggang Shi, Xiaoxi Xu, Grace Wang, Xu Lan, Peng Sun, Xiang Li, Baoren Zhang, Xiangying Gu, Thomas E. Ichim and Hao Wang
    Citation: Journal of Translational Medicine 2016 14:300
  2. Age has been reported as an independent prognostic factor for melanoma-specific survival (MSS). We tested the hypothesis that age impacts the host anti-tumor immune response, accounting for age-specific surviv...

    Authors: Sarah A. Weiss, Joseph Han, Farbod Darvishian, Jeremy Tchack, Sung Won Han, Karolina Malecek, Michelle Krogsgaard, Iman Osman and Judy Zhong
    Citation: Journal of Translational Medicine 2016 14:299
  3. Tumor microenvironment (TME) plays an integral part in the biology of cancer, participating in tumor initiation, progression, and response to therapy. Exosome is an important part of TME. Exosomes are small ve...

    Authors: Zhen Wang, Jun-Qiang Chen, Jin-lu Liu and Lei Tian
    Citation: Journal of Translational Medicine 2016 14:297
  4. The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The “1st International NTNU...

    Authors: Ana I. Robles, Karina Standahl Olsen, Dana W.T. Tsui, Vassilis Georgoulias, Jenette Creaney, Katalin Dobra, Mogens Vyberg, Nagahiro Minato, Robert A. Anders, Anne-Lise Børresen-Dale, Jianwei Zhou, Pål Sætrom, Boye Schnack Nielsen, Michaela B. Kirschner, Hans E. Krokan, Vassiliki Papadimitrakopoulou…
    Citation: Journal of Translational Medicine 2016 14:295
  5. The noble gas helium induces pre- and postconditioning in animals and humans. Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery. We hypothesized that...

    Authors: Kirsten F. Smit, Daniel Brevoord, Stefan De Hert, Bas A. de Mol, Raphaela P. Kerindongo, Susan van Dieren, Wolfgang S. Schlack, Markus W. Hollmann, Nina C. Weber and Benedikt Preckel
    Citation: Journal of Translational Medicine 2016 14:294
  6. Authors: Anne Hecksteden, Petra Leidinger, Christina Backes, Stefanie Rheinheimer, Mark Pfeiffer, Alexander Ferrauti, Michael Kellmann, Farbod Sedaghat-Hamedani, Benjamin Meder, Eckart Meese, Tim Meyer and Andreas Keller
    Citation: Journal of Translational Medicine 2016 14:293

    The original article was published in Journal of Translational Medicine 2016 14:219

  7. Activation of oncogenes downstream the EGFR gene contributes to colorectal tumorigenesis and determines the sensitivity to anti-EGFR treatments. The aim of this study was to evaluate the prognostic value of KRAS,...

    Authors: Grazia Palomba, Valentina Doneddu, Antonio Cossu, Panagiotis Paliogiannis, Antonella Manca, Milena Casula, Maria Colombino, Annamaria Lanzillo, Efisio Defraia, Antonio Pazzola, Giovanni Sanna, Carlo Putzu, Salvatore Ortu, Mario Scartozzi, Maria Teresa Ionta, Giovanni Baldino…
    Citation: Journal of Translational Medicine 2016 14:292
  8. Suboptimal health status (SHS) is a physical state between health and disease, characterized by the perception of health complaints, general weakness, chronic fatigue and low energy levels. SHS is proposed by ...

    Authors: Youxin Wang, Siqi Ge, Yuxiang Yan, Anxin Wang, Zhongyao Zhao, Xinwei Yu, Jing Qiu, Mohamed Ali Alzain, Hao Wang, Honghong Fang, Qing Gao, Manshu Song, Jie Zhang, Yong Zhou and Wei Wang
    Citation: Journal of Translational Medicine 2016 14:291
  9. Intermittent fasting (IF) is an increasingly popular dietary approach used for weight loss and overall health. While there is an increasing body of evidence demonstrating beneficial effects of IF on blood lipi...

    Authors: Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri and Antonio Paoli
    Citation: Journal of Translational Medicine 2016 14:290
  10. Certain glomerulopathies are associated with increased levels of CD80 (B7-1). We measured the urinary excretion of CD80, podocyturia and proteinuria in controls and in subjects with Fabry disease either untrea...

    Authors: H. Trimarchi, R. Canzonieri, A. Schiel, C. Costales-Collaguazo, J. Politei, A. Stern, M. Paulero, T. Rengel, J. Andrews, M. Forrester, M. Lombi, V. Pomeranz, R. Iriarte, A. Muryan, E. Zotta, M. D. Sanchez-Niño…
    Citation: Journal of Translational Medicine 2016 14:289
  11. Gene therapy protocols require robust and long-term gene expression. For two decades, retrovirus family vectors have offered several attractive properties as stable gene-delivery vehicles. These vectors repres...

    Authors: José Eduardo Vargas, Leonardo Chicaybam, Renato Tetelbom Stein, Amilcar Tanuri, Andrés Delgado-Cañedo and Martin H. Bonamino
    Citation: Journal of Translational Medicine 2016 14:288
  12. Bladder cancer (BCa) is among the most commonly diagnosed malignancies worldwide, and due the high rate of post-operative disease recurrence, it is one of the most prevalent in many countries. The development ...

    Authors: Steve Goodison, Osamu Ogawa, Yoshiyuki Matsui, Takashi Kobayashi, Makito Miyake, Sayuri Ohnishi, Kiyohide Fujimoto, Yunfeng Dai, Yoshiko Shimizu, Kazue Tsukikawa, Hideki Furuya and Charles J. Rosser
    Citation: Journal of Translational Medicine 2016 14:287
  13. Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Efficient antiviral T-cell responses are necessary to clear infect...

    Authors: Sabine Tischer, René Geyeregger, Julian Kwoczek, Albert Heim, Constanca Figueiredo, Rainer Blasczyk, Britta Maecker-Kolhoff and Britta Eiz-Vesper
    Citation: Journal of Translational Medicine 2016 14:286
  14. Several cellular functions relate to ion-channels activity. Physiologically relevant chains of events leading to angiogenesis, cell cycle and different forms of cell death, require transmembrane voltage contro...

    Authors: Antonella Biasiotta, Daniela D’Arcangelo, Francesca Passarelli, Ezio Maria Nicodemi and Antonio Facchiano
    Citation: Journal of Translational Medicine 2016 14:285
  15. Patients with lower extremity peripheral artery disease (PAD) have decreased mobility, which is not fully explained by impaired blood supply to the lower limb. Additionally, reports are conflicted regarding fi...

    Authors: Sarah H. White, Mary M. McDermott, Robert L. Sufit, Kate Kosmac, Alex W. Bugg, Marta Gonzalez-Freire, Luigi Ferrucci, Lu Tian, Lihui Zhao, Ying Gao, Melina R. Kibbe, Michael H. Criqui, Christiaan Leeuwenburgh and Charlotte A. Peterson
    Citation: Journal of Translational Medicine 2016 14:284

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:45

  16. Asthma is prone to Th2-mediated chronic airway inflammation. Interleukin-27 (IL-27) is a member of the IL-12 family that promotes the differentiation of Th1 cells and inhibits Th2 cells. We use human/mouse CD4+ T...

    Authors: Xiaoqiong Su, Jue Pan, Fengxi Bai, Honglei Yuan, Nian Dong, Dandan Li, Xiangdong Wang and Zhihong Chen
    Citation: Journal of Translational Medicine 2016 14:283
  17. Cancer immunotherapy can be potentiated by conditioning regimens such as cyclophosphamide, which reduces the level of regulatory T cells (tregs). However, myeloid suppressive cells are still remaining. Accordi...

    Authors: Emma Eriksson, Jessica Wenthe, Sandra Irenaeus, Angelica Loskog and Gustav Ullenhag
    Citation: Journal of Translational Medicine 2016 14:282
  18. Vitamin D (VitD) and thymoquinone (TQ) are nutraceutical agents with well-known immunomodulatory and hepatoprotective properties. This study measured whether VitD and TQ, individually or combined, could have d...

    Authors: Abdelghany Hassan Abdelghany, Mohammad A. BaSalamah, Shakir Idris, Jawwad Ahmad and Bassem Refaat
    Citation: Journal of Translational Medicine 2016 14:281
  19. Knowledge of the molecular mechanisms on malignant tumors is very critical for the development of new treatment strategies like molecularly targeted therapies. In last 5 years, many investigations suggest that...

    Authors: Rong Biaoxue, Cai Xiguang, Liu Hua and Yang Shuanying
    Citation: Journal of Translational Medicine 2016 14:279
  20. Small cell lung cancers (SCLC) are tumors of neuroendocrine origin. Previous in vitro studies from our laboratory showed that SCLC expresses high levels of the transmembrane dense core vesicle protein IA-2 (is...

    Authors: Huanyu Xu, Tao Cai, Gilberto N. Carmona, Liron Abuhatzira and Abner L. Notkins
    Citation: Journal of Translational Medicine 2016 14:278
  21. Ischemia reperfusion injury (IRI) induced immune response is a critical issue in transplantation. Complement and contact system activation are among its key mechanisms.

    Authors: Pierre-Olivier Delpech, Raphael Thuillier, Thibault SaintYves, Jerome Danion, Sylvain Le Pape, Edwin S. van Amersfoort, Beatrijs Oortwijn, Gilles Blancho and Thierry Hauet
    Citation: Journal of Translational Medicine 2016 14:277
  22. Previous studies have suggested that people with obesity showed elevated serum levels of leptin as well as lipid dysfunction and proprotein convertase subtilisin/kexin type 9 (PCSK9) played an important role i...

    Authors: Ying Du, Sha Li, Chuan-Jue Cui, Yan Zhang, Sheng-Hua Yang and Jian-Jun Li
    Citation: Journal of Translational Medicine 2016 14:276
  23. FEAT is an intracellular protein that potently drives tumorigenesis in vivo. It is only weakly expressed in normal human tissues, including the testis. In contrast, FEAT is aberrantly upregulated in most human...

    Authors: Yan Li, Kyosuke Kobayashi, Marwa M. Mona, Chikako Satomi, Shinji Okano, Hiroyuki Inoue, Kenzaburo Tani and Atsushi Takahashi
    Citation: Journal of Translational Medicine 2016 14:275
  24. Mutations in the isocitrate dehydrogenase enzyme are present in a majority of lower-grade gliomas and secondary glioblastomas. This mis-sense mutation results in the neomorphic reduction of isocitrate dehydrog...

    Authors: Gaurav Verma, Suyash Mohan, MacLean P. Nasrallah, Steven Brem, John Y. K. Lee, Sanjeev Chawla, Sumei Wang, Rajakumar Nagarajan, M. Albert Thomas and Harish Poptani
    Citation: Journal of Translational Medicine 2016 14:274
  25. The fifth “Melanoma Bridge Meeting” took place in Naples, December 1–5th, 2015. The main topics discussed at this meeting were: Molecular and Immuno advances, Immunotherapies and Combination Therapies, Tumor M...

    Authors: J. Galon, B. A. Fox, C. B. Bifulco, G. Masucci, T. Rau, G. Botti, F. M. Marincola, G. Ciliberto, F. Pages, P. A. Ascierto and M. Capone
    Citation: Journal of Translational Medicine 2016 14:273
  26. Chronic myelogenous leukemia (CML) is a hematological stem cell disorder. Tyrosine kinase inhibitors (TKIs) are the standard treatments for CML, but a number of patients fail to respond effectively due to gene...

    Authors: Ying Lu, Ling-Ling Liu, Shou-Sheng Liu, Zhi-Gang Fang, Yong Zou, Xu-Bin Deng, Zi-Jie Long, Quentin Liu and Dong-Jun Lin
    Citation: Journal of Translational Medicine 2016 14:270
  27. Research and development of new drugs requires both long time and high costs, whereas safety and tolerability profiles make the success rate of approval very low. Drug repurposing, applying known drugs and com...

    Authors: Junichi Ishida, Masaaki Konishi, Nicole Ebner and Jochen Springer
    Citation: Journal of Translational Medicine 2016 14:269
  28. To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)].

    Authors: Linfeng Xu, Xuefeng Qiu, Yanting Zhang, Kai Cao, Xiaozhi Zhao, Jinhui Wu, Yiqiao Hu and Hongqian Guo
    Citation: Journal of Translational Medicine 2016 14:268
  29. Despite standard treatment for epithelial ovarian cancer (EOC), that involves cytoreductive surgery followed by platinum-based chemotherapy, and initial high response rates to these, up to 80 % of patients exp...

    Authors: Anselmo Papa, Davide Caruso, Martina Strudel, Silverio Tomao and Federica Tomao
    Citation: Journal of Translational Medicine 2016 14:267
  30. We recently demonstrated a positive effect of berberine on nonalcoholic fatty liver disease patients after 16 weeks of treatment by comparing mere lifestyle intervention in type 2 diabetes patients with berber...

    Authors: Xinxia Chang, Zhe Wang, Jinlan Zhang, Hongmei Yan, Hua Bian, Mingfeng Xia, Huandong Lin, Jiandong Jiang and Xin Gao
    Citation: Journal of Translational Medicine 2016 14:266
  31. Although important advances in the management of breast cancer (BC) have been recently accomplished, it still constitutes the leading cause of cancer death in women worldwide. BC is a heterogeneous and complex...

    Authors: Maria Amorim, Sofia Salta, Rui Henrique and Carmen Jerónimo
    Citation: Journal of Translational Medicine 2016 14:265
  32. Cytokine-induced-killer (CIK) cells are a promising immunotherapeutic approach for impending relapse following hematopoietic stem cell transplantation (HSCT). However, there is a high risk for treatment failur...

    Authors: Melanie Bremm, Sabine Huenecke, Olga Zimmermann, Verena Pfirrmann, Andrea Quaiser, Halvard Bonig, Jan Soerensen, Thomas Klingebiel, Eva Rettinger, Peter Bader and Claudia Cappel
    Citation: Journal of Translational Medicine 2016 14:264
  33. Moniliformediquinone (MFD), a phenanthradiquinone in Dendrobium moniliforme, was synthesized in our laboratory. Beyond its in vitro inhibitory effects on cancer cells, other biological activity of MFD is unknown....

    Authors: Tsui-Hwa Tseng, Wea-Lung Lin, Zi-Hui Chen, Yean-Jang Lee, Ming-Shiun Shie, Kam-Fai Lee, Chien-Heng Shen and Hsing-Chun Kuo
    Citation: Journal of Translational Medicine 2016 14:263
  34. Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (...

    Authors: Laura Giusti, Francesca Sernissi, Elena Donadio, Federica Ciregia, Camillo Giacomelli, Gino Giannaccini, Maria Rosa Mazzoni, Antonio Lucacchini and Laura Bazzichi
    Citation: Journal of Translational Medicine 2016 14:262
  35. Treatment for acute myeloid leukemia (AML) has not significantly changed in the last decades and new therapeutic approaches are needed to achieve prolonged survival rates. Leukemia stem cells (LSC) are respons...

    Authors: María Carmen Lara-Castillo, Josep Maria Cornet-Masana, Amaia Etxabe, Antònia Banús-Mulet, Miguel Ángel Torrente, Meritxell Nomdedeu, Marina Díaz-Beyá, Jordi Esteve and Ruth M. Risueño
    Citation: Journal of Translational Medicine 2016 14:261
  36. Body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI), triglyceride glucose index (TyG), TyG-BMI, and TyG-WC have been reported as markers of insulin resistance or type 2 diabetes mel...

    Authors: Shuang Zheng, Sheng Shi, Xingxing Ren, Tingting Han, Yangxue Li, Yawen Chen, Wei Liu, Peter C. Hou and Yaomin Hu
    Citation: Journal of Translational Medicine 2016 14:260
  37. The Vk*MYC transgenic and transplant mouse models of multiple myeloma (MM) are well established as a research tool for anti-myeloma drug discovery. However, little is known of the immune response in these mode...

    Authors: Rachel E. Cooke, Nicholas A. Gherardin, Simon J. Harrison, Hang Quach, Dale I. Godfrey, Miles Prince, Rachel Koldej and David S. Ritchie
    Citation: Journal of Translational Medicine 2016 14:259
  38. Nonunion is a failure of healing following a bone fracture. Its physiopathology remains partially unclear and the discovery of new mediators could promote the understanding of bone healing.

    Authors: Dominique de Seny, Gaël Cobraiville, Pierre Leprince, Marianne Fillet, Charlotte Collin, Myrielle Mathieu, Jean-Philippe Hauzeur, Valérie Gangji and Michel G. Malaise
    Citation: Journal of Translational Medicine 2016 14:258
  39. TRIM5 and TRIM22 are restriction factors involved in innate immune response and exhibit anti-viral activity. Single nucleotide polymorphisms (SNPs) at TRIM5 and TRIM22 genes have shown to influence several viral ...

    Authors: Luz M. Medrano, Norma Rallón, Juan Berenguer, María A. Jiménez-Sousa, Vicente Soriano, Teresa Aldámiz-Echevarria, Amanda Fernández-Rodríguez, Marcial García, Francisco Tejerina, Isidoro Martínez, José M. Benito and Salvador Resino
    Citation: Journal of Translational Medicine 2016 14:257
  40. Idiopathic pulmonary fibrosis (IPF) identifies a specific lung disorder characterized by chronic, progressive fibrosing interstitial pneumonia of unknown etiology, which lacks effective treatment. According to...

    Authors: Giulia M. Stella, Alessandra Gentile, Alice Balderacchi, Federica Meloni, Melissa Milan and Silvia Benvenuti
    Citation: Journal of Translational Medicine 2016 14:256

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:194

  41. Cellular biobanking is a key resource for collaborative networks planning to use same cells in studies aimed at solving a variety of biological and biomedical issues. This approach is of great importance in st...

    Authors: Lucia Carmela Cosenza, Laura Breda, Giulia Breveglieri, Cristina Zuccato, Alessia Finotti, Ilaria Lampronti, Monica Borgatti, Francesco Chiavilli, Maria Rita Gamberini, Stefania Satta, Laura Manunza, Franca Rosa De Martis, Paolo Moi, Stefano Rivella, Roberto Gambari and Nicoletta Bianchi
    Citation: Journal of Translational Medicine 2016 14:255
  42. Urtica dioica has traditionally been used in the management of cardiovascular disorders especially hypertension. The aim of this study was to explore pharmacological base of its use in...

    Authors: Rahila Qayyum, Hafiz Misbah-ud-Din Qamar, Shamim Khan, Umme Salma, Taous Khan and Abdul Jabbar Shah
    Citation: Journal of Translational Medicine 2016 14:254
  43. Chronic low back pain due to disc degeneration represents a major social and economic burden worldwide. The current standard of care is limited to symptomatic relief and no current approved therapy promotes di...

    Authors: Christian Elabd, Christopher J. Centeno, John R. Schultz, Gregory Lutz, Thomas Ichim and Francisco J. Silva
    Citation: Journal of Translational Medicine 2016 14:253
  44. Although survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategie...

    Authors: Raffaele Frazzi, Charles Auffray, Angela Ferrari, Perla Filippini, Sergio Rutella and Alfredo Cesario
    Citation: Journal of Translational Medicine 2016 14:252
  45. Myalgic encephalomyelitis chronic fatigue syndrome (ME/CFS) is a common debilitating disorder associated with an intense fatigue, a reduced physical activity, and an impaired quality of life. There are no esta...

    Authors: Emmanuel Fenouillet, Aude Vigouroux, Jean Guillaume Steinberg, Alexandre Chagvardieff, Frédérique Retornaz, Regis Guieu and Yves Jammes
    Citation: Journal of Translational Medicine 2016 14:251

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