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  1. Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway has emerged as a crucial co...

    Authors: Muhammad Tufail, Jia-Ju Hu, Jie Liang, Cai-Yun He, Wen-Dong Wan, Yu-Qi Huang, Can-Hua Jiang, Hong Wu and Ning Li
    Citation: Journal of Translational Medicine 2024 22:15
  2. Neoantigens are patient- and tumor-specific peptides that arise from somatic mutations. They stand as promising targets for personalized therapeutic cancer vaccines. The identification process for neoantigens ...

    Authors: Ana Barajas, Pep Amengual-Rigo, Anna Pons-Grífols, Raquel Ortiz, Oriol Gracia Carmona, Victor Urrea, Nuria de la Iglesia, Juan Blanco-Heredia, Carla Anjos-Souza, Ismael Varela, Benjamin Trinité, Ferran Tarrés-Freixas, Carla Rovirosa, Rosalba Lepore, Miguel Vázquez, Leticia de Mattos-Arruda…
    Citation: Journal of Translational Medicine 2024 22:14
  3. Radioresistance and lymph node metastasis are common phenotypes of refractory oral squamous cell carcinoma (OSCC). As a result, understanding the mechanism for radioresistance and metastatic progression is urg...

    Authors: Hui-Wen Chiu, Hsin-Lun Lee, Hsun-Hua Lee, Hsiao-Wei Lu, Kent Yu-Hsien Lin, Yuan-Feng Lin and Che-Hsuan Lin
    Citation: Journal of Translational Medicine 2024 22:13
  4. Prostate cancer (PCa) is the second leading cause of cancer-related mortality among men worldwide, and its incidence has risen substantially in recent years. Therefore, there is an urgent need to identify nove...

    Authors: Enchong Zhang, Zhengjie Chen, Wangmin Liu, Lin Lin, Lina Wu, Johnny Guan, Jianfeng Wang, Chuize Kong, Jianbin Bi and Mo Zhang
    Citation: Journal of Translational Medicine 2024 22:12
  5. Gut microbiota alterations have been implicated in sepsis and related infectious diseases, but the causal relationship and underlying mechanisms remain unclear.

    Authors: Sha Yang, Jing Guo, Zhuo Kong, Mei Deng, Jingjing Da, Xin Lin, Shuo Peng, Junwu Fu, Tao Luo, Jun Ma, Hao Yin, Lin Liu, Jian Liu, Yan Zha, Ying Tan and Jiqin Zhang
    Citation: Journal of Translational Medicine 2024 22:10
  6. Epigenetic regulation is reported to play a significant role in the pathogenesis of various kidney diseases, including renal cell carcinoma, acute kidney injury, renal fibrosis, diabetic nephropathy, and lupus...

    Authors: Xinzhou Yan, Yuqi Xia, Bojun Li, Zehua Ye, Lei Li, Tianhui Yuan, Baofeng Song, Weimin Yu, Ting Rao, Jinzhuo Ning, Fangyou Lin, Shuqin Mei, Zhiguo Mao, Xiangjun Zhou, Wei Li and Fan Cheng
    Citation: Journal of Translational Medicine 2024 22:9
  7. No single marker of bladder cancer (BC) exists in urine samples with sufficient accuracy for disease diagnosis and treatment monitoring. The multiplex Oncuria BC assay noninvasively quantifies the concentratio...

    Authors: Hideki Furuya, Toru Sakatani, Sunao Tanaka, Kaoru Murakami, Richard T. Waldron, Wayne Hogrefe and Charles J. Rosser
    Citation: Journal of Translational Medicine 2024 22:8
  8. Prenatal exposure to intrauterine inflammation (IUI) is a crucial event in preterm birth (PTB) pathophysiology, increasing the incidence of neurodevelopmental disorders. Gut microbiota and metabolite profile a...

    Authors: Bei Jia, Lijun Tang, Huibing Liu, Wenqian Chen, Qian Chen, Mei Zhong and Ailan Yin
    Citation: Journal of Translational Medicine 2024 22:7
  9. Tandem C2 domains, nuclear (TC2N) is a C2 domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem C2 protein family, and acts as an oncogenic driver in several cancers. Previously,...

    Authors: Xiang-lin Hao, Yang-fan Lv, De-feng Li, Fu-hai Bai, Ji Gong, Guang-qiang Pan, Lin-xi Su, Ya-li Wang, Wan-lei Fu, Bo Liu, Lu Huang, Dong Yan, Qiu-lin Tan, Jin-yi Liu and Qiao-nan Guo
    Citation: Journal of Translational Medicine 2024 22:6
  10. Bladder cancer is very common worldwide. PIGT is a subunit of the glycosylphosphatidylinositol transamidase which involves in tumorigenesis and invasiveness. m6A modification of mRNA has been linked to cell pr...

    Authors: Mingyue Tan, Qi Pan, Chao Yu, Xinyu Zhai, Jianyi Gu, Le Tao and Dongliang Xu
    Citation: Journal of Translational Medicine 2024 22:5
  11. NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes...

    Authors: Li Yuhan, Maryam Khaleghi Ghadiri and Ali Gorji
    Citation: Journal of Translational Medicine 2024 22:4
  12. Liver cancer is a major malignant tumor, which seriously threatens human health and increases the economic burden on patients. At present, gene therapy has been comprehensively studied as an excellent therapeu...

    Authors: Junhe Zhang, Yunxi Xiao, Jie Zhang, Yun Yang, Liao Zhang and Fan Liang
    Citation: Journal of Translational Medicine 2024 22:3
  13. Diabetes mellitus (DM) is a progressive disease that involves multiple organs due to increased blood glucose, and diabetic retinopathy (DR) is the main complication of DM in the eyes and causes irreversible vi...

    Authors: Yihan Wang, Yujuan Liu, Junwei Fang, Xindan Xing, Hanying Wang, Xin Shi, Xinyi Liu, Tian Niu and Kun Liu
    Citation: Journal of Translational Medicine 2024 22:2
  14. No residual disease (R0 resection) after debulking surgery is the most critical independent prognostic factor for advanced ovarian cancer (AOC). There is an unmet clinical need for selecting primary or interva...

    Authors: Xiaofang Zhou, Mu Liu, Lijuan Sun, Yumei Cao, Shanmei Tan, Guangxia Luo, Tingting Liu, Ying Yao, Wangli Xiao, Ziqing Wan and Jie Tang
    Citation: Journal of Translational Medicine 2023 21:927
  15. While cartilage tissue engineering has significantly improved the speed and quality of cartilage regeneration, the underlying metabolic mechanisms are complex, making research in this area lengthy and challeng...

    Authors: Xiao-he Wang, Ning Liu, Hui Zhang, Zong-sheng Yin and Zhen-Gang Zha
    Citation: Journal of Translational Medicine 2023 21:926
  16. Heart transplantation (HT) has been approved as an optimal therapeutic regimen for patients with terminal-stage cardiac failure. However, cold ischaemia‒reperfusion (I/R) injury remains an unavoidable and outs...

    Authors: Shun Yuan, Yanjia Che, Zhiwei Wang, Kai Xing, Xiaoping Xie and Yuanyang Chen
    Citation: Journal of Translational Medicine 2023 21:925
  17. The tumor microenvironment clearly influences cancer progressing properties but less is known about how individual cancer microenvironments potentially moderate cancer treatment effects. By cultivating and tre...

    Authors: Maria Carmen Leiva, Anna Gustafsson, Elena Garre, Anders Ståhlberg, Anikó Kovács, Khalil Helou and Göran Landberg
    Citation: Journal of Translational Medicine 2023 21:924
  18. Intrahepatic cholangiocarcinoma (ICC) is poorly treated due to the presence of an inhibitory immune microenvironment. Tumor-associated macrophages (TAM) are an important component of TME. ALOX5 is an important...

    Authors: Jialu Chen, Yue Tang, Delong Qin, Xiaopeng Yu, Huanjun Tong, Chengwei Tang and Zhaohui Tang
    Citation: Journal of Translational Medicine 2023 21:923
  19. Pain is a worldwide problem requiring an effective, affordable, non-addictive therapy. Using the edible plant broccoli, a growth protocol was developed to induce a concentrated combinatorial of potential anti-...

    Authors: Aleksandra A. Gurgul, Yahya Najjar, Ana Chee, Howard An, Chun-Tao Che, Thomas J. Park and Katherine M. Warpeha
    Citation: Journal of Translational Medicine 2023 21:922
  20. Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most prevalent metabolic syndromes worldwide. However, no approved pharmacological treatments are available for MAFLD. Chenpi, one kin...

    Authors: Jing-wen Yang, Ying Zou, Jun Chen, Chen Cui, Jia Song, Meng-meng Yang, Jing Gao, Hui-qing Hu, Long-qing Xia, Li-ming Wang, Xiao-yu Lv, Li Chen and Xin-guo Hou
    Citation: Journal of Translational Medicine 2023 21:921
  21. Previous studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) plays an anti-atherosclerosis role through reverse cholesterol transport. Several studies have validated the efficacy and sa...

    Authors: Yilin Chen, Fengwei Zhang, Jijia Sun and Lei Zhang
    Citation: Journal of Translational Medicine 2023 21:920
  22. Mutations in TP53 gene is considered a main driver of hepatocellular carcinoma (HCC). While TP53 mutations are the leading cause of p53 dysfunction, their occurrence rates may drop to approximately 10% in cohorts...

    Authors: Chun Wang, Hui Kang, Yun Yi, Yang Ding, Fan Wang, Jie Luo, Mingliang Ye, Yinghui Hong, Chao Xia, Junwei Yan, Lan Liu, Jing Liu, Zibiao Zhong, Zhonglin Zhang, Qiu Zhao and Ying Chang
    Citation: Journal of Translational Medicine 2023 21:919
  23. Early diagnosis of hepatocellular carcinoma (HCC) is essential towards the improvement of prognosis and patient survival. Circulating markers such as α-fetoprotein (AFP) and micro-RNAs represent useful tools b...

    Authors: Vicky Caponigro, Anna L. Tornesello, Fabrizio Merciai, Danila La Gioia, Emanuela Salviati, Manuela G. Basilicata, Simona Musella, Francesco Izzo, Angelo S. Megna, Luigi Buonaguro, Eduardo Sommella, Franco M. Buonaguro, Maria L. Tornesello and Pietro Campiglia
    Citation: Journal of Translational Medicine 2023 21:918
  24. Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum (T. pallidum), has had a worldwide resurgence in recent years and remains a public health threat. As such, there has been a great deal o...

    Authors: Shun Xiong, Zhaoping Liu, Xiaohong Zhang, Shaobin Huang, Xuan Ding, Jie Zhou, Jiangchen Yao, Weiwei Li, Shuangquan Liu and Feijun Zhao
    Citation: Journal of Translational Medicine 2023 21:917
  25. Mounting attention has been focused on defects of the autophagy-lysosomal pathway in sepsis, however, the precise mechanisms governing the autophagy-lysosomal process in sepsis are poorly known. We have previo...

    Authors: Qing Fang, Guoqing Jing, Ying Zhang, Hongyu Wang, Huan Luo, Yun Xia, Qiyan Jin, Yuping Liu, Jing Zuo, Cheng Yang, Xiaodong Zhang, Shi Liu, Xiaojing Wu and Xuemin Song
    Citation: Journal of Translational Medicine 2023 21:916
  26. SARS-CoV-2, the pathogen of COVID-19, is a worldwide threat to human health and causes a long-term burden on the cardiovascular system. Individuals with pre-existing cardiovascular diseases are at higher risk ...

    Authors: Shiyu Dai, Ting Cao, Han Shen, Xuejing Zong, Wenyu Gu, Hanghang Li, Lei Wei, Haoyue Huang, Yunsheng Yu, Yihuan Chen, Wenxue Ye, Fei Hua, Hongyou Fan and Zhenya Shen
    Citation: Journal of Translational Medicine 2023 21:915
  27. Magnetic resonance fingerprinting (MRF) enables fast myelin quantification via the myelin water fraction (MWF), offering a noninvasive method to assess brain development and disease. However, MRF-derived MWF l...

    Authors: Hyun Gi Kim, Dongyeob Han, Jimin Kim, Jeong-Sun Choi and Kyung-Ok Cho
    Citation: Journal of Translational Medicine 2023 21:914
  28. Bioelectrical impedance analysis (BIA) is a rapid and user-friendly technique for assessing body composition in sports. Currently, no sport-specific predictive equations are available, and the utilization of g...

    Authors: Francesco Campa, Tindaro Bongiovanni, Alessio Rossi, Giuseppe Cerullo, Andrea Casolo, Giulia Martera, Athos Trecroci, Tatiana Moro and Antonio Paoli
    Citation: Journal of Translational Medicine 2023 21:912
  29. Pancreatic cancer is an aggressive malignancy with high mortality, and cancer cell stemness and related drug resistance are considered important contributors to its poor prognosis. The objective of this study ...

    Authors: Xiao-hui Li, Gui-zhong Huang, Zi-lan Xu, Chong-yu Zhao, Xiao-yuan Dong, Bo-kang Cui and Xiao-jun Lin
    Citation: Journal of Translational Medicine 2023 21:911
  30. Retinal degeneration (RD) is a group of disorders on irreversible vision loss. Multiple types of stem cells were used in clinical trials for RD treatment. However, it remains unknown what kinds of stem cells a...

    Authors: Qian Liu, Jun Liu, Minmei Guo, Tzu-Cheng Sung, Ting Wang, Tao Yu, Zeyu Tian, Guoping Fan, Wencan Wu and Akon Higuchi
    Citation: Journal of Translational Medicine 2023 21:910
  31. The occurrence of epithelial-mesenchymal transition (EMT) and immune evasion is considered to contribute to poor prognosis in lung adenocarcinoma (LUAD). Therefore, this study aims to explore the key oncogenes...

    Authors: Yafeng Liu, Tao Han, Jing Wu, Jiawei Zhou, Jianqiang Guo, Rui Miao, Zhi Xu, Yingru Xing, Ying Bai and Dong Hu
    Citation: Journal of Translational Medicine 2023 21:909
  32. Chronic itch (chronic pruritus) is a major therapeutic challenge that remains poorly understood despite the extensive recent analysis of human pruriceptors. It is unclear how the peripheral nervous system diff...

    Authors: Andrea Fiebig, Victoria Leibl, David Oostendorf, Saskia Lukaschek, Jens Frömbgen, Maral Masoudi, Andreas E. Kremer, Marion Strupf, Peter Reeh, Miriam Düll and Barbara Namer
    Citation: Journal of Translational Medicine 2023 21:908
  33. Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, with poor outcomes for patients with metastatic disease or chemotherapy resistance. Cirsiliol is a recently found ...

    Authors: Mengliang Luo, Zexin Su, Haotian Gao, Jianye Tan, Rongdong Liao, Jiancheng Yang and Lijun Lin
    Citation: Journal of Translational Medicine 2023 21:907
  34. Obesity, characterized by visceral adipose tissue (VAT) expansion, is closely associated with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatit...

    Authors: Noel Salvoza, Pablo Giraudi, Silvia Gazzin, Deborah Bonazza, Silvia Palmisano, Nicolò de Manzini, Fabrizio Zanconati, Alan Raseni, Francesca Sirianni, Claudio Tiribelli and Natalia Rosso
    Citation: Journal of Translational Medicine 2023 21:906
  35. CD8+ T cells are the executor in adaptive immune response, especially in anti-tumor immunity. They are the subset immune cells that are of high plasticity and multifunction. Their development, differentiation, ac...

    Authors: Jinghong Wu, Zhendong Lu, Hong Zhao, Mingjun Lu, Qing Gao, Nanying Che, Jinghui Wang and Teng Ma
    Citation: Journal of Translational Medicine 2023 21:905
  36. Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT). However...

    Authors: Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui and Jianxin Wan
    Citation: Journal of Translational Medicine 2023 21:904
  37. Pancreatic ductal adenocarcinoma (PDAC) is characterized by rapid progression and poor prognosis. Understanding the genetic mechanisms that affect cancer properties and reprogram tumor immune microenvironment ...

    Authors: Wenbo Yang, Hongze Chen, Guanqun Li, Tao Zhang, Yuhang Sui, Liwei Liu, Jisheng Hu, Gang Wang, Hua Chen, Yongwei Wang, Xina Li, Hongtao Tan, Rui Kong, Bei Sun and Le Li
    Citation: Journal of Translational Medicine 2023 21:903
  38. Congenital heart defect (CHD) is the most common congenital abnormality, and it has long been a clinical and public health concern. Our previous findings have found Periostin (POSTN) and Pappalysin-1 (PAPPA) a...

    Authors: Yi Xia, Liang Chen, JinWen Lu, Jianhong Ma and Yuanzhen Zhang
    Citation: Journal of Translational Medicine 2023 21:901
  39. Intrahepatic cholangiocarcinoma (ICC) accounts for about 15% of primary liver cancer, and the incidence rate has been rising in recent years. Surgical resection is the best treatment for ICC, but the 5-year su...

    Authors: Huhu Zhang, Xiaolei Dong, Xiaoyan Ding, Guoxiang Liu, Fanghao Yang, Qinghang Song, Hongxiao Sun, Guang Chen, Shuang Li, Ya Li, Mengjun Wang, Tingting Guo, Zhe Zhang, Bing Li and Lina Yang
    Citation: Journal of Translational Medicine 2023 21:900
  40. The consumption of various herbal infusions was and is common in the traditional Mediterranean diet, and apparently are used in many other regions of the world outside of the Mediterranean region. The present ...

    Authors: Ekaterina-Michaela Tomou, Eleni Peppa and Antonia Trichopoulou
    Citation: Journal of Translational Medicine 2023 21:899
  41. Early microbial exposure is associate with protective allergic asthma. We have previously demonstrated that Streptococcus pneumoniae aminopeptidase N (PepN), one of the pneumococcal components, inhibits ovalbumin...

    Authors: Shifei Yao, Danlin Weng, Yan Wang, Yanyu Zhang, Qi Huang, Kaifeng Wu, Honghui Li, Xuemei Zhang, Yibing Yin and Wenchun Xu
    Citation: Journal of Translational Medicine 2023 21:898
  42. The alkaloid camptothecin analog SN38 is a potent antineoplastic agent, but cannot be used directly for clinical application due to its poor water solubility. Currently, the prodrug approach on SN38 has result...

    Authors: Changjun Yu, Faqing Huang, Kinsley Wang, Mengmeng Liu, Warren A. Chow, Xiang Ling, Fengzhi Li, Jason L. Causey, Xiuzhen Huang, Galen Cook-Wiens and Xiaojiang Cui
    Citation: Journal of Translational Medicine 2023 21:897
  43. Attentional deficits are among the most common pain-induced cognitive disorders. Pain disrupts attention and may excessively occupy attentional resources in pathological states, leading to daily function impai...

    Authors: Huan-Yu Zheng, Yu-Meng Chen, Yao Xu, Cheng Cen and Yun Wang
    Citation: Journal of Translational Medicine 2023 21:896

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:217

  44. Chronic lung diseases include an array of conditions that impact airways and lung structures, leading to considerable societal burdens. Mesenchymal stem cells (MSCs) and their exosomes (MSC-exos) can be used f...

    Authors: Zhengyao Zhai, Tairong Cui, Jialiang Chen, Xulong Mao and Ting Zhang
    Citation: Journal of Translational Medicine 2023 21:895
  45. The immune-related microenvironment of thymic carcinoid has rarely been reported. We analyzed the expression of PD-L1 and VISTA, and the distribution of CD4+ T cells, CD8+ T cells and CD68+ macrophages in the thy...

    Authors: Jiaqi Zhang, Chao Guo, Lei Liu, Ke Zhao, Mengxin Zhou, Yeye Chen and Shanqing Li
    Citation: Journal of Translational Medicine 2023 21:894
  46. Glioblastoma (GBM) comprises 45.6% of all primary malignant brain cancers and is one of the most common and aggressive intracranial tumors in adults. Intratumoral heterogeneity with a wide range of proteomic, ...

    Authors: Christian K. Ramsoomair, Michele Ceccarelli, John D. Heiss and Ashish H. Shah
    Citation: Journal of Translational Medicine 2023 21:893

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