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  1. From a global viewpoint, endometrial cancer belongs to the most common female cancers. Despite the heavy burden of diseases and numerous unanswered questions, no detailed pictures of the global structure of en...

    Authors: Dörthe Brüggmann, Katja Ouassou, Doris Klingelhöfer, Michael K. Bohlmann, Jenny Jaque and David A. Groneberg

    Citation: Journal of Translational Medicine 2020 18:386

    Content type: Research

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  2. Many contradictory conclusions pertaining to the telomere length in peripheral leukocyte chromosomes as a potential biomarker for ischemic stroke (IS) risk have been reported by the various observational studi...

    Authors: Weijie Cao, Deqiang Zheng, Jie Zhang, Anxin Wang, Di Liu, Jinxia Zhang, Manjot Singh, Isinta Elijah Maranga, Mingyang Cao, Lijuan Wu, Manshu Song, Wei Wang and Youxin Wang

    Citation: Journal of Translational Medicine 2020 18:385

    Content type: Research

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  3. Autoimmune hepatitis (AIH) is a liver disease characterized by the autoimmune-induced injury of hepatocytes which can lead to cirrhosis and hepatic failure. The diagnosis and disease management of AIH patients...

    Authors: Rui Wu, Yan Liu, Ruyu Yan, Xiaoyu Liu and Liang Duan

    Citation: Journal of Translational Medicine 2020 18:384

    Content type: Research

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  4. A major obstacle to anti-viral and -tumor cell vaccination and T cell immunotherapy is the ability to produce dendritic cells (DCs) in a suitable clinical setting. It is imperative to develop closed cell cultu...

    Authors: Jean-Philippe Bastien, Natalie Fekete, Ariane V. Beland, Marie-Paule Lachambre, Veronique Laforte, David Juncker, Vibhuti Dave, Denis-Claude Roy and Corinne A. Hoesli

    Citation: Journal of Translational Medicine 2020 18:383

    Content type: Research

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  5. The gut microbiota was shown to play a crucial role in the development of vascular dysfunction, and the bacterial composition differed between healthy controls and coronary artery disease patients. The goal of...

    Authors: Honghong Liu, Ran Tian, Hui Wang, Siqin Feng, Hanyu Li, Ying Xiao, Xiaodong Luan, Zhiyu Zhang, Na Shi, Haitao Niu and Shuyang Zhang

    Citation: Journal of Translational Medicine 2020 18:382

    Content type: Research

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  6. Sepsis is a leading cause of mortality and morbidity in the intensive care unit. Regulatory mechanisms underlying the disease progression and prognosis are largely unknown. The study aimed to identify master r...

    Authors: Zhongheng Zhang, Lin Chen, Ping Xu, Lifeng Xing, Yucai Hong and Pengpeng Chen

    Citation: Journal of Translational Medicine 2020 18:381

    Content type: Research

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  7. The incidence of stage I and stage II lung adenocarcinoma (LUAD) is likely to increase with the introduction of annual screening programs for high-risk individuals. We aimed to identify a reliable prognostic s...

    Authors: Pancheng Wu, Yi Zheng, Yanyu Wang, Yadong Wang and Naixin Liang

    Citation: Journal of Translational Medicine 2020 18:380

    Content type: Research

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  8. Electronic cigarette use is on the rise despite a number of reports linking electronic cigarettes with adverse health outcomes. Recent studies have suggested that alterations in lipid signaling may be one mech...

    Authors: Holly R. Middlekauff, Kevin J. William, Baolong Su, Kacey Haptonstall, Jesus A. Araujo, Xiaohui Wu, Jason Kim and Tamer Sallam

    Citation: Journal of Translational Medicine 2020 18:379

    Content type: Research

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  9. Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes,...

    Authors: Qingyu Liang, Gefei Guan, Xue Li, Chunmi Wei, Jianqi Wu, Peng Cheng, Anhua Wu and Wen Cheng

    Citation: Journal of Translational Medicine 2020 18:378

    Content type: Research

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  10. It is well established that thymidylate synthase inhibitors can cause cellular toxicity through uracil DNA glycosylase (UNG2)-dependent pathways. Additionally, thymidylate synthase inhibitors and HDAC inhibito...

    Authors: Meredith S. Showler and Brian P. Weiser

    Citation: Journal of Translational Medicine 2020 18:377

    Content type: Commentary

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  11. It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in ...

    Authors: Ghazale Fahimian, Javad Zahiri, Seyed Shahriar Arab and Reza H. Sajedi

    Citation: Journal of Translational Medicine 2020 18:375

    Content type: Research

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  12. Cannabis has been documented for use in alleviating anxiety. However, certain research has also shown that it can produce feelings of anxiety, panic, paranoia and psychosis. In humans, Δ9-tetrahydrocannabinol (TH...

    Authors: Lara Sharpe, Justin Sinclair, Andrew Kramer, Michael de Manincor and Jerome Sarris

    Citation: Journal of Translational Medicine 2020 18:374

    Content type: Research

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  13. Elevated lipoprotein(a) [Lp(a)] and fibrinogen (Fib) are both associated with coronary artery disease (CAD). The atherogenicity of Lp(a) can be partly due to the potentially antifibrinolytic categories. We hyp...

    Authors: Yan Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Hui Liu, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Ying Gao, Qi Hua, Yan-Fang Li, Rui-Xia Xu, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun and Jian-Jun Li

    Citation: Journal of Translational Medicine 2020 18:373

    Content type: Research

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  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qiuyan Guo, Xia Mao, Yanqiong Zhang, Shuqin Meng, Yue Xi, Yi Ding, Xiaocun Zhang, Yuntao Dai, Xia Liu, Chao Wang, Yuting Li and Na Lin

    Citation: Journal of Translational Medicine 2020 18:372

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2016 14:165

  15. The non-classical human leukocyte antigen (HLA)-G is a strong immunomodulatory molecule. Under physiological conditions, HLA-G induces immunological tolerance in immune privileged tissues, while under pathophy...

    Authors: Michael Friedrich, Christine Stoehr, Simon Jasinski-Bergner, Arndt Hartmann, Sven Wach, Bernd Wullich, André Steven and Barbara Seliger

    Citation: Journal of Translational Medicine 2020 18:371

    Content type: Research

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  16. Kidney transplantation is the optimal treatment to cure the patients with end-stage renal disease (ESRD). However, the infectious complication, especially pneumonia, is the main cause of mortality in the early...

    Authors: Bo Peng, Hang Gong, Han Tian, Quan Zhuang, Junhui Li, Ke Cheng and Yingzi Ming

    Citation: Journal of Translational Medicine 2020 18:370

    Content type: Research

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  17. The complexities of modern biomedicine are rapidly increasing. Thus, modeling and simulation have become increasingly important as a strategy to understand and predict the trajectory of pathophysiology, diseas...

    Authors: Ahmet Erdemir, Lealem Mulugeta, Joy P. Ku, Andrew Drach, Marc Horner, Tina M. Morrison, Grace C. Y. Peng, Rajanikanth Vadigepalli, William W. Lytton and Jerry G. Myers Jr.

    Citation: Journal of Translational Medicine 2020 18:369

    Content type: Review

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  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hao Zhang, Fan Fan, Yuanqiang Yu, Zeyu Wang, Fangkun Liu, Ziyu Dai, Liyang Zhang, Zhixiong Liu and Quan Cheng

    Citation: Journal of Translational Medicine 2020 18:368

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2020 18:305

  19. The existence of active crosstalk between cells in a paracrine and juxtacrine manner dictates specific activity under physiological and pathological conditions. Upon juxtacrine interaction between the cells, v...

    Authors: Hesam Saghaei Bagheri, Farhad Bani, Savas Tasoglu, Amir Zarebkohan, Reza Rahbarghazi and Emel Sokullu

    Citation: Journal of Translational Medicine 2020 18:367

    Content type: Review

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  20. Pregnant women with gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) are at increased risks of pre-term labor, hypertension and preeclampsia. In this study, metabolic profiling of blood s...

    Authors: Ilhame Diboun, Manjunath Ramanjaneya, Yasser Majeed, Lina Ahmed, Mohammed Bashir, Alexandra E. Butler, Abdul Badi Abou-Samra, Stephen L. Atkin, Nayef A. Mazloum and Mohamed A. Elrayess

    Citation: Journal of Translational Medicine 2020 18:366

    Content type: Research

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  21. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious and complex physical illness that affects all body systems with a multiplicity of symptoms, but key hallmarks of the disease are pervasi...

    Authors: Eiren Sweetman, Torsten Kleffmann, Christina Edgar, Michel de Lange, Rosamund Vallings and Warren Tate

    Citation: Journal of Translational Medicine 2020 18:365

    Content type: Research

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  22. Adoptive transfer of engineered immune cells is a promising strategy for cancer treatment. However, low transduction efficiency particularly when large payload lentiviral vectors are used on primary T cells is...

    Authors: Lingyu Li, Yuan Gao, Richa Srivastava, Wei Wang, Qinghui Xiong, Zhiming Fang, Alejandra Pelayo, Carolyn Denson, Angshumala Goswami, Rona Harari-Steinfeld, Zhifen Yang, Lihong Weng, Lei Stanley Qi and Francesco M. Marincola

    Citation: Journal of Translational Medicine 2020 18:363

    Content type: Research

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  23. Since the first outbreak of SARS-CoV-2, the clinical characteristics of the Coronavirus Disease 2019 (COVID-19) have been progressively changed. Data reporting a viral intra-host and inter-host evolution favou...

    Authors: Francesca Caccuri, Alberto Zani, Serena Messali, Marta Giovanetti, Antonella Bugatti, Giovanni Campisi, Federica Filippini, Erika Scaltriti, Massimo Ciccozzi, Simona Fiorentini and Arnaldo Caruso

    Citation: Journal of Translational Medicine 2020 18:362

    Content type: Research

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  24. Extracellular vesicles (ECV) and bone extracellular matrix (ECM) have beneficial effects on the treatment of some pathological conditions. The purpose of this study was to find the synergic effects of decellul...

    Authors: Asrin Emami, Tahereh Talaei-Khozani, Saeid Tavanafar, Nehleh Zareifard, Negar Azarpira and Zahra Vojdani

    Citation: Journal of Translational Medicine 2020 18:361

    Content type: Research

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  25. Cancer stem cells (CSCs) are crucial to the malignant behaviour and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). In recent years, CSC biology has been widely studied, but practical prognostic sig...

    Authors: Zengyu Feng, Minmin Shi, Kexian Li, Yang Ma, Lingxi Jiang, Hao Chen and Chenghong Peng

    Citation: Journal of Translational Medicine 2020 18:360

    Content type: Research

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  26. More than seven months into the coronavirus disease -19 (COVID-19) pandemic, infection from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 21.2 million cases and resulted in o...

    Authors: Maurice A. Canham, John D. M. Campbell and Joanne C. Mountford

    Citation: Journal of Translational Medicine 2020 18:359

    Content type: Review

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  27. COVID-19 caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan (Hubei province, China) during late 2019. It has spread across the globe affecting nearly 21 million ...

    Authors: Sina Salajegheh Tazerji, Phelipe Magalhães Duarte, Parastoo Rahimi, Fatemeh Shahabinejad, Santosh Dhakal, Yashpal Singh Malik, Awad A. Shehata, Juan Lama, Jörn Klein, Muhammad Safdar, Md. Tanvir Rahman, Krzysztof J. Filipiak, Alfonso J. Rodríguez-Morales, Md. Abdus Sobur, Farrokhreza Kabir, Bita Vazir…

    Citation: Journal of Translational Medicine 2020 18:358

    Content type: Review

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  28. Epithelial ovarian cancer (EOC) is the most lethal disease among female genital malignant tumors. Peptidylarginine deiminase type II(PADI II) has been shown to enhance a variety of cancers carcinogenesis, incl...

    Authors: Lidong Liu, Zhiwei Zhang, Guoxiang Zhang, Ting Wang, Yingchun Ma and Wei Guo

    Citation: Journal of Translational Medicine 2020 18:357

    Content type: Research

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  29. Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants m...

    Authors: José María Lamo-Espinosa, Juan F. Blanco, Mikel Sánchez, Victoria Moreno, Froilán Granero-Moltó, Fermín Sánchez-Guijo, Íñigo Crespo-Cullel, Gonzalo Mora, Diego Delgado San Vicente, Orlando Pompei-Fernández, Jesús Dámaso Aquerreta, Jorge María Núñez-Córdoba, María Vitoria Sola, Andrés Valentí-Azcárate, Enrique J. Andreu, María del Consuelo del Cañizo…

    Citation: Journal of Translational Medicine 2020 18:356

    Content type: Research

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  30. Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an essential component of the linker of the cytoskeleton and nucleoskeleton (LINC) complex, namely nesprin-3. In a tumor, invasivenes...

    Authors: Liwei Liao, Longshan Zhang, Mi Yang, Xiaoqing Wang, Weiqiang Huang, Xixi Wu, Hua Pan, Lu Yuan, Wenqi Huang, Yuting Wu and Jian Guan

    Citation: Journal of Translational Medicine 2020 18:355

    Content type: Research

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  31. Severe COVID-19 infection results in a systemic inflammatory response (SIRS). This SIRS response shares similarities to the changes observed during the peri-operative period that are recognised to be associate...

    Authors: Donogh Maguire, Marylynne Woods, Conor Richards, Ross Dolan, Jesse Wilson Veitch, Wei M. J. Sim, Olivia E. H. Kemmett, David C. Milton, Sophie L. W. Randall, Ly D. Bui, Nicola Goldmann, Allan Cameron, Barry Laird, Dinesh Talwar, Ian Godber, Alan Davidson…

    Citation: Journal of Translational Medicine 2020 18:354

    Content type: Research

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  32. The outbreak of Coronavirus disease of 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), has posed a serious health threat. The increasing number of COVID-19 cases aro...

    Authors: Manoj Kumar and Souhaila Al Khodor

    Citation: Journal of Translational Medicine 2020 18:353

    Content type: Review

    Published on:

  33. Understanding how HLA polymorphisms may affect both susceptibility, course and severity of Covid-19 infection could help both at the clinical level to identify individuals at higher risk from the disease and a...

    Authors: Simona Pisanti, Joris Deelen, Anna Maria Gallina, Mariella Caputo, Marianna Citro, Mario Abate, Nicoletta Sacchi, Carmine Vecchione and Rosanna Martinelli

    Citation: Journal of Translational Medicine 2020 18:352

    Content type: Research

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  34. Foetal bovine serum (FBS), is the most commonly used culture medium additive for in vitro cultures, despite its undefined composition, its potential immunogenicity and possible prion/zoonotic transmission. For...

    Authors: M. Guiotto, W. Raffoul, A. M. Hart, M. O. Riehle and P. G. di Summa

    Citation: Journal of Translational Medicine 2020 18:351

    Content type: Review

    Published on:

  35. Unresectable or metastatic vulvar cancer has relatively poor outcomes despite chemotherapy-sensitized radiation therapy and combination cytotoxic therapy. Despite the virus-associated and immunogenic nature of...

    Authors: Oladapo Yeku, Andrea L. Russo, Hang Lee and David Spriggs

    Citation: Journal of Translational Medicine 2020 18:350

    Content type: Protocol

    Published on:

  36. Omega-3 fatty acids (Ω-3 PUFAs) may help to improve health status in polycystic ovarian syndrome (PCOS) by reducing numerous metabolic disorders (insulin sensitivity, hyperinsulinemia, lipid profile, obesity a...

    Authors: Fiza Komal, Muhammad Kamran Khan, Muhammad Imran, Muhammad Haseeb Ahmad, Haseeb Anwar, Usman Ali Ashfaq, Nazir Ahmad, Amna Masroor, Rabia Shabir Ahmad, Muhammad Nadeem and Mahr Un Nisa

    Citation: Journal of Translational Medicine 2020 18:349

    Content type: Research

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  37. To introduce the Hemorrhage Intensive Severity and Survivability (HISS) score, based on the fusion of multi-biomarker data; glucose, lactate, pH, potassium, and oxygen tension, to serve as a patient-specific a...

    Authors: Ankita Bhat, Daria Podstawczyk, Brandon K. Walther, John R. Aggas, David Machado-Aranda, Kevin R. Ward and Anthony Guiseppi-Elie

    Citation: Journal of Translational Medicine 2020 18:348

    Content type: Research

    Published on:

  38. The prediction of potential drug-target interactions (DTIs) not only provides a better comprehension of biological processes but also is critical for identifying new drugs. However, due to the disadvantages of...

    Authors: Bo-Ya Ji, Zhu-Hong You, Han-Jing Jiang, Zhen-Hao Guo and Kai Zheng

    Citation: Journal of Translational Medicine 2020 18:347

    Content type: Research

    Published on:

  39. The melanoma treatment landscape changed in 2011 with the approval of the first anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 checkpoint inhibitor and of the first BRAF-targeted monoclonal antibody, ...

    Authors: Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Christian Blank, Richard D. Carvajal, Sandra Demaria, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Roger S. Lo, Georgina V. Long, Jason J. Luke…

    Citation: Journal of Translational Medicine 2020 18:346

    Content type: Meeting report

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  40. Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads rapidly and has attracted worldwide attention.

    Authors: Shuo Jiang, Qiuyue Li, Chaoqun Li, Shanshan Liu, Xiaomeng He, Tao Wang, Hua Li, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu and Jin Wang

    Citation: Journal of Translational Medicine 2020 18:345

    Content type: Research

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  41. In the current systematic review and meta-analysis, we summarized the studies that evaluated the effects of sugar-sweetened beverages (SSBs) intake on blood pressure among children and adolescents.

    Authors: Mahdieh Abbasalizad Farhangi, Leila Nikniaz and Mahdieh Khodarahmi

    Citation: Journal of Translational Medicine 2020 18:344

    Content type: Review

    Published on:

  42. Distal cholangiocarcinoma is an aggressive malignancy with a dismal prognosis. Diagnostic and prognostic biomarkers for distal cholangiocarcinoma are lacking. The aim of the present study was to identify diffe...

    Authors: Johannes Byrling, Theresa Kristl, Dingyuan Hu, Indira Pla, Aniel Sanchez, Agata Sasor, Roland Andersson, György Marko-Varga and Bodil Andersson

    Citation: Journal of Translational Medicine 2020 18:343

    Content type: Research

    Published on:

  43. Hypoxia plays an indispensable role in the development of hepatocellular carcinoma (HCC). However, there are few studies on the application of hypoxia molecules in the prognosis predicting of HCC. We aim to id...

    Authors: Baohui Zhang, Bufu Tang, Jianyao Gao, Jiatong Li, Lingming Kong and Ling Qin

    Citation: Journal of Translational Medicine 2020 18:342

    Content type: Research

    Published on:

  44. Malignant pleural mesothelioma (MPM) is an aggressive neoplasm of the pleura, mainly related to asbestos exposure. As in other solid tumors, malignant cells exhibit high glucose uptake and glycolytic rates wit...

    Authors: Irene Dell’Anno, Elisa Barone, Luciano Mutti, Doris M. Rassl, Stefan J. Marciniak, Roberto Silvestri, Stefano Landi and Federica Gemignani

    Citation: Journal of Translational Medicine 2020 18:341

    Content type: Research

    Published on:

  45. Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered a thorough understanding of the pathogenesis of the disease and o...

    Authors: G. Donisi, G. Capretti, N. Cortese, A. Rigamonti, F. Gavazzi, G. Nappo, A. Pulvirenti, M. Sollai, P. Spaggiari, A. Zerbi and F. Marchesi

    Citation: Journal of Translational Medicine 2020 18:340

    Content type: Research

    Published on:

  46. The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute m...

    Authors: James S. Smith, Katrina M. Lappin, Stephanie G. Craig, Fabio G. Liberante, Clare M. Crean, Simon S. McDade, Alexander Thompson, Ken I. Mills and Kienan I. Savage

    Citation: Journal of Translational Medicine 2020 18:339

    Content type: Research

    Published on:

  47. Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the first coronavirus disease 2019 (COVID-19) outbreak in China and has become a public health emergency of international concern. SARS-CoV-2 outbrea...

    Authors: Maria Pachetti, Bruna Marini, Fabiola Giudici, Francesca Benedetti, Silvia Angeletti, Massimo Ciccozzi, Claudio Masciovecchio, Rudy Ippodrino and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:338

    Content type: Research

    Published on:

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