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  1. Radioresistance is a primary factor contributing to the failure of rectal cancer treatment. Immune suppression plays a significant role in the development of radioresistance. We have investigated the potential...

    Authors: Junxian Liang, Limin Liao, Lang Xie, WenWen Tang, Xiang Yu, Yinghao Lu, Hongzhen Chen, Juanli Xu, Lei Sun, Huanmei Wu, Chunhui Cui and Yujing Tan
    Citation: Journal of Translational Medicine 2024 22:117
  2. Liver fibrosis contributes to significant morbidity and mortality in Western nations, primarily attributed to chronic hepatitis C virus (HCV) infection. Hypoxia and immune status have been reported to be signi...

    Authors: Chuwen Chen, Haozheng Cai, Junyi Shen, Xiaoyun Zhang, Wei Peng, Chuan Li, Haopeng Lv and Tianfu Wen
    Citation: Journal of Translational Medicine 2024 22:116
  3. Several evidence demonstrated that glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce the risk of dementia in type 2 diabetes patients by improving memory, learning, and overcoming cognitive impairmen...

    Authors: Rosaria Anna Fontanella, Puja Ghosh, Ada Pesapane, Fatemeh Taktaz, Armando Puocci, Martina Franzese, Maria Federica Feliciano, Giovanni Tortorella, Lucia Scisciola, Eduardo Sommella, Concetta Ambrosino, Giuseppe Paolisso and Michelangela Barbieri
    Citation: Journal of Translational Medicine 2024 22:114
  4. Ovarian cancer poses a serious threat to women's health. Due to the difficulty of early detection, most patients are diagnosed with advanced-stage disease or peritoneal metastasis. We found that LncRNA MEG3 is...

    Authors: Yan Li, Shenghan Lou, Jian Zhang, Shilu Zhao and Ge Lou
    Citation: Journal of Translational Medicine 2024 22:113
  5. Malignant progression is the major cause of poor prognosis in breast cancer (BC) patients. Plasma exosomal miRNAs have been reported to be involved in tumor progression, but their roles in BC remain unclear.

    Authors: Yao Li, Lei Fan, An Yan, Xiaotian Ren, Yanyang Zhao and Bin Hua
    Citation: Journal of Translational Medicine 2024 22:112
  6. Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes and are involved in diabetogenesis. This study aimed to investigate the associatio...

    Authors: Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu and Wencan Xu
    Citation: Journal of Translational Medicine 2024 22:110
  7. Major depressive disorder (MDD) is a common mental illness that affects millions of people worldwide and imposes a heavy burden on individuals, families and society. Previous studies on MDD predominantly focus...

    Authors: Yinping Xie, Lijuan Chen, Leimin Wang, Tongou Liu, Yage Zheng, Lujia Si, Hailong Ge, Hong Xu, Ling Xiao and Gaohua Wang
    Citation: Journal of Translational Medicine 2024 22:109
  8. Patients with pancreatic ductal adenocarcinoma (PDCA) carrying impaired mismatch repair mechanisms seem to have an outcome advantage under treatment with conventional chemotherapy, whereas the role for the tum...

    Authors: Maria Cristina Sini, Maria Grazia Doro, Laura Frogheri, Angelo Zinellu, Panagiotis Paliogiannis, Alberto Porcu, Fabrizio Scognamillo, Daniele Delogu, Davide Adriano Santeufemia, Ivana Persico, Grazia Palomba, Giovanni Battista Maestrale, Antonio Cossu and Giuseppe Palmieri
    Citation: Journal of Translational Medicine 2024 22:108
  9. Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. This study aimed to construct immune-related long non-coding RNAs (lncRNAs) signature and radiomics signature to probe ...

    Authors: Jixin Luan, Di Zhang, Bing Liu, Aocai Yang, Kuan Lv, Pianpian Hu, Hongwei Yu, Amir Shmuel, Chuanchen Zhang and Guolin Ma
    Citation: Journal of Translational Medicine 2024 22:107
  10. Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to...

    Authors: Ali Rahnavard, Ranojoy Chatterjee, Hui Wen, Clark Gaylord, Sabina Mugusi, Kevin C. Klatt and Emily R. Smith
    Citation: Journal of Translational Medicine 2024 22:106
  11. Several large cohort studies in cardiovascular disease (CVD) patients have shown an increased incidence of cancer. Previous studies in a myocardial infarction (MI) mouse model reported increased colon, breast,...

    Authors: Tanawat Attachaipanich, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Translational Medicine 2024 22:105
  12. Prostate cancer (PCa) is one of the most common malignant tumors affecting the male genitourinary system. However, there is currently a lack of effective treatments for patients with advanced prostate cancer, ...

    Authors: Zefeng Wang, Zheng Chao, Qi Wang, Fan Zou, Tianbao Song, Lizhe Xu, Jinzhuo Ning and Fan Cheng
    Citation: Journal of Translational Medicine 2024 22:104
  13. Lymph node metastasis (LNM) is a prognostic biomarker and affects therapeutic selection in colorectal cancer (CRC). Current evaluation methods are not adequate for estimating LNM in CRC. H&E images contain muc...

    Authors: Wei Jiang, Huaiming Wang, Xiaoyu Dong, Yandong Zhao, Chenyan Long, Dexin Chen, Botao Yan, Jiaxin Cheng, Zexi Lin, Shuangmu Zhuo, Hui Wang and Jun Yan
    Citation: Journal of Translational Medicine 2024 22:103
  14. While antibiotics remain our primary tools against microbial infection, increasing antibiotic resistance (inherent and acquired) is a major detriment to their efficacy. A practical approach to maintaining or r...

    Authors: Amita Sekar, Dmitry Gil, Peyton Tierney, Madeline McCanne, Vikram Daesety, Darina Trendafilova, Orhun K. Muratoglu and Ebru Oral
    Citation: Journal of Translational Medicine 2024 22:102
  15. Asthma is a chronic respiratory disease affecting millions of people worldwide, but early detection can be challenging due to the time-consuming nature of the traditional technique. Machine learning has shown ...

    Authors: Dejing Li, Stanley Ebhohimhen Abhadiomhen, Dongmei Zhou, Xiang-Jun Shen, Lei Shi and Yubao Cui
    Citation: Journal of Translational Medicine 2024 22:100
  16. Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-bo...

    Authors: Guodong Xiao, Weiping Lu, Jing Yuan, Zuyue Liu, Peili Wang and Huijie Fan
    Citation: Journal of Translational Medicine 2024 22:99
  17. Interindividual variation characterizes the relief experienced by constipation-predominant irritable bowel syndrome (IBS-C) patients following linaclotide treatment. Complex bidirectional interactions occur be...

    Authors: Jianyun Zhou, Haoqi Wei, An Zhou, Xu Xiao, Xia Xie, Bo Tang, Hui Lin, Li Tang, Ruiping Meng, Xiaoying Yuan, Jing Zhang, Cheng Huang, Baobao Huang, Xiping Liao, Tingting Zhong, Suyu He…
    Citation: Journal of Translational Medicine 2024 22:98
  18. Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis r...

    Authors: Huiling Lin, Ming Zhang, Mi Hu, Yangkai Zhang, WeiWei Jiang, Wanying Tang, Yuxin Ouyang, Liping Jiang, Yali Mi, Zhi Chen, Pingping He, Guojun Zhao and Xinping Ouyang
    Citation: Journal of Translational Medicine 2024 22:97
  19. Periodontitis is a chronic oral inflammatory disease that seriously affects people's quality of life. The purpose of our study was to investigate the correlation between the systemic immune inflammation index ...

    Authors: Junfeng Guo, Rufu Xu, Rongxing Liu, Wenjing Lai, Changpeng Hu, Haitao He, Gang Zhang, Guobing Li, Weiwei Zheng and Rong Zhang
    Citation: Journal of Translational Medicine 2024 22:96
  20. Idiopathic pulmonary fibrosis (IPF) is a globally prevalent, progressive disease with limited treatment options and poor prognosis. Because of its irreversible disease progression, IPF affects the quality and ...

    Authors: Jie Tan, Qianfei Xue, Xiao Hu and Junling Yang
    Citation: Journal of Translational Medicine 2024 22:95
  21. Allergic diseases (ADs) such as asthma are presumed risk factors for COVID-19 infection. However, recent observational studies suggest that the assumed correlation contradicts each other. We therefore systemat...

    Authors: Xiao-tong Chen, Shuai Zhi, Xin-yu Han, Jian-wei Jiang, Guang-ming Liu and Shi-tao Rao
    Citation: Journal of Translational Medicine 2024 22:94
  22. Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare. Hypoxia and lipid metabolism-related gene acetyl-CoA synthetase 2 (ACSS2) is involved in tumor progression, but its role in pNENs is not reveale...

    Authors: Danyang Gu, Mujie Ye, Guoqin Zhu, Jianan Bai, Jinhao Chen, Lijun Yan, Ping Yu, Feiyu Lu, Chunhua Hu, Yuan Zhong, Pengfei Liu, Qibin He and Qiyun Tang
    Citation: Journal of Translational Medicine 2024 22:93
  23. Recent research increasingly highlights a strong correlation between gut microbiota and the risk of gastrointestinal diseases. However, whether this relationship is causal or merely coincidental remains uncert...

    Authors: Kaiwen Wu, Qiang Luo, Ye Liu, Aoshuang Li, Demeng Xia and Xiaobin Sun
    Citation: Journal of Translational Medicine 2024 22:92
  24. Novel biomarkers are required in gastric cancer (GC) treated by immunotherapy. Epstein-Barr virus (EBV) infection induces an immune-active tumor microenvironment, while its association with immunotherapy respo...

    Authors: Xiaoqin Li, Fen Xiong, Zhangmin Hu, Qing Tao, Yufei Yang, Xuehan Qiao, Chen Peng, Yuchun Jiang, Miao Han, Kebin Dong, Yi Hua, Wei Zhang, Min Xu, Weiguo Long, Yichuan Xiao and Deqiang Wang
    Citation: Journal of Translational Medicine 2024 22:90
  25. Various clinical similarities are present in ischemic (ICM) and idiopathic dilated cardiomyopathy (IDCM), leading to ambiguity on some occasions. Previous studies have reported that intestinal microbiota appea...

    Authors: Yusheng Wang, Yandan Xie, Gehendra Mahara, Yanling Xiong, Yalan Xiong, Qifang Zheng, Jianqin Chen, Wei Zhang, Honghao Zhou and Qing Li
    Citation: Journal of Translational Medicine 2024 22:89
  26. Risk stratification and personalized care are crucial in managing osteosarcoma due to its complexity and heterogeneity. However, current prognostic prediction using clinical variables has limited accuracy. Thu...

    Authors: Guanyu Huang, Xuelin Zhang, Yu Xu, Shuo Chen, Qinghua Cao, Weihai Liu, Yiwei Fu, Qiang Jia, Jingnan Shen, Junqiang Yin and Jiajun Zhang
    Citation: Journal of Translational Medicine 2024 22:88
  27. Identifying precise biomarkers of immunotherapy response for non-small cell lung carcinoma (NSCLC) before treatment is challenging. This study aimed to construct and investigate the potential performance of a ...

    Authors: Jie Peng, Dan Zou, Xudong Zhang, Honglian Ma, Lijie Han and Biao Yao
    Citation: Journal of Translational Medicine 2024 22:87
  28. Obesity, a condition associated with the development of widespread cardiovascular disease, metabolic disorders, and other health complications, has emerged as a significant global health issue. Oleanolic acid ...

    Authors: Tianfeng Liu, Jiliang Wang, Ying Tong, Lele Wu, Ying Xie, Ping He, Shujue Lin and Xuguang Hu
    Citation: Journal of Translational Medicine 2024 22:86
  29. The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) function is regulated by matrix ...

    Authors: Jiaqiang Xiong, Rourou Xiao, Jiahui Zhao, Qiuyan Zhao, Manwen Luo, Feng Li, Wei Zhang and Meng Wu
    Citation: Journal of Translational Medicine 2024 22:85
  30. The main challenge in personalized treatment of breast cancer (BC) is how to integrate massive amounts of computing resources and data. This study aimed to identify a novel molecular target that might be effec...

    Authors: Qinan Yin, Haodi Ma, Yirui Dong, Shunshun Zhang, Junxiang Wang, Jing Liang, Longfei Mao, Li Zeng, Xin Xiong, Xingang Chen, Jingjing Wang and Xuewei Zheng
    Citation: Journal of Translational Medicine 2024 22:84
  31. Non-alcoholic fatty liver disease (NAFLD) is a liver disorder characterized by the ac-cumulation of fat in hepatocytes without alcohol consumption. Mitochondrial dysfunction and endoplasmic reticulum (ER) stre...

    Authors: Lucia Longhitano, Alfio Distefano, Nicolò Musso, Paolo Bonacci, Laura Orlando, Sebastiano Giallongo, Daniele Tibullo, Simona Denaro, Giuseppe Lazzarino, Jessica Ferrigno, Anna Nicolosi, Amer M. Alanazi, Federico Salomone, Emanuela Tropea, Ignazio Alberto Barbagallo, Vincenzo Bramanti…
    Citation: Journal of Translational Medicine 2024 22:82
  32. The long-term impact of COVID-19-associated public health interventions on zoonotic and vector-borne infectious diseases (ZVBs) remains uncertain. This study sought to examine the changes in ZVBs in China duri...

    Authors: Yongbin Wang, Siyu Qing, Xianxiang Lan, Lun Li, Peiping Zhou, Yue Xi, Ziyue Liang, Chenguang Zhang and Chunjie Xu
    Citation: Journal of Translational Medicine 2024 22:81
  33. The cancer-immunity cycle (CI cycle) provides a theoretical framework to illustrate the process of the anticancer immune response. Recently, the update of the CI cycle theory emphasizes the importance of tumor...

    Authors: Ying Hu, Huaibo Sun, Wei Shi, Chen Chen, Xueying Wu, Yu Jiang, Guoying Zhang, Na Li, Jin Song, Hao Zhang, Baiyong Shen, Hui Zeng and Henghui Zhang
    Citation: Journal of Translational Medicine 2024 22:69
  34. Necrotic enteritis (NE) is a severe intestinal infection that affects both humans and poultry. It is caused by the bacterium Clostridium perfringens (CP), but the precise mechanisms underlying the disease pathoge...

    Authors: Hemlata Gautam, Lisanework E. Ayalew, Noor Ahmad Shaik, Iresha Subhasinghe, Shelly Popowich, Betty Chow-Lockerbie, Alexa Dixon, Khawaja Ashfaque Ahmed, Suresh K. Tikoo and Susantha Gomis
    Citation: Journal of Translational Medicine 2024 22:80
  35. Characterizing cancer molecular subtypes is crucial for improving prognosis and individualized treatment. Integrative analysis of multi-omics data has become an important approach for disease subtyping, yieldi...

    Authors: Xin Duan, Xinnan Ding and Zhuanzhe Zhao
    Citation: Journal of Translational Medicine 2024 22:79
  36. Inflammatory Bowel Diseases (IBD), an autoimmune disease characterised by abnormal intestinal immunity, are related to vital morbidity around the world. However, therapeutic agents for IBD have not achieved de...

    Authors: Teming Li, Ben Han, Liucan Wang, Lihua Sun, Yujiao Cai, Min Yu, Weidong Xiao and Hua Yang
    Citation: Journal of Translational Medicine 2024 22:78
  37. The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that SERCA2a stimulation may be a mechanism-based HF therapy. ...

    Authors: Martina Arici, Shih-Che Hsu, Mara Ferrandi, Paolo Barassi, Carlotta Ronchi, Eleonora Torre, Andrea Luraghi, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Francesco Peri, Antonio Zaza and Marcella Rocchetti
    Citation: Journal of Translational Medicine 2024 22:77
  38. Hepatocellular carcinoma (HCC) is a common liver malignancy with limited treatment options. Previous studies expressed the potential synergy of sorafenib and NK cell immunotherapy as a promising approach again...

    Authors: Guangbo Yu, Zigeng Zhang, Aydin Eresen, Qiaoming Hou, Emilie Elizabeth Garcia, Zeyang Yu, Nadine Abi-Jaoudeh, Vahid Yaghmai and Zhuoli Zhang
    Citation: Journal of Translational Medicine 2024 22:76
  39. Unilateral high myopia (uHM), commonly observed in patients with retinal diseases or only with high myopia, is frequently associated with amblyopia with poor prognosis. This study aims to reveal the clinical a...

    Authors: Yi Jiang, Xueshan Xiao, Wenmin Sun, Yingwei Wang, Shiqiang Li, Xiaoyun Jia, Panfeng Wang, J. Fielding Hejtmancik and Qingjiong Zhang
    Citation: Journal of Translational Medicine 2024 22:75
  40. Angiogenesis is essential for tissue repair in ischemic diseases, relying on glycolysis as its primary energy source. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1), the catalytic subunit of collagen prolyl 4-hy...

    Authors: Yating Xu, Di Xia, Kai Huang and Minglu Liang
    Citation: Journal of Translational Medicine 2024 22:74
  41. The role of mitochondrial dynamics, encompassing fission, fusion, and mitophagy, in cancer progression has been extensively studied. However, the specific impact of mitochondrial dynamics on hepatocellular car...

    Authors: La Zhang, Xiuzhen Zhang, Haichuan Liu, Changhong Yang, Jiyao Yu, Wei Zhao, Jiao Guo, Baoyong Zhou and Ning Jiang
    Citation: Journal of Translational Medicine 2024 22:73
  42. Nonalcoholic steatohepatitis (NASH) is a progressive manifestation of nonalcoholic fatty liver disease (NAFLD) that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Despite the growing know...

    Authors: Yuan Ni, Maoqing Lu, Ming Li, Xixi Hu, Feng Li, Yan Wang and Dong Xue
    Citation: Journal of Translational Medicine 2024 22:72
  43. The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate cancer (PCa). Therefore, the protein is the linch...

    Authors: Sherif Mehralivand, Christian Thomas, Martin Puhr, Frank Claessens, Arjanneke F. van de Merbel, Anna Dubrovska, Guido Jenster, Christof Bernemann, Ulrich Sommer and Holger H. H. Erb
    Citation: Journal of Translational Medicine 2024 22:71
  44. An observational study involving patients recovered from COVID-19 was conducted in order to evaluate the presence/absence of vein wall thickness increasing, according to the severity of pulmonary involvement q...

    Authors: Gennaro Quarto, Giacomo Benassai, Annamaria Colao, Antonio Cittadini, Paolo Antonio Ascierto, Rosario Pivonello, Andrea Elefante, Marialuisa Bocchino, Alberto Maria Marra, Ivan Gentile, Gianluca Benassai, Andrea Miletti, Francesca Calemma and Ermenegildo Furino
    Citation: Journal of Translational Medicine 2024 22:70
  45. Local skin flaps are frequently employed for wound closure to address surgical, traumatic, congenital, or oncologic defects. (1) Despite their clinical utility, skin flaps may fail due to inadequate perfusion,...

    Authors: Charlotte E. Berry, Thalia Le, Nicholas An, Michelle Griffin, Micheal Januszyk, Carter B. Kendig, Alexander Z. Fazilat, Andrew A. Churukian, Phoebe M. Pan and Derrick C. Wan
    Citation: Journal of Translational Medicine 2024 22:68

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