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  1. JAK1 and JAK2 have been implicated in fibrosis and cancer as a fibroblast-related marker; however, their role in liver fibrosis has not been elucidated. Here, we aim to determine the effect and underlying mech...

    Authors: Zhenghui Song, Xinhui Liu, Wan Zhang, Yue Luo, Hua Xiao, Yun Liu, Guanqi Dai, Jian Hong and Aimin Li
    Citation: Journal of Translational Medicine 2022 20:157
  2. Hepatocellular carcinoma (HCC), as the most common type of liver cancer, is characterized by high recurrence and metastasis. Circular RNA (circRNA) circ_0036412 was selected for studying the underlying mechani...

    Authors: Liyan Wang, Bin Li, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng and Lei Ma
    Citation: Journal of Translational Medicine 2022 20:154
  3. Authors: Malte Simon, Sadaf S. Mughal, Peter Horak, Sebastian Uhrig, Jonas Buchloh, Bogac Aybey, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Benedikt Brors and Charles D. Imbusch
    Citation: Journal of Translational Medicine 2022 20:152

    The original article was published in Journal of Translational Medicine 2021 19:204

  4. The NK cell line NK-92 and its genetically modified variants are receiving attention as immunotherapies to treat a range of malignancies. However, since NK-92 cells are themselves tumors, they require irradiat...

    Authors: Lydia Navarrete-Galvan, Michael Guglielmo, Judith Cruz Amaya, Julie Smith-Gagen, Vincent C. Lombardi, Rebecca Merica and Dorothy Hudig
    Citation: Journal of Translational Medicine 2022 20:151
  5. Oral squamous cell carcinoma (OSCC), as one of the commonest malignancies showing poor prognosis, has been increasingly suggested to be modulated by circular RNAs (circRNAs). Through GEO (Gene Expression Omnib...

    Authors: Liang Rong, Bo Chen, Ke Liu, Bingyao Liu, Xinyao He, Juan Liu, Junxia Li, Maodian He, Lei Zhu, Ke Liu, Xiaolei Shi, Yi Shuai and Lei Jin
    Citation: Journal of Translational Medicine 2022 20:148
  6. Diabetic nephropathy (DN), the most common microvascular complication in patients with diabetes, induces kidney failure. Previous research showed that endothelial-to-mesenchymal transition (EndMT) of human glo...

    Authors: Xue Li, Lihong Lu, Wenting Hou, Fei Wang, Ting Huang, Zhipeng Meng and Minmin Zhu
    Citation: Journal of Translational Medicine 2022 20:147
  7. The kallikrein-kinin system is assumed to have a multifunctional role in health and disease, but its in vivo role in humans currently remains unclear owing to the divergence of plasma kinin level data publishe...

    Authors: Tanja Gangnus, Anke Bartel and Bjoern B. Burckhardt
    Citation: Journal of Translational Medicine 2022 20:146
  8. To identify the critical genes in the onset and progression of Immunoglobulin A nephropathy (IgAN) and to explore its immune cell infiltration feature.

    Authors: Jie Xu, Xiahong Shen, Xing Wei, Jie Ding, Jiaojiao Yuan, Zhen Weng and Yang He
    Citation: Journal of Translational Medicine 2022 20:145
  9. Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal disorders characterized by ineffective haematopoiesis and immune deregulation. Emerging evidence has shown the effect of bone marrow ...

    Authors: Tong Xing, Zhong-Shi Lyu, Cai-Wen Duan, Hong-Yan Zhao, Shu-Qian Tang, Qi Wen, Yuan-Yuan Zhang, Meng Lv, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang and Yuan Kong
    Citation: Journal of Translational Medicine 2022 20:144
  10. Established prediction models of Diabetic kidney disease (DKD) are limited to the analysis of clinical research data or general population data and do not consider hospital visits. Construct a 3-year diabetic ...

    Authors: Zheyi Dong, Qian Wang, Yujing Ke, Weiguang Zhang, Quan Hong, Chao Liu, Xiaomin Liu, Jian Yang, Yue Xi, Jinlong Shi, Li Zhang, Ying Zheng, Qiang Lv, Yong Wang, Jie Wu, Xuefeng Sun…
    Citation: Journal of Translational Medicine 2022 20:143
  11. The phagocytosis checkpoints of CD47/SIRPα, PD1/PDL1, CD24/SIGLEC10, and MHC/LILRB1 have shown inhibited phagocytosis of macrophages in distinct tumors. However, phagocytosis checkpoints and their therapeutic ...

    Authors: Hui Yang, Meimei Yan, Wei Li and Linping Xu
    Citation: Journal of Translational Medicine 2022 20:140
  12. Metastasis is critical for endometrial cancer (EC) progression and prognosis. Accumulating evidence suggests that circular RNAs (circRNAs) can operate as independent functional entities. However, the functiona...

    Authors: Rui Shi, Wei Zhang, Jun Zhang, Zhicheng Yu, Lanfen An, Rong Zhao, Xing Zhou, Ziwei Wang, Sitian Wei and Hongbo Wang
    Citation: Journal of Translational Medicine 2022 20:139
  13. Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of Post-COVID Syndrome (PCS), with a subset of patients fulfilling criteria for Myalgic Encephalomyelitis/Chronic ...

    Authors: Milan Haffke, Helma Freitag, Gordon Rudolf, Martina Seifert, Wolfram Doehner, Nadja Scherbakov, Leif Hanitsch, Kirsten Wittke, Sandra Bauer, Frank Konietschke, Friedemann Paul, Judith Bellmann-Strobl, Claudia Kedor, Carmen Scheibenbogen and Franziska Sotzny
    Citation: Journal of Translational Medicine 2022 20:138
  14. Medical applications of ionising radiation and associated radiation protection research often encounter long delays and inconsistent implementation when translated into clinical practice. A coordinated effort ...

    Authors: Sophie Bockhold, Shane J. Foley, Louise A. Rainford, Riccardo Corridori, Annika Eberstein, Christoph Hoeschen, Mark W. Konijnenberg, Susan Molyneux-Hodgson, Graciano Paulo, Joana Santos and Jonathan P. McNulty
    Citation: Journal of Translational Medicine 2022 20:137
  15. Urokinase-type plasminogen activator receptor (uPAR) is an attractive target for the treatment of cancer, because it is expressed at low levels in healthy tissues but at high levels in malignant tumours. uPAR ...

    Authors: Bing-Tao Zhai, Huan Tian, Jing Sun, Jun-Bo Zou, Xiao-Fei Zhang, Jiang-Xue Cheng, Ya-Jun Shi, Yu Fan and Dong-Yan Guo
    Citation: Journal of Translational Medicine 2022 20:135
  16. A thorough understanding of a patient’s inflammatory response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is crucial to discerning the associated, underlying immunological process...

    Authors: Jonathan T. Sims, Josh Poorbaugh, Ching-Yun Chang, Timothy R. Holzer, Lin Zhang, Sarah M. Engle, Stephanie Beasley, Thompson N. Doman, Lynn Naughton, Richard E. Higgs, Nicole Kallewaard and Robert J. Benschop
    Citation: Journal of Translational Medicine 2022 20:134
  17. Determining the risk of Cardiovascular Disease (CVD) is a necessity for timely preventive interventions in high-risk groups. However, laboratory testing may be impractical in countries with limited resources. ...

    Authors: Fatemeh Rezaei, Mozhgan Seif, Abdullah Gandomkar, Mohammad Reza Fattahi, Fatemeh Malekzadeh, Sadaf G. Sepanlou and Jafar Hasanzadeh
    Citation: Journal of Translational Medicine 2022 20:133
  18. Osteoporosis is a disease threatening the health of millions of individuals. Melatonin is found to be a potential anti-osteoporosis drug. However, whether melatonin plays a role against osteoporosis at differe...

    Authors: Huanshuai Guan, Ning Kong, Run Tian, Ruomu Cao, Guanzhi Liu, Yiyang Li, Qilu Wei, Ming Jiao, Yutian Lei, Fangze Xing, Peng Tian, Kunzheng Wang and Pei Yang
    Citation: Journal of Translational Medicine 2022 20:132
  19. Immune checkpoint blockade therapy has revolutionized non-small cell lung cancer treatment. However, not all patients respond to this therapy. Assessing the tumor expression of immune checkpoint molecules, inc...

    Authors: Yen-Yu Lin, Lei-Chi Wang, Yu-Han Hsieh, Yu-Ling Hung, Yung-An Chen, Yu-Chieh Lin, Yen-Yin Lin and Teh-Ying Chou
    Citation: Journal of Translational Medicine 2022 20:131
  20. Asthma is a common respiratory disease, and immune system dysregulation has direct relevance to asthma pathogenesis. Probiotics and prebiotics have immunomodulatory effects and can regulate immune responses an...

    Authors: Zhiwei Wu, Entezar Mehrabi Nasab, Poonam Arora and Seyyed Shamsadin Athari
    Citation: Journal of Translational Medicine 2022 20:130
  21. Autoimmunity has emerged as a characteristic of the post-COVID syndrome (PCS), which may be related to sex. In order to further investigate the relationship between SARS-CoV-2 and autoimmunity in PCS, a clinic...

    Authors: Manuel Rojas, Yhojan Rodríguez, Yeny Acosta-Ampudia, Diana M. Monsalve, Chengsong Zhu, Quan-Zhen Li, Carolina Ramírez-Santana and Juan-Manuel Anaya
    Citation: Journal of Translational Medicine 2022 20:129
  22. Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases and has no safe and effective drug for treatment. We have previously reported the function of blueberry, but the effective monomer a...

    Authors: Juanjuan Zhu, Yuan Wen, Qiuling Zhang, Fei Nie, Mingliang Cheng and Xueke Zhao
    Citation: Journal of Translational Medicine 2022 20:128
  23. 90% of esophageal cancer are esophageal squamous cell carcinoma (ESCC) and ESCC has a very poor prognosis and high mortality. Nevertheless, the key metabolic pathways associated with ESCC progression haven’t b...

    Authors: Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng and Qingchen Wu
    Citation: Journal of Translational Medicine 2022 20:127
  24. Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. The adaptation and reorganization process following any neuronal damage is...

    Authors: Helia Mojtabavi, Zoha Shaka, Sara Momtazmanesh, Atra Ajdari and Nima Rezaei
    Citation: Journal of Translational Medicine 2022 20:126
  25. Nanocarriers as drug/biomolecule delivery systems have been significantly developed during recent decades. Given the stability, reasonable delivery efficiency, and safety of nanocarriers, there are several bar...

    Authors: Ala Amiri, Rafieh Bagherifar, Ehsan Ansari Dezfouli, Seyed Hossein Kiaie, Reza Jafari and Reihaneh Ramezani
    Citation: Journal of Translational Medicine 2022 20:125
  26. Chimeric antigen receptor (CAR) T-cell therapy has proven to be a valuable new treatment option for patients with B-cell malignancies. However, by applying selective pressure, outgrowth of antigen-negative tum...

    Authors: Gils Roex, Diana Campillo-Davo, Donovan Flumens, Philip Anthony Gilbert Shaw, Laurens Krekelbergh, Hans De Reu, Zwi N. Berneman, Eva Lion and Sébastien Anguille
    Citation: Journal of Translational Medicine 2022 20:124
  27. Sepsis is defined as a systemic inflammatory response to microbial infections with multiple organ dysfunction. This study analysed untargeted metabolomics combined with proteomics of serum from patients with s...

    Authors: Qi Chen, Xi Liang, Tianzhou Wu, Jing Jiang, Yongpo Jiang, Sheng Zhang, Yanyun Ruan, Huaping Zhang, Chao Zhang, Peng Chen, Yuhang Lv, Jiaojiao Xin, Dongyan Shi, Xin Chen, Jun Li and Yinghe Xu
    Citation: Journal of Translational Medicine 2022 20:123
  28. EGFR-mutant non-small cell lung cancer (NSCLC) is prone to leptomeningeal metastasis (LM) after Tyrosine kinase inhibitors (TKIs) treatment. Our previous study suggested that osimertinib plus bevacizumab was s...

    Authors: Yali Yi, Jing Cai, Peng Xu, Le Xiong, Zhiqin Lu, Zhimin Zeng and Anwen Liu
    Citation: Journal of Translational Medicine 2022 20:122

    The Correction to this article has been published in Journal of Translational Medicine 2022 20:292

  29. Safety, tolerability and efficacy of granulocyte colony-stimulating factor (G-CSF) for mobilization of hematopoietic stem and progenitor cells (HSPCs) from healthy donors have been conclusively demonstrated. T...

    Authors: J. Heyn, S. Bräuninger, M. Dimova-Dobreva, N. Mathieson, N. Koptelova, A. Kolpakova, C. Seidl, P. Reinhardt, C. Tsamadou, H. Schrezenmeier, R. Nakov, E. Seifried and H. Bonig
    Citation: Journal of Translational Medicine 2022 20:121
  30. Targeting glutamine metabolism is previously indicated as a potential and attractive strategy for gastric cancer (GC) therapy. However, the underlying mechanisms responsible for the modification of glutamine m...

    Authors: Haofeng Liu, Qiu Xue, Hongzhou Cai, Xiaohui Jiang, Guangxin Cao, Tie Chen, Yuan Chen and Ding Wang
    Citation: Journal of Translational Medicine 2022 20:120
  31. To identify the global and regional distribution of peripapillary vessel density (pVD) and try to find out the relationships between pVD and the visual field mean sensitivity (VFMS) in healthy myopic eyes.

    Authors: Hua Zhong, Qingqing Dong, Qing Cun, Guangyu He, Yijin Tao, Keyao Song, Yunqing Lu, Qin Zhu, Xi Chen and Qin Chen
    Citation: Journal of Translational Medicine 2022 20:119
  32. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including metastatic melanoma (MM). The BRAF o...

    Authors: Valentina Audrito, Enrico Moiso, Filippo Ugolini, Vincenzo Gianluca Messana, Lorenzo Brandimarte, Ilaria Manfredonia, Simonetta Bianchi, Francesco De Logu, Romina Nassini, Anna Szumera-Ciećkiewicz, Daniela Taverna, Daniela Massi and Silvia Deaglio
    Citation: Journal of Translational Medicine 2022 20:118
  33. Cholangiocarcinoma (CCA) refers to an aggressive malignancy with a high fatality rate and poor prognosis. Globally, the morbidity of CCA is increasing for the past few decades, which has progressed into a dise...

    Authors: Kai Zhao, Xiangyu Li, Yuanxin Shi, Yun Lu, Peng Qiu, Zhengdong Deng, Wei Yao and Jianming Wang
    Citation: Journal of Translational Medicine 2022 20:117
  34. Lenvatinib is a multitargeted tyrosine kinase inhibitor that is being tested in combination with immune checkpoint inhibitors to treat advanced gastric cancer; however, little data exists regarding the efficac...

    Authors: John D. Karalis, Lynn Y. Yoon, Suntrea T. G. Hammer, Changjin Hong, Min Zhu, Ibrahim Nassour, Michelle R. Ju, Shu Xiao, Esther C. Castro-Dubon, Deepak Agrawal, Jorge Suarez, Scott I. Reznik, John C. Mansour, Patricio M. Polanco, Adam C. Yopp, Herbert J. Zeh III…
    Citation: Journal of Translational Medicine 2022 20:116
  35. Gastric cancer (GC) is one of the most common malignancies, and an increasing number of studies have shown that its pathogenesis is regulated by various miRNAs. In this study, we investigated the role of miR-8...

    Authors: Shenshuo Gao, Zhikai Zhang, Xubin Wang, Yan Ma, Chensheng Li, Hongjun Liu, Changqing Jing, Leping Li and Xiaobo Guo
    Citation: Journal of Translational Medicine 2022 20:115
  36. Once malignancy tumors were diagnosed, the determination of tissue origin and tumor type is critical for clinical management. Although the significant advance in imaging techniques and histopathological approa...

    Authors: Wei Sun, Wei Wu, Qifeng Wang, Qian Yao, Qin Feng, Yue Wang, Yu Sun, Yunying Liu, Qian Lai, Gu Zhang, Peng Qi, Yifeng Sun, Chenhui Qian, Wanli Ren, Zhengzhi Luo, Jinying Chen…
    Citation: Journal of Translational Medicine 2022 20:114
  37. Triple negative breast cancer (TNBC) is an aggressive breast cancer for which there is currently no targeted therapy. Tumor-infiltrating B-cells (TIB) have been observed in tumor tissues of TNBC patients, but ...

    Authors: Nicole J. Toney, Lynn M. Opdenaker, Kader Cicek, Lisa Frerichs, Christopher Ryan Kennington, Samuel Oberly, Holly Archinal, Rajasekharan Somasundaram and Jennifer Sims-Mourtada
    Citation: Journal of Translational Medicine 2022 20:112
  38. The human gastrointestinal tract is inhabited by the largest microbial community within the human body consisting of trillions of microbes called gut microbiota. The normal flora is the site of many physiologi...

    Authors: Prisca Gebrayel, Carole Nicco, Souhaila Al Khodor, Jaroslaw Bilinski, Elisabetta Caselli, Elena M. Comelli, Markus Egert, Cristina Giaroni, Tomasz M. Karpinski, Igor Loniewski, Agata Mulak, Julie Reygner, Paulina Samczuk, Matteo Serino, Mariusz Sikora, Annalisa Terranegra…
    Citation: Journal of Translational Medicine 2022 20:111
  39. Body roundness index (BRI) is one of the obesity-related anthropometric indices. However, studies on the relationship between BRI and diabetes risk is limited. The purpose of this study was to explore the rela...

    Authors: Liling Wu, Hailu Pu, Man Zhang, Haofei Hu and Qijun Wan
    Citation: Journal of Translational Medicine 2022 20:110
  40. Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays an important role in the normal occurrence and development of the immune system, and pyroptosis has...

    Authors: Aibin Liu, Lin Shen, Na Li, Liangfang Shen and Zhanzhan Li
    Citation: Journal of Translational Medicine 2022 20:109
  41. Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension...

    Authors: Chen Tang, Hanxiang Jiang, Bin Zhao, Yi Lin, Shengnan Lin, Tianmu Chen, Yanhua Su, Yiqin Zhang, Lina Zhou, Lianmeng Li, Jincheng Lin, Zhonghua Lu, Yao Wang, Zeyu Zhao, Longjian Liu, Yuxin Wang…
    Citation: Journal of Translational Medicine 2022 20:108
  42. Plasma lipid profile and anthropometric variables are known to be under strong genetic control and the identification of genetic variants associated with bioclinical parameters is of considerable public health...

    Authors: Benedetta Perrone, Paola Ruffo, Samanta Zelasco, Cinzia Giordano, Catia Morelli, Ines Barone, Stefania Catalano, Sebastiano Andò, Diego Sisci, Giovanni Tripepi, Corrado Mammì, Daniela Bonofiglio and Francesca Luisa Conforti
    Citation: Journal of Translational Medicine 2022 20:107
  43. Colorectal cancer (CRC) is one of the lethal cancers with a high mortality rate worldwide and understanding the mechanisms behind its progression is critical for improving patients’ prognosis and developing th...

    Authors: Yu Liu, Wentao Tang, Li Ren, Tianyu Liu, Meng Yang, Ye Wei, Yijiao Chen, Meiling Ji, Guosong Chen, Wenju Chang and Jianmin Xu
    Citation: Journal of Translational Medicine 2022 20:106
  44. The COVID-19 pandemic has highlighted the importance of whole genome sequencing (WGS) of SARS-CoV-2 to inform public health policy. By enabling definition of lineages it facilitates tracking of the global spre...

    Authors: Marc Fuchs, Clara Radulescu, Miao Tang, Arun Mahesh, Deborah Lavin, Syed Umbreen, James McKenna, Mark Smyth, Eilís McColgan, Zoltan Molnar, Chris Baxter, Timofey Skvortsov, Aditi Singh, Fiona Rogan, Julia Miskelly, Stephen Bridgett…
    Citation: Journal of Translational Medicine 2022 20:105
  45. Graft-versus-host disease (GvHD) is a critical complication after allogeneic hematopoietic stem cell transplantation (HSCT). The immunosuppressants given to patients undergoing allogeneic HSCT disturb the microbi...

    Authors: Jin-Ah Beak, Min-Jung Park, Se-Young Kim, JooYeon Jhun, Jin Seok Woo, Jeong Won Choi, Hyun Sik Na, Soon Kyu Lee, Jong Young Choi and Mi-La Cho
    Citation: Journal of Translational Medicine 2022 20:104

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