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  1. We hypothesized that a gender difference in clinical response may exist to adjuvant CTLA4 blockade with ipilimumab versus high-dose IFNα (HDI). We investigated differences in candidate immune biomarkers in the...

    Authors: Mariam Saad, Sandra J. Lee, Aik Choon Tan, Issam M. El Naqa, F. Stephen Hodi, Lisa H. Butterfield, William A. LaFramboise, Walter Storkus, Arivarasan D. Karunamurthy, Jose Conejo-Garcia, Patrick Hwu, Howard Streicher, Vernon K. Sondak, John M. Kirkwood and Ahmad A. Tarhini
    Citation: Journal of Translational Medicine 2022 20:253
  2. Senescent cells have been identified in the aging prostate, and the senescence-associated secretory phenotype might be linked to prostate cancer (PCa). Thus, we established a cellular senescence-related gene p...

    Authors: Dechao Feng, Dengxiong Li, Xu Shi, Qiao Xiong, Facai Zhang, Qiang Wei and Lu Yang
    Citation: Journal of Translational Medicine 2022 20:252
  3. Nicotinamide (NAM, a variant of vitamin B3) has recently been shown to accelerate the activation of human CD4+ and CD8+ T cells exposed to repeated CD3/CD28 agonism in vitro. Here, we demonstrate that T cells inf...

    Authors: Yang Hu, Norma Bloy, Olivier Elemento and Aitziber Buqué
    Citation: Journal of Translational Medicine 2022 20:251
  4. Gastric cancer is a common type of gastrointestinal malignant tumor in China. The mechanism of the development and progression of gastric cancer remains the continuing research focus. The tumor microenvironmen...

    Authors: Weihua Yu, Guojun Chen, Jiafei Yan, Xianfa Wang, Yiping Zhu and Linghua Zhu
    Citation: Journal of Translational Medicine 2022 20:250
  5. The identification of early plasma biomarkers for clinical outcomes and drug resistance has key importance for risk stratification in anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer ...

    Authors: Shasha Wang, Ning Lou, Rongrong Luo, Xuezhi Hao, Yutao Liu, Lin Wang, Yuankai Shi and Xiaohong Han
    Citation: Journal of Translational Medicine 2022 20:248
  6. mTOR pathway is known to promote cancer malignancy and influence cancer immunity but is unknown for its role in immune checkpoint inhibitors (ICI) therapy.

    Authors: Lei Cheng, Yanan Wang, Lixin Qiu, Yuanyuan Chang, Haijiao Lu, Chenchen Liu, Bo Zhang, Yan Zhou, Hao Bai, Liwen Xiong, Hua Zhong, Wei Nie and Baohui Han
    Citation: Journal of Translational Medicine 2022 20:247
  7. Platinum based agents—cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistan...

    Authors: Shruthi Sriramkumar, Riddhi Sood, Thomas D. Huntington, Ahmed H. Ghobashi, Truc T. Vuong, Tara X. Metcalfe, Weini Wang, Kenneth P. Nephew and Heather M. O’Hagan
    Citation: Journal of Translational Medicine 2022 20:246
  8. Emerging evidence has highlighted the critical roles of long noncoding RNAs (lncRNAs) in tumor development and progression. However, the biological functions and underlying mechanisms of DLEU1 in esophageal sq...

    Authors: Qihang Li, Zhiyu Zhang, HongChao Jiang, Jun Hou, Yuhang Chai, Hongxing Nan, Feng Li and Lianghai Wang
    Citation: Journal of Translational Medicine 2022 20:245
  9. Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are...

    Authors: Halema Al-Farsi, Iman Al-Azwani, Joel A. Malek, Lotfi Chouchane, Arash Rafii and Najeeb M. Halabi
    Citation: Journal of Translational Medicine 2022 20:244
  10. Currently, remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered the principal residual cardiovascular risk (RCVR) factors. This study sought to evaluate the combined impact of RC, ...

    Authors: Hui-Hui Liu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qian Dong, Jie Qian, Ke-Fei Dou and Jian-Jun Li
    Citation: Journal of Translational Medicine 2022 20:243
  11. Tumor-draining lymph nodes (TDLNs) are primary sites, where anti-tumor lymphocytes are primed to tumor-specific antigens and play pivotal roles in immune responses against tumors. Although adoptive cell therap...

    Authors: Kazumi Okamura, Satoshi Nagayama, Tomohiro Tate, Hiu Ting Chan, Kazuma Kiyotani and Yusuke Nakamura
    Citation: Journal of Translational Medicine 2022 20:241
  12. As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have recently gained attention as an important type of innate immune regulatory cell. NK cells can rapidly kill multipl...

    Authors: Junfeng Chu, Fengcai Gao, Meimei Yan, Shuang Zhao, Zheng Yan, Bian Shi and Yanyan Liu
    Citation: Journal of Translational Medicine 2022 20:240
  13. Chimeric antigen receptor (CAR) T cell therapy has attracted attention for its promising therapeutic effects on hematological malignancies. However, there are problems such as relapse during long-term follow-u...

    Authors: Taku Kouro, Hidetomo Himuro and Tetsuro Sasada
    Citation: Journal of Translational Medicine 2022 20:239
  14. Only a small number of patients survive an out-of-hospital cardiac arrest (CA) and can be discharged from hospital alive with a large percentage of these patients retaining neurological impairments. In recent ...

    Authors: Patrick Bernhard, Berit Amelie Bretthauer, Sam Joé Brixius, Hannah Bügener, Johannes Elias Groh, Christian Scherer, Domagoj Damjanovic, Jörg Haberstroh, Georg Trummer, Christoph Benk, Friedhelm Beyersdorf, Oliver Schilling and Jan-Steffen Pooth
    Citation: Journal of Translational Medicine 2022 20:238
  15. Physical activity (PA) may protect against infertility by modulating the hypothalamic-pituitary–gonadal axis, thereby reducing gonadotropin levels, elevating immune function, and inhibiting inflammation and ci...

    Authors: Fangfang Xie, Yanli You, Chong Guan, Yuanjia Gu, Fei Yao and Jiatuo Xu
    Citation: Journal of Translational Medicine 2022 20:237
  16. Harnessing the effector mechanisms of the immune system to combat brain tumors with antigen specificity and memory has been in research and clinical testing for many years. Government grant mechanisms and non-...

    Authors: Christine E. Brown, Samantha Bucktrout, Lisa H. Butterfield, Olga Futer, Evanthia Galanis, Adilia Hormigo, Michael Lim, Hideho Okada, Robert Prins, Sara Siebel Marr and Kirk Tanner
    Citation: Journal of Translational Medicine 2022 20:236
  17. Necroptosis is a new form of programmed cell death that is associated with cancer initiation, progression, immunity, and chemoresistance. However, the roles of necroptosis-related genes (NRGs) in colorectal ca...

    Authors: Wenqin Luo, Wenqiang Xiang, Lu Gan, Ji Che, Jing Li, Yichao Wang, Lingyu Han, Ruiqi Gu, Li Ye, Renjie Wang, Xiuping Zhang, Ye Xu, Weixing Dai, Shaobo Mo, Qingguo Li and Guoxiang Cai
    Citation: Journal of Translational Medicine 2022 20:235
  18. Cardiometabolic disease (CMD) increases the risk of mortality, but the extent to which this can be offset by adherence to a healthy lifestyle is unknown. We aimed to investigate whether and to what extent a co...

    Authors: Chenjie Xu and Zhi Cao
    Citation: Journal of Translational Medicine 2022 20:234
  19. Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary ...

    Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Chuan-Jue Cui and Jian-Jun Li
    Citation: Journal of Translational Medicine 2022 20:233
  20. In 2010, November 16th, the Mediterranean diet was given the recognition of UNESCO as an “Intangible Heritage of Humanity” as this dietary pattern is rooted in the preservation of tradition, land, and biodiver...

    Authors: Annamaria Colao, Claudia Vetrani, Giovanna Muscogiuri, Luigi Barrea, Antonia Tricopoulou, Laura Soldati and Prisco Piscitelli
    Citation: Journal of Translational Medicine 2022 20:232
  21. According to international guidelines, Human Papillomavirus (HPV) DNA tests represent a valid alternative to Pap Test for primary cervical cancer screening, provided that they guarantee balanced clinical sensi...

    Authors: Alice Avian, Nicolò Clemente, Elisabetta Mauro, Erica Isidoro, Michela Di Napoli, Sandra Dudine, Anna Del Fabro, Stefano Morini, Tiziana Perin, Fabiola Giudici, Tamara Cammisuli, Nicola Foschi, Marco Mocenigo, Michele Montrone, Chiara Modena, Martina Polenghi…
    Citation: Journal of Translational Medicine 2022 20:231
  22. Little is known about SARS-CoV-2 seroconversion in asymptomatic patients affected by solid cancer, and whether it is associated with specific transcriptomics changes in peripheral blood mononuclear cells (PBMC).

    Authors: Francesco Ravera, Roberto Borea, Gabriella Cirmena, Martina Dameri, Lorenzo Ferrando, Maurizio Gallo, Cecilia Casini, Neri Fallani, Mario Stabile, Valentina Barbero, Roberto Murialdo, Lucia Tixi, Margherita Cappuccio, Andrea Cuboni, Irene Sivieri, Giuseppe Fornarini…
    Citation: Journal of Translational Medicine 2022 20:230
  23. Molecular chaperones assist protein folding, facilitate degradation of misfolded polypeptides, and thereby maintain protein homeostasis. Impaired chaperone activity leads to defective protein quality control t...

    Authors: Manar Elkenani, Amal Z. Barakat, Torsten Held, Daniel Marques Rodrigues, Sherok Mobarak, Surabhi Swarnka, Ibrahim M. Adham and Belal A. Mohamed
    Citation: Journal of Translational Medicine 2022 20:229
  24. RNA adenosine modifications, which are primarily mediated by “writer” enzymes (RMWs), play a key role in epigenetic regulation in various biological processes, including tumorigenesis. However, the expression ...

    Authors: Shijie Chen, Jin Zeng, Liping Huang, Yi Peng, Zuyun Yan, Aiqian Zhang, Xingping Zhao, Jun Li, Ziting Zhou, Sidan Wang, Shengyu Jing, Minghua Hu, Yuezhan Li, Dong Wang, Weiguo Wang, Haiyang Yu…
    Citation: Journal of Translational Medicine 2022 20:228
  25. Previous studies demonstrated a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations also emerged, and the nature of such relationship ...

    Authors: Meng Zhang, Jiahao Qiao, Shuo Zhang and Ping Zeng
    Citation: Journal of Translational Medicine 2022 20:227
  26. In polyglutamine (polyQ) diseases, the identification of modifiers and the construction of prediction model for progression facilitate genetic counseling, clinical management and therapeutic interventions.

    Authors: Linliu Peng, Yun Peng, Zhao Chen, Chunrong Wang, Zhe Long, Huirong Peng, Yuting Shi, Lu Shen, Kun Xia, Vanessa B. Leotti, Laura Bannach Jardim, Beisha Tang, Rong Qiu and Hong Jiang
    Citation: Journal of Translational Medicine 2022 20:226
  27. Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed a...

    Authors: Åslaug Helland, Hege G. Russnes, Gro Live Fagereng, Khalid Al-Shibli, Yvonne Andersson, Thomas Berg, Line Bjørge, Egil Blix, Bodil Bjerkehagen, Sigmund Brabrand, Marte Grønlie Cameron, Astrid Dalhaug, Dalia Dietzel, Tom Dønnem, Espen Enerly, Åsmund Flobak…
    Citation: Journal of Translational Medicine 2022 20:225

    The Correction to this article has been published in Journal of Translational Medicine 2022 20:317

  28. Extracellular vesicle (EV)-microRNAs (miRNAs) are potential biomarkers for various renal diseases. This study attempted to identify the circulating EV-miRNA signature not only for discriminating idiopathic mem...

    Authors: In O. Sun, Yun-Ui Bae, Haekyung Lee, Hyoungnae Kim, Jin Seok Jeon, Hyunjin Noh, Jong-Soo Choi, Kyung-Oh Doh and Soon Hyo Kwon
    Citation: Journal of Translational Medicine 2022 20:224
  29. While ondansetron (OND) is widespread availability, the contribution of OND to improve patient outcomes among intensive care unit (ICU) patients has not been examined. This study aimed to illustrate the associ...

    Authors: Yingying Fang, Chao Xiong and Xinghe Wang
    Citation: Journal of Translational Medicine 2022 20:223
  30. Cigarette smoking (CS) is a strong risk factor for idiopathic pulmonary fibrosis (IPF). It can activate lung fibroblasts (LF) by inducing redox imbalance. We previously showed that clearing mitochondrial react...

    Authors: Yue Zhang, Ting Li, Miaoxia Pan, Wei Wang, Wenhui Huang, Yafei Yuan, Zhanzhan Xie, Yixin Chen, Jun Peng, Xu Li and Ying Meng
    Citation: Journal of Translational Medicine 2022 20:222
  31. Sclerostin is the protein product of the SOST gene and is known for its inhibitory effects on bone formation. The monoclonal antibody against sclerostin has been approved as a novel treatment method for osteoporo...

    Authors: Chufang Liao, Shanshan Liang, Yining Wang, Ting Zhong and Xiangning Liu
    Citation: Journal of Translational Medicine 2022 20:221
  32. An increasing number of studies have demonstrated that long non-coding RNAs (lncRNAs) serve as key regulators in tumor development and progression. However, only a few lncRNAs have been functionally characteri...

    Authors: Jixu Wang, Futao Hou, Lusheng Tang, Ke Xiao, Tengfei Yang, Zhiqiang Wang and Gu Liu
    Citation: Journal of Translational Medicine 2022 20:220
  33. Diabetic retinopathy (DR), especially proliferative diabetic retinopathy (PDR) is a common cause of blindness and visual impairment. Early prediction of its occurrence and progression is important to improved ...

    Authors: Huan Wang, Zhen Guo and Yu Xu
    Citation: Journal of Translational Medicine 2022 20:219
  34. Early diagnosis and treatment of chronic pancreatitis (CP) are limited. In this study, St13, a co-chaperone protein, was investigated whether it constituted a novel regulatory target in CP. Meanwhile, we evalu...

    Authors: Rong-chang Cao, Wan-jun Yang, Wang Xiao, Lei Zhou, Jie-hui Tan, Meng Wang, Zhi-tao Zhou, Huo-ji Chen, Jia Xu, Xue-mei Chen, Yang-chen Jin, Jia-yu Lin, Jun-ling Zeng, Shu-ji Li, Min Luo, Guo-dong Hu…
    Citation: Journal of Translational Medicine 2022 20:218
  35. The two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), both downregulate immune surface molecules, such as MHC-I, ICAM-1, and B7-2, enabling them...

    Authors: Yiquan Wu, Prabha Shrestha, Natalie M. Heape and Robert Yarchoan
    Citation: Journal of Translational Medicine 2022 20:217
  36. The 2019 coronavirus disease pandemic (COVID-19) poses an enormous threat to public health worldwide, and the ensuing management of social isolation has greatly decreased opportunities for physical activity (P...

    Authors: Xiong Chen, Xiaosi Hong, Wenjing Gao, Shulu Luo, Jiahao Cai, Guochang Liu and Yinong Huang
    Citation: Journal of Translational Medicine 2022 20:216
  37. Acute kidney injury (AKI) is the most common and serious complication of sepsis, accompanied by high mortality and disease burden. The early prediction of AKI is critical for timely intervention and ultimately...

    Authors: Suru Yue, Shasha Li, Xueying Huang, Jie Liu, Xuefei Hou, Yumei Zhao, Dongdong Niu, Yufeng Wang, Wenkai Tan and Jiayuan Wu
    Citation: Journal of Translational Medicine 2022 20:215
  38. In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key player in regulating RNA metabolism and function through coding as well as non-coding RNAs. Accumulating evidence has shown that m5C m...

    Authors: Mingyang Li, Zijia Tao, Yiqiao Zhao, Lei Li, Jianyi Zheng, Zeyu Li and Xiaonan Chen
    Citation: Journal of Translational Medicine 2022 20:214
  39. This paper is a report of recommendations for addressing translational challenges in amyloid disease research. They were developed during and following an international online workshop organized by the LINXS I...

    Authors: Miriam Solomon, Vito Foderà, Annette Eva Langkilde, Perry Elliott, Fabrizio Tagliavini, Trevor Forsyth, Oxana Klementieva and Vittorio Bellotti
    Citation: Journal of Translational Medicine 2022 20:213
  40. Hepatocellular carcinoma (HCC) is the most common pathological type of liver cancer. Valosin-containing protein (VCP) is a member of the AAA-ATPase family associated with multiple molecular functions and invo...

    Authors: Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu and Xuegong Fan
    Citation: Journal of Translational Medicine 2022 20:212
  41. The correlations between circulating tumour DNA (ctDNA)-derived genomic markers and treatment response and survival outcome in Chinese patients with advanced breast cancer (ABC) have not been extensively chara...

    Authors: Hao Liao, Jiayang Zhang, Tiantian Zheng, Xiaoran Liu, Jianxin Zhong, Bin Shao, Xiaoxi Dong, Xiaohong Wang, Pan Du, Bonnie L. King, Shidong Jia, Jianjun Yu and Huiping Li
    Citation: Journal of Translational Medicine 2022 20:211
  42. Colorectal cancer is a commonly diagnosed cancer worldwide. Unfortunately, many patients do not respond to standard chemotherapy treatments and develop disease relapse and metastases. Besides cancer cell speci...

    Authors: Simona Salerno, Anders Ståhlberg, André Holdfeldt, Elinor Bexe Lindskog and Göran Landberg
    Citation: Journal of Translational Medicine 2022 20:209
  43. Extracellular vesicles (EVs) play a key role in constructing a microenvironment that favors the differentiation of stem cells. The present work aimed to determine the molecular mechanisms by which EV derived f...

    Authors: Chaoting Yan, Na Li, Tong Xiao, Xiaying Ye, Lin Fu, Yu Ye, Tao Xu and Jinhua Yu
    Citation: Journal of Translational Medicine 2022 20:208
  44. Tanimilast is a novel and selective inhaled inhibitor of phosphodiesterase-4 in advanced clinical development for chronic obstructive pulmonary disease (COPD). Tanimilast is known to exert prominent anti-infla...

    Authors: Hoang Oanh Nguyen, Valentina Salvi, Laura Tiberio, Fabrizio Facchinetti, Mirco Govoni, Gino Villetti, Maurizio Civelli, Ilaria Barbazza, Carolina Gaudenzi, Mauro Passari, Tiziana Schioppa, Francesca Sozio, Annalisa Del Prete, Silvano Sozzani and Daniela Bosisio
    Citation: Journal of Translational Medicine 2022 20:203
  45. As a common complication of epithelial ovarian cancer (EOC), malignant ascites contributes to the peritoneal metastasis of EOC. CircRNAs play essential roles in tumor metastasis. However, no circRNAs have been...

    Authors: Ning Luo, Zubaidan Sulaiman, Chunyan Wang, Jinye Ding, Yingying Chen, Biting Liu, Zhongping Cheng and Shupeng Liu
    Citation: Journal of Translational Medicine 2022 20:201
  46. Urinary extracellular vesicles (EVs) are a source of biomarkers with broad potential applications across clinical research, including monitoring radiation exposure. A key limitation to their implementation is ...

    Authors: Charles P. Hinzman, Meth Jayatilake, Sunil Bansal, Brian L. Fish, Yaoxiang Li, Yubo Zhang, Shivani Bansal, Michael Girgis, Anton Iliuk, Xiao Xu, Jose A. Fernandez, John H. Griffin, Elizabeth A. Ballew, Keith Unger, Marjan Boerma, Meetha Medhora…
    Citation: Journal of Translational Medicine 2022 20:199

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