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  1. In 1918 an unknown infectious agent spread around the world infecting over one-third of the general population and killing almost 50 million people. Many countries were at war, the First World War. Since Spain...

    Authors: Raffaele Scarpa, Francesco Caso, Luisa Costa, Saverio Passavanti, Maria Grazia Vitale, Claudia Trojaniello, Antonio Del Puente and Paolo A. Ascierto

    Citation: Journal of Translational Medicine 2020 18:489

    Content type: Review

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  2. The easy access to a quick diagnosis of coronavirus disease 2019 (COVID-19) is a key point to improve the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to contain its spread. U...

    Authors: Leonardo Miscio, Antonio Olivieri, Francesco Labonia, Gianfranco De Feo, Paolo Chiodini, Giuseppe Portella, Luigi Atripaldi, Roberto Parrella, Rodolfo Conenna, Franco Maria Buonaguro, Ernesta Cavalcanti, Paolo Ascierto, Gerardo Botti and Attilio Bianchi

    Citation: Journal of Translational Medicine 2020 18:488

    Content type: Research

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  3. Healthy volunteer registry donors have become the backbone of stem cell transplantation programs. While most registrants will never become actual donors, a small minority are called upon twice, most commonly f...

    Authors: Soo-Zin Kim-Wanner, Seo-Youn Lee, Erhard Seifried and Halvard Bonig

    Citation: Journal of Translational Medicine 2020 18:487

    Content type: Research

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  4. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is understood as a complex condition, likely triggered and sustained by an interplay of biological, psychological, and social factors. Little oversig...

    Authors: Ashley Elizabeth Muller, Kari Tveito, Inger Johanne Bakken, Signe A. Flottorp, Siri Mjaaland and Lillebeth Larun

    Citation: Journal of Translational Medicine 2020 18:484

    Content type: Review

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  5. Myeloid-derived suppressor cells (MDSCs) play a critical role in modulating the immune response and promoting immune tolerance in models of autoimmunity and transplantation. Regulatory T cells (Tregs) exert th...

    Authors: Min-Jung Park, Jin-Ah Baek, Se-Young Kim, Kyung-Ah Jung, Jeong Won Choi, Sung-Hwan Park, Seung‐Ki Kwok and Mi-La Cho

    Citation: Journal of Translational Medicine 2020 18:483

    Content type: Research

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  6. Driver genes of GBM may be crucial for the onset of isocitrate dehydrogenase (IDH)-wildtype (WT) glioblastoma (GBM). However, it is still unknown whether the genes are expressed in the identical cluster of cells....

    Authors: Seon-Jin Yoon, Hye Young Son, Jin-Kyoung Shim, Ju Hyung Moon, Eui-Hyun Kim, Jong Hee Chang, Wan Yee Teo, Se Hoon Kim, Sahng Wook Park, Yong-Min Huh and Seok-Gu Kang

    Citation: Journal of Translational Medicine 2020 18:482

    Content type: Research

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  7. In the past two decades, sphingolipids have become increasingly appreciated as bioactive molecules playing important roles in a wide array of pathophysiology mechanisms. Despite advances in the field, sphingol...

    Authors: Michele Dei Cas, Rita Paroni, Paola Signorelli, Alessandra Mirarchi, Laura Cerquiglini, Stefania Troiani, Samuela Cataldi, Michela Codini, Tommaso Beccari, Riccardo Ghidoni and Elisabetta Albi

    Citation: Journal of Translational Medicine 2020 18:481

    Content type: Research

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  8. Childhood obesity persists as a serious public health problem. In the current meta-analysis, we summarized the results of controlled trials that evaluated the effect of obesity prevention policies in children ...

    Authors: Shahnaz Taghizadeh and Mahdieh Abbasalizad Farhangi

    Citation: Journal of Translational Medicine 2020 18:480

    Content type: Review

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  9. Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar bone loss in periodontitis ...

    Authors: Xiaofei Huang, Mengru Xie, Yanling Xie, Feng Mei, Xiaofeng Lu, Xiaoshuang Li and Lili Chen

    Citation: Journal of Translational Medicine 2020 18:479

    Content type: Review

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  10. Mammary carcinogenesis is partly regulated by the transforming growth factor beta (TGFβ) signaling pathway. Its function in cancer progression and metastasis is highly dependent on disease stage, and it is lik...

    Authors: Lovorka Grgurevic, Ruder Novak, Vladimir Trkulja, Stela Hrkac, Grgur Salai, Josko Bilandzic, Lejla Ferhatovic Hamzic, Ivan Milas, Tiha Vucemilo, Melita Peric Balja and Karmen Bilic

    Citation: Journal of Translational Medicine 2020 18:478

    Content type: Research

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  11. Interleukin-33 (IL-33) is an effective inducer of pro-inflammatory cytokines regulating innate and adaptive immunity. Inflammation could be a double-edged sword, promoting or inhibiting tumour growth. To date,...

    Authors: Wenxiu Wang, Jun Wu, Mei Ji and Changping Wu

    Citation: Journal of Translational Medicine 2020 18:477

    Content type: Research

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  12. Nonalcoholic fatty liver disease (NAFLD) is primarily characterized by the hepatic cholesterol accumulation. Circular RNA (circRNA), one of noncoding RNA, involves in many liver diseases progression. However, ...

    Authors: Xinlu Yuan, Jianjun Diao, Anqing Du, Song Wen, Ligang Zhou and Yangbin Pan

    Citation: Journal of Translational Medicine 2020 18:476

    Content type: Research

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  13. The outcomes of immune checkpoint inhibitors in cancer patients with liver metastases are poor, which may be related to a different tumor microenvironment in liver metastases from primary tumors. This study wa...

    Authors: Xiao-Li Wei, Xuan Luo, Hui Sheng, Yun Wang, Dong-Liang Chen, Jia-Ning Li, Feng-Hua Wang and Rui-Hua Xu

    Citation: Journal of Translational Medicine 2020 18:475

    Content type: Research

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  14. The solid tumor microenvironment possesses a hypoxic condition, which promotes aggressiveness and resistance to therapies. Hypoxic tumor cells undergo broadly metabolic and molecular adaptations and communicat...

    Authors: Reza Jafari, Reza Rahbarghazi, Mahdi Ahmadi, Mehdi Hassanpour and Jafar Rezaie

    Citation: Journal of Translational Medicine 2020 18:474

    Content type: Review

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  15. The diagnosis of check-point inhibitor-related pneumonitis (CIP) relies on radiological and clinical patterns which are not specific and can mimic other conditions (cancer progression, infectious diseases or i...

    Authors: Sabino Strippoli, Livia Fucci, Antonio Negri, Daniela Putignano, Marco Luigi Cisternino, Gaetano Napoli, Ruggiero Filannino, Ivana De Risi, Angela Monica Sciacovelli and Michele Guida

    Citation: Journal of Translational Medicine 2020 18:473

    Content type: Research

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  16. Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to health and leading to diminished life expectancy. A dysregulated metabolism induces the secretion of several mo...

    Authors: Murugan Subramanian, Anne Wojtusciszyn, Lucie Favre, Sabri Boughorbel, Jingxuan Shan, Khaled B. Letaief, Nelly Pitteloud and Lotfi Chouchane

    Citation: Journal of Translational Medicine 2020 18:472

    Content type: Review

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  17. Immunotherapy is an efficient way to cure cancer by modulating the patient’s immune response. However, the immunotherapy response is heterogeneous and varies between individual patients and cancer subtypes, re...

    Authors: Sabah Nisar, Ajaz A. Bhat, Sheema Hashem, Santosh K. Yadav, Arshi Rizwan, Mayank Singh, Puneet Bagga, Muzafar A. Macha, Michael P. Frenneaux, Ravinder Reddy and Mohammad Haris

    Citation: Journal of Translational Medicine 2020 18:471

    Content type: Review

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  18. Cardiomyopathy is a common side effect of doxorubicin (DOX) chemotherapy. Despite intensive research efforts in the field, there is still no evidence available for routine cardioprotective prophylaxis to preve...

    Authors: Mária Lódi, Viktor Bánhegyi, Beáta Bódi, Alexandra Gyöngyösi, Árpád Kovács, Anita Árokszállási, Nazha Hamdani, Miklós Fagyas, István Édes, Zoltán Csanádi, István Czuriga, Zoltán Kisvárday, István Lekli, Péter Bai, Attila Tóth, Zoltán Papp…

    Citation: Journal of Translational Medicine 2020 18:470

    Content type: Research

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  19. Human cytomegalovirus (HCMV) is a beta-hersvirinae that has a high latent infection rate worldwide and can cause serious consequences in immunocompromised patients when reactivation; however, the mechanism of ...

    Authors: Wanqing Zhou, Cheng Wang, Meng Ding, Yuying Bian, Yujie Zhong, Han Shen, Junjun Wang, Chen-Yu Zhang and Chunni Zhang

    Citation: Journal of Translational Medicine 2020 18:469

    Content type: Research

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  20. In pre-clinical research, systematic reviews have the potential to mitigate translational challenges by facilitating understanding of how pre-clinical studies can inform future clinical research. Yet their con...

    Authors: Nicola L. Harman, Adrián Sanz-Moreno, Stamatia Papoutsopoulou, Katie A. Lloyd, Kamar E. Ameen-Ali, Malcolm Macleod and Paula R. Williamson

    Citation: Journal of Translational Medicine 2020 18:468

    Content type: Research

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  21. Late-onset asthma (LOA) is beginning to account for an increasing proportion of asthma patients, which is often underdiagnosed in the elderly. Studies on the possible relations between aging-related genes and ...

    Authors: Lin Yuan, Leyuan Wang, Xizi Du, Ling Qin, Ming Yang, Kai Zhou, Mengping Wu, Yu Yang, Zhiyuan Zheng, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin and Chi Liu

    Citation: Journal of Translational Medicine 2020 18:467

    Content type: Research

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  22. An important task in developing accurate public health intervention evaluation methods based on historical interrupted time series (ITS) records is to determine the exact lag time between pre- and post-interve...

    Authors: Hossein Bonakdari, Jean-Pierre Pelletier and Johanne Martel-Pelletier

    Citation: Journal of Translational Medicine 2020 18:466

    Content type: Research

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  23. Healthcare-associated pneumonia (HCAP) is a heterogeneous disease. We redefined nursing-home- and hospital-associated infections (NHAI) group by revising existing HCAP risk factors. The NHAI group comprised nu...

    Authors: Min-gyung Baek, Seong Ji Woo, Nam Eun Kim, Chaeyun Baek, Sungho Won, Youngmi Kim, Jae Jun Lee, Hana Yi and Ji Young Hong

    Citation: Journal of Translational Medicine 2020 18:464

    Content type: Research

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  24. Alternative splicing (AS) plays critical roles in generating protein diversity and complexity. Dysregulation of AS underlies the initiation and progression of tumors. Machine learning approaches have emerged a...

    Authors: Qidong Cai, Boxue He, Pengfei Zhang, Zhenyu Zhao, Xiong Peng, Yuqian Zhang, Hui Xie and Xiang Wang

    Citation: Journal of Translational Medicine 2020 18:463

    Content type: Research

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  25. Sepsis is a significant cause of mortality in-hospital, especially in ICU patients. Early prediction of sepsis is essential, as prompt and appropriate treatment can improve survival outcomes. Machine learning ...

    Authors: Nianzong Hou, Mingzhe Li, Lu He, Bing Xie, Lin Wang, Rumin Zhang, Yong Yu, Xiaodong Sun, Zhengsheng Pan and Kai Wang

    Citation: Journal of Translational Medicine 2020 18:462

    Content type: Research

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  26. Information regarding characteristics and risk factors of COVID-19 amongst middle-aged (40–59 years) patients without comorbidities is scarce.

    Authors: Peng Wang, Jing Sha, Mei Meng, Cuiyan Wang, Qingchun Yao, Zhongfa Zhang, Wenqing Sun, Xingguang Wang, Guoqiang Qie, Xue Bai, Keke Liu and Yufeng Chu

    Citation: Journal of Translational Medicine 2020 18:461

    Content type: Research

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  27. Increasing evidence showed that carbamylated lipoprotein accelerated atherosclerosis. However, whether such modification of high-density lipoprotein (HDL) particles alters in type 2 diabetes mellitus (T2DM) pa...

    Authors: Zhongli Chen, Song Ding, Yan Ping Wang, Liang Chen, Jing Yan Mao, Ying Yang, Jia Teng Sun and Ke Yang

    Citation: Journal of Translational Medicine 2020 18:460

    Content type: Research

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  28. Exosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant rs1799858] and environmental [elevated serum low...

    Authors: Cheng Liu, Yanxian Lai, Songsong Ying, Junfang Zhan and Yan Shen

    Citation: Journal of Translational Medicine 2020 18:459

    Content type: Research

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  29. Magnesium is a fundamental cation that regulates neuronal transmission, protein synthesis, energy metabolism. Magnesium deficiency mostly affects nervous and cardiovascular systems determining weakness, tremor...

    Authors: Clementina Sitzia, Michele Sterlicchio, Calogero Crapanzano, Elena Dozio, Elena Vianello and Massimiliano Marco Corsi Romanelli

    Citation: Journal of Translational Medicine 2020 18:458

    Content type: Research

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  30. Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting...

    Authors: Mathieu Blot, Jean-Baptiste Bour, Jean Pierre Quenot, Abderrahmane Bourredjem, Maxime Nguyen, Julien Guy, Serge Monier, Marjolaine Georges, Audrey Large, Auguste Dargent, Alexandre Guilhem, Suzanne Mouries-Martin, Jeremy Barben, Belaid Bouhemad, Pierre-Emmanuel Charles, Pascal Chavanet…

    Citation: Journal of Translational Medicine 2020 18:457

    Content type: Research

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  31. Ankylosing spondylitis (AS) is characterized by excessive production of inflammatory cytokines. Recent evidence suggests that inflammation underlies the neurodegenerative process of Parkinson’s disease (PD). W...

    Authors: Fu-Chiang Yeh, Hsiang-Cheng Chen, Yu-Ching Chou, Cheng-Li Lin, Chia-Hung Kao, Hsin-Yi Lo, Feng-Cheng Liu and Tse-Yen Yang

    Citation: Journal of Translational Medicine 2020 18:455

    Content type: Research

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  32. Myopathies are a heterogenous collection of disorders characterized by dysfunction of skeletal muscle. In practice, myopathies are frequently encountered by physicians and precise diagnosis remains a challenge...

    Authors: Andrew Tran, Chris J. Walsh, Jane Batt, Claudia C. dos Santos and Pingzhao Hu

    Citation: Journal of Translational Medicine 2020 18:454

    Content type: Research

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  33. Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth fa...

    Authors: Krishnath M. Jayatilleke and Mark D. Hulett

    Citation: Journal of Translational Medicine 2020 18:453

    Content type: Review

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  34. Dysregulation of transcription and cytokine expression has been implicated in the pathogenesis of a variety inflammatory diseases. The resulting imbalance between inflammatory and resolving transcriptional pro...

    Authors: Gregory Thomas, Elizabeth Frederick, Lisa Thompson, Raphael Bar-Or, Yetti Mulugeta, Melissa Hausburg, Michael Roshon, Charles Mains and David Bar-Or

    Citation: Journal of Translational Medicine 2020 18:452

    Content type: Research

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  35. During the coronavirus disease-2019 (COVID-19) pandemic, Italian hospitals faced the most daunting challenges of their recent history, and only essential therapeutic interventions were feasible. From March to ...

    Authors: Giuseppe Astori, Martina Bernardi, Angela Bozza, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Monica Santimaria, Roberto Barbazza, Giuseppe Amodeo, Rachele Ciccocioppo, Francesca Elice and Marco Ruggeri

    Citation: Journal of Translational Medicine 2020 18:451

    Content type: Research

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  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaojun Fu, Pei Zhang, Hongwang Song, Chenxing Wu, Shengzhen Li, Shouwei Li and Changxiang Yan

    Citation: Journal of Translational Medicine 2020 18:450

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2020 18:391

  37. Mesenchymal stem cells (MSCs) have captured great attention in regenerative medicine for over a few decades by virtue of their differentiation capacity, potent immunomodulatory properties, and their ability to...

    Authors: Sepideh Nikfarjam, Jafar Rezaie, Naime Majidi Zolbanin and Reza Jafari

    Citation: Journal of Translational Medicine 2020 18:449

    Content type: Review

    Published on:

  38. Q fever fatigue syndrome (QFS) is characterised by a state of prolonged fatigue that is seen in 20% of acute Q fever infections and has major health-related consequences. The molecular mechanisms underlying QF...

    Authors: Ruud P. H. Raijmakers, Megan E. Roerink, Anne F. M. Jansen, Stephan P. Keijmel, Ranko Gacesa, Yang Li, Leo A. B. Joosten, Jos W. M. van der Meer, Mihai G. Netea, Chantal P. Bleeker-Rovers and Cheng-Jian Xu

    Citation: Journal of Translational Medicine 2020 18:448

    Content type: Research

    Published on:

  39. Ipilimumab and Nivolumab, targeting the molecules CTLA-4, PD-1, respectively,have shown efficacy against several types of cancer. Despite these results, only a small percentage of patients maintains a long-las...

    Authors: Paolo Marchetti, Andrea Botticelli, Antonio Paolo Ascierto, Giuseppe Curigliano and Diana Giannarelli

    Citation: Journal of Translational Medicine 2020 18:446

    Content type: Research

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  40. Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a critical signaling molecule in thymocyte development. This study aimed to investigate the regulatory effect of Tespa1 on mast cells in the pat...

    Authors: Ruhui Yang, Guangli Wang, Lingyun Li, Hanjiang He, Mingzhu Zheng, Linrong Lu and Songquan Wu

    Citation: Journal of Translational Medicine 2020 18:444

    Content type: Research

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  41. The tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally char...

    Authors: Ilseon Hwang, Jeong Won Kim, Kris Ylaya, Eun Joo Chung, Haruhisa Kitano, Candice Perry, Jun Hanaoka, Junya Fukuoka, Joon-Yong Chung and Stephen M. Hewitt

    Citation: Journal of Translational Medicine 2020 18:443

    Content type: Research

    Published on:

  42. Breast cancer is a highly heterogeneous disease, this poses challenges for classification and management. Long non-coding RNAs play acrucial role in the breast cancersdevelopment and progression, especially in...

    Authors: Wei Ma, Fangkun Zhao, Xinmiao Yu, Shu Guan, Huandan Suo, Zuo Tao, Yue Qiu, Yunfei Wu, Yu Cao and Feng Jin

    Citation: Journal of Translational Medicine 2020 18:442

    Content type: Research

    Published on:

  43. The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives. Notably, obesity and its related com...

    Authors: Antonio Paoli, Stefania Gorini and Massimiliano Caprio

    Citation: Journal of Translational Medicine 2020 18:441

    Content type: Review

    Published on:

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