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  1. According to the scientific literature, less than 30 borderline ovarian tumors have been karyotyped and less than 100 analyzed for genomic imbalances by CGH.

    Authors: Francesca Micci, Lisbeth Haugom, Terje Ahlquist, Hege K Andersen, Vera M Abeler, Ben Davidson, Claes G Trope, Ragnhild A Lothe and Sverre Heim
    Citation: Journal of Translational Medicine 2010 8:21
  2. To test the hypothesis that modulation of Bcl-2 with 13-cis retinoic acid (CRA)/interferon-alpha2b (IFN) with paclitaxel (TAX), or mitoxantrone, estramustine and vinorelbine (MEV) will have clinical activity i...

    Authors: Robert S DiPaola, Yu-Hui Chen, Mark Stein, David Vaughn, Linda Patrick-Miller, Michael Carducci, Bruce Roth, Eileen White and George Wilding
    Citation: Journal of Translational Medicine 2010 8:20
  3. Increased levels of cryptic collagen epitope HU177 in the sera of melanoma patients have been shown to be associated with thicker primary melanomas and with the nodular histologic subtype. In this study, we in...

    Authors: Heather K Hamilton, Amy E Rose, Paul J Christos, Richard L Shapiro, Russell S Berman, Madhu Mazumdar, Michelle W Ma, Daniel Krich, Leonard Liebes, Peter C Brooks and Iman Osman
    Citation: Journal of Translational Medicine 2010 8:19
  4. Hepatitis C virus (HCV) is one of the major risk factors for chronic hepatitis, which may progress to cirrhosis and hepatocellular carcinoma, as well as for type II mixed cryoglobulinemia (MC), which may furth...

    Authors: Luigi Buonaguro, Annacarmen Petrizzo, Marialina Tornesello, Maria Napolitano, Debora Martorelli, Giuseppe Castello, Gerardo Beneduce, Amalia De Renzo, Oreste Perrella, Luca Romagnoli, Vitor Sousa, Valli De Re, Riccardo Dolcetti and Franco M Buonaguro
    Citation: Journal of Translational Medicine 2010 8:18
  5. Type-1 T cells are critical for effective anti-tumor immune responses. The recently discovered microRNAs (miRs) are a large family of small regulatory RNAs that control diverse aspects of cell function, includ...

    Authors: Kotaro Sasaki, Gary Kohanbash, Aki Hoji, Ryo Ueda, Heather A McDonald, Todd A Reinhart, Jeremy Martinson, Michael T Lotze, Francesco M Marincola, Ena Wang, Mitsugu Fujita and Hideho Okada
    Citation: Journal of Translational Medicine 2010 8:17
  6. The medical use of low level laser (LLL) irradiation has been occurring for decades, primarily in the area of tissue healing and inflammatory conditions. Despite little mechanistic knowledge, the concept of a ...

    Authors: Feng Lin, Steven F Josephs, Doru T Alexandrescu, Famela Ramos, Vladimir Bogin, Vincent Gammill, Constantin A Dasanu, Rosalia De Necochea-Campion, Amit N Patel, Ewa Carrier and David R Koos
    Citation: Journal of Translational Medicine 2010 8:16
  7. Although there have been many studies on the p73 gene, some of its functions still remain unclear. There is little research on the relationship between p73 gene transcription and its protein expression and the...

    Authors: Marta Herreros-Villanueva, Pilar Muñiz, Carlos García-Girón, Mónica Cavia-Saiz and María J Coma del Corral
    Citation: Journal of Translational Medicine 2010 8:15
  8. Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart. Rapamycin has been show...

    Authors: Chelsey Woodrum, Alison Nobil and Sandra L Dabora
    Citation: Journal of Translational Medicine 2010 8:14
  9. Although an abundance of evidence has indicated that tumor-associated macrophages (TAMs) are associated with a favorable prognosis in patients with colon cancer, it is still unknown how TAMs exert a protective...

    Authors: Qiang Zhou, Rui-Qing Peng, Xiao-Jun Wu, Qing Xia, Jing-Hui Hou, Ya Ding, Qi-Ming Zhou, Xing Zhang, Zhi-Zhong Pang, De-Sen Wan, Yi-Xin Zeng and Xiao-Shi Zhang
    Citation: Journal of Translational Medicine 2010 8:13
  10. In recent years the concept of "translational medicine" has been advanced in an attempt to catalyze the medical applications of basic biomedical research. However, there has been little discussion about the re...

    Authors: Robert B Nussenblatt, Francesco M Marincola and Alan N Schechter
    Citation: Journal of Translational Medicine 2010 8:12
  11. Ileal pouch-anal anastomosis (IPAA) is the surgical procedure of choice for patients with refractory ulcerative colitis (UC) and for familial adenomatous polyposis (FAP) with many rectal polyps. Pouchitis is o...

    Authors: Raquel F Leal, Maria de Lourdes S Ayrizono, Marciane Milanski, João J Fagundes, Juliana C Moraes, Luciana R Meirelles, Lício A Velloso and Cláudio SR Coy
    Citation: Journal of Translational Medicine 2010 8:11
  12. Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer mortality for which novel gene therapy approaches relying on tumor-tropic adenoviruses are being tested.

    Authors: Vladia Monsurrò, Stefania Beghelli, Richard Wang, Stefano Barbi, Silvia Coin, Giovanni Di Pasquale, Samantha Bersani, Monica Castellucci, Claudio Sorio, Stefano Eleuteri, Andrea Worschech, Jay A Chiorini, Paolo Pederzoli, Harvey Alter, Francesco M Marincola and Aldo Scarpa
    Citation: Journal of Translational Medicine 2010 8:10
  13. Glycoprotein-96, a non-polymorphic heat-shock protein, associates with intracellular peptides. Autologous tumor-derived heat shock protein-peptide complex 96 (HSPPC-96) can elicit potent tumor-specific T cell ...

    Authors: Omar Eton, Merrick I Ross, Mary Jo East, Paul F Mansfield, Nicholas Papadopoulos, Julie A Ellerhorst, Agop Y Bedikian and Jeffrey E Lee
    Citation: Journal of Translational Medicine 2010 8:9
  14. Due to the lack of specific tumor antigens, the majority of tested cancer vaccines for renal cell carcinoma (RCC) are based on tumor cell lysate. The identification of the von Hippel-Lindau (VHL) gene mutations i...

    Authors: Osama E Rahma, Ed Ashtar, Ramy Ibrahim, Antoun Toubaji, Barry Gause, Vincent E Herrin, W Marston Linehan, Seth M Steinberg, Frank Grollman, George Grimes, Sarah A Bernstein, Jay A Berzofsky and Samir N Khleif
    Citation: Journal of Translational Medicine 2010 8:8
  15. The conventional treatment protocol in high-intensity focused ultrasound (HIFU) therapy utilizes a dense-scan strategy to produce closely packed thermal lesions aiming at eradicating as much tumor mass as poss...

    Authors: Fang Liu, Zhenlin Hu, Lei Qiu, Chun Hui, Chao Li, Pei Zhong and Junping Zhang
    Citation: Journal of Translational Medicine 2010 8:7
  16. Activation of Toll-like receptors (TLRs) is widely accepted as an essential event for defence against infection. Many TLRs utilize a common signalling pathway that relies on activation of the kinase IRAK4 and ...

    Authors: Kelly L Brown, Reza Falsafi, Winnie Kum, Pamela Hamill, Jennifer L Gardy, Donald J Davidson, Stuart Turvey, Brett B Finlay, David P Speert and Robert EW Hancock
    Citation: Journal of Translational Medicine 2010 8:6
  17. Efficacy of cancer vaccines may be limited due to immune escape mechanisms like loss or mutation of target antigens. Here, we analyzed 10 HLA-A2 positive patients with acute myeloid leukemia (AML) for loss or ...

    Authors: Antonia Busse, Anne Letsch, Carmen Scheibenbogen, Anika Nonnenmacher, Sebastian Ochsenreither, Eckhard Thiel and Ulrich Keilholz
    Citation: Journal of Translational Medicine 2010 8:5
  18. Dendritic cells (DCs) are often produced by granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) stimulation of monocytes. To improve the effectiveness of DC adoptive immune cance...

    Authors: Ping Jin, Tae Hee Han, Jiaqiang Ren, Stefanie Saunders, Ena Wang, Francesco M Marincola and David F Stroncek
    Citation: Journal of Translational Medicine 2010 8:4
  19. Staphylococcal enterotoxins (SEs), SE-like (SEl) toxins, and toxic shock syndrome toxin-1 (TSST-1), produced by Staphylococcus aureus, belong to the subgroup of microbial superantigens (SAgs). SAgs induce clonal ...

    Authors: Keun Seok Seo, Joo Youn Park, David S Terman and Gregory A Bohach
    Citation: Journal of Translational Medicine 2010 8:2
  20. Chronic Fatigue Syndrome (CFS) is a multifactorial disorder that affects various physiological systems including immune and neurological systems. The immune system has been substantially examined in CFS with e...

    Authors: Ekua W Brenu, Donald R Staines, Oguz K Baskurt, Kevin J Ashton, Sandra B Ramos, Rhys M Christy and Sonya M Marshall-Gradisnik
    Citation: Journal of Translational Medicine 2010 8:1
  21. The detection of circulating tumor cells (CTC) is considered a promising tool for improving risk stratification in patients with solid tumors. We investigated on whether the expression of CTC related genes add...

    Authors: Loris Bertazza, Simone Mocellin, Alberto Marchet, Pierluigi Pilati, Joseph Gabrieli, Romano Scalerta and Donato Nitti
    Citation: Journal of Translational Medicine 2009 7:111
  22. Tumor Protein p53 (p53), cyclin-dependent kinase inhibitor 1A (p21/WAF1), and murine double minute 2 (MDM2) participate in the regulation of cell growth. Altered expression of these gene products has been foun...

    Authors: Mei-Fang Zhang, Zhi-Yi Zhang, Jia Fu, Yu-Feng Yang and Jing-Ping Yun
    Citation: Journal of Translational Medicine 2009 7:110
  23. Optimization of the current dendritic cell (DC) culture protocol in order to promote the therapeutic efficacy of DC-based immunotherapy is warranted. Alternative differentiation of monocyte-derived DCs using g...

    Authors: Sébastien Anguille, Evelien LJM Smits, Nathalie Cools, Herman Goossens, Zwi N Berneman and Vigor FI Van Tendeloo
    Citation: Journal of Translational Medicine 2009 7:109
  24. HIV and HPV can both cause chronic infections and are acquired during sexual contact. HIV infection results in a progressive loss of CD4+ T cells that is associated with an increased prevalence of HPV infectio...

    Authors: Sjoerd H van der Burg and Joel M Palefsky
    Citation: Journal of Translational Medicine 2009 7:108
  25. The aim of the present study was to compare the effects of Daivobet® and calcipotriol on clinical score and biomarker responses in a modified version of the Scholtz-Dumas psoriasis plaque assay. Furthermore, it w...

    Authors: Peter H Kvist, Lars Svensson, Oskar Hagberg, Vibeke Hoffmann, Kaare Kemp and Mads A Røpke
    Citation: Journal of Translational Medicine 2009 7:107
  26. Endothelial dysfunction is associated with major causes of morbidity and mortality, as well as numerous age-related conditions. The possibility of preserving or even rejuvenating endothelial function offers a ...

    Authors: Nina A Mikirova, James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle WH Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Doru T Alexandrescu, Thomas E Ichim and Neil H Riordan
    Citation: Journal of Translational Medicine 2009 7:106
  27. Pancreatic cancer continues to prove difficult to clinically diagnose. Multiple simultaneous measurements of plasma biomarkers can increase sensitivity and selectivity of diagnosis. Proximity ligation assay (P...

    Authors: Stephanie T Chang, Jacob M Zahn, Joe Horecka, Pamela L Kunz, James M Ford, George A Fisher, Quynh T Le, Daniel T Chang, Hanlee Ji and Albert C Koong
    Citation: Journal of Translational Medicine 2009 7:105
  28. Liposomal doxorubicin (Doxil) is a cytotoxic chemotherapy drug with a favorable hematologic toxicity profile. Its active drug, doxorubicin, has interesting immunomodulatory properties. Here, the effects of Dox...

    Authors: Ioannis Alagkiozidis, Andrea Facciabene, Carmine Carpenito, Fabian Benencia, Zdenka Jonak, Sarah Adams, Richard G Carroll, Phyllis A Gimotty, Rachel Hammond, Gwen-äel Danet-Desnoyers, Carl H June, Daniel J Powell Jr and George Coukos
    Citation: Journal of Translational Medicine 2009 7:104
  29. Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. High expression levels of AMACR have been described ...

    Authors: Ichiya Honma, Toshihiko Torigoe, Yoshihiko Hirohashi, Hiroshi Kitamura, Eiji Sato, Naoya Masumori, Yasuaki Tamura, Taiji Tsukamoto and Noriyuki Sato
    Citation: Journal of Translational Medicine 2009 7:103
  30. The search for a suitable biomarker which indicates immune system responses in cancer patients has been long and arduous, but a widely known biomarker has emerged as a potential candidate for this purpose. C-R...

    Authors: Brendon J Coventry, Martin L Ashdown, Michael A Quinn, Svetomir N Markovic, Steven L Yatomi-Clarke and Andrew P Robinson
    Citation: Journal of Translational Medicine 2009 7:102
  31. HIV-1 exposure causes several dramatic unbalances in the immune system homeostasis. Here, we will focus on the paradox whereby CD4 specific autoimmune responses, which are expected to contribute to the catastr...

    Authors: Samuele E Burastero, Mariangela Figini, Barbara Frigerio, Paolo Lusso, Luca Mollica and Lucia Lopalco
    Citation: Journal of Translational Medicine 2009 7:101
  32. Macrophage migration inhibitory factor (MIF) plays an important regulatory role in sepsis. In the promoter region a C/G single nucleotide polymorphism (SNP) at position -173 (rs755622) and a CATT5-8 microsatellit...

    Authors: Lutz E Lehmann, Malte Book, Wolfgang Hartmann, Stefan U Weber, Jens-Christian Schewe, Sven Klaschik, Andreas Hoeft and Frank Stüber
    Citation: Journal of Translational Medicine 2009 7:100
  33. There are many diagnostic techniques and methods available for diagnosis of medically important microorganisms like bacteria, viruses, fungi and parasites. But, almost all these techniques and methods have som...

    Authors: Aamir Shahzad, Gottfried Köhler, Martin Knapp, Erwin Gaubitzer, Martin Puchinger and Michael Edetsberger
    Citation: Journal of Translational Medicine 2009 7:99
  34. MicroRNAs are ~22nt-long small non-coding RNAs that negatively regulate protein expression through mRNA degradation or translational repression in eukaryotic cells. Based upon their importance in regulating de...

    Authors: Seung-Jae Noh, Samuel H Miller, Y Terry Lee, Sung-Ho Goh, Francesco M Marincola, David F Stroncek, Christopher Reed, Ena Wang and Jeffery L Miller
    Citation: Journal of Translational Medicine 2009 7:98
  35. Acute ischemic stroke is the third leading cause of death in industrialized countries and the most frequent cause of permanent disability in adults worldwide. Despite advances in the understanding of the patho...

    Authors: Shaheen E Lakhan, Annette Kirchgessner and Magdalena Hofer
    Citation: Journal of Translational Medicine 2009 7:97
  36. Chronic Fatigue Syndrome (CFS) studies from our laboratory and others have described cytokine abnormalities. Other studies reported no difference between CFS and controls. However, methodologies varied widely ...

    Authors: Mary Ann Fletcher, Xiao Rong Zeng, Zachary Barnes, Silvina Levis and Nancy G Klimas
    Citation: Journal of Translational Medicine 2009 7:96
  37. Medical research to improve health care faces a major problem in the relatively limited availability of adequately annotated and collected biospecimens. This limitation is creating a growing gap between the pa...

    Authors: Peter H Watson, Janet E Wilson-McManus, Rebecca O Barnes, Sara C Giesz, Adrian Png, Richard G Hegele, Jacquelyn N Brinkman, Ian R Mackenzie, David G Huntsman, Anne Junker, Blake Gilks, Erik Skarsgard, Michael Burgess, Samuel Aparicio and Bruce M McManus
    Citation: Journal of Translational Medicine 2009 7:95
  38. Peri-tumoral inflammation is a common tumor response that plays a central role in tumor invasion and metastasis, and inflammatory cell recruitment is essential to this process. The purpose of this study was to...

    Authors: Akhilesh K Sista, Robert J Knebel, Sidhartha Tavri, Magnus Johansson, David G DeNardo, Sophie E Boddington, Sirish A Kishore, Celina Ansari, Verena Reinhart, Fergus V Coakley, Lisa M Coussens and Heike E Daldrup-Link
    Citation: Journal of Translational Medicine 2009 7:94
  39. CD40 activation of antigen presenting cells (APC) such as dendritic cells (DC) and B cells plays an important role in immunological licensing of T cell immunity. Agonist CD40 antibodies have been previously sh...

    Authors: Erica L Carpenter, Rosemarie Mick, Jens Rüter and Robert H Vonderheide
    Citation: Journal of Translational Medicine 2009 7:93
  40. The signal transducer and activator of transcription 3 (STAT-3) is frequently overexpressed in cancer cells, propagates tumorigenesis, and is a key regulator of immune suppression in cancer patients. The prese...

    Authors: William Humphries, Yongtao Wang, Wei Qiao, Chantal Reina-Ortiz, Mohamed K Abou-Ghazal, Lamonne M Crutcher, Jun Wei, Ling-Yuan Kong, Raymond Sawaya, Ganesh Rao, Jeffrey Weinberg, Sujit S Prabhu, Gregory N Fuller and Amy B Heimberger
    Citation: Journal of Translational Medicine 2009 7:92
  41. Our goal was to determine whether short-term intermittent hypoxia exposure, at a level well tolerated by healthy humans and previously shown by our group to increase EPO and erythropoiesis, could mobilize hema...

    Authors: Ginés Viscor, Casimiro Javierre, Teresa Pagès, Josep-Lluis Ventura, Antoni Ricart, Gregorio Martin-Henao, Carmen Azqueta and Ramon Segura
    Citation: Journal of Translational Medicine 2009 7:91
  42. The ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) gene involved in the regulation of cellular ubiquitin levels plays an important role in different cellular processes including cell growth and differentiatio...

    Authors: Barbara Seliger, Diana Handke, Elisabeth Schabel, Juergen Bukur, Rudolf Lichtenfels and Reinhard Dammann
    Citation: Journal of Translational Medicine 2009 7:90
  43. Foxp3 has been suggested to be a standard marker for murine Tregs whereas its role as marker for human Tregs is controversial. While some reports have shown that human Foxp3+ T cells had no regulatory function...

    Authors: Maciej Kmieciak, Madhu Gowda, Laura Graham, Kamar Godder, Harry D Bear, Francesco M Marincola and Masoud H Manjili
    Citation: Journal of Translational Medicine 2009 7:89
  44. Establishing a large rodent model of brain metastasis that can be monitored using clinically relevant magnetic resonance imaging (MRI) techniques is challenging. Non-invasive imaging of brain metastasis in mic...

    Authors: Ho-Taek Song, Elaine K Jordan, Bobbi K Lewis, Wei Liu, Justin Ganjei, Brenda Klaunberg, Daryl Despres, Diane Palmieri and Joseph A Frank
    Citation: Journal of Translational Medicine 2009 7:88
  45. This commentary discusses a study on measurements of matrix metalloproteinase 9 (MMP-9) in serum of pseudoxanthoma elasticum patients recently published in Journal of Molecular Medicine. This study can be cons...

    Authors: Klaus Jung, Ferdinando Mannello and Michael Lein
    Citation: Journal of Translational Medicine 2009 7:87
  46. The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underlying aggressiveness, clinical behavior, and respon...

    Authors: Giuseppe Palmieri, Mariaelena Capone, Maria Libera Ascierto, Giusy Gentilcore, David F Stroncek, Milena Casula, Maria Cristina Sini, Marco Palla, Nicola Mozzillo and Paolo A Ascierto
    Citation: Journal of Translational Medicine 2009 7:86
  47. Hepatitis C virus (HCV) infection is a major cause of hepatocellular carcinoma (HCC) worldwide. The molecular mechanisms of HCV-induced hepatocarcinogenesis are not yet fully elucidated. Besides indirect effec...

    Authors: Valeria De Giorgi, Alessandro Monaco, Andrea Worchech, MariaLina Tornesello, Francesco Izzo, Luigi Buonaguro, Francesco M Marincola, Ena Wang and Franco M Buonaguro
    Citation: Journal of Translational Medicine 2009 7:85
  48. Recent advances in animal models of glioma have facilitated a better understanding of biological mechanisms underlying gliomagenesis and glioma progression. The limitations of existing therapy, including surge...

    Authors: Michael E Sughrue, Isaac Yang, Ari J Kane, Martin J Rutkowski, Shanna Fang, C David James and Andrew T Parsa
    Citation: Journal of Translational Medicine 2009 7:84
  49. Sjögren's syndrome (SjS) is a relatively common autoimmune disease characterized by oral and ocular dryness. There is an increasing need for simple, sensitive and rapid technologies for the diagnosis of SjS an...

    Authors: Peter D Burbelo, Kathryn H Ching, Alexandra T Issa, Caroline M Loftus, Yi Li, Minoru Satoh, Westley H Reeves and Michael J Iadarola
    Citation: Journal of Translational Medicine 2009 7:83

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