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  1. Angiogenesis is essential for the growth and metastasis of solid tumors. The tumor endothelium exists in a state of chronic activation and proliferation, fueled by the tumor milieu where angiogenic mediators a...

    Authors: Samuel C. Wagner, Thomas E. Ichim, Hong Ma, Julia Szymanski, Jesus A. Perez, Javier Lopez, Vladimir Bogin, Amit N. Patel, Francisco M. Marincola and Santosh Kesari
    Citation: Journal of Translational Medicine 2015 13:340
  2. Autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease are treated with TNF-alpha-blocking antibodies such as infliximab and adalimumab. A common side effect of therapeutic antibodies is...

    Authors: Arne Homann, Niels Röckendorf, Arno Kromminga, Andreas Frey and Uta Jappe
    Citation: Journal of Translational Medicine 2015 13:339
  3. Heat shock factor 1 (HSF1) is a powerful, multifaceted modifier of carcinogenesis. However, the clinical significance and biologic function of HSF1 in esophageal squamous cell carcinoma (ESCC) remain unknown.

    Authors: Yuehua Liao, Ying Xue, Lin Zhang, Xinwei Feng, Wanli Liu and Ge Zhang
    Citation: Journal of Translational Medicine 2015 13:338
  4. This study aimed to investigate the expression of CD147 and MMP-11 in human colorectal cancer (CRC) and to evaluate their clinical significance.

    Authors: Xiuyun Tian, Chunxiang Ye, Yongyong Yang, Xiaoya Guan, Bin Dong, Min Zhao and Chunyi Hao
    Citation: Journal of Translational Medicine 2015 13:337
  5. Asthma is a multifactorial disease for which a variety of mouse models have been developed. A major drawback of these models is represented by the transient nature of the airway pathology peaking 24–72 h after...

    Authors: Fabio Stellari, Angelo Sala, Francesca Ruscitti, Chiara Carnini, Prisco Mirandola, Marco Vitale, Maurizio Civelli and Gino Villetti
    Citation: Journal of Translational Medicine 2015 13:336
  6. Studies report conflicting evidence regarding the existence of a DCIS-associated premalignant pathway in BRCA mutation carriers. We aimed to examine the prevalence, phenotype, and expression of oncodrivers in ...

    Authors: Rachel L. Yang, Rosemarie Mick, Kathreen Lee, Holly L. Graves, Katherine L. Nathanson, Susan M. Domchek, Rachel R. Kelz, Paul J. Zhang and Brian J. Czerniecki
    Citation: Journal of Translational Medicine 2015 13:335
  7. Achromatopsia (ACHM) is a severe congenital autosomal recessive retinal disorder caused by loss of cone photoreceptors. Here, we aimed to determine the underlying genetic lesions and phenotypic correlations in...

    Authors: Fen-Fen Li, Xiu-Feng Huang, Jie Chen, Xu-Dong Yu, Mei-Qin Zheng, Fan Lu, Zi-Bing Jin and De-Kang Gan
    Citation: Journal of Translational Medicine 2015 13:334
  8. The mechanisms by which varicella zoster virus (VZV) reactivation causes postherpetic neuralgia (PHN), a debilitating chronic pain condition, have not been fully elucidated. Based on previous studies identifyi...

    Authors: Ahmad Bayat, Peter D. Burbelo, Sarah K. Browne, Mark Quinlivan, Bianca Martinez, Steven M. Holland, Asokumar Buvanendran, Jeffrey S. Kroin, Andrew J. Mannes, Judith Breuer, Jeffrey I. Cohen and Michael J. Iadarola
    Citation: Journal of Translational Medicine 2015 13:333
  9. Several promising biomarkers have been found for RCC, but none of them has been used in clinical practice for predicting tumour progression. The most widely used features for predicting tumour aggressiveness s...

    Authors: Clizia Chinello, Marta Cazzaniga, Gabriele De Sio, Andrew James Smith, Angelica Grasso, Bernardo Rocco, Stefano Signorini, Marco Grasso, Silvano Bosari, Italo Zoppis, Giancarlo Mauri and Fulvio Magni
    Citation: Journal of Translational Medicine 2015 13:332
  10. Human constitution, the fundamental basis of oriental medicine, is categorized into different patterns for a particular disease according to the physical, physiological, and clinical characteristics of the ind...

    Authors: Sun Woo Hong, Jae-Wook Yoo, Shambhunath Bose, Jung-Hyun Park, Kyungsun Han, Soyoun Kim, Chi-Yeon Lim, Hojun Kim and Dong-ki Lee
    Citation: Journal of Translational Medicine 2015 13:331
  11. The wingless-type MMTV integration site (Wnt) signaling is a group of signal transduction pathways. In canonical Wnt pathway, Wnt ligands bind to low-density lipoprotein receptor-related protein 5 or 6 (LRP5 o...

    Authors: Jingsheng Tuo, Yujuan Wang, Rui Cheng, Yichao Li, Mei Chen, Fangfang Qiu, Haohua Qian, Defen Shen, Rosana Penalva, Heping Xu, Jian-Xing Ma and Chi-Chao Chan
    Citation: Journal of Translational Medicine 2015 13:330
  12. Many kidneys are rejected for transplantation due to inadequate in situ perfusion during organ retrieval because of the risk of additional ischaemic injury and microvasculature thrombosis. This study describes...

    Authors: Sarah A. Hosgood, A. D. Barlow, J. Dormer and M. L. Nicholson
    Citation: Journal of Translational Medicine 2015 13:329
  13. Cisplatin is the main chemotherapeutic drug for the treatment of cervical cancers, however resistance to cisplatin is increasingly common and therefore has limited the efficacy and use of this drug in the clin...

    Authors: Gina Leisching, Benjamin Loos, Matthys Botha and Anna-Mart Engelbrecht
    Citation: Journal of Translational Medicine 2015 13:328
  14. A great deal of attention has been focused on adverse effects of tobacco smoking on conception, pregnancy, fetal, and child health. The aim of this paper is to discuss the current evidence regarding short and ...

    Authors: G. Banderali, A. Martelli, M. Landi, F. Moretti, F. Betti, G. Radaelli, C. Lassandro and E. Verduci
    Citation: Journal of Translational Medicine 2015 13:327
  15. Insulin growth factor 1 (IGF-1) has multiple effects on metabolism. Much evidence suggests that the deficiency of this hormone increases insulin resistance, impairs lipid metabolism, augments oxidative damage ...

    Authors: J. Rodríguez De Ita, I. Castilla-Cortázar, G. A. Aguirre, C. Sánchez-Yago, M. Olleros Santos-Ruiz, L. Guerra-Menéndez, I. Martín-Estal, M. García-Magariño, V. J. Lara-Díaz, J. E. Puche and U. Muñoz
    Citation: Journal of Translational Medicine 2015 13:326
  16. Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT ...

    Authors: Eugenia Belcastro, Maria Franzini, Silvana Cianchetti, Evelina Lorenzini, Silvia Masotti, Vanna Fierabracci, Angela Pucci, Alfonso Pompella and Alessandro Corti
    Citation: Journal of Translational Medicine 2015 13:325
  17. Trastuzumab is a humanized monoclonal antibody (mAb) currently used for the treatment of breast cancer (BC) patients with HER-2 overexpressing tumor subtype. Previous data reported the involvement of FcγRIIIA/...

    Authors: Silvia Boero, Anna Morabito, Barbara Banelli, Barbara Cardinali, Beatrice Dozin, Gianluigi Lunardi, Patrizia Piccioli, Sonia Lastraioli, Roberta Carosio, Sandra Salvi, Alessia Levaggi, Francesca Poggio, Alessia D’Alonzo, Massimo Romani, Lucia Del Mastro, Alessandro Poggi…
    Citation: Journal of Translational Medicine 2015 13:324

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:24

  18. Inflammation mediated by nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of hypertensive nephropathy (HN). Cytoskeletal remodelling is necessary for the activation of NF-κB. An actin-bindin...

    Authors: Quan-zhen Wang, Hai-qing Gao, Ying Liang, Jun Zhang, Jian Wang and Jie Qiu
    Citation: Journal of Translational Medicine 2015 13:323
  19. Acute-on-chronic liver failure (ACLF) is a form of liver disease with high short-term mortality. ACLF offers considerable potential to affect the cortical areas by significant tissue injury due to loss of neur...

    Authors: Santosh K. Yadav, Rakesh K. Gupta, Vivek A. Saraswat, Murali Rangan, Michael A. Thomas, Sergio Rutella, Silvio Danese, Ena Wang, Francesco M. Marincola and Mohammad Haris
    Citation: Journal of Translational Medicine 2015 13:322
  20. Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, and its underlying molecular mechanisms are poorly understood. Recent large-scale genome-wide association studies in Chinese Han populations...

    Authors: Xiao-Bin Cui, Yao-yuan Shen, Ting-ting Jin, Su Li, Ting-ting Li, Shu-mao Zhang, Hao Peng, Chun-xia Liu, Shu-gang Li, Lan Yang, Na Li, Jian-ming Hu, Jin-Fang Jiang, Man Li, Wei-hua Liang, Yong Li…
    Citation: Journal of Translational Medicine 2015 13:321
  21. There is growing evidence that variations in the gene encoding inosine triphosphate pyrophosphohydrolase (ITPase), known as inosine triphosphatase (ITPA), are related to hemolytic anemia, which is frequently obse...

    Authors: Daniel Pineda-Tenor, Mónica García-Álvarez, María A. Jiménez-Sousa, Sonia Vázquez-Morón and Salvador Resino
    Citation: Journal of Translational Medicine 2015 13:320
  22. Characterization of PD-L1 expression within clinically/radiologically negative but microscopically tumor positive sentinel lymph nodes (SLN) is important to our understanding of the relevance of this immune ch...

    Authors: Ahmad A. Tarhini, Haris Zahoor, Jennifer H. Yearley, Christopher Gibson, Zahra Rahman, Rachel Dubner, Uma N. M. Rao, Cindy Sander and John M. Kirkwood
    Citation: Journal of Translational Medicine 2015 13:319
  23. Telocytes (TCs) are suggested as a new type of interstitial cells with specific telopodes. Our previous study evidenced that TCs differed from fibroblasts and stem cells at the aspect of gene expression profil...

    Authors: Yichun Zhu, Minghuan Zheng, Dongli Song, Ling Ye and Xiangdong Wang
    Citation: Journal of Translational Medicine 2015 13:318
  24. Previous researches has depicted that the performance of the recommended glomerular filtration rate (GFR)-estimating equations in the type 2 diabetic population is inferior to that in the non-diabetic populati...

    Authors: Jinxia Chen, Hua Tang, Hui Huang, Linsheng Lv, Yanni Wang, Xun Liu and Tanqi Lou
    Citation: Journal of Translational Medicine 2015 13:317
  25. Methionine sulfoxide reductase A (MsrA) is a potent intracellular oxidoreductase and serves as an essential factor that protects cells against oxidative damage. However, therapeutic use of exogenous MsrA in ox...

    Authors: Yao Wu, Guanghui Xie, Yanyong Xu, Li Ma, Chuanfeng Tong, Daping Fan, Fen Du and Hong Yu
    Citation: Journal of Translational Medicine 2015 13:316
  26. Emerging evidence indicates that mesenchymal stromal cells (MSCs) isolated from different tissue sources may be used in vivo as tissue restorative agents. To date, there is no evidence, however, on migration a...

    Authors: Hatixhe Latifi-Pupovci, Zyrafete Kuçi, Sibylle Wehner, Halvard Bönig, Ralf Lieberz, Thomas Klingebiel, Peter Bader and Selim Kuçi
    Citation: Journal of Translational Medicine 2015 13:315
  27. Circulating microRNAs may represent novel markers for cardiovascular diseases. We evaluated whether circulating miRNAs served as potential biomarkers for diffuse myocardial fibrosis in patients with hypertroph...

    Authors: Lu Fang, Andris H. Ellims, Xiao-lei Moore, David A. White, Andrew J. Taylor, Jaye Chin-Dusting and Anthony M. Dart
    Citation: Journal of Translational Medicine 2015 13:314
  28. The ability to identify key biomolecules and molecular changes associated with cancer malignancy and the capacity to monitor the therapeutic outcome against these targets is critically important for cancer tre...

    Authors: Mohammad Haris, Santosh K. Yadav, Arshi Rizwan, Anup Singh, Ena Wang, Hari Hariharan, Ravinder Reddy and Francesco M. Marincola
    Citation: Journal of Translational Medicine 2015 13:313
  29. From a pharmacological perspective, readily-available, well-characterized animal models of cardiovascular disease, including relevant in vivo markers of atherosclerosis are important for evaluation of novel dr...

    Authors: Trine Pagh Ludvigsen, Rikke Kaae Kirk, Berit Østergaard Christoffersen, Henrik Duelund Pedersen, Torben Martinussen, Jonas Kildegaard, Peter M. H. Heegaard, Jens Lykkesfeldt and Lisbeth Høier Olsen
    Citation: Journal of Translational Medicine 2015 13:312
  30. Energy loss (EL) was regarded to be one of the key parameters in predicting the rupture risk of IA. In this paper, we took varied aspect ratio (AR) as a scaling law to create a series of longitudinal models to...

    Authors: Yunling Long, Jingru Zhong, Hongyu Yu, Huagang Yan, Zhizheng Zhuo, Qianqian Meng, Xinjian Yang and Haiyun Li
    Citation: Journal of Translational Medicine 2015 13:311
  31. Hepatitis B (HB) is an infectious disease with unfavorable consequence for patients and involved in chronic inflammation of liver. The present study aimed to investigate whether High-mobility group protein B (...

    Authors: JooYeon Jhun, SeungHoon Lee, HeeYeon Kim, Yang-Mi Her, Jae Kyeong Byun, Eun-Kyung Kim, Soon Kyu Lee, Mi-La Cho and Jong Young Choi
    Citation: Journal of Translational Medicine 2015 13:310
  32. A real-time objective evaluation for the extent of liver steatosis during liver transplantation is currently not available. Diffuse reflectance spectroscopy (DRS) rapidly and accurately assesses the extent of...

    Authors: Andrie C. Westerkamp, Vishnu V. Pully, Golnar Karimian, Fernanda Bomfati, Zwanida J. Veldhuis, Janneke Wiersema-Buist, Benno H. W. Hendriks, Ton Lisman and Robert J. Porte
    Citation: Journal of Translational Medicine 2015 13:309
  33. Within the last few years, it has become evident that LPS-preconditioned mesenchymal stromal cells (LPS pre-MSCs) show enhanced paracrine effects, including increased trophic support and improved regenerative ...

    Authors: Dongdong Ti, Haojie Hao, Chuan Tong, Jiejie Liu, Liang Dong, Jingxi Zheng, Yali Zhao, Huiling Liu, Xiaobing Fu and Weidong Han
    Citation: Journal of Translational Medicine 2015 13:308
  34. Angiogenesis is a hallmark feature in the initiation, progression and growth of tumour. There are various factors for promotion of angiogenesis on one hand and on the other hand, biomolecules have been report...

    Authors: Rashmi K. Ambasta, Saurabh Kumar Jha, Dhiraj Kumar, Renu Sharma, Niraj Kumar Jha and Pravir Kumar
    Citation: Journal of Translational Medicine 2015 13:307
  35. Constitutive MET signaling promotes invasiveness in most primary and recurrent GBM. However, deployment of available MET-targeting agents is confounded by lack of effective biomarkers for selecting suitable pa...

    Authors: Jennifer Johnson, Maria Libera Ascierto, Sandeep Mittal, David Newsome, Liang Kang, Michael Briggs, Kirk Tanner, Francesco M. Marincola, Michael E. Berens, George F. Vande Woude and Qian Xie
    Citation: Journal of Translational Medicine 2015 13:306
  36. The association between malnutrition and worse outcomes as pressure ulcers and mortality is well established in a variety of setting. Currently none investigation was conducted in patients with long-term conse...

    Authors: Tiziana Montalcini, Marta Moraca, Yvelise Ferro, Stefano Romeo, Sebastiano Serra, Maria Girolama Raso, Francesco Rossi, Walter G. Sannita, Giuliano Dolce and Arturo Pujia
    Citation: Journal of Translational Medicine 2015 13:305
  37. The gastric cancer is one of the most common and mortal cancer worldwide. The initial asymptomatic development and further nonspecific symptoms result in diagnosis at the advanced stage with poor prognosis. Ye...

    Authors: Agata Abramowicz, Anna Wojakowska, Agnieszka Gdowicz-Klosok, Joanna Polanska, Pawel Rodziewicz, Pawel Polanowski, Agnieszka Namysl-Kaletka, Monika Pietrowska, Jerzy Wydmanski and Piotr Widlak
    Citation: Journal of Translational Medicine 2015 13:304
  38. Western dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association be...

    Authors: Luigi Barrea, Paolo Emidio Macchia, Giovanni Tarantino, Carolina Di Somma, Elena Pane, Nicola Balato, Maddalena Napolitano, Annamaria Colao and Silvia Savastano
    Citation: Journal of Translational Medicine 2015 13:303
  39. Malignant pleural effusion resulting mainly from pleural metastases of lung adenocarcinoma has clinical relevance, being a sign of poor prognosis and low life expectancy. Experimental models can mimic the hum...

    Authors: Milena Marques Pagliarelli Acencio, Juliana Puka, Evaldo Marchi, Leila Antonangelo, Ricardo Mingarini Terra, Francisco Suso Vargas, Vera Luiza Capelozzi and Lisete Ribeiro Teixeira
    Citation: Journal of Translational Medicine 2015 13:302
  40. Authors: Imran Khan, Mohammad Khalid Zakaria, Mukesh Kumar, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar and Subrata Sinha
    Citation: Journal of Translational Medicine 2015 13:300

    The original article was published in Journal of Translational Medicine 2015 13:254

  41. Research has identified immunological abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), a heterogeneous illness with an unknown cause and absence of diagnostic test. There have been...

    Authors: Sharni Lee Hardcastle, Ekua Weba Brenu, Samantha Johnston, Thao Nguyen, Teilah Huth, Sandra Ramos, Donald Staines and Sonya Marshall-Gradisnik
    Citation: Journal of Translational Medicine 2015 13:299
  42. The strategy of using fecal microbiota transplantation (FMT) for refractory ulcerative colitis (UC) remains unclear if single FMT failed to induce remission. This study aimed to evaluate the efficacy and safet...

    Authors: Bota Cui, Pan Li, Lijuan Xu, Youquan Zhao, Huiquan Wang, Zhaoyuan Peng, Hai’e Xu, Jie Xiang, Zhi He, Ting Zhang, Yongzhan Nie, Kaichun Wu, Daiming Fan, Guozhong Ji and Faming Zhang
    Citation: Journal of Translational Medicine 2015 13:298
  43. Heart failure (HF) is characterized by a series of adaptive changes in energy metabolism. The use of metabolomics enables the parallel assessment of a wide range of metabolites. In this study, we appraised whe...

    Authors: Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Emanuela Locci, Luigi Barberini, Federica Torri, Federica Ascedu, Luigi Atzori and Giuseppe Mercuro
    Citation: Journal of Translational Medicine 2015 13:297
  44. Peripheral nerve injury and bone lesions, well known leprosy complications, lead to deformities and incapacities. The phosphate-regulating gene with homologies to endopeptidase on the X chromosome (PHEX) encodes ...

    Authors: Sandra R. Boiça Silva, Ximena Illarramendi, Antonio J. Tempone, Pedro H. L. Silva, José A. C. Nery, Alexandra M. V. Monteiro, Maria Cristina V. Pessolani, Edson Boasquevisque, Euzenir N. Sarno, Geraldo M. B. Pereira and Danuza Esquenazi
    Citation: Journal of Translational Medicine 2015 13:296
  45. Deep invasion of the normal surrounding tissue by primary cervical cancers is a prognostic parameter for postoperative radiotherapy and relatively worse survival. However, patients with tumor-specific immunity...

    Authors: Arko Gorter, Frans Prins, Merel van Diepen, Simone Punt and Sjoerd H. van der Burg
    Citation: Journal of Translational Medicine 2015 13:295
  46. Progressive bone marrow fibrosis (BMF) is a cardinal feature of many myeloproliferative neoplasms (MPNs) and there is a documented association between the severity of BMF and overall prognosis. We conducted an...

    Authors: Catriona Jamieson, Robert Hasserjian, Jason Gotlib, Jorge Cortes, Richard Stone, Moshe Talpaz, Jürgen Thiele, Scott Rodig and Olga Pozdnyakova
    Citation: Journal of Translational Medicine 2015 13:294
  47. Interferons (IFNs) have potent anti-proliferative, pro-apoptotic, and immunomodulatory activities against cancer. However, the clinical utility of IFNs is limited by toxicity and pharmacokinetics making it dif...

    Authors: Junjie Chen, Jialu Zhao, Lefu Chen, Nian Dong, Zhaojian Ying, Zhenzhen Cai, Dongxiang Ji, Yong Zhang, Li Dong, Yuping Li, Lei Jiang, Michael J. Holtzman and Chengshui Chen
    Citation: Journal of Translational Medicine 2015 13:293
  48. Liver fibrosis is a public health problem worldwide. There is a need of noninvasive imaging based methods for better diagnosis of this disease. In the current study, we aim to evaluate the potential of T1ρ MRI...

    Authors: Anup Singh, Damodar Reddy, Mohammad Haris, Kejia Cai, K. Rajender Reddy, Hari Hariharan and Ravinder Reddy
    Citation: Journal of Translational Medicine 2015 13:292

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