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  1. Ovarian cancer represents the fifth leading cause of death from all cancers for women. During the last decades overall survival has improved due to the use of new chemotherapy schedules. Still, the majority of...

    Authors: HW Nijman, A Lambeck, SH van der Burg, AGJ van der Zee and T Daemen

    Citation: Journal of Translational Medicine 2005 3:34

    Content type: Review

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  2. New developments in science are rapidly influencing and shaping basic and clinical research and medicine. This has led to the emergence of multiple opportunities and challenges on many levels in the bio-medica...

    Authors: Kai-Christian Sonntag

    Citation: Journal of Translational Medicine 2005 3:33

    Content type: Commentary

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  3. Our goal was to identify gene signatures predictive of response to preoperative systemic chemotherapy (PST) with epirubicin/cyclophosphamide (EC) in patients with primary breast cancer.

    Authors: Olga Modlich, Hans-Bernd Prisack, Marc Munnes, Werner Audretsch and Hans Bojar

    Citation: Journal of Translational Medicine 2005 3:32

    Content type: Research

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  4. Over the past three decades, there have been remarkable advances in the treatment of bone and soft tissue sarcomas. These include the introduction of adjuvant chemotherapy, establishment of guidelines for adeq...

    Authors: Satoshi Kawaguchi, Takuro Wada, Tomohide Tsukahara, Kazunori Ida, Toshihiko Torigoe, Noriyuki Sato and Toshihiko Yamashita

    Citation: Journal of Translational Medicine 2005 3:31

    Content type: Review

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  5. Previous studies have shown that in platelets of mild Alzheimer Disease (AD) patients there are alterations of specific APP forms, paralleled by alteration in expression level of both ADAM 10 and BACE when com...

    Authors: Monica Di Luca, Enzo Grossi, Barbara Borroni, Martina Zimmermann, Elena Marcello, Francesca Colciaghi, Fabrizio Gardoni, Marco Intraligi, Alessandro Padovani and Massimo Buscema

    Citation: Journal of Translational Medicine 2005 3:30

    Content type: Research

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  6. We present a generic dendritic cell (DC) vaccine strategy for patients with renal cell carcinoma (RCC) based on the use of RNA as a source of multiplex tumor-associated antigens (TAAs). Instead of preparing RN...

    Authors: Christiane Geiger, Sybille Regn, Andreas Weinzierl, Elfriede Noessner and Dolores J Schendel

    Citation: Journal of Translational Medicine 2005 3:29

    Content type: Research

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  7. The study of clinical samples is often limited by the amount of material available to study. While proteins cannot be multiplied in their natural form, DNA and RNA can be amplified from small specimens and use...

    Authors: Ena Wang

    Citation: Journal of Translational Medicine 2005 3:28

    Content type: Review

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  8. The purpose of the present investigation was to determine if the salivary counts of 40 common oral bacteria in subjects with an oral squamous cell carcinoma (OSCC) lesion would differ from those found in cance...

    Authors: DL Mager, AD Haffajee, PM Devlin, CM Norris, MR Posner and JM Goodson

    Citation: Journal of Translational Medicine 2005 3:27

    Content type: Research

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  9. Nasopharyngeal carcinoma (NPC) is a tumor derived from epithelial cells and Epstein-Barr virus infection has been reported to be a cause of this disease. Chemokine receptor CXCR4 was found to be involved in HI...

    Authors: Na Wang, Qiu-Liang Wu, Yan Fang, Hai-Qiang Mai, Mu-Sheng Zeng, Guo-Ping Shen, Jing-Hui Hou and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2005 3:26

    Content type: Research

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  10. Epithelial ovarian cancer (EOC) represents the most frequent cause of death in the United States from a cancer involving the female genital tract. Contributing to the overall poor outcome in EOC patients, are ...

    Authors: Xipeng Wang, Ena Wang, John J Kavanagh and Ralph S Freedman

    Citation: Journal of Translational Medicine 2005 3:25

    Content type: Review

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  11. Interferon (IFN)-α is considered a key modulator of immunopathological processes through a signature-specific activation of mononuclear phagocytes (MPs). This study utilized global transcript analysis to chara...

    Authors: David F Stroncek, Christopher Basil, Dirk Nagorsen, Sara Deola, Eleonora Aricó, Kina Smith, Ena Wang, Francesco M Marincola and Monica C Panelli

    Citation: Journal of Translational Medicine 2005 3:24

    Content type: Research

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  12. The continuous efforts aimed at the identification of new immune epitopes across the MHC system has led to the discovery that more than one peptide may be restricted to the same HLA antigen and function as an ...

    Authors: Monica Ghei, David F Stroncek and Maurizio Provenzano

    Citation: Journal of Translational Medicine 2005 3:23

    Content type: Research

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  13. Apo2L/TRAIL has considerable promise for cancer therapy based on the fact that this member of the tumor necrosis factor family induces apoptosis in the majority of malignant cells, while normal cells are more ...

    Authors: Bonnie L Hylander, Rose Pitoniak, Remedios B Penetrante, John F Gibbs, Dilek Oktay, Jinrong Cheng and Elizabeth A Repasky

    Citation: Journal of Translational Medicine 2005 3:22

    Content type: Research

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  14. Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblast...

    Authors: Andreina Baj, Alessia A Bettaccini, Rosario Casalone, Andrea Sala, Paolo Cherubino and Antonio Q Toniolo

    Citation: Journal of Translational Medicine 2005 3:21

    Content type: Research

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  15. The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell responses agai...

    Authors: Florian K Bihl, Elisabetta Loggi, John V Chisholm III, Hannah S Hewitt, Leah M Henry, Caitlyn Linde, Todd J Suscovich, Johnson T Wong, Nicole Frahm, Pietro Andreone and Christian Brander

    Citation: Journal of Translational Medicine 2005 3:20

    Content type: Methodology

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  16. Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2) and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, an...

    Authors: Craig L Slingluff Jr and Daniel E Speiser

    Citation: Journal of Translational Medicine 2005 3:18

    Content type: Commentary

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  17. In vitro stimulation of CD34+ cells with IL-2 induces NK cell differentiation. In order to define the stages of NK cell development, which influence their generation from CD34 cells, we cultured G-CSF mobilize...

    Authors: Giuseppe Sconocchia, Maurizio Provenzano, Katayoun Rezvani, Jongming Li, Jos Melenhorst, Nancy Hensel and A John Barrett

    Citation: Journal of Translational Medicine 2005 3:15

    Content type: Research

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  18. Although several genes and proteins have been implicated in the development of melanomas, the molecular mechanisms involved in the development of these tumors are not well understood. To gain a better understa...

    Authors: Suraiya Rasheed, Zisu Mao, Jane MC Chan and Linda S Chan

    Citation: Journal of Translational Medicine 2005 3:14

    Content type: Research

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  19. The aim of this study was to determine the basis for anti-tumor immune reactivity observed in patients with human epidermal growth factor receptor-2 (HER-2) (3+) breast carcinoma using an in vitro model in which ...

    Authors: Zorica D Juranic, Zora Neskovic-Konstantinovic, Tatjana P Stanojkovic, Zeljko Zizak, Tatjana Srdic, Nevenka Stanojevic-Bakic, Dusanka Milosevic and Danica Jovanovic

    Citation: Journal of Translational Medicine 2005 3:13

    Content type: Research

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  20. Sixty cancer cell lines have been extensively characterized and used by the National Cancer Institute's Developmental Therapeutics Program (NCI-60) since the early 90's as screening tools for anti-cancer drug ...

    Authors: Sharon Adams, Fu-Meei Robbins, Deborah Chen, Devika Wagage, Susan L Holbeck, Herbert C Morse III, David Stroncek and Francesco M Marincola

    Citation: Journal of Translational Medicine 2005 3:11

    Content type: Research

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  21. DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor rejection. Here we report the feasability and safety of the first Ph...

    Authors: Bernard Escudier, Thierry Dorval, Nathalie Chaput, Fabrice André, Marie-Pierre Caby, Sophie Novault, Caroline Flament, Christophe Leboulaire, Christophe Borg, Sebastian Amigorena, Catherine Boccaccio, Christian Bonnerot, Olivier Dhellin, Mojgan Movassagh, Sophie Piperno, Caroline Robert…

    Citation: Journal of Translational Medicine 2005 3:10

    Content type: Protocol

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  22. There is a continued need to develop more effective cancer immunotherapy strategies. Exosomes, cell-derived lipid vesicles that express high levels of a narrow spectrum of cell proteins represent a novel platf...

    Authors: Michael A Morse, Jennifer Garst, Takuya Osada, Shubi Khan, Amy Hobeika, Timothy M Clay, Nancy Valente, Revati Shreeniwas, Mary Ann Sutton, Alain Delcayre, Di-Hwei Hsu, Jean-Bernard Le Pecq and H Kim Lyerly

    Citation: Journal of Translational Medicine 2005 3:9

    Content type: Research

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  23. Nitric oxide-releasing nonsteroidal antiinflammatory drugs (NO-NSAIDs) are reported to be safer than NSAIDs because of their lower gastric toxicity. We compared the effect of a novel NO-releasing derivate, NCX...

    Authors: Anna Tesei, Paola Ulivi, Francesco Fabbri, Marco Rosetti, Carlo Leonetti, Marco Scarsella, Gabriella Zupi, Dino Amadori, Manlio Bolla and Wainer Zoli

    Citation: Journal of Translational Medicine 2005 3:7

    Content type: Research

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  24. Serologic tests for HIV infection in infants less than 18 months do not differentiate exposure and infection since maternally acquired IgG antibodies may be detected in infants. Thus, the gold standard for dia...

    Authors: Lynn S Zijenah, David A Katzenstein, Kusum J Nathoo, Simbarashe Rusakaniko, Ocean Tobaiwa, Christine Gwanzura, Arsene Bikoue, Margaret Nhembe, Petronella Matibe and George Janossy

    Citation: Journal of Translational Medicine 2005 3:6

    Content type: Research

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  25. CD4+CD25+ regulatory T lymphocytes (TR) constitute 5–10% of peripheral CD4+ T cells in naive mice and humans, and play an important role in controlling immune responses. Accumulating evidences show that TR cells ...

    Authors: Ji-Yan Liu, Xiao-Shi Zhang, Ya Ding, Rui-Qing Peng, Xia Cheng, Nian-Hua Zhang, Jian-Chuan Xia and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2005 3:5

    Content type: Research

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  26. Metastatic, chemotherapy-resistant melanoma is an intractable cancer with a very poor prognosis. As to immunotherapy targeting metastatic melanoma, HLA-A2+ patients were mainly enrolled in the study in Western co...

    Authors: Yasuto Akiyama, Ryuji Tanosaki, Naoki Inoue, Makiko Shimada, Yukie Hotate, Akifumi Yamamoto, Naoya Yamazaki, Ichiro Kawashima, Ikuei Nukaya, Kazutoh Takesako, Kouji Maruyama, Yoichi Takaue and Ken Yamaguchi

    Citation: Journal of Translational Medicine 2005 3:4

    Content type: Research

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  27. Spontaneous T cell responses against specific tumor-associated antigens (TAA) are frequently detected in peripheral blood of tumor patients of various histiotypes. However, little is known about whether these ...

    Authors: Dirk Nagorsen, Carmen Scheibenbogen, Anne Letsch, Christoph-Thomas Germer, Heinz-Johannes Buhr, Susanna Hegewisch-Becker, Licia Rivoltini, Eckhard Thiel and Ulrich Keilholz

    Citation: Journal of Translational Medicine 2005 3:3

    Content type: Research

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  28. Synovial sarcoma is a high-grade malignant tumor of soft tissue, characterized by the specific chromosomal translocation t(X;18), and its resultant SYT-SSX fusion gene. Despite intensive multimodality therapy,...

    Authors: Satoshi Kawaguchi, Takuro Wada, Kazunori Ida, Yuriko Sato, Satoshi Nagoya, Tomohide Tsukahara, Sigeharu Kimura, Hiroeki Sahara, Hideyuki Ikeda, Kumiko Shimozawa, Hiroko Asanuma, Toshihiko Torigoe, Hiroaki Hiraga, Takeshi Ishii, Shin-ichiro Tatezaki, Noriyuki Sato…

    Citation: Journal of Translational Medicine 2005 3:1

    Content type: Research

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  29. Forty to eighty percent of melanoma tumors have activating mutations in BRAF although the clinical importance of these mutations is not clear. We previously reported an analysis of BRAF mutations in metastatic me...

    Authors: David Z Chang, Katherine S Panageas, Iman Osman, David Polsky, Klaus Busam and Paul B Chapman

    Citation: Journal of Translational Medicine 2004 2:46

    Content type: Research

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  30. Immunosuppression is documented in several malignant diseases, including breast cancer. Subsequently, future therapeutic concepts might include immunological approaches. However, detailed knowledge about tumor...

    Authors: Jana M Schüle, Leif Bergkvist, Leif Håkansson, Bertil Gustafsson and Annika Håkansson

    Citation: Journal of Translational Medicine 2004 2:45

    Content type: Research

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  31. Walking along disease-associated protein sequences in the search for specific segments able to induce cellular immune response may direct clinical research towards effective peptide-based vaccines. To this aim...

    Authors: Alberta Lucchese, Abraham Mittelman, Mong-Shang Lin, Darja Kanduc and Animesh A Sinha

    Citation: Journal of Translational Medicine 2004 2:43

    Content type: Research

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  32. Tumors and viruses have developed many mechanisms to evade the immune system, including down-regulation of target antigens and MHC molecules. These immune escape mechanisms may be able to be circumvented by ad...

    Authors: Alexander Langerman, Glenda G Callender and Michael I Nishimura

    Citation: Journal of Translational Medicine 2004 2:42

    Content type: Research

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  33. T cell-mediated cancer immunotherapy is dose dependent and optimally requires participation of antigen-specific CD4+ and CD8+ T cells. Here, we isolated tumor-sensitized T cells and activated them in vitro using ...

    Authors: Li-Xin Wang, Wen-Xin Huang, Hallie Graor, Peter A Cohen, Julian A Kim, Suyu Shu and Gregory E Plautz

    Citation: Journal of Translational Medicine 2004 2:41

    Content type: Research

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  34. A novel tyrosine kinase receptor EphA2 is expressed at high levels in advanced and metastatic cancers. We examined whether vaccinations with synthetic mouse EphA2 (mEphA2)-derived peptides that serve as T cell...

    Authors: Manabu Hatano, Naruo Kuwashima, Tomohide Tatsumi, Jill E Dusak, Fumihiko Nishimura, Karlyne M Reilly, Walter J Storkus and Hideho Okada

    Citation: Journal of Translational Medicine 2004 2:40

    Content type: Research

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  35. Over the past decade RNA interference (RNAi) has emerged as a natural mechanism for silencing gene expression. This ancient cellular antiviral response can be exploited to allow specific inhibition of the func...

    Authors: Simone Mocellin and Maurizio Provenzano

    Citation: Journal of Translational Medicine 2004 2:39

    Content type: Review

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  36. D-dimer is considered a marker of hypercoagulable state and of endogenous fibrinolysis, so increased d-dimer is detectable in patients affected by thrombosis. Yet, several studies showed that also infertility,...

    Authors: Pierpaolo Di Micco, Maristella D'Uva, Ida Strina, Antonio Mollo, Valeria Amato, Alferio Niglio and Giuseppe De Placido

    Citation: Journal of Translational Medicine 2004 2:38

    Content type: Research

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  37. During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well wit...

    Authors: Nigel J Waterhouse, Karin A Sedelies and Chris JP Clarke

    Citation: Journal of Translational Medicine 2004 2:36

    Content type: Commentary

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  38. Human metastatic cutaneous melanoma has gained a well deserved reputation for its immune responsiveness. The reason(s) remain(s) unknown. We attempted previously to characterize several variables that may affe...

    Authors: Ena Wang, Monica C Panelli, Katia Zavaglia, Susanna Mandruzzato, Nan Hu, Phil R Taylor, Barbara Seliger, Paola Zanovello, Ralph S Freedman and Francesco M Marincola

    Citation: Journal of Translational Medicine 2004 2:34

    Content type: Research

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  39. Past studies suggested that tumor necrosis factor (TNF) assisted anti-tumor treatment and intensified the sensitivity of chemotherapy. However its clinical application has been curbed because of its low purity...

    Authors: Xing Liu, Xiang-fu Zhang, Zhi-weng Zheng, Huishan Lu, Xinyuan Wu, Changmin Huang, Chuan Wang and Guoxiang Guang

    Citation: Journal of Translational Medicine 2004 2:33

    Content type: Research

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  40. Recently BRCA1 has been implicated in the regulation of gene expression from the X chromosome. In this study the influence of BRCA1 on expression of X chromosome genes was investigated. Complementary DNA micro...

    Authors: Amir A Jazaeri, Gadisetti VR Chandramouli, Olga Aprelikova, Ulrike A Nuber, Christos Sotiriou, Edison T Liu, H Hilger Ropers, Cindy J Yee, Jeff Boyd and J Carl Barrett

    Citation: Journal of Translational Medicine 2004 2:32

    Content type: Research

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  41. This study assessed the Granzyme B (GrB) ELISPOT as a viable alternative to the 51Cr-release assay for measuring cytotoxic activity of innate immune effector cells. We strategically selected the GrB ELISPOT assay...

    Authors: Kimberly A Shafer-Weaver, Thomas Sayers, Douglas B Kuhns, Susan L Strobl, Mark W Burkett, Michael Baseler and Anatoli Malyguine

    Citation: Journal of Translational Medicine 2004 2:31

    Content type: Methodology

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