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  1. Understanding the underlying mechanism of thrombus formation and its components is critical for effective prevention and treatment of ischemic stroke. The generation of thrombotic clots requires conversion of ...

    Authors: Slaven Pikija, Vladimir Trkulja, Johannes Sebastian Mutzenbach, Mark R. McCoy, Patricia Ganger and Johann Sellner
    Citation: Journal of Translational Medicine 2016 14:250
  2. Epigenetic silencing mediated by CpG island methylation is a common feature of many cancers. Characterizing aberrant DNA methylation changes associated with prostate carcinogenesis could potentially identify a...

    Authors: Giorgia Gurioli, Samanta Salvi, Filippo Martignano, Flavia Foca, Roberta Gunelli, Matteo Costantini, Giacomo Cicchetti, Ugo De Giorgi, Persio Dello Sbarba, Daniele Calistri and Valentina Casadio
    Citation: Journal of Translational Medicine 2016 14:249
  3. Myocardial fibrosis (MF) is a deleterious consequence of aortic valve stenosis (AVS). Global longitudinal strain (GLS) is a novel left ventricular (LV) functional parameter potentially useful to non-invasively...

    Authors: Iacopo Fabiani, Cristian Scatena, Chiara Maria Mazzanti, Lorenzo Conte, Nicola Riccardo Pugliese, Sara Franceschi, Francesca Lessi, Michele Menicagli, Andrea De Martino, Stefano Pratali, Uberto Bortolotti, Antonio Giuseppe Naccarato, Salvatore La Carrubba and Vitantonio Di Bello
    Citation: Journal of Translational Medicine 2016 14:248
  4. The administration of supplemental oxygen to treat ventilatory insufficiency may lead to the formation of reactive oxygen species and subsequent tissue damage. Cytochrome P4501A1 (CYP1A1) can modulate hyperoxi...

    Authors: Jute Richter, Julio Jimenez, Taro Nagatomo, Jaan Toelen, Paul Brady, Thomas Salaets, Flore Lesage, Jeroen Vanoirbeek and Jan Deprest
    Citation: Journal of Translational Medicine 2016 14:247
  5. Mesenchymal stromal cells are a promising option to treat knee osteoarthritis. Their safety and usefulness must be confirmed and the optimal dose established. We tested increasing doses of bone marrow mesenchy...

    Authors: José M. Lamo-Espinosa, Gonzalo Mora, Juan F. Blanco, Froilán Granero-Moltó, Jorge M. Nuñez-Córdoba, Carmen Sánchez-Echenique, José M. Bondía, Jesús Dámaso Aquerreta, Enrique J. Andreu, Enrique Ornilla, Eva M. Villarón, Andrés Valentí-Azcárate, Fermín Sánchez-Guijo, María Consuelo del Cañizo, Juan Ramón Valentí-Nin and Felipe Prósper
    Citation: Journal of Translational Medicine 2016 14:246
  6. Authors: Felix Poppelaars, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen and Marc A. J. Seelen
    Citation: Journal of Translational Medicine 2016 14:245

    The original article was published in Journal of Translational Medicine 2016 14:236

  7. Muscle wasting negatively impacts the progress of chronic diseases such as lung cancer (LC) and emphysema, which are in turn interrelated.

    Authors: Anna Salazar-Degracia, David Blanco, Mònica Vilà-Ubach, Gabriel de Biurrun, Carlos Ortiz de Solórzano, Luis M. Montuenga and Esther Barreiro
    Citation: Journal of Translational Medicine 2016 14:244
  8. Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary ar...

    Authors: Inmaculada Moreno-Santos, Luis Miguel Pérez-Belmonte, Manuel Macías-González, María José Mataró, Daniel Castellano, Miguel López-Garrido, Carlos Porras-Martín, Pedro L. Sánchez-Fernández, Juan José Gómez-Doblas, Fernando Cardona, Eduardo de Teresa-Galván and Manuel Jiménez-Navarro
    Citation: Journal of Translational Medicine 2016 14:243
  9. The Wellcome Trust, the World Health Organization, and cardiologists have advocated for the idea of a “polypill” containing multiple cardiovascular drugs to be co-formulated into a single pill for over a decad...

    Authors: Reed F. Beall, Jon-David R. Schwalm, Mark D. Huffman, Tara McCready, Salim Yusuf and Amir Attaran
    Citation: Journal of Translational Medicine 2016 14:242
  10. Tumour resistance to a wide range of drugs (multiple drug resistant, MDR) acquired after intensive chemotherapy is considered to be the main obstacle of the curative treatment of cancer patients. Recent work h...

    Authors: Elena P. Goncharova, Julia S. Ruzhenkova, Ivan S. Petrov, Sergey N. Shchelkunov and Marina A. Zenkova
    Citation: Journal of Translational Medicine 2016 14:241

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:280

  11. Severe early childhood caries (s-ECC), which has quite high prevalence among children, is a widespread problem with significant impacts among both developing and developed countries. At present, it is widely k...

    Authors: Xiangyu Sun, Xin Huang, Xu Tan, Yan Si, Xiaozhe Wang, Feng Chen and Shuguo Zheng
    Citation: Journal of Translational Medicine 2016 14:240
  12. NK cell cytotoxicity is regulated by the types of the interaction between killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands on target cells and the different binding...

    Authors: Angelica Canossi, Anna Aureli, Tiziana Del Beato, Piero Rossi, Luana Franceschilli, Flavio De Sanctis, Pierpaolo Sileri, Nicola di Lorenzo, Oreste Buonomo, Davide Lauro, Adriano Venditti and Giuseppe Sconocchia
    Citation: Journal of Translational Medicine 2016 14:239
  13. To study the safety, feasibility and skin effects of irreversible electroporation (IRE) for breast tissue and breast cancer in animal models.

    Authors: Sheng Li, Fei Chen, Lujun Shen, Qi Zeng and Peihong Wu
    Citation: Journal of Translational Medicine 2016 14:238
  14. Hyperlipidemia is a major component of metabolic syndrome, and often predicts cardiovascular diseases. We developed a new therapeutic agent berberine compounds (BC), consisting of berberine, oryzanol and vitam...

    Authors: Meng Li, Xiangbing Shu, Hanchen Xu, Chunlei Zhang, Lili Yang, Li Zhang and Guang Ji
    Citation: Journal of Translational Medicine 2016 14:237
  15. Hemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an important role in the development of cardiovascular d...

    Authors: Felix Poppelaars, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen and Marc A. J. Seelen
    Citation: Journal of Translational Medicine 2016 14:236

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:245

  16. Translational research is a key area of focus of the National Institutes of Health (NIH), as demonstrated by the substantial investment in the Clinical and Translational Science Award (CTSA) program. The goal ...

    Authors: Alisa Surkis, Janice A. Hogle, Deborah DiazGranados, Joe D. Hunt, Paul E. Mazmanian, Emily Connors, Kate Westaby, Elizabeth C. Whipple, Trisha Adamus, Meridith Mueller and Yindalon Aphinyanaphongs
    Citation: Journal of Translational Medicine 2016 14:235
  17. Diabetes is the western world’s leading cause of end-stage renal disease. Glucose-dependent, oxidative stress is linked to the development of renal inflammation and sclerosis, which, in animal models of diabet...

    Authors: Kenneth A. Earle, Karima Zitouni, John Pepe, Maria Karaflou and James Godbold Jr
    Citation: Journal of Translational Medicine 2016 14:234
  18. Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host’s health and disease. Gut microbiota in fact plays a crucial role in modulating innate an...

    Authors: Andrea Picchianti Diamanti, M. Manuela Rosado, Bruno Laganà and Raffaele D’Amelio
    Citation: Journal of Translational Medicine 2016 14:233
  19. Ipilimumab (Ipi) improves the survival of advanced melanoma patients with an incremental long-term benefit in 10–15 % of patients. A tumor signature that correlates with this survival benefit could help optimi...

    Authors: Teofila Seremet, Alexander Koch, Yanina Jansen, Max Schreuer, Sofie Wilgenhof, Véronique Del Marmol, Danielle Liènard, Kris Thielemans, Kelly Schats, Mark Kockx, Wim Van Criekinge, Pierre G. Coulie, Tim De Meyer, Nicolas van Baren and Bart Neyns
    Citation: Journal of Translational Medicine 2016 14:232
  20. Traditional research in the health sciences has involved control and experimental groups of patients, and descriptive and inferential statistical analyses performed on the measurements obtained from the sample...

    Authors: Garabed G. Demerjian, Andre Barkhordarian and Francesco Chiappelli
    Citation: Journal of Translational Medicine 2016 14:231
  21. Epstein-Barr virus and Cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (SCT).

    Authors: Julia Drylewicz, Ingrid M. M. Schellens, Rogier Gaiser, Nening M. Nanlohy, Esther D. Quakkelaar, Henny Otten, Suzanne van Dorp, Ronald Jacobi, Leonie Ran, Sanne Spijkers, Dan Koning, Rob Schuurman, Ellen Meijer, Floortje L. Pietersma, Jurgen Kuball and Debbie van Baarle
    Citation: Journal of Translational Medicine 2016 14:230
  22. Potentiation of glucose-induced insulin secretion is the main mechanism of exenatide (EXE) antidiabetic action, however, increased glucose utilization by peripheral tissues has been also reported. We here stud...

    Authors: Francesco Andreozzi, Gregory Alexander Raciti, Cecilia Nigro, Gaia Chiara Mannino, Teresa Procopio, Alberto M. Davalli, Francesco Beguinot, Giorgio Sesti, Claudia Miele and Franco Folli
    Citation: Journal of Translational Medicine 2016 14:229
  23. Intra-operative cell salvage (CS) was reported to have no impairment on blood coagulation in low-bleeding-risk cardiac surgery with cardiopulmonary bypass (CPB), but studies in high-bleeding-risk cardiac surge...

    Authors: Sheliang Shen, Jun Zhang, Wenyuan Wang, Jiayin Zheng and Yihong Xie
    Citation: Journal of Translational Medicine 2016 14:228
  24. Molecular subtypes of breast cancer and presence of tumor-infiltrating immune cells have both been implicated as important predictive and prognostic factors for improved risk stratification and treatment indiv...

    Authors: M. Miyan, J. Schmidt-Mende, R. Kiessling, I. Poschke and J. de Boniface
    Citation: Journal of Translational Medicine 2016 14:227
  25. Experimentally, lung inflammation in laboratory animals is usually detected by the presence of inflammatory markers, such as immune cells and cytokines, in the bronchoalveolar lavage fluid (BALF) of sacrificed...

    Authors: Fabio Stellari, Gabriella Bergamini, Francesca Ruscitti, Angela Sandri, Francesca Ravanetti, Gaetano Donofrio, Federico Boschi, Gino Villetti, Claudio Sorio, Barouk M. Assael, Paola Melotti and Maria M. Lleo
    Citation: Journal of Translational Medicine 2016 14:226
  26. Acquired radioresistance during radiotherapy is considered as the most important reason for local tumor recurrence or treatment failure. Circular RNAs (circRNAs) have recently been identified as microRNA spong...

    Authors: Huafang Su, Fuqiang Lin, Xia Deng, Lanxiao Shen, Ya Fang, Zhenghua Fei, Lihao Zhao, Xuebang Zhang, Huanle Pan, Deyao Xie, Xiance Jin and Congying Xie
    Citation: Journal of Translational Medicine 2016 14:225
  27. High-risk human papillomaviruses (HR-HPVs) types 16 and 18 are the main etiological agents of cervical cancer, with more than 550,000 new cases each year worldwide. HPVs are also associated with other ano-geni...

    Authors: Elena Illiano, Olivia Costantina Demurtas, Silvia Massa, Paola Di Bonito, Valerio Consalvi, Roberta Chiaraluce, Carlo Zanotto, Carlo De Giuli Morghen, Antonia Radaelli, Aldo Venuti and Rosella Franconi
    Citation: Journal of Translational Medicine 2016 14:224
  28. Studies have indicated that bone marrow stromal cell (BMSC) administration is a promising approach for stroke treatment. For our study, we chose sodium ferulate (SF) and n-butylidenephthalide (BP) combined with B...

    Authors: Qian Zhang, Yonghua Zhao, Youhua Xu, Zhenwei Chen, Naiwei Liu, Chienchih Ke, Bowen Liu and Weikang Wu
    Citation: Journal of Translational Medicine 2016 14:223
  29. Authors: Deborah Ryan, Steven Carberry, Áine C. Murphy, Andreas U. Lindner, Joanna Fay, Suzanne Hector, Niamh McCawley, Orna Bacon, Caoimhin G. Concannon, Elaine W. Kay, Deborah A. McNamara and Jochen H. M. Prehn
    Citation: Journal of Translational Medicine 2016 14:222

    The original article was published in Journal of Translational Medicine 2016 14:196

  30. Authors: Mi-Kyung Park, Young Ok Jung, Seon-Yeong Lee, Seung Hoon Lee, Yu-Jung Heo, Eun-Kyung Kim, Hye-Jwa Oh, Young-Mee Moon, Hye-Jin Son, Min-Jung Park, Sung-Hwan Park, Ho-Youn Kim, Mi-La Cho and Jun-Ki Min
    Citation: Journal of Translational Medicine 2016 14:221

    The original article was published in Journal of Translational Medicine 2016 14:191

  31. The aim of the study was to develop and validate a new localized 1H MRS pulse sequence and automated post-processing software for the quantification of brain Glutamate (Glu) in clinical conditions at 7.0T in orde...

    Authors: Ravi Prakash Reddy Nanga, Hari Hariharan and Ravinder Reddy
    Citation: Journal of Translational Medicine 2016 14:220
  32. The dependency of miRNA abundance from physiological processes such as exercises remains partially understood. We set out to analyze the effect of physical exercises on miRNA profiles in blood and plasma of en...

    Authors: Anne Hecksteden, Petra Leidinger, Christina Backes, Stefanie Rheinheimer, Mark Pfeiffer, Alexander Ferrauti, Michael Kellmann, Farbod Sedaghat, Benjamin Meder, Eckart Meese, Tim Meyer and Andreas Keller
    Citation: Journal of Translational Medicine 2016 14:219

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:293

  33. MELANOMA BRIDGE 2015

    Authors: Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies, Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini, Stefani Spranger, Thomas F. Gajewski, Yangyang Wang, Soldano Ferrone, Claire Vanpouille-Box…
    Citation: Journal of Translational Medicine 2016 14(Suppl 1):65

    This article is part of a Supplement: Volume 14 Supplement 1

  34. Psoriasis is a chronic inflammatory disease of the skin and joints that may also have systemic inflammatory effects, including the development of cardiovascular disease (CVD). Multiple epidemiologic studies ha...

    Authors: S. Santilli, D. R. Kast, I. Grozdev, L. Cao, R. L. Feig, J. B. Golden, S. M. Debanne, R. C. Gilkeson, C. E. Orringer, T. S. McCormick, N. L. Ward, K. D. Cooper and N. J. Korman
    Citation: Journal of Translational Medicine 2016 14:217
  35. Many investigators detected the simian polyomavirus SV40 footprints in human brain tumors and neurologic diseases and recently it has been indicated that SV40 seems to be associated with multiple sclerosis (MS...

    Authors: Roberta Rizzo, Silvia Pietrobon, Elisa Mazzoni, Daria Bortolotti, Fernanda Martini, Massimiliano Castellazzi, Ilaria Casetta, Enrico Fainardi, Dario Di Luca, Enrico Granieri and Mauro Tognon
    Citation: Journal of Translational Medicine 2016 14:216
  36. Colorectal cancer is a preventable disease if caught at early stages. This disease is highly aggressive and has a higher incidence in African Americans. Several biomarkers and mutations of aggressive tumor beh...

    Authors: Hassan Ashktorab, Pia Hermann, Mehdi Nouraie, Babak Shokrani, Edward Lee, Tahmineh Haidary, Hassan Brim and Ulrike Stein
    Citation: Journal of Translational Medicine 2016 14:215
  37. Immunotherapy based on the adoptive transfer of gene modified T cells is an emerging approach for the induction of tumor-specific immune responses. Memory stem T cells, due to their enhanced antitumor and self...

    Authors: C. Alvarez-Fernández, L. Escribà-Garcia, S. Vidal, J. Sierra and J. Briones
    Citation: Journal of Translational Medicine 2016 14:214
  38. Endothelial dysfunction associated with hypercholesterolemia is an early event in atherosclerosis characterized by redox imbalance associated with high superoxide production and reduced nitric oxide (NO) and h...

    Authors: Daniele M. Guizoni, Gabriel G. Dorighello, Helena C. F. Oliveira, Maria A. Delbin, Marta H. Krieger and Ana P. Davel
    Citation: Journal of Translational Medicine 2016 14:213
  39. Adipose tissue regulates postprandial lipid metabolism by storing dietary fat through lipoprotein lipase-mediated hydrolysis of exogenous triglycerides, and by inhibiting delivery of endogenous non-esterified ...

    Authors: Bimit Mahat, Étienne Chassé, Jean-François Mauger and Pascal Imbeault
    Citation: Journal of Translational Medicine 2016 14:212

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:136

  40. Aspirin (ASA) is the most widely used medicine to prevent cardiovascular diseases; however, the mechanisms by which ASA exerts its anti-proliferative effect remain not fully understood. This study was designed...

    Authors: Xin Guo, Lijin Yu, Min Chen, Tian Wu, Xiangdong Peng, Ren Guo and Bikui Zhang
    Citation: Journal of Translational Medicine 2016 14:211
  41. Macrophages play important roles in adipose tissue inflammation and its consequences. Unfortunately, a detailed description of the macrophage phenotypes in different human adipose tissues is not available.

    Authors: Ivana Kralova Lesna, Anna Kralova, Sona Cejkova, Jiri Fronek, Marek Petras, Alena Sekerkova, Filip Thieme, Libor Janousek and Rudolf Poledne
    Citation: Journal of Translational Medicine 2016 14:208
  42. Age-associated changes in genomic DNA methylation have been primarily attributed to 5-methylcytosine (5mC). However, the recent discovery of 5-hydroxymethylcytosine (5hmC) suggests that this epigenetic mark mi...

    Authors: Estela G. Toraño, Gustavo F. Bayón, Álvaro del Real, Marta I. Sierra, María G. García, Antonella Carella, Thalia Belmonte, Rocío G. Urdinguio, Isabel Cubillo, Javier García-Castro, Jesús Delgado-Calle, Flor M. Pérez-Campo, José A. Riancho, Mario F. Fraga and Agustín F. Fernández
    Citation: Journal of Translational Medicine 2016 14:207
  43. T helper (Th) 17 cells are a subset of T helper cells that express interleukin (IL)-17 and initiate the inflammatory response in autoimmune diseases. Regulatory T cells (Tregs) are a subpopulation of T cells t...

    Authors: Min-Jung Park, Seung Hoon Lee, Sung-Hee Lee, Eun-Kyung Kim, Eun Jung Lee, Young-Mee Moon and Mi- La Cho
    Citation: Journal of Translational Medicine 2016 14:206
  44. Aseptic loosening (AL) of hip prosthesis presents inflammation and pain as sign and symptom similarly to arthritis pathologies. Still, the immune and innervation profiles in hip AL remain unclear and their int...

    Authors: Daniel M. Vasconcelos, Manuel Ribeiro-da-Silva, António Mateus, Cecília Juliana Alves, Gil Costa Machado, Joana Machado-Santos, Diogo Paramos-de-Carvalho, Inês S. Alencastre, Rui Henrique, Gilberto Costa, Mário A. Barbosa and Meriem Lamghari
    Citation: Journal of Translational Medicine 2016 14:205
  45. Individual patients show a large variability in albuminuria response to angiotensin receptor blockers (ARB). Identifying novel biomarkers that predict ARB response may help tailor therapy. We aimed to discover...

    Authors: Michelle J. Pena, Andreas Heinzel, Peter Rossing, Hans-Henrik Parving, Guido Dallmann, Kasper Rossing, Steen Andersen, Bernd Mayer and Hiddo J. L. Heerspink
    Citation: Journal of Translational Medicine 2016 14:203
  46. The human microfibrillar-associated protein 4 (MFAP4) is located to extracellular matrix fibers and plays a role in disease-related tissue remodeling. Previously, we identified MFAP4 as a serum biomarker candi...

    Authors: Thilo Bracht, Christian Mölleken, Maike Ahrens, Gereon Poschmann, Anders Schlosser, Martin Eisenacher, Kai Stühler, Helmut E. Meyer, Wolff H. Schmiegel, Uffe Holmskov, Grith L. Sorensen and Barbara Sitek
    Citation: Journal of Translational Medicine 2016 14:201

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