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  1. Interleukin-2 (IL-2) induces durable objective responses in a small cohort of patients with metastatic renal cell carcinoma (RCC) but the antigen(s) responsible for tumor rejection are not known. 5T4 is a non-...

    Authors: Howard L Kaufman, Bret Taback, William Sherman, Dae Won Kim, William H Shingler, Dorota Moroziewicz, Gail DeRaffele, Josephine Mitcham, Miles W Carroll, Richard Harrop, Stuart Naylor and Seunghee Kim-Schulze

    Citation: Journal of Translational Medicine 2009 7:2

    Content type: Research

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  2. We previously reported an HLA-A24-restricted cytotoxic T-cell epitope, Survivin-2B80-88, derived from a splice variant of survivin, survivin-2B. In this report, we show a novel HLA-A24-restricted T-cell epitop...

    Authors: Jun-ichi Kobayashi, Toshihiko Torigoe, Yoshihiko Hirohashi, Satomi Idenoue, Akihiro Miyazaki, Akira Yamaguchi, Hiroyoshi Hiratsuka and Noriyuki Sato

    Citation: Journal of Translational Medicine 2009 7:1

    Content type: Research

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  3. The International Society for the Biological Therapy of Cancer (iSBTc) has initiated in collaboration with the United States Food and Drug Administration (FDA) a programmatic look at innovative avenues for the...

    Authors: Lisa H Butterfield, Mary L Disis, Bernard A Fox, Peter P Lee, Samir N Khleif, Magdalena Thurin, Giorgio Trinchieri, Ena Wang, Jon Wigginton, Damien Chaussabel, George Coukos, Madhav Dhodapkar, Leif Håkansson, Sylvia Janetzki, Thomas O Kleen, John M Kirkwood…

    Citation: Journal of Translational Medicine 2008 6:81

    Content type: Commentary

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  4. Effective transvascular delivery of nanoparticle-based chemotherapeutics across the blood-brain tumor barrier of malignant gliomas remains a challenge. This is due to our limited understanding of nanoparticle ...

    Authors: Hemant Sarin, Ariel S Kanevsky, Haitao Wu, Kyle R Brimacombe, Steve H Fung, Alioscka A Sousa, Sungyoung Auh, Colin M Wilson, Kamal Sharma, Maria A Aronova, Richard D Leapman, Gary L Griffiths and Matthew D Hall

    Citation: Journal of Translational Medicine 2008 6:80

    Content type: Research

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  5. A large percentage of patients with recurrent ovarian cancer develop resistance to the taxane class of chemotherapeutics. While mechanisms of resistance are being discovered, novel treatment options and a bett...

    Authors: Christopher D Scharer, Noelani Laycock, Adeboye O Osunkoya, Sanjay Logani, John F McDonald, Benedict B Benigno and Carlos S Moreno

    Citation: Journal of Translational Medicine 2008 6:79

    Content type: Research

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  6. Animal models greatly facilitate understanding of cancer and importantly, serve pre-clinically for evaluating potential anti-cancer therapies. We developed an invasive orthotopic human glioblastoma multiforme ...

    Authors: Qian Xie, Ryan Thompson, Kim Hardy, Lisa DeCamp, Bree Berghuis, Robert Sigler, Beatrice Knudsen, Sandra Cottingham, Ping Zhao, Karl Dykema, Brian Cao, James Resau, Rick Hay and George F Vande Woude

    Citation: Journal of Translational Medicine 2008 6:77

    Content type: Research

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  7. Pharmacodynamic assays are important in clinical trial design to investigate the relationship between drug concentration (pharmacokinetics) and drug "effect' or biological activity. Increasingly flow cytometry...

    Authors: Timothy Wyant, Alan Lackey and Marie Green

    Citation: Journal of Translational Medicine 2008 6:76

    Content type: Methodology

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  8. Multiple physiologic impairments are responsible for chronic wounds. A cell line grown which retains its phenotype from patient wounds would provide means of testing new therapies. Clinical information on pati...

    Authors: Harold Brem, Michael S Golinko, Olivera Stojadinovic, Arber Kodra, Robert F Diegelmann, Sasa Vukelic, Hyacinth Entero, Donald L Coppock and Marjana Tomic-Canic

    Citation: Journal of Translational Medicine 2008 6:75

    Content type: Methodology

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  9. The molecular etiology of hearing impairment in Chinese has not been thoroughly investigated. Study of GJB2 gene revealed that 30.4% of the patients with hearing loss in Inner Mongolia carried GJB2 mutations. The...

    Authors: Pu Dai, Yongyi Yuan, Deliang Huang, Xiuhui Zhu, Fei Yu, Dongyang Kang, Huijun Yuan, Bailin Wu, Dongyi Han and Lee-Jun C Wong

    Citation: Journal of Translational Medicine 2008 6:74

    Content type: Research

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  10. The development of postoperative granulation tissue is one of the main postoperative risks after lumbar spine surgery. This granulation tissue may lead to persistent or new clinical symptoms or complicate a fo...

    Authors: Reinhard Meier, Sophie Boddington, Christian Krug, Frank L Acosta, Daniel Thullier, Tobias D Henning, Elizabeth J Sutton, Sidhartha Tavri, Jeffrey C Lotz and Heike E Daldrup-Link

    Citation: Journal of Translational Medicine 2008 6:73

    Content type: Research

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  11. Inside the spectrum of non-alcoholic fatty liver disease, simple fatty liver is generally thought of as being "non progressive", differently from non-alcoholic steatohepatitis, which increases in severity due ...

    Authors: Giovanni Tarantino, Paolo Conca, Antonio Riccio, Marianna Tarantino, Matteo N Di Minno, Domenico Chianese, Fabrizio Pasanisi, Franco Contaldo, Francesco Scopacasa and Domenico Capone

    Citation: Journal of Translational Medicine 2008 6:72

    Content type: Research

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  12. Different Insulin-like Growth Factor Binding Proteins (IGFBPs) have been investigated as potential biomarkers in several types of tumors. In this study, we examined both IGFBP-3 and -4 levels in tissues and se...

    Authors: Jessie Z Yu, Melanie A Warycha, Paul J Christos, Farbod Darvishian, Herman Yee, Hideko Kaminio, Russell S Berman, Richard L Shapiro, Michael T Buckley, Leonard F Liebes, Anna C Pavlick, David Polsky, Peter C Brooks and Iman Osman

    Citation: Journal of Translational Medicine 2008 6:70

    Content type: Research

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  13. We examined gene expression profiles of tumor cells from 29 untreated patients with lung cancer (10 adenocarcinomas (AC), 10 squamous cell carcinomas (SCC), and 9 small cell lung cancer (SCLC)) in comparison t...

    Authors: Astrid Rohrbeck, Judith Neukirchen, Michael Rosskopf, Guillermo G Pardillos, Helene Geddert, Andreas Schwalen, Helmut E Gabbert, Arndt von Haeseler, Gerald Pitschke, Matthias Schott, Ralf Kronenwett, Rainer Haas and Ulrich-Peter Rohr

    Citation: Journal of Translational Medicine 2008 6:69

    Content type: Research

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  14. Essential tremor (ET) is the most common movement disorder and its pathophysiology is unknown. We hypothesize that increased membrane excitability in motor circuits has a key role in the pathogenesis of ET. Sp...

    Authors: Aasef G Shaikh, Kenichiro Miura, Lance M Optican, Stefano Ramat, Robert M Tripp and David S Zee

    Citation: Journal of Translational Medicine 2008 6:68

    Content type: Research

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  15. The implantation of neural stem cells (NSCs) in artificial scaffolds for peripheral nerve injuries draws much attention. NSCs were ex-vivo expanded in hyaluronic acid (HA)-collagen composite with neurotrophin-3, ...

    Authors: Han Zhang, Yue Teng Wei, Kam Sze Tsang, Chong Ran Sun, Jin Li, Hua Huang, Fu Zhai Cui and Yi Hua An

    Citation: Journal of Translational Medicine 2008 6:67

    Content type: Research

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  16. This study determined the kinetics of gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntron™) and ribavirin (administered by weight) in HCV patients and compared it w...

    Authors: Milton W Taylor, Takuma Tsukahara, Jeanette N McClintick, Howard J Edenberg and Paul Kwo

    Citation: Journal of Translational Medicine 2008 6:66

    Content type: Research

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  17. Docetaxel and gemcitabine combinations have proven active for the treatment of non-small cell lung cancer (NSCLC). The aim of the present study was to evaluate and compare two treatment schedules, one based on...

    Authors: Alessandro Passardi, Lorenzo Cecconetto, Monia Dall'Agata, Claudio Dazzi, Enzo Pasquini, Giovanni Oliverio, Federica Zumaglini, Wainer Zoli, Oriana Nanni, Carlo Milandri, Giovanni Luca Frassineti and Dino Amadori

    Citation: Journal of Translational Medicine 2008 6:65

    Content type: Research

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  18. The need for fast, efficient, and less costly means to screen genetic variants associated with disease predisposition led us to develop an oligo-nucleotide array-based process for gene-specific single nucleoti...

    Authors: Alessandro Monaco, Filippo Menolascina, Yingdong Zhao, Stefania Tommasi, Marianna Sabatino, Ross Fasano, Angelo Paradiso, Francesco M Marincola and Ena Wang

    Citation: Journal of Translational Medicine 2008 6:64

    Content type: Methodology

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  19. HLA-A2 tetramer flow cytometry, IFNγ real time RT-PCR and IFNγ ELISPOT assays are commonly used as surrogate immunological endpoints for cancer immunotherapy. While these are often used as research assays to a...

    Authors: Yuanxin Xu, Valerie Theobald, Crystal Sung, Kathleen DePalma, Laura Atwater, Keirsten Seiger, Michael A Perricone and Susan M Richards

    Citation: Journal of Translational Medicine 2008 6:61

    Content type: Research

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  20. The adoptive transfer of autologous tumor reactive lymphocytes can mediate significant tumor regression in some patients with refractory metastatic cancer. However, a significant obstacle for this promising th...

    Authors: Udai S Kammula and Oscar K Serrano

    Citation: Journal of Translational Medicine 2008 6:60

    Content type: Methodology

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  21. LXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR activation causes upregulation of genes involved in reverse cholesterol transport (RCT), including ...

    Authors: Elizabeth A DiBlasio-Smith, Maya Arai, Elaine M Quinet, Mark J Evans, Tad Kornaga, Michael D Basso, Liang Chen, Irene Feingold, Anita R Halpern, Qiang-Yuan Liu, Ponnal Nambi, Dawn Savio, Shuguang Wang, William M Mounts, Jennifer A Isler, Anna M Slager…

    Citation: Journal of Translational Medicine 2008 6:59

    Content type: Research

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  22. Monitoring of cellular immune responses is indispensable in a number of clinical research areas, including microbiology, virology, oncology and autoimmunity. Purification and culture of peripheral blood mononu...

    Authors: Elke Schultz-Thater, Daniel M Frey, Daniela Margelli, Nermin Raafat, Chantal Feder-Mengus, Giulio C Spagnoli and Paul Zajac

    Citation: Journal of Translational Medicine 2008 6:58

    Content type: Methodology

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  23. The recruitment of vascular stromal and endothelial cells is an early event occurring during cancer cell growth at premetastatic niches, but how the microenvironment created by the initial three-dimensional (3...

    Authors: María Valcárcel, Beatriz Arteta, Arrate Jaureguibeitia, Aritz Lopategi, Iñigo Martínez, Lorea Mendoza, Francisco J Muruzabal, Clarisa Salado and Fernando Vidal-Vanaclocha

    Citation: Journal of Translational Medicine 2008 6:57

    Content type: Research

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  24. Recent studies demonstrate that recombinant adeno-associated virus (rAAV)-based antigen loading of dendritic cells (DCs) generates in vitro, significant and rapid cytotoxic T-lymphocyte (CTL) responses against vi...

    Authors: Yuefei Yu, Petra Pilgrim, Juqiang Yan, Wei Zhou, Marjorie Jenkins, Nicoletta Gagliano, Klaus Bumm, Martin Cannon, Aldo Milzani, Isabella Dalle-Donne, W Martin Kast, Everardo Cobos and Maurizio Chiriva-Internati

    Citation: Journal of Translational Medicine 2008 6:56

    Content type: Research

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  25. High resistance to drug is taken as a characteristic of human tumors, which is usually mediated by multidrug resistance-associated genes. ABCC2, an ATP-binding cassette multidrug resistance transporter, is fou...

    Authors: Si Ming Xie, Wei Yi Fang, Zhen Liu, Shuang Xi Wang, Xin Li, Teng Fei Liu, Wei Bing Xie and Kai Tai Yao

    Citation: Journal of Translational Medicine 2008 6:55

    Content type: Research

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  26. We previously demonstrated that vascular endothelial growth factor receptor type 2 (VEGF-R2)-positive cells induced from mouse embryonic stem (ES) cells can differentiate into both endothelial cells (ECs) and ...

    Authors: Naofumi Oyamada, Hiroshi Itoh, Masakatsu Sone, Kenichi Yamahara, Kazutoshi Miyashita, Kwijun Park, Daisuke Taura, Megumi Inuzuka, Takuhiro Sonoyama, Hirokazu Tsujimoto, Yasutomo Fukunaga, Naohisa Tamura and Kazuwa Nakao

    Citation: Journal of Translational Medicine 2008 6:54

    Content type: Research

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  27. Metastatic melanoma is a highly chemotherapy resistant tumour. The use of newer targeted therapies alone and in combination with chemotherapy may offer new hope of improving response to treatment. Dasatinib, a...

    Authors: Alex J Eustace, John Crown, Martin Clynes and Norma O'Donovan

    Citation: Journal of Translational Medicine 2008 6:53

    Content type: Research

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  28. Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic monitoring. However, currently available cancer biomarkers have the disadvantage of lacking specificity and/or sensitivity. Dev...

    Authors: Hua Xue, Bingjian Lu and Maode Lai

    Citation: Journal of Translational Medicine 2008 6:52

    Content type: Review

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  29. Human hepatocellular carcinoma (HCC) cells express WT1 and/or carcinoembryonic antigen (CEA) as potential targets for the induction of antitumor immunity. In this study, generation of cytotoxic T lymphocytes (...

    Authors: Shigeo Koido, Sadamu Homma, Eiichi Hara, Makoto Mitsunaga, Yoshihisa Namiki, Akitaka Takahara, Eijiro Nagasaki, Hideo Komita, Yukiko Sagawa, Toshifumi Ohkusa, Kiyotaka Fujise, Jianlin Gong and Hisao Tajiri

    Citation: Journal of Translational Medicine 2008 6:51

    Content type: Research

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  30. Pharmaceutical doses of ascorbic acid (AA, vitamin C, or its salts) have been reported to exert anticancer activity in vitro and in vivo. One proposed mechanism involves direct cytotoxicity mediated by accumulati...

    Authors: Nina A Mikirova, Thomas E Ichim and Neil H Riordan

    Citation: Journal of Translational Medicine 2008 6:50

    Content type: Research

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  31. To determine the role of interferon-alpha in controlling HIV infection we phenotypically and functionally analyzed circulating plasmacytoid dendritic cells (pDC), which are known to be the highest interferon-a...

    Authors: Raffaele Badolato, Claudia Ghidini, Fabio Facchetti, Federico Serana, Alessandra Sottini, Marco Chiarini, Elena Spinelli, Silvia Lonardi, Alessandro Plebani, Luigi Caimi and Luisa Imberti

    Citation: Journal of Translational Medicine 2008 6:49

    Content type: Research

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  32. Ayurveda is an ancient system of personalized medicine documented and practiced in India since 1500 B.C. According to this system an individual's basic constitution to a large extent determines predisposition ...

    Authors: Bhavana Prasher, Sapna Negi, Shilpi Aggarwal, Amit K Mandal, Tav P Sethi, Shailaja R Deshmukh, Sudha G Purohit, Shantanu Sengupta, Sangeeta Khanna, Farhan Mohammad, Gaurav Garg, Samir K Brahmachari and Mitali Mukerji

    Citation: Journal of Translational Medicine 2008 6:48

    Content type: Research

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  33. Our previous publication showed that 9% of patients with a history of myocardial infarction MI. could be labeled as aspirin resistant; all of these patients were aspirin resistant because of non-compliance. Th...

    Authors: Kenneth A Schwartz, Dianne E Schwartz, Kimberly Barber, Mathew Reeves and Anthony C De Franco

    Citation: Journal of Translational Medicine 2008 6:46

    Content type: Research

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  34. Critical limb ischemia (CLI) is an advanced form of peripheral artery disease which is responsible for approximately 100,000 amputations per year in the US. Trials to date have reported clinical improvement an...

    Authors: Michael P Murphy, Hao Wang, Amit N Patel, Suman Kambhampati, Niren Angle, Kyle Chan, Annette M Marleau, Andrew Pyszniak, Ewa Carrier, Thomas E Ichim and Neil H Riordan

    Citation: Journal of Translational Medicine 2008 6:45

    Content type: Research

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  35. The status of a disease can be reflected by specific transcriptional profiles resulting from the induction or repression activity of a number of genes. Here, we proposed a time-dependent diagnostic model to pr...

    Authors: Tao Huang, Kang Tu, Yu Shyr, Chao-Chun Wei, Lu Xie and Yi-Xue Li

    Citation: Journal of Translational Medicine 2008 6:44

    Content type: Methodology

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  36. In prostate cancer, the identification of drug combinations that could reduce the tumor cell population and rapidly eradicate hormone-resistant cells potentially present would be a remarkable breakthrough in t...

    Authors: Francesco Fabbri, Giovanni Brigliadori, Silvia Carloni, Paola Ulivi, Ivan Vannini, Anna Tesei, Rosella Silvestrini, Dino Amadori and Wainer Zoli

    Citation: Journal of Translational Medicine 2008 6:43

    Content type: Research

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  37. This study was aimed to investigate the short- and long-term outcomes of percutaneous coronary intervention (PCI) between single bare metal stent (BMS) and single drug eluting stent (DES) in nondiabetic patien...

    Authors: Yue-jin Yang, Sheng Kang, Bo Xu, Ji-lin Chen, Shu-bin Qiao, Xue-wen Qin, Min Yao, Jue Chen, Yong-jian Wu, Hai-bo Liu, Jin-qing Yuan, Shi-jie You, Jian-jun Li, Jun Dai and Run-lin Gao

    Citation: Journal of Translational Medicine 2008 6:42

    Content type: Research

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  38. Strategies to discover circulating protein markers of ovarian cancer are urgently needed. We developed a novel technology that permits us to isolate recombinant antibodies directed against the potential serum ...

    Authors: Nathalie Scholler, Jennifer A Gross, Barbara Garvik, Lance Wells, Yan Liu, Christian M Loch, Arturo B Ramirez, Martin W McIntosh, Paul D Lampe and Nicole Urban

    Citation: Journal of Translational Medicine 2008 6:41

    Content type: Research

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  39. Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HSC mobilization include G-CSF and the CX...

    Authors: Ping Jin, Ena Wang, Jiaqiang Ren, Richard Childs, Jeong Won Shin, Hanh Khuu, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2008 6:39

    Content type: Research

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  40. Our previous studies have demonstrated that transduction of human dendritic cells (DC) with adenovirus encoding secondary lymphoid chemokine, CCL21, led to secretion of biologically active CCL21 without alteri...

    Authors: Felicita Baratelli, Hiroko Takedatsu, Saswati Hazra, Katherine Peebles, Jie Luo, Pam S Kurimoto, Gang Zeng, Raj K Batra, Sherven Sharma, Steven M Dubinett and Jay M Lee

    Citation: Journal of Translational Medicine 2008 6:38

    Content type: Research

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  41. Advances in cancer therapy have been substantial in terms of molecular understanding of disease mechanisms, however these advances have not translated into increased survival in the majority of cancer types. O...

    Authors: Thomas E Ichim, Zhaohui Zhong, Shalesh Kaushal, Xiufen Zheng, Xiubao Ren, Xishan Hao, James A Joyce, Harold H Hanley, Neil H Riordan, James Koropatnick, Vladimir Bogin, Boris R Minev, Wei-Ping Min and Richard H Tullis

    Citation: Journal of Translational Medicine 2008 6:37

    Content type: Research

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  42. Prothrombin G20210A gene variant (FII G20210A) is a risk factor for venous thrombotic disease while conflicting results have been reported for the risk of arterial thrombotic events. However, vascular episodes...

    Authors: Pierpaolo Di Micco, Rosanna Di Fiore, Alferio Niglio, Sandro Quaranta, Antonella Angiolillo, Giuseppe Cardillo and Giuseppe Castaldo

    Citation: Journal of Translational Medicine 2008 6:36

    Content type: Research

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  43. The golden retriever muscular dystrophy (GRMD) dogs represent the best available animal model for therapeutic trials aiming at the future treatment of human Duchenne muscular dystrophy (DMD). We have obtained ...

    Authors: Irina Kerkis, Carlos E Ambrosio, Alexandre Kerkis, Daniele S Martins, Eder Zucconi, Simone AS Fonseca, Rosa M Cabral, Carlos MC Maranduba, Thais P Gaiad, Adriana C Morini, Natassia M Vieira, Marina P Brolio, Osvaldo A Sant'Anna, Maria A Miglino and Mayana Zatz

    Citation: Journal of Translational Medicine 2008 6:35

    Content type: Research

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  44. Quantification of T-cell receptor (TCR) chain families can be utilized for detection of clonal T-cell populations. Besides southern blotting and antibody-based approaches, quantitative real time PCR (qRT PCR) ...

    Authors: Sebastian Ochsenreither, Alberto Fusi, Antonia Busse, Dirk Nagorsen, David Schrama, Jürgen Becker, Eckhard Thiel and Ulrich Keilholz

    Citation: Journal of Translational Medicine 2008 6:34

    Content type: Methodology

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