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  1. This study explores the psychological, socio-cultural and economic consequences of infertility on couples' life. The purpose of this research is to improve knowledge about the potentially serious implications ...

    Authors: Nicole J Wiersema, Anouck J Drukker, Mai Ba Tien Dung, Giang Huynh Nhu, Nguyen Thanh Nhu and Cornelis B Lambalk

    Citation: Journal of Translational Medicine 2006 4:54

    Content type: Research

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  2. Limb-girdle muscular dystrophy (LGMD) is a group of heterogeneous muscular disorders with autosomal dominant and recessive inheritance, in which the pelvic or shoulder girdle musculature is predominantly or pr...

    Authors: Yong Zhang, Jianwei Ye, Dazhi Chen, Xinyi Zhao, Xingjun Xiao, Sheng Tai, Wei Yang and Dahai Zhu

    Citation: Journal of Translational Medicine 2006 4:53

    Content type: Research

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  3. The immune system spontaneously responds to tumor-associated antigens in peripheral blood of colorectal cancer (CRC) patients. Regulatory T cells (Treg) are suspected of influencing the interaction between the...

    Authors: Christoph Loddenkemper, Martin Schernus, Michel Noutsias, Harald Stein, Eckhard Thiel and Dirk Nagorsen

    Citation: Journal of Translational Medicine 2006 4:52

    Content type: Research

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  4. Current clinical and histopathological criteria used to define the prognosis of melanoma patients are inadequate for accurate prediction of clinical outcome. We investigated whether genome screening by means o...

    Authors: Susanna Mandruzzato, Andrea Callegaro, Gianluca Turcatel, Samuela Francescato, Maria C Montesco, Vanna Chiarion-Sileni, Simone Mocellin, Carlo R Rossi, Silvio Bicciato, Ena Wang, Francesco M Marincola and Paola Zanovello

    Citation: Journal of Translational Medicine 2006 4:50

    Content type: Research

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  5. Besides being the effectors of native anti-tumor cytotoxicity, NK cells participate in T-lymphocyte responses by promoting the maturation of dendritic cells (DC). Adherent NK (A-NK) cells constitute a subset o...

    Authors: Lina Matera, Alessandra Galetto, Marilena Bello, Cinzia Baiocco, Isabella Chiappino, Giancarlo Castellano, Alessandra Stacchini, Maria A Satolli, Michele Mele, Sergio Sandrucci, Antonio Mussa, Gianni Bisi and Theresa L Whiteside

    Citation: Journal of Translational Medicine 2006 4:49

    Content type: Research

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  6. The tumor microenvironment consists of tumor, immune, stromal, and inflammatory cells which produce cytokines, growth factors, and adhesion molecules that promote tumor progression and metastasis. Of particula...

    Authors: Anne M Lewis, Sheelu Varghese, Hui Xu and H Richard Alexander

    Citation: Journal of Translational Medicine 2006 4:48

    Content type: Review

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  7. Human polyomavirus BK (BKV) has been implicated in oncogenic transformation. Its ability to replicate is determined by the binding of its large tumor antigen (LTag) to products of tumor-suppressor genes regula...

    Authors: Maurizio Provenzano, Laura Bracci, Stephen Wyler, Tvrtko Hudolin, Giovanni Sais, Rainer Gosert, Paul Zajac, Giorgio Palu', Michael Heberer, Hans H Hirsch and Giulio C Spagnoli

    Citation: Journal of Translational Medicine 2006 4:47

    Content type: Research

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  8. Candida albicans is a dimorphic fungus that can grow in yeast morphology or hyphal form depending on the surrounding environment. This ubiquitous fungus is present in skin and mucus membranes as a potential patho...

    Authors: Viachaslau M Barodka, Edward Acheampong, Garry Powell, Ludmila Lobach, David A Logan, Zahida Parveen, Valerie Armstead and Muhammad Mukhtar

    Citation: Journal of Translational Medicine 2006 4:46

    Content type: Research

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  9. Very little is known of the regulation of the function of human osteoclasts, largely due to the virtual impossibility of obtaining human osteoclasts ex vivo. It has recently become possible to generate human oste...

    Authors: Barrie Kirstein, Urszula Grabowska, Bertil Samuelsson, Masahiro Shiroo, Timothy J Chambers and Karen Fuller

    Citation: Journal of Translational Medicine 2006 4:45

    Content type: Methodology

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  10. Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activatory receptors that are expressed by most natural killer (NK) cells. The KIR gene family is polymorphic: genomic diversity ...

    Authors: A Bontadini, M Testi, MC Cuccia, M Martinetti, C Carcassi, A Chiesa, E Cosentini, E Dametto, S Frison, AM Iannone, C Lombardo, A Malagoli, M Mariani, L Mariotti, L Mascaretti, L Mele…

    Citation: Journal of Translational Medicine 2006 4:44

    Content type: Research

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  11. Although described by Hippocrates in 400 B.C., pemphigus disease still needs a safe therapeutical approach, given that the currently used therapies (i.e. corticosteroids and immunosuppressive drugs) often prov...

    Authors: Giovanni Angelini, Domenico Bonamonte, Alberta Lucchese, Gianfranco Favia, Rosario Serpico, Abraham Mittelman, Simone Simone, Animesh A Sinha and Darja Kanduc

    Citation: Journal of Translational Medicine 2006 4:43

    Content type: Research

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  12. Incomplete Freund's adjuvant (IFA) serves as a carrier for water-in-oil emulsion (W/O) vaccines. The stability of such emulsions greatly affects vaccine safety and efficacy since continued presence of antigen ...

    Authors: Yi T Koh, Sean A Higgins, Jeffrey S Weber and W Martin Kast

    Citation: Journal of Translational Medicine 2006 4:42

    Content type: Research

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  13. The culture and expansion of human cells for clinical use requires the presence of human serum or plasma in culture media. Although these supplements have been extensively characterized in their chemical compo...

    Authors: Saleh Ayache, Monica C Panelli, Karen M Byrne, Stefanie Slezak, Susan F Leitman, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2006 4:40

    Content type: Research

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  14. Aberrant signaling by ErbB-2 (HER 2, Neu), a member of the human Epidermal Growth Factor (EGF) receptor family, is associated with an aggressive clinical behaviour of carcinomas, particularly breast tumors. An...

    Authors: Patrizia Galeffi, Alessio Lombardi, Immacolata Pietraforte, Flavia Novelli, Monica Di Donato, Maria Sperandei, Andrea Tornambé, Rocco Fraioli, Aline Martayan, Pier Giorgio Natali, Maria Benevolo, Marcella Mottolese, Francisco Ylera, Cristina Cantale and Patrizio Giacomini

    Citation: Journal of Translational Medicine 2006 4:39

    Content type: Research

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  15. Recently, it was described that an HLA-A24 restricted peptide derived from the survivin splice variant survivin-2B can be recognized by CD8(+) cytotoxic T-cells. The identification of an HLA-A24 epitope is cri...

    Authors: Mads Hald Andersen, Rikke B Soerensen, Jürgen C Becker and Per thor Straten

    Citation: Journal of Translational Medicine 2006 4:38

    Content type: Commentary

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  16. A number of autoimmune diseases have been clinically and pathologically characterized. In contrast, target antigens have been identified only in a few cases and, in these few cases, the knowledge of the exact ...

    Authors: Alberta Lucchese, Abraham Mittelman, Luciana Tessitore, Rosario Serpico, Animesh A Sinha and Darja Kanduc

    Citation: Journal of Translational Medicine 2006 4:37

    Content type: Research

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  17. We present our experience of therapeutic vaccination using dendritic cells (DC) pulsed with autologous tumor antigens in patients with advanced melanoma.

    Authors: Ruggero Ridolfi, Massimiliano Petrini, Laura Fiammenghi, Monica Stefanelli, Laura Ridolfi, Michela Ballardini, Giuseppe Migliori and Angela Riccobon

    Citation: Journal of Translational Medicine 2006 4:36

    Content type: Research

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  18. Dendritic cells (DCs) have been used as vaccines in clinical trials of immunotherapy of cancer and other diseases. Nonetheless, progress towards the use of DCs in the clinic has been slow due in part to the ab...

    Authors: Svetomir N Markovic, Allan B Dietz, Carl W Greiner, Mary L Maas, Greg W Butler, Douglas J Padley, Peggy A Bulur, Jacob B Allred, Edward T Creagan, James N Ingle, Dennis A Gastineau and Stanimir Vuk-Pavlovic

    Citation: Journal of Translational Medicine 2006 4:35

    Content type: Methodology

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  19. The World Health Organization (WHO)'s "3 × 5 program" has spurred efforts to place 3 million people on combination antiretroviral therapy (ART) for treatment of AIDS in resource-limited countries. Paradoxicall...

    Authors: Lynn S Zijenah, Gerard Kadzirange, Simon Madzime, Margaret Borok, Chiedza Mudiwa, Ocean Tobaiwa, Mary Mucheche, Simbarashe Rusakaniko and David A Katzenstein

    Citation: Journal of Translational Medicine 2006 4:33

    Content type: Research

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  20. The development of resistance to cytotoxic chemotherapy continues to be a major obstacle for successful anticancer therapy. It has been shown that cells exposed to toxic concentrations of commonly used cancer ...

    Authors: Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Alma Chavez-Blanco, Alma Revilla-Vazquez, Luis Benitez-Bribiesca and Alfonso Duenas-González

    Citation: Journal of Translational Medicine 2006 4:32

    Content type: Research

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  21. It is well known that the use of the α-adrenergic receptor antagonists in the BPH therapy may induce ejaculatory disorder. A review of clinical literature shows a greater incidence of ejaculatory disorder duri...

    Authors: Marco Grasso, Flavio Fortuna, Caterina Lania and Salvatore Blanco

    Citation: Journal of Translational Medicine 2006 4:31

    Content type: Research

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  22. We previously showed that tumor-free peritoneum of patients with epithelial ovarian cancer (EOC) exhibited enhanced expression of several inflammatory response genes compared to peritoneum of benign disease. H...

    Authors: Xipeng Wang, Michael Deavers, Rebecca Patenia, Roland L Bassett Jr, Peter Mueller, Qing Ma, Ena Wang and Ralph S Freedman

    Citation: Journal of Translational Medicine 2006 4:30

    Content type: Research

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  23. We compared gene expression profiles in acutely dissected aorta with those in normal control aorta.

    Authors: Barbara Theresia Weis-Müller, Olga Modlich, Irina Drobinskaya, Derya Unay, Rita Huber, Hans Bojar, Jochen D Schipke, Peter Feindt, Emmeran Gams, Wolfram Müller, Timm Goecke and Wilhelm Sandmann

    Citation: Journal of Translational Medicine 2006 4:29

    Content type: Research

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  24. Thyroid papillary microcarcinoma (TPM) is defined according to WHO criteria as a thyroid tumor smaller than 1–1.5 cm. TPMs are encountered in 0.5–35.6 % of autopsies or surgical specimens where carcinoma had b...

    Authors: Demet Corapcioglu, Serpil D Sak, Tuncay Delibasi, Vedia Tonyukuk, Nuri Kamel, Ali R Uysal, Savas Kocak, Semih Aydintug and Gurbuz Erdogan

    Citation: Journal of Translational Medicine 2006 4:28

    Content type: Research

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  25. Experimentally, interleukin-2 (IL-2) exerts complex immunological functions promoting the proliferation, survival and activation of T cells on one hand and inducing immune regulatory mechanisms on the other. T...

    Authors: Ping Jin, Ena Wang, Maurizio Provenzano, Sara Deola, Silvia Selleri, Jiaqiang Ren, Sonia Voiculescu, David Stroncek, Monica C Panelli and Francesco M Marincola

    Citation: Journal of Translational Medicine 2006 4:26

    Content type: Research

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  26. Oxidative stress could play a role in pathogenesis of hepatitis C virus (HCV) infection. The aim of our study is to determine oxidant/antioxidant status of patients with chronic hepatitis C (CHC), and the effe...

    Authors: Görenek Levent, Acar Ali, Aydın Ahmet, Eyigun Can Polat, Çetinkaya Aytaç, Eken Ayşe and Sayal Ahmet

    Citation: Journal of Translational Medicine 2006 4:25

    Content type: Research

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  27. In vivo studies have recently demonstrated that interleukin 21 (IL-21) enhances the anti-tumor function of T-cells and NK cells in murine tumor models, and the combined use of IL-21 and IL-15 has resulted in p...

    Authors: Hong He, Preya Wisner, Guojun Yang, Hong-Ming Hu, Dan Haley, William Miller, Aisling O'Hara, W Gregory Alvord, Christopher H Clegg, Bernard A Fox, Walter J Urba and Edwin B Walker

    Citation: Journal of Translational Medicine 2006 4:24

    Content type: Research

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  28. Nasopharyngeal carcinoma (NPC) is common among Southern Chinese and the main histology is the undifferentiated carcinoma associated with Epstein-Barr virus (EBV) infection. p63 is a recently proved member of t...

    Authors: Can Guo, Zhi-Gang Pan, Da-Jiang Li, Jing-Ping Yun, Mei-Zhen Zheng, Zhe-Yu Hu, Li-Zhen Cheng and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2006 4:23

    Content type: Research

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  29. Historically cancer vaccines have yielded suboptimal clinical results. We have developed a novel strategy for eliciting antitumor immunity based upon homology between neoplastic tissue and the developing place...

    Authors: Zhaohui Zhong, Kornel P Kusznieruk, Igor A Popov, Neil H Riordan, Hamid Izadi, Li Yijian, Salman Sher, Orest M Szczurko, Michael G Agadjanyan, Richard H Tullis, Amir Harandi, Boris N Reznik, Grigor V Mamikonyan and Thomas E Ichim

    Citation: Journal of Translational Medicine 2006 4:22

    Content type: Research

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  30. To evaluate embryonic stem cell (ESC) harvesting methods with an emphasis on derivation of ESC lines without feeder cells or sera. Using a murine model, laser-assisted blastocyst dissection was performed and c...

    Authors: Noriko Tanaka, Takumi Takeuchi, Queenie V Neri, Eric Scott Sills and Gianpiero D Palermo

    Citation: Journal of Translational Medicine 2006 4:20

    Content type: Methodology

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  31. Enumeration of circulating peripheral blood dendritic cells (DCs) is complicated by the absence of a unique cell surface marker expressed on all DC subsets and by the use of various biological adjuvants to mod...

    Authors: Kehui Wang, Kevin P Nishimoto, Rita S Mehta and Edward L Nelson

    Citation: Journal of Translational Medicine 2006 4:18

    Content type: Methodology

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  32. Monocyte/macrophages (MO/MA), a polymorphic population of innate immune cells, have the potential to mediate antitumor effects, and may also contribute to protumor effects. A priming and post-chemotherapy sche...

    Authors: Sachin M Apte, Saroj Vadhan-Raj, Lorenzo Cohen, Roland L Bassett, Ilyssa O Gordon, Charles F Levenback, Pedro T Ramirez, Stacie T Gallardo, Rebecca S Patenia, Michael E Garcia, Revathy B Iyer and Ralph S Freedman

    Citation: Journal of Translational Medicine 2006 4:16

    Content type: Research

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  33. Innate immunity is considered the first line of host defense and microglia presumably play a critical role in mediating potent innate immune responses to traumatic and infectious challenges in the human brain....

    Authors: S Farzana Hussain, David Yang, Dima Suki, Elizabeth Grimm and Amy B Heimberger

    Citation: Journal of Translational Medicine 2006 4:15

    Content type: Research

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  34. Research has found that certain bacteria are associated with human cancers. Their role, however, is still unclear. Convincing evidence links some species to carcinogenesis while others appear promising in the ...

    Authors: DL Mager

    Citation: Journal of Translational Medicine 2006 4:14

    Content type: Review

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  35. A functional blood supply is essential for tumor growth and proliferation. However, the mechanism of blood vessel recruitment to the tumor is still poorly understood. Ideally, a thorough molecular assessment o...

    Authors: Amelia C Grover, Michael A Tangrea, Karen G Woodson, Benjamin S Wallis, Jeffrey C Hanson, Rodrigo F Chuaqui, John W Gillespie, Heidi S Erickson, Robert F Bonner, Thomas J Pohida, Michael R Emmert-Buck and Steven K Libutti

    Citation: Journal of Translational Medicine 2006 4:13

    Content type: Research

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  36. Multicellular spheroids, an appropriate in vitro system for simulating 3-D tumor micro-milieu can be used for evaluating and predicting tumor response to therapeutic agents including metabolic inhibitors. However...

    Authors: Divya Khaitan, Sudhir Chandna, MB Arya and BS Dwarakanath

    Citation: Journal of Translational Medicine 2006 4:12

    Content type: Research

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  37. Studies of gene expression profiling have been successfully used for the identification of molecules to be employed as potential prognosticators. In analogy with gene expression profiling, we have recently pro...

    Authors: Antonella Zucchetto, Paolo Sonego, Massimo Degan, Riccardo Bomben, Michele Dal Bo, Pietro Bulian, Dania Benedetti, Maurizio Rupolo, Giovanni Del Poeta, Renato Campanini and Valter Gattei

    Citation: Journal of Translational Medicine 2006 4:11

    Content type: Review

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  38. Hydralazine was one of the first orally active antihypertensive drugs developed. Currently, it is used principally to treat pregnancy-associated hypertension. Hydralazine causes two types of side effects. The ...

    Authors: Claudia Arce, Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Myrna Candelaria and Alfonso Dueñnas-Gonzalez

    Citation: Journal of Translational Medicine 2006 4:10

    Content type: Review

    Published on:

  39. Thrombopoietin (TPO), the primary cytokine regulating megakaryocyte proliferation and differentiation, exerts significant influence on other hematopoietic lineages as well, including erythroid, granulocytic an...

    Authors: John M Ninos, Leigh C Jefferies, Christopher R Cogle and William G Kerr

    Citation: Journal of Translational Medicine 2006 4:9

    Content type: Research

    Published on:

  40. Malignant ascites often develops in advanced stages of ovarian carcinoma, consisting of single and aggregated tumor cells, or spheroids. Spheroids have commonly been used as tumor models to study drug efficacy...

    Authors: Kathryn M Burleson, Matthew P Boente, Stefan E Pambuccian and Amy PN Skubitz

    Citation: Journal of Translational Medicine 2006 4:6

    Content type: Research

    Published on:

  41. Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. Recent evidence d...

    Authors: Leonardo Rossi, Ramy Moharram, Brian M Martin, Richard L White and Monica C Panelli

    Citation: Journal of Translational Medicine 2006 4:5

    Content type: Methodology

    Published on:

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