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  1. Supported by the Office of International Affairs, National Cancer Institute (NCI), the "US-Japan Workshop on Immunological Biomarkers in Oncology" was held in March 2009. The workshop was related to a task force ...

    Authors: Hideaki Tahara, Marimo Sato, Magdalena Thurin, Ena Wang, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Peter P Lee, Samir N Khleif, Jon M Wigginton, Stefan Ambs, Yasunori Akutsu, Damien Chaussabel, Yuichiro Doki, Oleg Eremin, Wolf Hervé Fridman…

    Citation: Journal of Translational Medicine 2009 7:45

    Content type: Commentary

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  2. To develop peptide-based immunotherapy for osteosarcoma, we previously identified papillomavirus binding factor (PBF) as a CTL-defined osteosarcoma antigen in the context of HLA-B55. However, clinical applicat...

    Authors: Tomohide Tsukahara, Satoshi Kawaguchi, Toshihiko Torigoe, Akari Takahashi, Masaki Murase, Masanobu Kano, Takuro Wada, Mitsunori Kaya, Satoshi Nagoya, Toshihiko Yamashita and Noriyuki Sato

    Citation: Journal of Translational Medicine 2009 7:44

    Content type: Research

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  3. Pancreatic cancer retains a poor prognosis among the gastrointestinal cancers. It affects 230,000 individuals worldwide, has a very high mortality rate, and remains one of the most challenging malignancies to ...

    Authors: David O Azorsa, Irma M Gonzales, Gargi D Basu, Ashish Choudhary, Shilpi Arora, Kristen M Bisanz, Jeffrey A Kiefer, Meredith C Henderson, Jeffrey M Trent, Daniel D Von Hoff and Spyro Mousses

    Citation: Journal of Translational Medicine 2009 7:43

    Content type: Research

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  4. Despite the use of anti-platelet agents such as acetylsalicylic acid (ASA) and clopidogrel in coronary heart disease, some patients continue to suffer from atherothrombosis. This has stimulated development of ...

    Authors: Andreas C Eriksson, Lena Jonasson, Tomas L Lindahl, Bo Hedbäck and Per A Whiss

    Citation: Journal of Translational Medicine 2009 7:42

    Content type: Research

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  5. The main regulator of neovascularization is Vascular Endothelial Growth Factor (VEGF). We recently demonstrated that QK, a de novo engineered VEGF mimicking peptide, shares in vitro the same biological properties...

    Authors: Gaetano Santulli, Michele Ciccarelli, Gianluigi Palumbo, Alfonso Campanile, Gennaro Galasso, Barbara Ziaco, Giovanna Giuseppina Altobelli, Vincenzo Cimini, Federico Piscione, Luca Domenico D'Andrea, Carlo Pedone, Bruno Trimarco and Guido Iaccarino

    Citation: Journal of Translational Medicine 2009 7:41

    Content type: Research

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  6. Fibroblasts are actually considered pivotal in inflammation and tissue remodelling process and for these reasons they are involved in the pathogenesis of autoimmune disorders such as celiac disease. Investigat...

    Authors: Leda Roncoroni, Luca Elli, Luisa Doneda, Luca Piodi, Michele M Ciulla, Roberta Paliotti and Maria Teresa Bardella

    Citation: Journal of Translational Medicine 2009 7:40

    Content type: Research

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  7. Since the V617F mutation in JAK2 may not be the initiating event in myeloprofilerative disorders (MPDs) we compared molecular changes in neutrophils from patients with polycythemia vera (PV) and essential thro...

    Authors: Stefanie Slezak, Ping Jin, Lorraine Caruccio, Jiaqiang Ren, Michael Bennett, Nausheen Zia, Sharon Adams, Ena Wang, Joao Ascensao, Geraldine Schechter and David Stroncek

    Citation: Journal of Translational Medicine 2009 7:39

    Content type: Research

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  8. High mobility group box-1 (HMGB1) is a newly recognized factor regulating cancer cell tumorigenesis, expansion and invasion. We investigated the correlation between the serum HMGB1 levels and the clinical and ...

    Authors: Hye Won Chung, Sang-Guk Lee, Heejung Kim, Duck Jin Hong, Jae Bock Chung, David Stroncek and Jong-Baeck Lim

    Citation: Journal of Translational Medicine 2009 7:38

    Content type: Research

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  9. Endocervical adenocarcinomas (ECA) and endometrial adenocarcinomas (EMA) are uterine malignancies that have differing biological behaviors. The choice of an appropriate therapeutic plan rests on the tumor's si...

    Authors: Chiung-Ling Liao, Ming-Yung Lee, Yeu-Sheng Tyan, Lai-Fong Kok, Tina S Wu, Chiew-Loon Koo, Po-Hui Wang, Kuan-Chong Chao and Chih-Ping Han

    Citation: Journal of Translational Medicine 2009 7:37

    Content type: Research

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  10. PAX2 is a transcription factor with an important role in embryogenic development. However, PAX2 expression was frequently identified in neoplasia responsible for the growth and survival of cancer cells. Due to...

    Authors: Antonia Busse, Anika Rietz, Stefan Schwartz, Eckhard Thiel and Ulrich Keilholz

    Citation: Journal of Translational Medicine 2009 7:36

    Content type: Research

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  11. Th17 cells are CD4+ cells that produce interleukin 17 (IL-17) and are potent inducers of tissue inflammation and autoimmunity. We studied the levels of this T cell subset in peripheral blood of patients treate...

    Authors: Erika von Euw, Thinle Chodon, Narsis Attar, Jason Jalil, Richard C Koya, Begonya Comin-Anduix and Antoni Ribas

    Citation: Journal of Translational Medicine 2009 7:35

    Content type: Research

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  12. Ginseng is believed to have beneficial effects against human diseases, and its active components, ginsenosides, may play critical roles in its diverse physiological actions. However, the mechanisms underlying ...

    Authors: Davy CW Lee, Cindy LH Yang, Stanley CC Chik, James CB Li, Jian-hui Rong, Godfrey CF Chan and Allan SY Lau

    Citation: Journal of Translational Medicine 2009 7:34

    Content type: Research

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  13. The intravenous co-infusion of labradimil, a metabolically stable bradykinin B2 receptor agonist, has been shown to temporarily enhance the transvascular delivery of small chemotherapy drugs, such as carboplat...

    Authors: Hemant Sarin, Ariel S Kanevsky, Steve H Fung, John A Butman, Robert W Cox, Daniel Glen, Richard Reynolds and Sungyoung Auh

    Citation: Journal of Translational Medicine 2009 7:33

    Content type: Research

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  14. The AAAS has announced the launch of Science Translational Medicine. This is further and critical recognition of this discipline and we are deeply gratified that translational medicine has risen to the level of r...

    Authors: Christian Brander and Francesco M Marincola

    Citation: Journal of Translational Medicine 2009 7:32

    Content type: Editorial

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  15. Noninvasive detection of innate immune function such as the accumulation of neutrophils remains a challenge in many areas of clinical medicine. We hypothesized that granulocytes could generate volatile organic...

    Authors: Hye-Won Shin, Brandon J Umber, Simone Meinardi, Szu-Yun Leu, Frank Zaldivar, Donald R Blake and Dan M Cooper

    Citation: Journal of Translational Medicine 2009 7:31

    Content type: Methodology

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  16. Low birth weight has been related to an increased risk for developing high blood pressure in adult life. The molecular and cellular analysis of umbilical cord artery and vein may provide information about the ...

    Authors: José Javier Martín de Llano, Graciela Fuertes, Isabel Torró, Consuelo García Vicent, José Luis Fayos and Empar Lurbe

    Citation: Journal of Translational Medicine 2009 7:30

    Content type: Research

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  17. The stromal vascular fraction (SVF) of adipose tissue is known to contain mesenchymal stem cells (MSC), T regulatory cells, endothelial precursor cells, preadipocytes, as well as anti-inflammatory M2 macrophag...

    Authors: Neil H Riordan, Thomas E Ichim, Wei-Ping Min, Hao Wang, Fabio Solano, Fabian Lara, Miguel Alfaro, Jorge Paz Rodriguez, Robert J Harman, Amit N Patel, Michael P Murphy, Roland R Lee and Boris Minev

    Citation: Journal of Translational Medicine 2009 7:29

    Content type: Review

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  18. Vitamin D insufficiency is common in hospitalized patients. Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial pept...

    Authors: Leo Jeng, Alexandra V Yamshchikov, Suzanne E Judd, Henry M Blumberg, Gregory S Martin, Thomas R Ziegler and Vin Tangpricha

    Citation: Journal of Translational Medicine 2009 7:28

    Content type: Research

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  19. It has been suggested that the initial differentiation of endothelial and hematopoietic cells during embryogenesis occurs from a common progenitor, called hemangioblast (hB). We hypothesized that these cells w...

    Authors: Grzegorz Wladyslaw Basak, Satoshi Yasukawa, Andre Alfaro, Samantha Halligan, Anand S Srivastava, Wei-Ping Min, Boris Minev and Ewa Carrier

    Citation: Journal of Translational Medicine 2009 7:27

    Content type: Research

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  20. Mutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among different ethnic groups.

    Authors: Pu Dai, Fei Yu, Bing Han, Xuezhong Liu, Guojian Wang, Qi Li, Yongyi Yuan, Xin Liu, Deliang Huang, Dongyang Kang, Xin Zhang, Huijun Yuan, Kun Yao, Jinsheng Hao, Jia He, Yong He…

    Citation: Journal of Translational Medicine 2009 7:26

    Content type: Research

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  21. Endocervical adenocarcinomas (ECAs) and endometrial adenocarcinomas (EMAs) are malignancies that affect uterus; however, their biological behaviors are quite different. This distinction has clinical significan...

    Authors: Chiew-Loon Koo, Lai-Fong Kok, Ming-Yung Lee, Tina S Wu, Ya-Wen Cheng, Jeng-Dong Hsu, Alexandra Ruan, Kuan-Chong Chao and Chih-Ping Han

    Citation: Journal of Translational Medicine 2009 7:25

    Content type: Research

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  22. We have previously reported that the sigma-2 receptor is highly expressed in pancreas cancer. Furthermore, we have demonstrated that sigma-2 receptor specific ligands induce apoptosis in a dose-dependent fashi...

    Authors: Hiroyuki Kashiwagi, Jonathan E McDunn, Peter O Simon Jr, Peter S Goedegebuure, Suwanna Vangveravong, Katherine Chang, Richard S Hotchkiss, Robert H Mach and William G Hawkins

    Citation: Journal of Translational Medicine 2009 7:24

    Content type: Research

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  23. The norovirus group (NVG) of caliciviruses are the etiological agents of most institutional outbreaks of gastroenteritis in North America and Europe. Identification of NVG is complicated by the non-culturable ...

    Authors: David N Fisman, Amy L Greer, George Brouhanski and Steven J Drews

    Citation: Journal of Translational Medicine 2009 7:23

    Content type: Research

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  24. Resveratrol (RES), an estrogen analog, is considered as a potential cancer chemo-preventive agent. However, it remains unclear how RES is transported into cells. In this study, we observed that Caveolin-1(CAV1...

    Authors: Hui-ling Yang, Wei-qiong Chen, Xuan Cao, Andrea Worschech, Li-fen Du, Wei-yi Fang, Yang-yan Xu, David F Stroncek, Xin Li, Ena Wang and Francesco M Marincola

    Citation: Journal of Translational Medicine 2009 7:22

    Content type: Research

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  25. Assessment of T-cell diversity, besides giving insights about the molecular basis of tumor antigen recognition, has clinical implications since it provides criteria for evaluating antigen-specific T cells clin...

    Authors: Federico Serana, Alessandra Sottini, Luigi Caimi, Belinda Palermo, Pier Giorgio Natali, Paola Nisticò and Luisa Imberti

    Citation: Journal of Translational Medicine 2009 7:21

    Content type: Research

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  26. The unique features of human embryonic stem (hES) cells make them the best candidate resource for both cell replacement therapy and development research. However, the molecular mechanisms responsible for the s...

    Authors: Jiaqiang Ren, Ping Jin, Ena Wang, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2009 7:20

    Content type: Research

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  27. Tetrapyrrole molecules are distributed in virtually all living organisms on Earth. In mammals, tetrapyrrole end products are closely linked to oxygen metabolism. Since increasingly complex trophic functional s...

    Authors: Jose-Ignacio Arias, María-Angeles Aller and Jaime Arias

    Citation: Journal of Translational Medicine 2009 7:19

    Content type: Review

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  28. Optimal techniques for DC generation for immunotherapy in cancer are yet to be established. Study aims were to evaluate: (i) DC activation/maturation milieu (TNF-α +/- IFN-α) and its effects on CD8+ hTERT-specifi...

    Authors: Mark M Aloysius, Alastair J Mc Kechnie, Richard A Robins, Chandan Verma, Jennifer M Eremin, Farzin Farzaneh, Nagy A Habib, Joti Bhalla, Nicola R Hardwick, Sukchai Satthaporn, Thiagarajan Sreenivasan, Mohammed El-Sheemy and Oleg Eremin

    Citation: Journal of Translational Medicine 2009 7:18

    Content type: Research

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  29. The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily recent member of the immunoglobulin super-family, encoded in the Class III region of the major histocompatability complex. RAGE is hi...

    Authors: Louis J Sparvero, Denise Asafu-Adjei, Rui Kang, Daolin Tang, Neilay Amin, Jaehyun Im, Ronnye Rutledge, Brenda Lin, Andrew A Amoscato, Herbert J Zeh and Michael T Lotze

    Citation: Journal of Translational Medicine 2009 7:17

    Content type: Review

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  30. High-risk neuroblastoma has an overall five-year survival of less than 40%, indicating a need for new treatment strategies such as angiogenesis inhibition. Recent studies have shown that chemotherapeutic drugs...

    Authors: Dieter Fuchs, Rolf Christofferson, Mats Stridsberg, Elin Lindhagen and Faranak Azarbayjani

    Citation: Journal of Translational Medicine 2009 7:16

    Content type: Research

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  31. Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC a...

    Authors: Zhaohui Zhong, Amit N Patel, Thomas E Ichim, Neil H Riordan, Hao Wang, Wei-Ping Min, Erik J Woods, Michael Reid, Eduardo Mansilla, Gustavo H Marin, Hugo Drago, Michael P Murphy and Boris Minev

    Citation: Journal of Translational Medicine 2009 7:15

    Content type: Research

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  32. High grade gliomas are one of the most difficult cancers to treat and despite surgery, radiotherapy and temozolomide-based chemotherapy, the prognosis of glioma patients is poor. Resistance to temozolomide is ...

    Authors: Annalisa Lena, Mariarosa Rechichi, Alessandra Salvetti, Barbara Bartoli, Donatella Vecchio, Vittoria Scarcelli, Rosina Amoroso, Lucia Benvenuti, Rolando Gagliardi, Vittorio Gremigni and Leonardo Rossi

    Citation: Journal of Translational Medicine 2009 7:13

    Content type: Research

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  33. TGFβ has emerged as an attractive target for the therapeutic intervention of glioblastomas. Aberrant TGFβ overproduction in glioblastoma and other high-grade gliomas has been reported, however, to date, none o...

    Authors: Xie L Xu and Ann M Kapoun

    Citation: Journal of Translational Medicine 2009 7:12

    Content type: Research

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  34. Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. Among the different DC subsets, plasmacytoid DC (pDC) are well k...

    Authors: Philippe Veron, Sylvie Boutin, Samia Martin, Laurence Chaperot, Joel Plumas, Jean Davoust and Carole Masurier

    Citation: Journal of Translational Medicine 2009 7:10

    Content type: Research

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  35. Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage ...

    Authors: Lawrence Leung

    Citation: Journal of Translational Medicine 2009 7:9

    Content type: Commentary

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  36. Members of the TRIP-Br/SERTAD family of mammalian transcriptional coregulators have recently been implicated in E2F-mediated cell cycle progression and tumorigenesis. We, herein, focus on the detailed function...

    Authors: Jit Kong Cheong, Lakshman Gunaratnam, Zhi Jiang Zang, Christopher M Yang, Xiaoming Sun, Susan L Nasr, Khe Guan Sim, Bee Keow Peh, Suhaimi Bin Abdul Rashid, Joseph V Bonventre, Manuel Salto-Tellez and Stephen I Hsu

    Citation: Journal of Translational Medicine 2009 7:8

    Content type: Research

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  37. When comparing myelogenous blasts from bone marrow and peripheral blood, immunophenotyping usually show a strong correlation of expression of surface antigens. However, it remains to be determined, whether thi...

    Authors: Gero Hütter, Anne Letsch, Daniel Nowak, Julia Poland, Pranav Sinha, Eckhard Thiel and Wolf-K Hofmann

    Citation: Journal of Translational Medicine 2009 7:7

    Content type: Methodology

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  38. The dystrophin gene, located at Xp21, codifies dystrophin, which is part of a protein complex responsible for the membrane stability of muscle cells. Its absence on muscle causes Duchenne Muscular Dystrophy (D...

    Authors: Tatiana Jazedje, Mariane Secco, Natássia M Vieira, Eder Zucconi, Thomaz R Gollop, Mariz Vainzof and Mayana Zatz

    Citation: Journal of Translational Medicine 2009 7:6

    Content type: Research

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  39. Angiostatin, an endogenous angiogenesis inhibitor, is a fragment of plasminogen. Its anti-angiogenic activity was discovered with functional assays in vivo, however, its direct action on endothelial cells is m...

    Authors: Adriana Albini, Claudio Brigati, Agostina Ventura, Girieca Lorusso, Marta Pinter, Monica Morini, Alessandra Mancino, Antonio Sica and Douglas M Noonan

    Citation: Journal of Translational Medicine 2009 7:5

    Content type: Research

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  40. Recently, nanometer sized vesicles (termed exosomes) have been described as a component of urine. Such vesicles may be a useful non-invasive source of markers in renal disease. Their utility as a source of mar...

    Authors: Paul J Mitchell, Joanne Welton, John Staffurth, Jacquelyn Court, Malcolm D Mason, Zsuzsanna Tabi and Aled Clayton

    Citation: Journal of Translational Medicine 2009 7:4

    Content type: Research

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  41. Experimental results from studies with inbred mice and their syngeneic tumors indicated that the inoculation of semi-allogeneic cell hybrids (derived from the fusion between syngeneic tumor cells and an alloge...

    Authors: Jin Yu, Mark S Kindy and Sebastiano Gattoni-Celli

    Citation: Journal of Translational Medicine 2009 7:3

    Content type: Research

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  42. Interleukin-2 (IL-2) induces durable objective responses in a small cohort of patients with metastatic renal cell carcinoma (RCC) but the antigen(s) responsible for tumor rejection are not known. 5T4 is a non-...

    Authors: Howard L Kaufman, Bret Taback, William Sherman, Dae Won Kim, William H Shingler, Dorota Moroziewicz, Gail DeRaffele, Josephine Mitcham, Miles W Carroll, Richard Harrop, Stuart Naylor and Seunghee Kim-Schulze

    Citation: Journal of Translational Medicine 2009 7:2

    Content type: Research

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  43. We previously reported an HLA-A24-restricted cytotoxic T-cell epitope, Survivin-2B80-88, derived from a splice variant of survivin, survivin-2B. In this report, we show a novel HLA-A24-restricted T-cell epitop...

    Authors: Jun-ichi Kobayashi, Toshihiko Torigoe, Yoshihiko Hirohashi, Satomi Idenoue, Akihiro Miyazaki, Akira Yamaguchi, Hiroyoshi Hiratsuka and Noriyuki Sato

    Citation: Journal of Translational Medicine 2009 7:1

    Content type: Research

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  44. The International Society for the Biological Therapy of Cancer (iSBTc) has initiated in collaboration with the United States Food and Drug Administration (FDA) a programmatic look at innovative avenues for the...

    Authors: Lisa H Butterfield, Mary L Disis, Bernard A Fox, Peter P Lee, Samir N Khleif, Magdalena Thurin, Giorgio Trinchieri, Ena Wang, Jon Wigginton, Damien Chaussabel, George Coukos, Madhav Dhodapkar, Leif Håkansson, Sylvia Janetzki, Thomas O Kleen, John M Kirkwood…

    Citation: Journal of Translational Medicine 2008 6:81

    Content type: Commentary

    Published on:

  45. Effective transvascular delivery of nanoparticle-based chemotherapeutics across the blood-brain tumor barrier of malignant gliomas remains a challenge. This is due to our limited understanding of nanoparticle ...

    Authors: Hemant Sarin, Ariel S Kanevsky, Haitao Wu, Kyle R Brimacombe, Steve H Fung, Alioscka A Sousa, Sungyoung Auh, Colin M Wilson, Kamal Sharma, Maria A Aronova, Richard D Leapman, Gary L Griffiths and Matthew D Hall

    Citation: Journal of Translational Medicine 2008 6:80

    Content type: Research

    Published on:

  46. A large percentage of patients with recurrent ovarian cancer develop resistance to the taxane class of chemotherapeutics. While mechanisms of resistance are being discovered, novel treatment options and a bett...

    Authors: Christopher D Scharer, Noelani Laycock, Adeboye O Osunkoya, Sanjay Logani, John F McDonald, Benedict B Benigno and Carlos S Moreno

    Citation: Journal of Translational Medicine 2008 6:79

    Content type: Research

    Published on:

  47. Animal models greatly facilitate understanding of cancer and importantly, serve pre-clinically for evaluating potential anti-cancer therapies. We developed an invasive orthotopic human glioblastoma multiforme ...

    Authors: Qian Xie, Ryan Thompson, Kim Hardy, Lisa DeCamp, Bree Berghuis, Robert Sigler, Beatrice Knudsen, Sandra Cottingham, Ping Zhao, Karl Dykema, Brian Cao, James Resau, Rick Hay and George F Vande Woude

    Citation: Journal of Translational Medicine 2008 6:77

    Content type: Research

    Published on:

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