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  1. Anti-IL-21R antibodies are potential therapeutics for the treatment of autoimmune diseases. This study evaluated correlations between the pharmacodynamic (PD) activity, pharmacokinetics, and anti-product antib...

    Authors: Yulia Vugmeyster, Scott Allen, Pamela Szklut, Andrea Bree, Mark Ryan, Margery Ma, Vikki Spaulding, Deborah Young, Heath Guay, Laird Bloom, Michael W Leach, Margot O'Toole and Karissa Adkins

    Citation: Journal of Translational Medicine 2010 8:41

    Content type: Research

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  2. Around half million new cases of cervical cancer arise each year, making the development of an effective therapeutic vaccine against HPV a high priority. As the E6 and E7 oncoproteins are expressed in all HPV-...

    Authors: Antonia Radaelli, Eleana Pozzi, Sole Pacchioni, Carlo Zanotto and Carlo De Giuli Morghen

    Citation: Journal of Translational Medicine 2010 8:40

    Content type: Research

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  3. Blocking oncogenic signaling induced by the BRAFV600E mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in m...

    Authors: Jonas N Søndergaard, Ramin Nazarian, Qi Wang, Deliang Guo, Teli Hsueh, Stephen Mok, Hooman Sazegar, Laura E MacConaill, Jordi G Barretina, Sarah M Kehoe, Narsis Attar, Erika von Euw, Jonathan E Zuckerman, Bartosz Chmielowski, Begoña Comin-Anduix, Richard C Koya…

    Citation: Journal of Translational Medicine 2010 8:39

    Content type: Research

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  4. Treatment for both early and advanced melanoma has changed little since the introduction of interferon and IL-2 in the early 1990s. Recent data from trials testing targeted agents or immune modulators suggest ...

    Authors: Paolo A Ascierto, Howard Z Streicher and Mario Sznol

    Citation: Journal of Translational Medicine 2010 8:38

    Content type: Commentary

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  5. NSC-741909 is a novel anticancer agent that can effectively suppress the growth of several cell lines derived from lung, colon, breast, ovarian, and kidney cancers. We recently showed that NSC-741909-induced a...

    Authors: Xiaoli Wei, Wei Guo, Shuhong Wu, Li Wang, Peng Huang, Jinsong Liu and Bingliang Fang

    Citation: Journal of Translational Medicine 2010 8:37

    Content type: Research

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  6. Responsiveness to Cetuximab alone can be mediated by an increase of Epidermal Growth factor Receptor (EGFR) Gene Copy Number (GCN). Aim of this study was to assess the role of EGFR-GCN in advanced colorectal c...

    Authors: Carla Campanella, Marcella Mottolese, Anna Cianciulli, Angela Torsello, Roberta Merola, Isabella Sperduti, Elisa Melucci, Salvatore Conti, Maria Grazia Diodoro, Massimo Zeuli, Giancarlo Paoletti, Francesco Cognetti and Carlo Garufi

    Citation: Journal of Translational Medicine 2010 8:36

    Content type: Research

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  7. Several immunotherapeutic approaches rely on antigen-specific T-cells. Restrictions in the T-cell receptor (TCR) repertoire were reported as indicator of anti-tumor cytotoxic T-lymphocyte (CTL) response in var...

    Authors: Sebastian Ochsenreither, Alberto Fusi, Susanne Wojtke, Antonia Busse, Natascha C Nüssler, Eckhard Thiel, Ulrich Keilholz and Dirk Nagorsen

    Citation: Journal of Translational Medicine 2010 8:35

    Content type: Research

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  8. The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in pr...

    Authors: Nina A Mikirova, James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle WH Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Famela Ramos, Thomas E Ichim and Neil H Riordan

    Citation: Journal of Translational Medicine 2010 8:34

    Content type: Research

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  9. In damaged organs tissue repair and replacement of cells by connective tissue provokes a response of fibroblasts to cellular stress factors such as hypoxia.

    Authors: Michaela Muth, Katharina Theophile, Kais Hussein, Christoph Jacobi, Hans Kreipe and Oliver Bock

    Citation: Journal of Translational Medicine 2010 8:33

    Content type: Research

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  10. The oncoprotein Epstain-Barr Virus (EBV)-encoded latent membrane protein1 (LMP1) modulates the pathological effects of the NF-κB, AP-1 and JAK/STAT pathways in nasopharyngeal carcinoma (NPC).

    Authors: Jing Chen, Chun-Fang Hu, Jing-Hui Hou, Qiong Shao, Li-Xu Yan, Xiao-Feng Zhu, Yi-Xin Zeng and Jian-Yong Shao

    Citation: Journal of Translational Medicine 2010 8:30

    Content type: Research

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  11. Concurrent chemoradiation with 5-fluorouracil (5-FU) is widely accepted for treatment of abdominal malignancy. Nonetheless, the interactions between radiation and 5-FU remain unclear. We evaluated the influenc...

    Authors: Chen-Hsi Hsieh, Yen-Ju Hsieh, Chia-Yuan Liu, Hung-Chi Tai, Yu-Chuen Huang, Pei-Wei Shueng, Le-Jung Wu, Li-Ying Wang, Tung-Hu Tsai and Yu-Jen Chen

    Citation: Journal of Translational Medicine 2010 8:29

    Content type: Research

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  12. Current vaccines against HPVs are constituted of L1 protein self-assembled into virus-like particles (VLPs) and they have been shown to protect against natural HPV16 and HPV18 infections and associated lesions...

    Authors: Nicolas Combelas, Emilie Saussereau, Maxime JJ Fleury, Tatiana Ribeiro, Julien Gaitan, Diego F Duarte-Forero, Pierre Coursaget and Antoine Touzé

    Citation: Journal of Translational Medicine 2010 8:28

    Content type: Research

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  13. This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of primary cutaneous melanocytic neoplasms in young adult and older age gr...

    Authors: Drazen M Jukic, Uma NM Rao, Lori Kelly, Jihad S Skaf, Laura M Drogowski, John M Kirkwood and Monica C Panelli

    Citation: Journal of Translational Medicine 2010 8:27

    Content type: Research

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  14. There are countless reasons nearly every scientist should learn how to communicate effectively with the media, including increased understanding of critical research findings to attract or sustain funding and ...

    Authors: Laura Van Eperen, Francesco M Marincola and Jennifer Strohm

    Citation: Journal of Translational Medicine 2010 8:25

    Content type: Editorial

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  15. Human stem cells from adult sources have been shown to contribute to the regeneration of muscle, liver, heart, and vasculature. The mechanisms by which this is accomplished are, however, still not well underst...

    Authors: Claus S Sondergaard, David A Hess, Dustin J Maxwell, Carla Weinheimer, Ivana Rosová, Michael H Creer, David Piwnica-Worms, Attila Kovacs, Lene Pedersen and Jan A Nolta

    Citation: Journal of Translational Medicine 2010 8:24

    Content type: Research

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  16. ZAP-70 is an independent negative prognostic marker in chronic lymphocytic leukemia (CLL). Usually, its expression is investigated by flow cytometric protocols in which the percentage of ZAP-70 positive CLL ce...

    Authors: Francesca M Rossi, Maria Ilaria Del Principe, Davide Rossi, Maria Irno Consalvo, Fabrizio Luciano, Antonella Zucchetto, Pietro Bulian, Riccardo Bomben, Michele Dal Bo, Marco Fangazio, Dania Benedetti, Massimo Degan, Gianluca Gaidano, Giovanni Del Poeta and Valter Gattei

    Citation: Journal of Translational Medicine 2010 8:23

    Content type: Research

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  17. Biomedical informatics involves a core set of methodologies that can provide a foundation for crossing the "translational barriers" associated with translational medicine. To this end, the fundamental aspects ...

    Authors: Indra Neil Sarkar

    Citation: Journal of Translational Medicine 2010 8:22

    Content type: Review

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  18. According to the scientific literature, less than 30 borderline ovarian tumors have been karyotyped and less than 100 analyzed for genomic imbalances by CGH.

    Authors: Francesca Micci, Lisbeth Haugom, Terje Ahlquist, Hege K Andersen, Vera M Abeler, Ben Davidson, Claes G Trope, Ragnhild A Lothe and Sverre Heim

    Citation: Journal of Translational Medicine 2010 8:21

    Content type: Research

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  19. To test the hypothesis that modulation of Bcl-2 with 13-cis retinoic acid (CRA)/interferon-alpha2b (IFN) with paclitaxel (TAX), or mitoxantrone, estramustine and vinorelbine (MEV) will have clinical activity i...

    Authors: Robert S DiPaola, Yu-Hui Chen, Mark Stein, David Vaughn, Linda Patrick-Miller, Michael Carducci, Bruce Roth, Eileen White and George Wilding

    Citation: Journal of Translational Medicine 2010 8:20

    Content type: Research

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  20. Increased levels of cryptic collagen epitope HU177 in the sera of melanoma patients have been shown to be associated with thicker primary melanomas and with the nodular histologic subtype. In this study, we in...

    Authors: Heather K Hamilton, Amy E Rose, Paul J Christos, Richard L Shapiro, Russell S Berman, Madhu Mazumdar, Michelle W Ma, Daniel Krich, Leonard Liebes, Peter C Brooks and Iman Osman

    Citation: Journal of Translational Medicine 2010 8:19

    Content type: Research

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  21. Hepatitis C virus (HCV) is one of the major risk factors for chronic hepatitis, which may progress to cirrhosis and hepatocellular carcinoma, as well as for type II mixed cryoglobulinemia (MC), which may furth...

    Authors: Luigi Buonaguro, Annacarmen Petrizzo, Marialina Tornesello, Maria Napolitano, Debora Martorelli, Giuseppe Castello, Gerardo Beneduce, Amalia De Renzo, Oreste Perrella, Luca Romagnoli, Vitor Sousa, Valli De Re, Riccardo Dolcetti and Franco M Buonaguro

    Citation: Journal of Translational Medicine 2010 8:18

    Content type: Research

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  22. Type-1 T cells are critical for effective anti-tumor immune responses. The recently discovered microRNAs (miRs) are a large family of small regulatory RNAs that control diverse aspects of cell function, includ...

    Authors: Kotaro Sasaki, Gary Kohanbash, Aki Hoji, Ryo Ueda, Heather A McDonald, Todd A Reinhart, Jeremy Martinson, Michael T Lotze, Francesco M Marincola, Ena Wang, Mitsugu Fujita and Hideho Okada

    Citation: Journal of Translational Medicine 2010 8:17

    Content type: Research

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  23. The medical use of low level laser (LLL) irradiation has been occurring for decades, primarily in the area of tissue healing and inflammatory conditions. Despite little mechanistic knowledge, the concept of a ...

    Authors: Feng Lin, Steven F Josephs, Doru T Alexandrescu, Famela Ramos, Vladimir Bogin, Vincent Gammill, Constantin A Dasanu, Rosalia De Necochea-Campion, Amit N Patel, Ewa Carrier and David R Koos

    Citation: Journal of Translational Medicine 2010 8:16

    Content type: Review

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  24. Although there have been many studies on the p73 gene, some of its functions still remain unclear. There is little research on the relationship between p73 gene transcription and its protein expression and the...

    Authors: Marta Herreros-Villanueva, Pilar Muñiz, Carlos García-Girón, Mónica Cavia-Saiz and María J Coma del Corral

    Citation: Journal of Translational Medicine 2010 8:15

    Content type: Research

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  25. Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart. Rapamycin has been show...

    Authors: Chelsey Woodrum, Alison Nobil and Sandra L Dabora

    Citation: Journal of Translational Medicine 2010 8:14

    Content type: Research

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  26. Although an abundance of evidence has indicated that tumor-associated macrophages (TAMs) are associated with a favorable prognosis in patients with colon cancer, it is still unknown how TAMs exert a protective...

    Authors: Qiang Zhou, Rui-Qing Peng, Xiao-Jun Wu, Qing Xia, Jing-Hui Hou, Ya Ding, Qi-Ming Zhou, Xing Zhang, Zhi-Zhong Pang, De-Sen Wan, Yi-Xin Zeng and Xiao-Shi Zhang

    Citation: Journal of Translational Medicine 2010 8:13

    Content type: Research

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  27. In recent years the concept of "translational medicine" has been advanced in an attempt to catalyze the medical applications of basic biomedical research. However, there has been little discussion about the re...

    Authors: Robert B Nussenblatt, Francesco M Marincola and Alan N Schechter

    Citation: Journal of Translational Medicine 2010 8:12

    Content type: Editorial

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  28. Ileal pouch-anal anastomosis (IPAA) is the surgical procedure of choice for patients with refractory ulcerative colitis (UC) and for familial adenomatous polyposis (FAP) with many rectal polyps. Pouchitis is o...

    Authors: Raquel F Leal, Maria de Lourdes S Ayrizono, Marciane Milanski, João J Fagundes, Juliana C Moraes, Luciana R Meirelles, Lício A Velloso and Cláudio SR Coy

    Citation: Journal of Translational Medicine 2010 8:11

    Content type: Research

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  29. Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer mortality for which novel gene therapy approaches relying on tumor-tropic adenoviruses are being tested.

    Authors: Vladia Monsurrò, Stefania Beghelli, Richard Wang, Stefano Barbi, Silvia Coin, Giovanni Di Pasquale, Samantha Bersani, Monica Castellucci, Claudio Sorio, Stefano Eleuteri, Andrea Worschech, Jay A Chiorini, Paolo Pederzoli, Harvey Alter, Francesco M Marincola and Aldo Scarpa

    Citation: Journal of Translational Medicine 2010 8:10

    Content type: Research

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  30. Glycoprotein-96, a non-polymorphic heat-shock protein, associates with intracellular peptides. Autologous tumor-derived heat shock protein-peptide complex 96 (HSPPC-96) can elicit potent tumor-specific T cell ...

    Authors: Omar Eton, Merrick I Ross, Mary Jo East, Paul F Mansfield, Nicholas Papadopoulos, Julie A Ellerhorst, Agop Y Bedikian and Jeffrey E Lee

    Citation: Journal of Translational Medicine 2010 8:9

    Content type: Research

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  31. Due to the lack of specific tumor antigens, the majority of tested cancer vaccines for renal cell carcinoma (RCC) are based on tumor cell lysate. The identification of the von Hippel-Lindau (VHL) gene mutations i...

    Authors: Osama E Rahma, Ed Ashtar, Ramy Ibrahim, Antoun Toubaji, Barry Gause, Vincent E Herrin, W Marston Linehan, Seth M Steinberg, Frank Grollman, George Grimes, Sarah A Bernstein, Jay A Berzofsky and Samir N Khleif

    Citation: Journal of Translational Medicine 2010 8:8

    Content type: Research

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  32. The conventional treatment protocol in high-intensity focused ultrasound (HIFU) therapy utilizes a dense-scan strategy to produce closely packed thermal lesions aiming at eradicating as much tumor mass as poss...

    Authors: Fang Liu, Zhenlin Hu, Lei Qiu, Chun Hui, Chao Li, Pei Zhong and Junping Zhang

    Citation: Journal of Translational Medicine 2010 8:7

    Content type: Research

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  33. Activation of Toll-like receptors (TLRs) is widely accepted as an essential event for defence against infection. Many TLRs utilize a common signalling pathway that relies on activation of the kinase IRAK4 and ...

    Authors: Kelly L Brown, Reza Falsafi, Winnie Kum, Pamela Hamill, Jennifer L Gardy, Donald J Davidson, Stuart Turvey, Brett B Finlay, David P Speert and Robert EW Hancock

    Citation: Journal of Translational Medicine 2010 8:6

    Content type: Research

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  34. Efficacy of cancer vaccines may be limited due to immune escape mechanisms like loss or mutation of target antigens. Here, we analyzed 10 HLA-A2 positive patients with acute myeloid leukemia (AML) for loss or ...

    Authors: Antonia Busse, Anne Letsch, Carmen Scheibenbogen, Anika Nonnenmacher, Sebastian Ochsenreither, Eckhard Thiel and Ulrich Keilholz

    Citation: Journal of Translational Medicine 2010 8:5

    Content type: Research

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  35. Dendritic cells (DCs) are often produced by granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) stimulation of monocytes. To improve the effectiveness of DC adoptive immune cance...

    Authors: Ping Jin, Tae Hee Han, Jiaqiang Ren, Stefanie Saunders, Ena Wang, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2010 8:4

    Content type: Research

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  36. Staphylococcal enterotoxins (SEs), SE-like (SEl) toxins, and toxic shock syndrome toxin-1 (TSST-1), produced by Staphylococcus aureus, belong to the subgroup of microbial superantigens (SAgs). SAgs induce clonal ...

    Authors: Keun Seok Seo, Joo Youn Park, David S Terman and Gregory A Bohach

    Citation: Journal of Translational Medicine 2010 8:2

    Content type: Methodology

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  37. Chronic Fatigue Syndrome (CFS) is a multifactorial disorder that affects various physiological systems including immune and neurological systems. The immune system has been substantially examined in CFS with e...

    Authors: Ekua W Brenu, Donald R Staines, Oguz K Baskurt, Kevin J Ashton, Sandra B Ramos, Rhys M Christy and Sonya M Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2010 8:1

    Content type: Research

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  38. The detection of circulating tumor cells (CTC) is considered a promising tool for improving risk stratification in patients with solid tumors. We investigated on whether the expression of CTC related genes add...

    Authors: Loris Bertazza, Simone Mocellin, Alberto Marchet, Pierluigi Pilati, Joseph Gabrieli, Romano Scalerta and Donato Nitti

    Citation: Journal of Translational Medicine 2009 7:111

    Content type: Research

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  39. Tumor Protein p53 (p53), cyclin-dependent kinase inhibitor 1A (p21/WAF1), and murine double minute 2 (MDM2) participate in the regulation of cell growth. Altered expression of these gene products has been foun...

    Authors: Mei-Fang Zhang, Zhi-Yi Zhang, Jia Fu, Yu-Feng Yang and Jing-Ping Yun

    Citation: Journal of Translational Medicine 2009 7:110

    Content type: Research

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  40. Optimization of the current dendritic cell (DC) culture protocol in order to promote the therapeutic efficacy of DC-based immunotherapy is warranted. Alternative differentiation of monocyte-derived DCs using g...

    Authors: Sébastien Anguille, Evelien LJM Smits, Nathalie Cools, Herman Goossens, Zwi N Berneman and Vigor FI Van Tendeloo

    Citation: Journal of Translational Medicine 2009 7:109

    Content type: Research

    Published on:

  41. HIV and HPV can both cause chronic infections and are acquired during sexual contact. HIV infection results in a progressive loss of CD4+ T cells that is associated with an increased prevalence of HPV infectio...

    Authors: Sjoerd H van der Burg and Joel M Palefsky

    Citation: Journal of Translational Medicine 2009 7:108

    Content type: Review

    Published on:

  42. The aim of the present study was to compare the effects of Daivobet® and calcipotriol on clinical score and biomarker responses in a modified version of the Scholtz-Dumas psoriasis plaque assay. Furthermore, it w...

    Authors: Peter H Kvist, Lars Svensson, Oskar Hagberg, Vibeke Hoffmann, Kaare Kemp and Mads A Røpke

    Citation: Journal of Translational Medicine 2009 7:107

    Content type: Research

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  43. Endothelial dysfunction is associated with major causes of morbidity and mortality, as well as numerous age-related conditions. The possibility of preserving or even rejuvenating endothelial function offers a ...

    Authors: Nina A Mikirova, James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle WH Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Doru T Alexandrescu, Thomas E Ichim and Neil H Riordan

    Citation: Journal of Translational Medicine 2009 7:106

    Content type: Review

    Published on:

  44. Pancreatic cancer continues to prove difficult to clinically diagnose. Multiple simultaneous measurements of plasma biomarkers can increase sensitivity and selectivity of diagnosis. Proximity ligation assay (P...

    Authors: Stephanie T Chang, Jacob M Zahn, Joe Horecka, Pamela L Kunz, James M Ford, George A Fisher, Quynh T Le, Daniel T Chang, Hanlee Ji and Albert C Koong

    Citation: Journal of Translational Medicine 2009 7:105

    Content type: Research

    Published on:

  45. Liposomal doxorubicin (Doxil) is a cytotoxic chemotherapy drug with a favorable hematologic toxicity profile. Its active drug, doxorubicin, has interesting immunomodulatory properties. Here, the effects of Dox...

    Authors: Ioannis Alagkiozidis, Andrea Facciabene, Carmine Carpenito, Fabian Benencia, Zdenka Jonak, Sarah Adams, Richard G Carroll, Phyllis A Gimotty, Rachel Hammond, Gwen-äel Danet-Desnoyers, Carl H June, Daniel J Powell Jr and George Coukos

    Citation: Journal of Translational Medicine 2009 7:104

    Content type: Research

    Published on:

  46. Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. High expression levels of AMACR have been described ...

    Authors: Ichiya Honma, Toshihiko Torigoe, Yoshihiko Hirohashi, Hiroshi Kitamura, Eiji Sato, Naoya Masumori, Yasuaki Tamura, Taiji Tsukamoto and Noriyuki Sato

    Citation: Journal of Translational Medicine 2009 7:103

    Content type: Research

    Published on:

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