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  1. The goal of this study was to evaluate changes in gene expression in SW-620 cells in response to SN-38 in order to further elucidate the mechanisms by which SN-38 causes apoptosis and cell cycle arrest.

    Authors: Vinicius Souza, Yan Bin Dong, H Sam Zhou, Wolfgang Zacharias and Kelly M McMasters

    Citation: Journal of Translational Medicine 2005 3:44

    Content type: Research

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  2. Antiphospholipid syndrome (APS) has been often associated to RPL since 1980 and some reports in the Literature rarely described antibodies to factor XII in patients with APS.

    Authors: Maristella D'Uva, Ida Strina, Antonio Mollo, Antonio Ranieri, Giuseppe De Placido and Pierpaolo Di Micco

    Citation: Journal of Translational Medicine 2005 3:43

    Content type: Methodology

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  3. The tetraspan protein CD63, originally described as a stage-specific melanoma antigen but also present in a number of normal cells, regulates melanoma cell growth in nude mice, motility in serum containing med...

    Authors: Joji Iida, Amy PN Skubitz, James B McCarthy and Keith M Skubitz

    Citation: Journal of Translational Medicine 2005 3:42

    Content type: Research

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  4. A CD8+ cytotoxic T lymphocyte (CTL) line was derived from the peripheral blood mononuclear cells of a patient with primary melanoma. The CD8+ CTL line specifically lysed the autologous primary melanoma cells and ...

    Authors: Rajasekharan Somasundaram, Laura Caputo, DuPont Guerry and Dorothee Herlyn

    Citation: Journal of Translational Medicine 2005 3:41

    Content type: Research

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  5. A sizeable number of HIV-infected patients receiving HAART do not maintain prolonged virologic suppression. We evaluated long-term HIV viral load (VL) responses to HAART as a risk factor for AIDS events (AE) t...

    Authors: Powel Kazanjian, Wei Wei, Morton Brown, Tejal Gandhi and Kamal Amin

    Citation: Journal of Translational Medicine 2005 3:40

    Content type: Research

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  6. Targeted inhibition of protein kinases is now acknowledged as an effective approach for cancer therapy. However, targeted therapies probably have limited success because cancer cells have alternate pathways fo...

    Authors: Kerrington R Molhoek, David L Brautigan and Craig L Slingluff Jr

    Citation: Journal of Translational Medicine 2005 3:39

    Content type: Research

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  7. The epidermal growth factor receptor (EGFR) is over expressed in approximately 50–60% of glioblastoma (GBM) tumors, and the most common EGFR mutant, EGFRvIII, is expressed in 24–67% of cases. This study was de...

    Authors: Amy B Heimberger, Dima Suki, David Yang, Weiming Shi and Kenneth Aldape

    Citation: Journal of Translational Medicine 2005 3:38

    Content type: Research

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  8. IL-1β is a pleotropic cytokine that may mediate increased procoagulant activity and permeability in endothelial tissue during inflammatory conditions. The procoagulant effects of IL-1β are mediated through ind...

    Authors: Markus Puhlmann, David M Weinreich, Jeffrey M Farma, Nancy M Carroll, Ewa M Turner and H Richard Alexander Jr

    Citation: Journal of Translational Medicine 2005 3:37

    Content type: Research

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  9. Myeloid-related protein 8 (MRP8) and MRP14 are S100 family calcium binding proteins that form a heterodimer known as calprotectin or MRP8/14 that is present in the cytosol of neutrophils and monocytes. MRP8/14...

    Authors: David F Stroncek, Raji A Shankar and Keith M Skubitz

    Citation: Journal of Translational Medicine 2005 3:36

    Content type: Research

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  10. Ovarian cancer represents the fifth leading cause of death from all cancers for women. During the last decades overall survival has improved due to the use of new chemotherapy schedules. Still, the majority of...

    Authors: HW Nijman, A Lambeck, SH van der Burg, AGJ van der Zee and T Daemen

    Citation: Journal of Translational Medicine 2005 3:34

    Content type: Review

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  11. New developments in science are rapidly influencing and shaping basic and clinical research and medicine. This has led to the emergence of multiple opportunities and challenges on many levels in the bio-medica...

    Authors: Kai-Christian Sonntag

    Citation: Journal of Translational Medicine 2005 3:33

    Content type: Commentary

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  12. Our goal was to identify gene signatures predictive of response to preoperative systemic chemotherapy (PST) with epirubicin/cyclophosphamide (EC) in patients with primary breast cancer.

    Authors: Olga Modlich, Hans-Bernd Prisack, Marc Munnes, Werner Audretsch and Hans Bojar

    Citation: Journal of Translational Medicine 2005 3:32

    Content type: Research

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  13. Over the past three decades, there have been remarkable advances in the treatment of bone and soft tissue sarcomas. These include the introduction of adjuvant chemotherapy, establishment of guidelines for adeq...

    Authors: Satoshi Kawaguchi, Takuro Wada, Tomohide Tsukahara, Kazunori Ida, Toshihiko Torigoe, Noriyuki Sato and Toshihiko Yamashita

    Citation: Journal of Translational Medicine 2005 3:31

    Content type: Review

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  14. Previous studies have shown that in platelets of mild Alzheimer Disease (AD) patients there are alterations of specific APP forms, paralleled by alteration in expression level of both ADAM 10 and BACE when com...

    Authors: Monica Di Luca, Enzo Grossi, Barbara Borroni, Martina Zimmermann, Elena Marcello, Francesca Colciaghi, Fabrizio Gardoni, Marco Intraligi, Alessandro Padovani and Massimo Buscema

    Citation: Journal of Translational Medicine 2005 3:30

    Content type: Research

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  15. We present a generic dendritic cell (DC) vaccine strategy for patients with renal cell carcinoma (RCC) based on the use of RNA as a source of multiplex tumor-associated antigens (TAAs). Instead of preparing RN...

    Authors: Christiane Geiger, Sybille Regn, Andreas Weinzierl, Elfriede Noessner and Dolores J Schendel

    Citation: Journal of Translational Medicine 2005 3:29

    Content type: Research

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  16. The study of clinical samples is often limited by the amount of material available to study. While proteins cannot be multiplied in their natural form, DNA and RNA can be amplified from small specimens and use...

    Authors: Ena Wang

    Citation: Journal of Translational Medicine 2005 3:28

    Content type: Review

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  17. The purpose of the present investigation was to determine if the salivary counts of 40 common oral bacteria in subjects with an oral squamous cell carcinoma (OSCC) lesion would differ from those found in cance...

    Authors: DL Mager, AD Haffajee, PM Devlin, CM Norris, MR Posner and JM Goodson

    Citation: Journal of Translational Medicine 2005 3:27

    Content type: Research

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  18. Nasopharyngeal carcinoma (NPC) is a tumor derived from epithelial cells and Epstein-Barr virus infection has been reported to be a cause of this disease. Chemokine receptor CXCR4 was found to be involved in HI...

    Authors: Na Wang, Qiu-Liang Wu, Yan Fang, Hai-Qiang Mai, Mu-Sheng Zeng, Guo-Ping Shen, Jing-Hui Hou and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2005 3:26

    Content type: Research

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  19. Epithelial ovarian cancer (EOC) represents the most frequent cause of death in the United States from a cancer involving the female genital tract. Contributing to the overall poor outcome in EOC patients, are ...

    Authors: Xipeng Wang, Ena Wang, John J Kavanagh and Ralph S Freedman

    Citation: Journal of Translational Medicine 2005 3:25

    Content type: Review

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  20. Interferon (IFN)-α is considered a key modulator of immunopathological processes through a signature-specific activation of mononuclear phagocytes (MPs). This study utilized global transcript analysis to chara...

    Authors: David F Stroncek, Christopher Basil, Dirk Nagorsen, Sara Deola, Eleonora Aricó, Kina Smith, Ena Wang, Francesco M Marincola and Monica C Panelli

    Citation: Journal of Translational Medicine 2005 3:24

    Content type: Research

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  21. The continuous efforts aimed at the identification of new immune epitopes across the MHC system has led to the discovery that more than one peptide may be restricted to the same HLA antigen and function as an ...

    Authors: Monica Ghei, David F Stroncek and Maurizio Provenzano

    Citation: Journal of Translational Medicine 2005 3:23

    Content type: Research

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  22. Apo2L/TRAIL has considerable promise for cancer therapy based on the fact that this member of the tumor necrosis factor family induces apoptosis in the majority of malignant cells, while normal cells are more ...

    Authors: Bonnie L Hylander, Rose Pitoniak, Remedios B Penetrante, John F Gibbs, Dilek Oktay, Jinrong Cheng and Elizabeth A Repasky

    Citation: Journal of Translational Medicine 2005 3:22

    Content type: Research

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  23. Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblast...

    Authors: Andreina Baj, Alessia A Bettaccini, Rosario Casalone, Andrea Sala, Paolo Cherubino and Antonio Q Toniolo

    Citation: Journal of Translational Medicine 2005 3:21

    Content type: Research

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  24. The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell responses agai...

    Authors: Florian K Bihl, Elisabetta Loggi, John V Chisholm III, Hannah S Hewitt, Leah M Henry, Caitlyn Linde, Todd J Suscovich, Johnson T Wong, Nicole Frahm, Pietro Andreone and Christian Brander

    Citation: Journal of Translational Medicine 2005 3:20

    Content type: Methodology

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  25. Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2) and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, an...

    Authors: Craig L Slingluff Jr and Daniel E Speiser

    Citation: Journal of Translational Medicine 2005 3:18

    Content type: Commentary

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  26. In vitro stimulation of CD34+ cells with IL-2 induces NK cell differentiation. In order to define the stages of NK cell development, which influence their generation from CD34 cells, we cultured G-CSF mobilize...

    Authors: Giuseppe Sconocchia, Maurizio Provenzano, Katayoun Rezvani, Jongming Li, Jos Melenhorst, Nancy Hensel and A John Barrett

    Citation: Journal of Translational Medicine 2005 3:15

    Content type: Research

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  27. Although several genes and proteins have been implicated in the development of melanomas, the molecular mechanisms involved in the development of these tumors are not well understood. To gain a better understa...

    Authors: Suraiya Rasheed, Zisu Mao, Jane MC Chan and Linda S Chan

    Citation: Journal of Translational Medicine 2005 3:14

    Content type: Research

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  28. The aim of this study was to determine the basis for anti-tumor immune reactivity observed in patients with human epidermal growth factor receptor-2 (HER-2) (3+) breast carcinoma using an in vitro model in which ...

    Authors: Zorica D Juranic, Zora Neskovic-Konstantinovic, Tatjana P Stanojkovic, Zeljko Zizak, Tatjana Srdic, Nevenka Stanojevic-Bakic, Dusanka Milosevic and Danica Jovanovic

    Citation: Journal of Translational Medicine 2005 3:13

    Content type: Research

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  29. Sixty cancer cell lines have been extensively characterized and used by the National Cancer Institute's Developmental Therapeutics Program (NCI-60) since the early 90's as screening tools for anti-cancer drug ...

    Authors: Sharon Adams, Fu-Meei Robbins, Deborah Chen, Devika Wagage, Susan L Holbeck, Herbert C Morse III, David Stroncek and Francesco M Marincola

    Citation: Journal of Translational Medicine 2005 3:11

    Content type: Research

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  30. DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor rejection. Here we report the feasability and safety of the first Ph...

    Authors: Bernard Escudier, Thierry Dorval, Nathalie Chaput, Fabrice André, Marie-Pierre Caby, Sophie Novault, Caroline Flament, Christophe Leboulaire, Christophe Borg, Sebastian Amigorena, Catherine Boccaccio, Christian Bonnerot, Olivier Dhellin, Mojgan Movassagh, Sophie Piperno, Caroline Robert…

    Citation: Journal of Translational Medicine 2005 3:10

    Content type: Protocol

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  31. There is a continued need to develop more effective cancer immunotherapy strategies. Exosomes, cell-derived lipid vesicles that express high levels of a narrow spectrum of cell proteins represent a novel platf...

    Authors: Michael A Morse, Jennifer Garst, Takuya Osada, Shubi Khan, Amy Hobeika, Timothy M Clay, Nancy Valente, Revati Shreeniwas, Mary Ann Sutton, Alain Delcayre, Di-Hwei Hsu, Jean-Bernard Le Pecq and H Kim Lyerly

    Citation: Journal of Translational Medicine 2005 3:9

    Content type: Research

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  32. Nitric oxide-releasing nonsteroidal antiinflammatory drugs (NO-NSAIDs) are reported to be safer than NSAIDs because of their lower gastric toxicity. We compared the effect of a novel NO-releasing derivate, NCX...

    Authors: Anna Tesei, Paola Ulivi, Francesco Fabbri, Marco Rosetti, Carlo Leonetti, Marco Scarsella, Gabriella Zupi, Dino Amadori, Manlio Bolla and Wainer Zoli

    Citation: Journal of Translational Medicine 2005 3:7

    Content type: Research

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  33. Serologic tests for HIV infection in infants less than 18 months do not differentiate exposure and infection since maternally acquired IgG antibodies may be detected in infants. Thus, the gold standard for dia...

    Authors: Lynn S Zijenah, David A Katzenstein, Kusum J Nathoo, Simbarashe Rusakaniko, Ocean Tobaiwa, Christine Gwanzura, Arsene Bikoue, Margaret Nhembe, Petronella Matibe and George Janossy

    Citation: Journal of Translational Medicine 2005 3:6

    Content type: Research

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  34. CD4+CD25+ regulatory T lymphocytes (TR) constitute 5–10% of peripheral CD4+ T cells in naive mice and humans, and play an important role in controlling immune responses. Accumulating evidences show that TR cells ...

    Authors: Ji-Yan Liu, Xiao-Shi Zhang, Ya Ding, Rui-Qing Peng, Xia Cheng, Nian-Hua Zhang, Jian-Chuan Xia and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2005 3:5

    Content type: Research

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  35. Metastatic, chemotherapy-resistant melanoma is an intractable cancer with a very poor prognosis. As to immunotherapy targeting metastatic melanoma, HLA-A2+ patients were mainly enrolled in the study in Western co...

    Authors: Yasuto Akiyama, Ryuji Tanosaki, Naoki Inoue, Makiko Shimada, Yukie Hotate, Akifumi Yamamoto, Naoya Yamazaki, Ichiro Kawashima, Ikuei Nukaya, Kazutoh Takesako, Kouji Maruyama, Yoichi Takaue and Ken Yamaguchi

    Citation: Journal of Translational Medicine 2005 3:4

    Content type: Research

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  36. Spontaneous T cell responses against specific tumor-associated antigens (TAA) are frequently detected in peripheral blood of tumor patients of various histiotypes. However, little is known about whether these ...

    Authors: Dirk Nagorsen, Carmen Scheibenbogen, Anne Letsch, Christoph-Thomas Germer, Heinz-Johannes Buhr, Susanna Hegewisch-Becker, Licia Rivoltini, Eckhard Thiel and Ulrich Keilholz

    Citation: Journal of Translational Medicine 2005 3:3

    Content type: Research

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  37. Synovial sarcoma is a high-grade malignant tumor of soft tissue, characterized by the specific chromosomal translocation t(X;18), and its resultant SYT-SSX fusion gene. Despite intensive multimodality therapy,...

    Authors: Satoshi Kawaguchi, Takuro Wada, Kazunori Ida, Yuriko Sato, Satoshi Nagoya, Tomohide Tsukahara, Sigeharu Kimura, Hiroeki Sahara, Hideyuki Ikeda, Kumiko Shimozawa, Hiroko Asanuma, Toshihiko Torigoe, Hiroaki Hiraga, Takeshi Ishii, Shin-ichiro Tatezaki, Noriyuki Sato…

    Citation: Journal of Translational Medicine 2005 3:1

    Content type: Research

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  38. Forty to eighty percent of melanoma tumors have activating mutations in BRAF although the clinical importance of these mutations is not clear. We previously reported an analysis of BRAF mutations in metastatic me...

    Authors: David Z Chang, Katherine S Panageas, Iman Osman, David Polsky, Klaus Busam and Paul B Chapman

    Citation: Journal of Translational Medicine 2004 2:46

    Content type: Research

    Published on:

  39. Immunosuppression is documented in several malignant diseases, including breast cancer. Subsequently, future therapeutic concepts might include immunological approaches. However, detailed knowledge about tumor...

    Authors: Jana M Schüle, Leif Bergkvist, Leif Håkansson, Bertil Gustafsson and Annika Håkansson

    Citation: Journal of Translational Medicine 2004 2:45

    Content type: Research

    Published on:

  40. Walking along disease-associated protein sequences in the search for specific segments able to induce cellular immune response may direct clinical research towards effective peptide-based vaccines. To this aim...

    Authors: Alberta Lucchese, Abraham Mittelman, Mong-Shang Lin, Darja Kanduc and Animesh A Sinha

    Citation: Journal of Translational Medicine 2004 2:43

    Content type: Research

    Published on:

  41. Tumors and viruses have developed many mechanisms to evade the immune system, including down-regulation of target antigens and MHC molecules. These immune escape mechanisms may be able to be circumvented by ad...

    Authors: Alexander Langerman, Glenda G Callender and Michael I Nishimura

    Citation: Journal of Translational Medicine 2004 2:42

    Content type: Research

    Published on:

  42. T cell-mediated cancer immunotherapy is dose dependent and optimally requires participation of antigen-specific CD4+ and CD8+ T cells. Here, we isolated tumor-sensitized T cells and activated them in vitro using ...

    Authors: Li-Xin Wang, Wen-Xin Huang, Hallie Graor, Peter A Cohen, Julian A Kim, Suyu Shu and Gregory E Plautz

    Citation: Journal of Translational Medicine 2004 2:41

    Content type: Research

    Published on:

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