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Page 77 of 82

  1. We previously reported that survivin-2B, a splicing variant of survivin, was expressed in various types of tumors and that survivin-2B peptide might serve as a potent immunogenic cancer vaccine. The objective ...

    Authors: Tetsuhiro Tsuruma, Yuji Iwayama, Tosei Ohmura, Tadashi Katsuramaki, Fumitake Hata, Tomohisa Furuhata, Koji Yamaguchi, Yasutoshi Kimura, Toshihiko Torigoe, Nobuhiko Toyota, Atsuhito Yagihashi, Yoshihiko Hirohashi, Hiroko Asanuma, Kumiko Shimozawa, Minoru Okazaki, Yasuhiro Mizushima…

    Citation: Journal of Translational Medicine 2008 6:24

    Content type: Research

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  2. The heterogeneity that soft tissue sarcomas (STS) exhibit in their clinical behavior, even within histological subtypes, complicates patient care. Histological appearance is determined by gene expression. Morp...

    Authors: Keith M Skubitz, Stefan Pambuccian, J Carlos Manivel and Amy PN Skubitz

    Citation: Journal of Translational Medicine 2008 6:23

    Content type: Research

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  3. CTLA4-blocking antibodies induce tumor regression in a subset of patients with melanoma. Analysis of immune parameters in peripheral blood may help define how responses are mediated.

    Authors: Begoña Comin-Anduix, Yohan Lee, Jason Jalil, Alain Algazi, Pilar de la Rocha, Luis H Camacho, Viviana A Bozon, Cecile A Bulanhagui, Elisabeth Seja, Arturo Villanueva, Bradley R Straatsma, Antonio Gualberto, James S Economou, John A Glaspy, Jesus Gomez-Navarro and Antoni Ribas

    Citation: Journal of Translational Medicine 2008 6:22

    Content type: Research

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  4. Because of the lack of full characterization of tumor associated antigens for solid tumors, whole antigen use is a convenient approach to tumor vaccination. Tumor RNA and apoptotic tumor cells have been used a...

    Authors: Fabian Benencia, Maria C Courrèges and George Coukos

    Citation: Journal of Translational Medicine 2008 6:21

    Content type: Research

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  5. Transcription factor forkhead box protein 3 (Foxp3) specifically characterizes the thymically derived naturally occurring regulatory T cells (Tregs). Limited evidence indicates that it is also expressed, albei...

    Authors: Vaios Karanikas, Matthaios Speletas, Maria Zamanakou, Fani Kalala, Gedeon Loules, Theodora Kerenidi, Angeliki K Barda, Konstantinos I Gourgoulianis and Anastasios E Germenis

    Citation: Journal of Translational Medicine 2008 6:19

    Content type: Research

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  6. Management considerations in hypokalemic periodic paralysis include accurate diagnosis, potassium dosage for acute attacks, choice of diuretic for prophylaxis, identification of triggers, creating a safe physi...

    Authors: Jacob O Levitt

    Citation: Journal of Translational Medicine 2008 6:18

    Content type: Commentary

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    The Erratum to this article has been published in Journal of Translational Medicine 2014 12:198

  7. Upon Ag-activation cytotoxic T cells (CTLs) produce IFN-γ GM-CSF and TNF-α, which deliver simultaneously pro-apoptotic and pro-inflammatory signals to the surrounding microenvironment. Whether this secretion a...

    Authors: Silvia Selleri, Sara Deola, Zoltan Pos, Ping Jin, Andrea Worschech, Stefanie L Slezak, Cristiano Rumio, Monica C Panelli, Dragan Maric, David F Stroncek, Ena Wang and Francesco M Marincola

    Citation: Journal of Translational Medicine 2008 6:17

    Content type: Research

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  8. Idiopathic pulmonary fibrosis (IPF) is a treatment resistant disease with poor prognosis. Numerous compounds have been demonstrated to efficiently prevent pulmonary fibrosis (PF) in animal models but only a fe...

    Authors: Kjetil Ask, Renee Labiris, Laszlo Farkas, Antje Moeller, Aaron Froese, Troy Farncombe, Grant B McClelland, Mark Inman, Jack Gauldie and Martin RJ Kolb

    Citation: Journal of Translational Medicine 2008 6:16

    Content type: Research

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  9. Multiple Myeloma is a cancer of B plasma cells, which produce non-specific antibodies and proliferate uncontrolled. Due to the potential relapse and non-specificity of current treatments, immunotherapy promise...

    Authors: Maurizio Chiriva-Internati, Raffaele Ferrari, Madhavi Prabhakar, Yuefei Yu, Luigi Baglioni, Jorge Moreno, Nicoletta Gagliano, Nicola Portinaro, Marjorie R Jenkins, Eldo E Frezza, Fred Hardwicke, Nicholas D'Cunha, W Martin Kast and Everardo Cobos

    Citation: Journal of Translational Medicine 2008 6:15

    Content type: Research

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  10. Ayurveda is one of the ancient systems of health care of Indian origin. Roughly translated into "Knowledge of life", it is based on the use of natural herbs and herb products for therapeutic measures to boost ...

    Authors: Custer C Deocaris, Nashi Widodo, Renu Wadhwa and Sunil C Kaul

    Citation: Journal of Translational Medicine 2008 6:14

    Content type: Review

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  11. Tumor-derived aberrantly methylated DNA might serve as diagnostic biomarkers for cancer, but so far, few such markers have been identified. The aim of the present study was to investigate the potential of the MAL

    Authors: Guro E Lind, Terje Ahlquist, Matthias Kolberg, Marianne Berg, Mette Eknæs, Miguel A Alonso, Anne Kallioniemi, Gunn I Meling, Rolf I Skotheim, Torleiv O Rognum, Espen Thiis-Evensen and Ragnhild A Lothe

    Citation: Journal of Translational Medicine 2008 6:13

    Content type: Research

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  12. Cognate immunity against neoplastic cells depends on a balance between effector T cells and regulatory T (Treg) cells. Treg cells prevent immune attack against normal and neoplastic cells by directly suppressi...

    Authors: Mary Ann Rasku, Amy L Clem, Sucheta Telang, Beverly Taft, Kelly Gettings, Hana Gragg, Daniel Cramer, Sheron C Lear, Kelly M McMasters, Donald M Miller and Jason Chesney

    Citation: Journal of Translational Medicine 2008 6:12

    Content type: Research

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  13. Adrenergic gene polymorphisms are associated with cardiovascular and metabolic phenotypes. We investigated the influence of adrenergic gene polymorphisms on cardiovascular risk in women with suspected myocardi...

    Authors: Michael A Pacanowski, Issam Zineh, Haihong Li, B Delia Johnson, Rhonda M Cooper-DeHoff, Vera Bittner, Dennis M McNamara, Barry L Sharaf, C Noel Bairey Merz, Carl J Pepine and Julie A Johnson

    Citation: Journal of Translational Medicine 2008 6:11

    Content type: Research

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  14. The mouse is an important and widely utilized animal model for bone marrow transplant (BMT) translational studies. Here, we document the course of an unexpected increase in mortality of congenic mice that unde...

    Authors: Raimon Duran-Struuck, Adam Hartigan, Shawn G Clouthier, Melissa C Dyson, Kathi Lowler, Erin Gatza, Isao Tawara, Tomomi Toubai, Elisabeth Weisiger, Kelly Hugunin, Pavan Reddy and John E Wilkinson

    Citation: Journal of Translational Medicine 2008 6:10

    Content type: Research

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  15. Ovarian carcinoma is the leading cause of mortality among gynecological cancers in the world. The high mortality rate is associated with lack of early diagnosis and development of drug resistance. The antitumo...

    Authors: Anna Bratasz, Karuppaiyah Selvendiran, Tomasz Wasowicz, Andrey Bobko, Valery V Khramtsov, Louis J Ignarro and Periannan Kuppusamy

    Citation: Journal of Translational Medicine 2008 6:9

    Content type: Research

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  16. As for a consolidated tradition, the 5th annual meeting of the Italian Network for Cancer Biotherapy took place in the Certosa of Pontignano, a Tuscan monastery, on September 20–22, 2007. The congress gathered mo...

    Authors: Michele Maio, Hugues JM Nicolay, Paolo Ascierto, Filippo Belardelli, Roberto Camerini, Mario P Colombo, Paola Queirolo, Ruggero Ridolfi, Vincenzo Russo, Lucia Anzalone, Ester Fonsatti and Giorgio Parmiani

    Citation: Journal of Translational Medicine 2008 6:8

    Content type: Commentary

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  17. Human embryonic stem cells (hESCs) have been extensively discussed in public and scientific communities for their potential in treating diseases and injuries. However, not much has been achieved in turning the...

    Authors: Kaushik Dilip Deb and Kanchan Sarda

    Citation: Journal of Translational Medicine 2008 6:7

    Content type: Review

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  18. Sixteen melanoma patients (1 stage IIC, 8 stage III, and 7 stage IV) were treated in a Phase I study with a vaccine (DC/Apo-Nec) composed of autologous dendritic cells (DCs) loaded with a mixture of apoptotic/...

    Authors: Erika M von Euw, María M Barrio, David Furman, Estrella M Levy, Michele Bianchini, Isabelle Peguillet, Olivier Lantz, Alejandra Vellice, Abraham Kohan, Matías Chacón, Cassian Yee, Rosa Wainstok and José Mordoh

    Citation: Journal of Translational Medicine 2008 6:6

    Content type: Research

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  19. Among the challenges facing translational medicine today is the need for greater productivity and safety during the drug development process. To meet this need, practitioners of translational medicine are deve...

    Authors: C Gerald Curtis, Kevin Bilyard and Hugo Stephenson

    Citation: Journal of Translational Medicine 2008 6:5

    Content type: Commentary

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  20. The role of basic fibroblast growth factor (bFGF) in chemoresistance is controversial; some studies showed a relationship between higher bFGF level and chemoresistance while other studies showed the opposite f...

    Authors: Colin T Walsh, Yong Wei, M Guillaume Wientjes and Jessie LS Au

    Citation: Journal of Translational Medicine 2008 6:4

    Content type: Research

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  21. Because of its low toxicity, low-dose (LD) chemotherapy is ideally suited for combination with antiangiogenic drugs. We investigated the impact of tumor vascular endothelial growth factor A (VEGF-A) expression...

    Authors: David O Holtz, Robert T Krafty, Alisha Mohamed-Hadley, Lin Zhang, Ioannis Alagkiozidis, Benjamin Leiby, Wensheng Guo, Phyllis A Gimotty and George Coukos

    Citation: Journal of Translational Medicine 2008 6:2

    Content type: Research

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  22. Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in southern China. The China 1992 TNM staging system has been widely used for prognosis prediction of NPC patients in China. Although NPC p...

    Authors: Yu-Hong Li, Chun-Fang Hu, Qiong Shao, Ma-Yan Huang, Jing-Hui Hou, Dan Xie, Yi-Xin Zeng and Jian-Yong Shao

    Citation: Journal of Translational Medicine 2008 6:1

    Content type: Research

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  23. To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, -M1, and -T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer survivors (TCSs).

    Authors: Jan Oldenburg, Sigrid M Kraggerud, Marianne Brydøy, Milada Cvancarova, Ragnhild A Lothe and Sophie D Fossa

    Citation: Journal of Translational Medicine 2007 5:70

    Content type: Research

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  24. Native Factor V is an anticoagulant, but when activated by thrombin, Factor X or platelet proteases, it becomes a procoagulant. Due to these double properties, Factor V plays a crucial role in the regulation o...

    Authors: Biagio Di Micco, Marilena Lepretti, Lidia Rota, Ilaria Quaglia, Paola Ferrazzi, Gianluca Di Micco and Pierpaolo Di Micco

    Citation: Journal of Translational Medicine 2007 5:69

    Content type: Research

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  25. In patients with high grade glioma, little is known regarding existence of naturally occurring adaptive T cell reactivity against glioma-associated antigens (GAAs). In this report, we characterized GAA-specifi...

    Authors: Ryo Ueda, Keri L Low, Xinmei Zhu, Mitsugu Fujita, Kotaro Sasaki, Theresa L Whiteside, Lisa H Butterfield and Hideho Okada

    Citation: Journal of Translational Medicine 2007 5:68

    Content type: Research

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  26. The prognosis for malignant gliomas remains dismal. We addressed the safety, feasibility and preliminary clinical activity of the vaccinations using autologous glioma cells and interleukin (IL)-4 gene transfec...

    Authors: Hideho Okada, Frank S Lieberman, Kevin A Walter, L Dade Lunsford, Douglas S Kondziolka, Ghassan K Bejjani, Ronald L Hamilton, Alejandro Torres-Trejo, Pawel Kalinski, Quan Cai, Jennifer L Mabold, Howard D Edington, Lisa H Butterfield, Theresa L Whiteside, Douglas M Potter, S Clifford Schold Jr…

    Citation: Journal of Translational Medicine 2007 5:67

    Content type: Research

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  27. Pharmacokinetic advantages of intraperitoneal (IP) rhIL-12, tumor response to IP delivery of other cytokines as well as its potential anti-angiogenic effect provided the rationale for further evaluation of IPr...

    Authors: Renato Lenzi, Robert Edwards, Carl June, Michael V Seiden, Michael E Garcia, Michael Rosenblum and Ralph S Freedman

    Citation: Journal of Translational Medicine 2007 5:66

    Content type: Research

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  28. Interactions between mononuclear cells and activated pancreatic myofibroblasts (pancreatic stellate cells; PSC) may contribute to inflammation and fibrosis in chronic pancreatitis (CP).

    Authors: Christoph W Michalski, Andre Gorbachevski, Mert Erkan, Carolin Reiser, Stefanie Deucker, Frank Bergmann, Thomas Giese, Markus Weigand, Nathalia A Giese, Helmut Friess and Jörg Kleeff

    Citation: Journal of Translational Medicine 2007 5:63

    Content type: Research

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  29. Although systemic T-cell responses against tumor antigens and tumor infiltration by T cells have been investigated in colorectal cancer (CRC), the initiation of spontaneous immune responses in situ is not well un...

    Authors: Dirk Nagorsen, Sabine Voigt, Erika Berg, Harald Stein, Eckhard Thiel and Christoph Loddenkemper

    Citation: Journal of Translational Medicine 2007 5:62

    Content type: Research

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  30. Integrins are important adhesion molecules that regulate tumor and endothelial cell survival, proliferation and migration. The integrin α5β1 has been shown to play a critical role during angiogenesis. An inhib...

    Authors: Vinay Bhaskar, Dong Zhang, Melvin Fox, Pui Seto, Melanie HL Wong, Pauline E Wales, David Powers, Debra T Chao, Robert B DuBridge and Vanitha Ramakrishnan

    Citation: Journal of Translational Medicine 2007 5:61

    Content type: Research

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  31. An open-label Phase 1 study of recombinant prime-boost poxviruses targeting CEA and MUC-1 in patients with advanced pancreatic cancer was conducted to determine safety, tolerability and obtain preliminary data...

    Authors: Howard L Kaufman, Seunghee Kim-Schulze, Kelledy Manson, Gail DeRaffele, Josephine Mitcham, Kang Seok Seo, Dae Won Kim and John Marshall

    Citation: Journal of Translational Medicine 2007 5:60

    Content type: Research

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  32. A recent Keystone Symposium Meeting on "Immunological Intervention in Human Disease" was held in Big Sky, Montana on January, 6–11, 2007, organized by Jacques Banchereau, Federica Sallusto and Robert Coffman. ...

    Authors: Hideki Ueno, Catherine M Hawrylowicz and Jacques Banchereau

    Citation: Journal of Translational Medicine 2007 5:59

    Content type: Review

    Published on:

  33. Colon cancer is the second leading cause of cancer deaths in the western world. If detected early, colorectal cancer is one of the most treatable forms of cancer. Unfortunately, very few people are screened. N...

    Authors: Anuraag Shrivastav, Shailly Varma, Anurag Saxena, John DeCoteau and Rajendra K Sharma

    Citation: Journal of Translational Medicine 2007 5:58

    Content type: Research

    Published on:

  34. Angiogenesis is a critical component of the proliferative endometrial phase of the menstrual cycle. Thus, we hypothesized that a stem cell-like population exist and can be isolated from menstrual blood. Mononu...

    Authors: Xiaolong Meng, Thomas E Ichim, Jie Zhong, Andrea Rogers, Zhenglian Yin, James Jackson, Hao Wang, Wei Ge, Vladimir Bogin, Kyle W Chan, Bernard Thébaud and Neil H Riordan

    Citation: Journal of Translational Medicine 2007 5:57

    Content type: Research

    Published on:

  35. The mechanisms by which tumor-specific T cells induce regression of established metastases are not fully characterized. In using the poorly immunogenic B16BL6-D5 (D5) melanoma model we reported that T cell-med...

    Authors: Hauke Winter, Natasja K van den Engel, Dominik Rüttinger, Jürgen Schmidt, Matthias Schiller, Christian H Poehlein, Florian Löhe, Bernard A Fox, Karl-Walter Jauch, Rudolf A Hatz and Hong-Ming Hu

    Citation: Journal of Translational Medicine 2007 5:56

    Content type: Research

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  36. The stromal vascular fraction (SVF) is a heterogeneous cell population derived from the adipose tissue. There is still a lack of information concerning the characterization of the cell subpopulations constitut...

    Authors: Giuseppe Astori, Francesca Vignati, Silvana Bardelli, Monica Tubio, Mauro Gola, Veronica Albertini, Franco Bambi, Giancarlo Scali, Damiano Castelli, Valeria Rasini, Gianni Soldati and Tiziano Moccetti

    Citation: Journal of Translational Medicine 2007 5:55

    Content type: Research

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  37. Autologous mobilised peripheral blood stem cell (PBSC) transplantation is now a standard approach in the treatment of haematological diseases to reconstitute haematopoiesis following myeloablative chemotherapy...

    Authors: Olga Tura, G Robin Barclay, Huw Roddie, John Davies and Marc L Turner

    Citation: Journal of Translational Medicine 2007 5:53

    Content type: Research

    Published on:

  38. Despite numerous studies aimed at verifying the antitumor activity of nitric oxide-releasing nonsteroidal antiflammatory drugs (NO-NSAIDs), little is known about the molecular targets responsible for their ant...

    Authors: Anna Tesei, Marco Rosetti, Paola Ulivi, Francesco Fabbri, Laura Medri, Ivan Vannini, Manlio Bolla, Dino Amadori and Wainer Zoli

    Citation: Journal of Translational Medicine 2007 5:52

    Content type: Research

    Published on:

  39. Metastatic renal cell carcinoma (MRCC) has a poor prognosis with a median overall survival of about one year. Since only a minority of patients experienced therapeutic benefit to current treatments, several st...

    Authors: Michele Guida, Addolorata Casamassima, Giulia Monticelli, Michele Quaranta and Giuseppe Colucci

    Citation: Journal of Translational Medicine 2007 5:51

    Content type: Research

    Published on:

  40. Treatment options for patients with recurrent superficial bladder cancer are limited, necessitating aggressive exploration of new treatment strategies that effectively prevent recurrence and progression to inv...

    Authors: Michael T Buckley, Joanne Yoon, Herman Yee, Luis Chiriboga, Leonard Liebes, Gulshan Ara, Xiaozhong Qian, Dean F Bajorin, Tung-Tien Sun, Xue-Ru Wu and Iman Osman

    Citation: Journal of Translational Medicine 2007 5:49

    Content type: Research

    Published on:

  41. Electrochemotherapy (ECT) is a novel anticancer therapy that is currently being evaluated in human and pet cancer patients. ECT associates the administration of an anti-tumor agent to the delivery of trains of...

    Authors: Enrico P Spugnini, Feliciano Baldi, Pasquale Mellone, Florinda Feroce, Alfredo D'Avino, Francesco Bonetto, Bruno Vincenzi, Gennaro Citro and Alfonso Baldi

    Citation: Journal of Translational Medicine 2007 5:48

    Content type: Research

    Published on:

  42. Toxicogenomics can measure the expression of thousands of genes to identify changes associated with drug induced toxicities. It is expected that toxicogenomics can be an alternative or complementary approach i...

    Authors: Ying Jiang, David L Gerhold, Daniel J Holder, David J Figueroa, Wendy J Bailey, Ping Guan, Thomas R Skopek, Frank D Sistare and Joseph F Sina

    Citation: Journal of Translational Medicine 2007 5:47

    Content type: Research

    Published on:

  43. Dendritic cell (DC) vaccines can induce antitumor immune responses in patients with malignant diseases, while the most suitable DC culture conditions have not been established yet. In this study we compared mo...

    Authors: Mark Korthals, Nancy Safaian, Ralf Kronenwett, Dagmar Maihöfer, Matthias Schott, Claudia Papewalis, Elena Diaz Blanco, Meike Winter, Akos Czibere, Rainer Haas, Guido Kobbe and Roland Fenk

    Citation: Journal of Translational Medicine 2007 5:46

    Content type: Research

    Published on:

  44. Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder with monogenic mutations setting the stage for successful gene therapy treatment. We have completed a study that directly deals with the foll...

    Authors: Louise R Rodino-Klapac, Paul ML Janssen, Chrystal L Montgomery, Brian D Coley, Louis G Chicoine, K Reed Clark and Jerry R Mendell

    Citation: Journal of Translational Medicine 2007 5:45

    Content type: Research

    Published on:

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