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  1. Portal hypertension is a clinical syndrome that is difficult to study in an isolated manner since it is always associated with a greater or lesser degree of liver functional impairment. The aim of this review ...

    Authors: María-Angeles Aller, Jorge-Luis Arias and Jaime Arias

    Citation: Journal of Translational Medicine 2007 5:44

    Content type: Review

    Published on:

  2. Given the considerable toxicity and modest benefit of adjuvant chemotherapy for non-small cell lung cancer (NSCLC), there is clearly a need for new treatment modalities in the adjuvant setting. Active specific...

    Authors: Dominik Rüttinger, Natasja K van den Engel, Hauke Winter, Marcus Schlemmer, Heike Pohla, Stefanie Grützner, Beate Wagner, Dolores J Schendel, Bernard A Fox, K-W Jauch and Rudolf A Hatz

    Citation: Journal of Translational Medicine 2007 5:43

    Content type: Research

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  3. The HER2-inhibiting antibody trastuzumab, in combination with chemotherapy, significantly improves survival of women with resected, HER2-overexpressing breast cancers, but is associated with toxicities includi...

    Authors: Michael A Morse, Amy Hobeika, Takuya Osada, Donna Niedzwiecki, Paul Kelly Marcom, Kimberly L Blackwell, Carey Anders, Gayathri R Devi, H Kim Lyerly and Timothy M Clay

    Citation: Journal of Translational Medicine 2007 5:42

    Content type: Research

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  4. Sub-clinical variant Creutzfeldt-Jakob disease (vCJD) infection and reports of vCJD transmission through blood transfusion emphasise the need for blood screening assays to ensure the safety of blood and transp...

    Authors: Timothy J Fagge, G Robin Barclay, G Colin Stove, Gordon Stove, Michael J Robinson, Mark W Head, James W Ironside and Marc L Turner

    Citation: Journal of Translational Medicine 2007 5:41

    Content type: Research

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  5. In our endeavor to recognize outstanding contributions in the field of translational medicine, the Editorial Board of the Journal of Translational Medicine (JTM) in collaboration with Global Translational Medicin...

    Authors: Richard J Ablin and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2007 5:40

    Content type: Editorial

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  6. Experimental results from studies with inbred mice and their syngeneic tumors indicated that the inoculation of semi-allogeneic cell hybrids (derived from the fusion between syngeneic tumor cells and an alloge...

    Authors: Jin Yu, Mark S Kindy and Sebastiano Gattoni-Celli

    Citation: Journal of Translational Medicine 2007 5:39

    Content type: Research

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  7. Ocular melanoma is the leading intraocular malignancy. There is no effective treatment for metastatic ocular melanoma. We sought a treatment targeting the tumor microenvironment as well as the tumor cells.

    Authors: David P Mangiameli, Joseph A Blansfield, Stephan Kachala, Dominique Lorang, Peter H Schafer, George W Muller, David I Stirling and Steven K Libutti

    Citation: Journal of Translational Medicine 2007 5:38

    Content type: Research

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  8. The discovery of adult endothelial progenitor cells (EPC) offers potential for vascular regenerative therapies. The expression of CD34 and VEGFR2 by EPC indicates a close relationship with haematopoietic proge...

    Authors: Olga Tura, G Robin Barclay, Huw Roddie, John Davies and Marc L Turner

    Citation: Journal of Translational Medicine 2007 5:37

    Content type: Research

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  9. Bcl-3 as an oncoprotein is overexpressed in nasopharyngeal carcinoma (NPC). Nedd4 binding protein 2 (N4BP2), which is located in the NPC susceptibility locus, is a Bcl-3 binding protein. This study is aimed to...

    Authors: Mei-Zhen Zheng, Hai-De Qin, Xing-Juan Yu, Ru-Hua Zhang, Li-Zhen Chen, Qi-Sheng Feng and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2007 5:36

    Content type: Research

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  10. Tumor cell contamination of the apheresis in multiple myeloma is likely to affect disease-free and overall survival after autografting.

    Authors: Sara Deola, Samantha Scaramuzza, Roberto Sciarretta Birolo, Massimiliano Cergnul, Francesca Ficara, Jonathan Dando, Claudia Voena, Sergio Vai, Marta Monari, Enrico Pogliani, Gianmarco Corneo, Jacopo Peccatori, Silvia Selleri, Claudio Bordignon, Maria Grazia Roncarolo, Alessandro Aiuti…

    Citation: Journal of Translational Medicine 2007 5:35

    Content type: Research

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  11. High intensity focused ultrasound (HIFU) is an emerging non-invasive treatment modality for localized treatment of cancers. While current clinical strategies employ HIFU exclusively for thermal ablation of the...

    Authors: Zhenlin Hu, Xiao Yi Yang, Yunbo Liu, Georgy N Sankin, Eric C Pua, Michael A Morse, H Kim Lyerly, Timothy M Clay and Pei Zhong

    Citation: Journal of Translational Medicine 2007 5:34

    Content type: Research

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  12. Despite its widespread use to assess fibrosis, liver biopsy has several important drawbacks, including that is it semi-quantitative, invasive, and limited by sampling and observer variability. Non-invasive ser...

    Authors: Ian R White, Keyur Patel, William T Symonds, Anouk Dev, Philip Griffin, Nikos Tsokanas, Mark Skehel, Chiang Liu, Amany Zekry, Paul Cutler, Mahanandeeshwar Gattu, Don C Rockey, Michelle M Berrey and John G McHutchison

    Citation: Journal of Translational Medicine 2007 5:33

    Content type: Research

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  13. Sunitinib malate (SUTENT®) is an oral, multitargeted tyrosine kinase inhibitor, approved multinationally for the treatment of advanced RCC and of imatinib-resistant or – intolerant GIST. The purpose of this study...

    Authors: Samuel E DePrimo, Carlo L Bello, John Smeraglia, Charles M Baum, Dominic Spinella, Brian I Rini, M Dror Michaelson and Robert J Motzer

    Citation: Journal of Translational Medicine 2007 5:32

    Content type: Research

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  14. Medical implants often fail as a result of so-called foreign body reactions during which inflammatory cells are recruited to implant surfaces. Despite the clinical importance of this phenomenon, the mechanisms...

    Authors: Johann Zdolsek, John W Eaton and Liping Tang

    Citation: Journal of Translational Medicine 2007 5:31

    Content type: Research

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  15. Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions whose incidence is reaching epidemic proportions, afflicting approximately 1 in 166 children. Autistic disorder, or autism is the mo...

    Authors: Thomas E Ichim, Fabio Solano, Eduardo Glenn, Frank Morales, Leonard Smith, George Zabrecky and Neil H Riordan

    Citation: Journal of Translational Medicine 2007 5:30

    Content type: Review

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  16. The anti-tumor efficacy of human immune effector cells, such as cytolytic T lymphocytes (CTLs), has been difficult to study in lung cancer patients in the clinical setting. Improved experimental models for the...

    Authors: Ezogelin Oflazoglu, Mark Elliott, Hiroshi Takita, Soldano Ferrone, Robert A Henderson and Elizabeth A Repasky

    Citation: Journal of Translational Medicine 2007 5:29

    Content type: Research

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  17. Plant lectins such as Galanthus nivalis agglutinin (GNA) and Hippeastrum hybrid agglutinin (HHA) are natural proteins able to link mannose residues, and therefore inhibit HIV-target cell interactions. Plant lecti...

    Authors: Hela Saïdi, Nadine Nasreddine, Mohammad-Ali Jenabian, Maxime Lecerf, Dominique Schols, Corinne Krief, Jan Balzarini and Laurent Bélec

    Citation: Journal of Translational Medicine 2007 5:28

    Content type: Research

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  18. Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease.

    Authors: Francesca Chamian, Shao-Lee Lin, Edmund Lee, Toyoko Kikuchi, Patricia Gilleaudeau, Mary Sullivan-Whalen, Irma Cardinale, Artemis Khatcherian, Inna Novitskaya, Knut M Wittkowski, James G Krueger and Michelle A Lowes

    Citation: Journal of Translational Medicine 2007 5:27

    Content type: Research

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  19. The incidence of cancer increases significantly in later life, yet few pre-clinical studies of cancer immunotherapy use mice of advanced age. A novel vaccine delivery platform (VacciMax®,VM) is described that enc...

    Authors: Pirouz M Daftarian, Marc Mansour, Bill Pohajdak, Antar Fuentes-Ortega, Ella Korets-Smith, Lisa MacDonald, Genevieve Weir, Robert G Brown and W Martin Kast

    Citation: Journal of Translational Medicine 2007 5:26

    Content type: Research

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  20. Although the risk of transfusion-transmitted infections today is lower than ever, the supply of safe blood products remains subject to contamination with known and yet to be identified human pathogens. Only co...

    Authors: Florian Bihl, Damiano Castelli, Francesco Marincola, Roger Y Dodd and Christian Brander

    Citation: Journal of Translational Medicine 2007 5:25

    Content type: Review

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  21. Chronic lymphocytic leukemia (CLL) is characterized by accumulation of mature appearing lymphocytes and is rarely complicated by thrombosis. One possible explanation for the paucity of thrombotic events in the...

    Authors: Dianne Pulte, Kim E Olson, M Johan Broekman, Naziba Islam, Harold S Ballard, Richard R Furman, Ashley E Olson and Aaron J Marcus

    Citation: Journal of Translational Medicine 2007 5:23

    Content type: Research

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  22. The high prevalence of nasopharyngeal cancer (NPC) in Southern Asia and Mediterranean Northern Africa suggests genetic predisposition among other factors. While Human Leukocyte Antigen (HLA) haplotypes have be...

    Authors: Xin Li, Nahla Ghandri, Daniela Piancatelli, Sharon Adams, Deborah Chen, Fu-Meei Robbins, Ena Wang, Alessandro Monaco, Silvia Selleri, Noureddine Bouaouina, David Stroncek, Domenico Adorno, Lotfi Chouchane and Francesco M Marincola

    Citation: Journal of Translational Medicine 2007 5:22

    Content type: Research

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  23. Melanoma tumors are known to express antigens that usually induce weak immune responses of short duration. Expression of both tumor-associated antigens p53 and TRP2 by melanoma cells raises the possibility of ...

    Authors: Marc Mansour, Bill Pohajdak, W Martin Kast, Antar Fuentes-Ortega, Ella Korets-Smith, Genevieve M Weir, Robert G Brown and Pirouz Daftarian

    Citation: Journal of Translational Medicine 2007 5:20

    Content type: Research

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  24. In the present study, we demonstrate, in rigorous fashion, that human monocyte-derived immature dendritic cells (DCs) can efficiently cross-present tumor-associated antigens when co-cultured with a mixture of ...

    Authors: Erika M von Euw, María M Barrio, David Furman, Michele Bianchini, Estrella M Levy, Cassian Yee, Yongqing Li, Rosa Wainstok and José Mordoh

    Citation: Journal of Translational Medicine 2007 5:19

    Content type: Research

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  25. For optimal T cell activation it is desirable that dendritic cells (DCs) display peptides within MHC molecules as signal 1, costimulatory molecules as signal 2 and, in addition, produce IL-12p70 as signal 3. I...

    Authors: Anke Zobywalski, Miran Javorovic, Bernhard Frankenberger, Heike Pohla, Elisabeth Kremmer, Iris Bigalke and Dolores J Schendel

    Citation: Journal of Translational Medicine 2007 5:18

    Content type: Research

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  26. Adoptive immune and vaccine therapies have been used to prevent cytomegalovirus (CMV) disease in recipients of hematopoietic progenitor cell transplants, but the nature of T cell responses to CMV have not been...

    Authors: Stefanie L Slezak, Maria Bettinotti, Silvia Selleri, Sharon Adams, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2007 5:17

    Content type: Research

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  27. Dendritic cells (DC) pulsed with tumor-derived antigenic material have widely been used in antitumor vaccination protocols. However, the optimal strategy of DC loading has not yet been established. Our aim was...

    Authors: Christian Adam, Josef Mysliwietz and Ralph Mocikat

    Citation: Journal of Translational Medicine 2007 5:16

    Content type: Research

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  28. Treatment records and follow-up data on 40 patients with primary and metastatic liver malignancies who underwent a single whole-liver treatment with Y-90 resin microspheres (SIR-Spheres® Sirtex Medical, Lake Fore...

    Authors: Seza A Gulec, Geraldine Mesoloras, William A Dezarn, Patrick McNeillie and Andrew S Kennedy

    Citation: Journal of Translational Medicine 2007 5:15

    Content type: Research

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  29. Previously, we reported that adoptively transferred perforin k/o (PKO), and IFN-γ k/o (GKO), or perforin/IFN-γ double k/o (PKO/GKO) effector T cells mediated regression of B16BL6-D5 (D5) pulmonary metastases a...

    Authors: Hauke Winter, Natasja K van den Engel, Christian H Poehlein, Rudolf A Hatz, Bernard A Fox and Hong-Ming Hu

    Citation: Journal of Translational Medicine 2007 5:14

    Content type: Research

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  30. With the present study we introduce a novel and simple biomaterial able to induce regeneration of bone. We theorized that nourishing a bone defect with calcium and with a large amount of activated platelets ma...

    Authors: Giuseppe Intini, Sebastiano Andreana, Francesco E Intini, Robert J Buhite and Libuse A Bobek

    Citation: Journal of Translational Medicine 2007 5:13

    Content type: Research

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  31. Telomerase, a reverse transcriptase primarily devoted to the elongation of telomeres in mammalian cells, is also the first bona fide common tumor antigen. In fact, telomerase is over-expressed in > 85% of tumo...

    Authors: Xochtil Cortez-Gonzalez and Maurizio Zanetti

    Citation: Journal of Translational Medicine 2007 5:12

    Content type: Review

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  32. Although the sequence of events leading to wound repair has been described at the cellular and, to a limited extent, at the protein level this process has yet to be fully elucidated. Genome wide transcriptiona...

    Authors: Kavita Deonarine, Monica C Panelli, Mitchell E Stashower, Ping Jin, Kina Smith, Herbert B Slade, Christopher Norwood, Ena Wang, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2007 5:11

    Content type: Research

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  33. Toll-like receptor (TLR)3 ligands serve as natural inducers of pro-inflammatory cytokines capable of promoting Type-1 adaptive immunity, and TLR3 is abundantly expressed by cells within the central nervous sys...

    Authors: Xinmei Zhu, Fumihiko Nishimura, Kotaro Sasaki, Mitsugu Fujita, Jill E Dusak, Junichi Eguchi, Wendy Fellows-Mayle, Walter J Storkus, Paul R Walker, Andres M Salazar and Hideho Okada

    Citation: Journal of Translational Medicine 2007 5:10

    Content type: Research

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  34. As part of the Houston Vanguard study, a subset of 10 patients randomized to receive IL-2 therapy were compared to 4 patients randomized to not receive IL-2, for markers of T cell activation and death during t...

    Authors: Dorothy E Lewis, Kimber L Gross, Martine M Diez, Maria L Martinez, Helen N Lukefahr, Claudia A Kozinetz and Roberto C Arduino

    Citation: Journal of Translational Medicine 2007 5:9

    Content type: Research

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  35. Cord blood is currently used as an alternative to bone marrow as a source of stem cells for hematopoietic reconstitution after ablation. It is also under intense preclinical investigation for a variety of indi...

    Authors: Neil H Riordan, Kyle Chan, Annette M Marleau and Thomas E Ichim

    Citation: Journal of Translational Medicine 2007 5:8

    Content type: Review

    Published on:

  36. The objective of this study was to identify the molecular processes responsible for the anti-lesional activity of imiquimod in subjects with actinic keratosis using global gene expression profiling.

    Authors: Abel Torres, Leslie Storey, Makala Anders, Richard L Miller, Barbara J Bulbulian, Jizhong Jin, Shalini Raghavan, James Lee, Herbert B Slade and Woubalem Birmachu

    Citation: Journal of Translational Medicine 2007 5:7

    Content type: Research

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  37. XIAP up-regulation is associated with chemotherapy resistance. Phenoxodiol causes XIAP degradation and chemotherapy sensitization in ovarian cancer. Here we assessed XIAP expression in melanomas, using tissue ...

    Authors: Harriet M Kluger, Mary M McCarthy, Ayesha B Alvero, Mario Sznol, Stephan Ariyan, Robert L Camp, David L Rimm and Gil Mor

    Citation: Journal of Translational Medicine 2007 5:6

    Content type: Research

    Published on:

  38. Previously, we have successfully targeted the mannose receptor (MR) expressed on monocyte-derived dendritic cells (DCs) using a fully human MR-specific antibody, B11, as a vehicle to deliver whole protein tumo...

    Authors: Venky Ramakrishna, John P Vasilakos, Joseph D Tario Jr, Marc A Berger, Paul K Wallace and Tibor Keler

    Citation: Journal of Translational Medicine 2007 5:5

    Content type: Research

    Published on:

  39. The potent clinical responses seen in patients with chronic myeloid leukemia (CML) after administration of donor-specific lymphocytes, as well as the correlation between the presence of antigen specific T cell...

    Authors: Annette M Marleau, Jeffrey H Lipton, Neil H Riordan and Thomas E Ichim

    Citation: Journal of Translational Medicine 2007 5:4

    Content type: Review

    Published on:

  40. Despite advances in our cellular and molecular knowledge, hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. It is now known to be highly heterogeneous: it enc...

    Authors: Fabio Grizzi, Barbara Franceschini, Cody Hamrick, Eldo E Frezza, Everardo Cobos and Maurizio Chiriva-Internati

    Citation: Journal of Translational Medicine 2007 5:3

    Content type: Review

    Published on:

  41. Overexpression of Neutral Endopeptidase (NEP) has been reported in metastatic carcinomas, implicating NEP in tumor progression and suggesting a role for NEP inhibitors in its treatment. We investigated the rol...

    Authors: Elsa F Velazquez, Molly Yancovitz, Anna Pavlick, Russell Berman, Richard Shapiro, Dusan Bogunovic, David O'Neill, Yi-Lo Yu, Joanna Spira, Paul J Christos, Xi Kathy Zhou, Madhu Mazumdar, David M Nanus, Leonard Liebes, Nina Bhardwaj, David Polsky…

    Citation: Journal of Translational Medicine 2007 5:2

    Content type: Research

    Published on:

  42. While insulin replacement remains the cornerstone treatment for type I diabetes mellitus (T1DM), the transplantation of pancreatic islets of Langerhans has the potential to become an important alternative. And...

    Authors: Jiaqiang Ren, Ping Jin, Ena Wang, Eric Liu, David M Harlan, Xin Li and David F Stroncek

    Citation: Journal of Translational Medicine 2007 5:1

    Content type: Review

    Published on:

  43. DNA hypermethylation and histone deacetylation are epigenetic events that contribute to the absence or downregulated expression of different components of the tumor recognition complex. These events affect the...

    Authors: María de Lourdes Mora-García, Alfonso Duenas-González, Jorge Hernández-Montes, Erick De la Cruz-Hernández, Enrique Pérez-Cárdenas, Benny Weiss-Steider, Edelmiro Santiago-Osorio, Vianney Francisco Ortíz-Navarrete, Víctor Hugo Rosales, David Cantú, Marcela Lizano-Soberón, Martha Patricia Rojo-Aguilar and Alberto Monroy-García

    Citation: Journal of Translational Medicine 2006 4:55

    Content type: Research

    Published on:

  44. This study explores the psychological, socio-cultural and economic consequences of infertility on couples' life. The purpose of this research is to improve knowledge about the potentially serious implications ...

    Authors: Nicole J Wiersema, Anouck J Drukker, Mai Ba Tien Dung, Giang Huynh Nhu, Nguyen Thanh Nhu and Cornelis B Lambalk

    Citation: Journal of Translational Medicine 2006 4:54

    Content type: Research

    Published on:

  45. Limb-girdle muscular dystrophy (LGMD) is a group of heterogeneous muscular disorders with autosomal dominant and recessive inheritance, in which the pelvic or shoulder girdle musculature is predominantly or pr...

    Authors: Yong Zhang, Jianwei Ye, Dazhi Chen, Xinyi Zhao, Xingjun Xiao, Sheng Tai, Wei Yang and Dahai Zhu

    Citation: Journal of Translational Medicine 2006 4:53

    Content type: Research

    Published on:

  46. The immune system spontaneously responds to tumor-associated antigens in peripheral blood of colorectal cancer (CRC) patients. Regulatory T cells (Treg) are suspected of influencing the interaction between the...

    Authors: Christoph Loddenkemper, Martin Schernus, Michel Noutsias, Harald Stein, Eckhard Thiel and Dirk Nagorsen

    Citation: Journal of Translational Medicine 2006 4:52

    Content type: Research

    Published on:

  47. Current clinical and histopathological criteria used to define the prognosis of melanoma patients are inadequate for accurate prediction of clinical outcome. We investigated whether genome screening by means o...

    Authors: Susanna Mandruzzato, Andrea Callegaro, Gianluca Turcatel, Samuela Francescato, Maria C Montesco, Vanna Chiarion-Sileni, Simone Mocellin, Carlo R Rossi, Silvio Bicciato, Ena Wang, Francesco M Marincola and Paola Zanovello

    Citation: Journal of Translational Medicine 2006 4:50

    Content type: Research

    Published on:

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