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Page 71 of 75

  1. Content type: Research

    Metastatic renal cell carcinoma (MRCC) has a poor prognosis with a median overall survival of about one year. Since only a minority of patients experienced therapeutic benefit to current treatments, several st...

    Authors: Michele Guida, Addolorata Casamassima, Giulia Monticelli, Michele Quaranta and Giuseppe Colucci

    Citation: Journal of Translational Medicine 2007 5:51

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  2. Content type: Research

    Treatment options for patients with recurrent superficial bladder cancer are limited, necessitating aggressive exploration of new treatment strategies that effectively prevent recurrence and progression to inv...

    Authors: Michael T Buckley, Joanne Yoon, Herman Yee, Luis Chiriboga, Leonard Liebes, Gulshan Ara, Xiaozhong Qian, Dean F Bajorin, Tung-Tien Sun, Xue-Ru Wu and Iman Osman

    Citation: Journal of Translational Medicine 2007 5:49

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  3. Content type: Research

    Electrochemotherapy (ECT) is a novel anticancer therapy that is currently being evaluated in human and pet cancer patients. ECT associates the administration of an anti-tumor agent to the delivery of trains of...

    Authors: Enrico P Spugnini, Feliciano Baldi, Pasquale Mellone, Florinda Feroce, Alfredo D'Avino, Francesco Bonetto, Bruno Vincenzi, Gennaro Citro and Alfonso Baldi

    Citation: Journal of Translational Medicine 2007 5:48

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  4. Content type: Research

    Toxicogenomics can measure the expression of thousands of genes to identify changes associated with drug induced toxicities. It is expected that toxicogenomics can be an alternative or complementary approach i...

    Authors: Ying Jiang, David L Gerhold, Daniel J Holder, David J Figueroa, Wendy J Bailey, Ping Guan, Thomas R Skopek, Frank D Sistare and Joseph F Sina

    Citation: Journal of Translational Medicine 2007 5:47

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  5. Content type: Research

    Dendritic cell (DC) vaccines can induce antitumor immune responses in patients with malignant diseases, while the most suitable DC culture conditions have not been established yet. In this study we compared mo...

    Authors: Mark Korthals, Nancy Safaian, Ralf Kronenwett, Dagmar Maihöfer, Matthias Schott, Claudia Papewalis, Elena Diaz Blanco, Meike Winter, Akos Czibere, Rainer Haas, Guido Kobbe and Roland Fenk

    Citation: Journal of Translational Medicine 2007 5:46

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  6. Content type: Research

    Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder with monogenic mutations setting the stage for successful gene therapy treatment. We have completed a study that directly deals with the foll...

    Authors: Louise R Rodino-Klapac, Paul ML Janssen, Chrystal L Montgomery, Brian D Coley, Louis G Chicoine, K Reed Clark and Jerry R Mendell

    Citation: Journal of Translational Medicine 2007 5:45

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  7. Content type: Review

    Portal hypertension is a clinical syndrome that is difficult to study in an isolated manner since it is always associated with a greater or lesser degree of liver functional impairment. The aim of this review ...

    Authors: María-Angeles Aller, Jorge-Luis Arias and Jaime Arias

    Citation: Journal of Translational Medicine 2007 5:44

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  8. Content type: Research

    Given the considerable toxicity and modest benefit of adjuvant chemotherapy for non-small cell lung cancer (NSCLC), there is clearly a need for new treatment modalities in the adjuvant setting. Active specific...

    Authors: Dominik Rüttinger, Natasja K van den Engel, Hauke Winter, Marcus Schlemmer, Heike Pohla, Stefanie Grützner, Beate Wagner, Dolores J Schendel, Bernard A Fox, K-W Jauch and Rudolf A Hatz

    Citation: Journal of Translational Medicine 2007 5:43

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  9. Content type: Research

    The HER2-inhibiting antibody trastuzumab, in combination with chemotherapy, significantly improves survival of women with resected, HER2-overexpressing breast cancers, but is associated with toxicities includi...

    Authors: Michael A Morse, Amy Hobeika, Takuya Osada, Donna Niedzwiecki, Paul Kelly Marcom, Kimberly L Blackwell, Carey Anders, Gayathri R Devi, H Kim Lyerly and Timothy M Clay

    Citation: Journal of Translational Medicine 2007 5:42

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  10. Content type: Research

    Sub-clinical variant Creutzfeldt-Jakob disease (vCJD) infection and reports of vCJD transmission through blood transfusion emphasise the need for blood screening assays to ensure the safety of blood and transp...

    Authors: Timothy J Fagge, G Robin Barclay, G Colin Stove, Gordon Stove, Michael J Robinson, Mark W Head, James W Ironside and Marc L Turner

    Citation: Journal of Translational Medicine 2007 5:41

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  11. Content type: Editorial

    In our endeavor to recognize outstanding contributions in the field of translational medicine, the Editorial Board of the Journal of Translational Medicine (JTM) in collaboration with Global Translational Medicin...

    Authors: Richard J Ablin and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2007 5:40

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  12. Content type: Research

    Experimental results from studies with inbred mice and their syngeneic tumors indicated that the inoculation of semi-allogeneic cell hybrids (derived from the fusion between syngeneic tumor cells and an alloge...

    Authors: Jin Yu, Mark S Kindy and Sebastiano Gattoni-Celli

    Citation: Journal of Translational Medicine 2007 5:39

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  13. Content type: Research

    Ocular melanoma is the leading intraocular malignancy. There is no effective treatment for metastatic ocular melanoma. We sought a treatment targeting the tumor microenvironment as well as the tumor cells.

    Authors: David P Mangiameli, Joseph A Blansfield, Stephan Kachala, Dominique Lorang, Peter H Schafer, George W Muller, David I Stirling and Steven K Libutti

    Citation: Journal of Translational Medicine 2007 5:38

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  14. Content type: Research

    The discovery of adult endothelial progenitor cells (EPC) offers potential for vascular regenerative therapies. The expression of CD34 and VEGFR2 by EPC indicates a close relationship with haematopoietic proge...

    Authors: Olga Tura, G Robin Barclay, Huw Roddie, John Davies and Marc L Turner

    Citation: Journal of Translational Medicine 2007 5:37

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  15. Content type: Research

    Bcl-3 as an oncoprotein is overexpressed in nasopharyngeal carcinoma (NPC). Nedd4 binding protein 2 (N4BP2), which is located in the NPC susceptibility locus, is a Bcl-3 binding protein. This study is aimed to...

    Authors: Mei-Zhen Zheng, Hai-De Qin, Xing-Juan Yu, Ru-Hua Zhang, Li-Zhen Chen, Qi-Sheng Feng and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2007 5:36

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  16. Content type: Research

    Tumor cell contamination of the apheresis in multiple myeloma is likely to affect disease-free and overall survival after autografting.

    Authors: Sara Deola, Samantha Scaramuzza, Roberto Sciarretta Birolo, Massimiliano Cergnul, Francesca Ficara, Jonathan Dando, Claudia Voena, Sergio Vai, Marta Monari, Enrico Pogliani, Gianmarco Corneo, Jacopo Peccatori, Silvia Selleri, Claudio Bordignon, Maria Grazia Roncarolo, Alessandro Aiuti…

    Citation: Journal of Translational Medicine 2007 5:35

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  17. Content type: Research

    High intensity focused ultrasound (HIFU) is an emerging non-invasive treatment modality for localized treatment of cancers. While current clinical strategies employ HIFU exclusively for thermal ablation of the...

    Authors: Zhenlin Hu, Xiao Yi Yang, Yunbo Liu, Georgy N Sankin, Eric C Pua, Michael A Morse, H Kim Lyerly, Timothy M Clay and Pei Zhong

    Citation: Journal of Translational Medicine 2007 5:34

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  18. Content type: Research

    Despite its widespread use to assess fibrosis, liver biopsy has several important drawbacks, including that is it semi-quantitative, invasive, and limited by sampling and observer variability. Non-invasive ser...

    Authors: Ian R White, Keyur Patel, William T Symonds, Anouk Dev, Philip Griffin, Nikos Tsokanas, Mark Skehel, Chiang Liu, Amany Zekry, Paul Cutler, Mahanandeeshwar Gattu, Don C Rockey, Michelle M Berrey and John G McHutchison

    Citation: Journal of Translational Medicine 2007 5:33

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  19. Content type: Research

    Sunitinib malate (SUTENT®) is an oral, multitargeted tyrosine kinase inhibitor, approved multinationally for the treatment of advanced RCC and of imatinib-resistant or – intolerant GIST. The purpose of this study...

    Authors: Samuel E DePrimo, Carlo L Bello, John Smeraglia, Charles M Baum, Dominic Spinella, Brian I Rini, M Dror Michaelson and Robert J Motzer

    Citation: Journal of Translational Medicine 2007 5:32

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  20. Content type: Research

    Medical implants often fail as a result of so-called foreign body reactions during which inflammatory cells are recruited to implant surfaces. Despite the clinical importance of this phenomenon, the mechanisms...

    Authors: Johann Zdolsek, John W Eaton and Liping Tang

    Citation: Journal of Translational Medicine 2007 5:31

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  21. Content type: Review

    Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions whose incidence is reaching epidemic proportions, afflicting approximately 1 in 166 children. Autistic disorder, or autism is the mo...

    Authors: Thomas E Ichim, Fabio Solano, Eduardo Glenn, Frank Morales, Leonard Smith, George Zabrecky and Neil H Riordan

    Citation: Journal of Translational Medicine 2007 5:30

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  22. Content type: Research

    The anti-tumor efficacy of human immune effector cells, such as cytolytic T lymphocytes (CTLs), has been difficult to study in lung cancer patients in the clinical setting. Improved experimental models for the...

    Authors: Ezogelin Oflazoglu, Mark Elliott, Hiroshi Takita, Soldano Ferrone, Robert A Henderson and Elizabeth A Repasky

    Citation: Journal of Translational Medicine 2007 5:29

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  23. Content type: Research

    Plant lectins such as Galanthus nivalis agglutinin (GNA) and Hippeastrum hybrid agglutinin (HHA) are natural proteins able to link mannose residues, and therefore inhibit HIV-target cell interactions. Plant lecti...

    Authors: Hela Saïdi, Nadine Nasreddine, Mohammad-Ali Jenabian, Maxime Lecerf, Dominique Schols, Corinne Krief, Jan Balzarini and Laurent Bélec

    Citation: Journal of Translational Medicine 2007 5:28

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  24. Content type: Research

    Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease.

    Authors: Francesca Chamian, Shao-Lee Lin, Edmund Lee, Toyoko Kikuchi, Patricia Gilleaudeau, Mary Sullivan-Whalen, Irma Cardinale, Artemis Khatcherian, Inna Novitskaya, Knut M Wittkowski, James G Krueger and Michelle A Lowes

    Citation: Journal of Translational Medicine 2007 5:27

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  25. Content type: Research

    The incidence of cancer increases significantly in later life, yet few pre-clinical studies of cancer immunotherapy use mice of advanced age. A novel vaccine delivery platform (VacciMax®,VM) is described that enc...

    Authors: Pirouz M Daftarian, Marc Mansour, Bill Pohajdak, Antar Fuentes-Ortega, Ella Korets-Smith, Lisa MacDonald, Genevieve Weir, Robert G Brown and W Martin Kast

    Citation: Journal of Translational Medicine 2007 5:26

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  26. Content type: Review

    Although the risk of transfusion-transmitted infections today is lower than ever, the supply of safe blood products remains subject to contamination with known and yet to be identified human pathogens. Only co...

    Authors: Florian Bihl, Damiano Castelli, Francesco Marincola, Roger Y Dodd and Christian Brander

    Citation: Journal of Translational Medicine 2007 5:25

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  27. Content type: Research

    Chronic lymphocytic leukemia (CLL) is characterized by accumulation of mature appearing lymphocytes and is rarely complicated by thrombosis. One possible explanation for the paucity of thrombotic events in the...

    Authors: Dianne Pulte, Kim E Olson, M Johan Broekman, Naziba Islam, Harold S Ballard, Richard R Furman, Ashley E Olson and Aaron J Marcus

    Citation: Journal of Translational Medicine 2007 5:23

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  28. Content type: Research

    The high prevalence of nasopharyngeal cancer (NPC) in Southern Asia and Mediterranean Northern Africa suggests genetic predisposition among other factors. While Human Leukocyte Antigen (HLA) haplotypes have be...

    Authors: Xin Li, Nahla Ghandri, Daniela Piancatelli, Sharon Adams, Deborah Chen, Fu-Meei Robbins, Ena Wang, Alessandro Monaco, Silvia Selleri, Noureddine Bouaouina, David Stroncek, Domenico Adorno, Lotfi Chouchane and Francesco M Marincola

    Citation: Journal of Translational Medicine 2007 5:22

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  29. Content type: Research

    Melanoma tumors are known to express antigens that usually induce weak immune responses of short duration. Expression of both tumor-associated antigens p53 and TRP2 by melanoma cells raises the possibility of ...

    Authors: Marc Mansour, Bill Pohajdak, W Martin Kast, Antar Fuentes-Ortega, Ella Korets-Smith, Genevieve M Weir, Robert G Brown and Pirouz Daftarian

    Citation: Journal of Translational Medicine 2007 5:20

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  30. Content type: Research

    In the present study, we demonstrate, in rigorous fashion, that human monocyte-derived immature dendritic cells (DCs) can efficiently cross-present tumor-associated antigens when co-cultured with a mixture of ...

    Authors: Erika M von Euw, María M Barrio, David Furman, Michele Bianchini, Estrella M Levy, Cassian Yee, Yongqing Li, Rosa Wainstok and José Mordoh

    Citation: Journal of Translational Medicine 2007 5:19

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  31. Content type: Research

    For optimal T cell activation it is desirable that dendritic cells (DCs) display peptides within MHC molecules as signal 1, costimulatory molecules as signal 2 and, in addition, produce IL-12p70 as signal 3. I...

    Authors: Anke Zobywalski, Miran Javorovic, Bernhard Frankenberger, Heike Pohla, Elisabeth Kremmer, Iris Bigalke and Dolores J Schendel

    Citation: Journal of Translational Medicine 2007 5:18

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  32. Content type: Research

    Adoptive immune and vaccine therapies have been used to prevent cytomegalovirus (CMV) disease in recipients of hematopoietic progenitor cell transplants, but the nature of T cell responses to CMV have not been...

    Authors: Stefanie L Slezak, Maria Bettinotti, Silvia Selleri, Sharon Adams, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2007 5:17

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  33. Content type: Research

    Dendritic cells (DC) pulsed with tumor-derived antigenic material have widely been used in antitumor vaccination protocols. However, the optimal strategy of DC loading has not yet been established. Our aim was...

    Authors: Christian Adam, Josef Mysliwietz and Ralph Mocikat

    Citation: Journal of Translational Medicine 2007 5:16

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  34. Content type: Research

    Treatment records and follow-up data on 40 patients with primary and metastatic liver malignancies who underwent a single whole-liver treatment with Y-90 resin microspheres (SIR-Spheres® Sirtex Medical, Lake Fore...

    Authors: Seza A Gulec, Geraldine Mesoloras, William A Dezarn, Patrick McNeillie and Andrew S Kennedy

    Citation: Journal of Translational Medicine 2007 5:15

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  35. Content type: Research

    Previously, we reported that adoptively transferred perforin k/o (PKO), and IFN-γ k/o (GKO), or perforin/IFN-γ double k/o (PKO/GKO) effector T cells mediated regression of B16BL6-D5 (D5) pulmonary metastases a...

    Authors: Hauke Winter, Natasja K van den Engel, Christian H Poehlein, Rudolf A Hatz, Bernard A Fox and Hong-Ming Hu

    Citation: Journal of Translational Medicine 2007 5:14

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  36. Content type: Research

    With the present study we introduce a novel and simple biomaterial able to induce regeneration of bone. We theorized that nourishing a bone defect with calcium and with a large amount of activated platelets ma...

    Authors: Giuseppe Intini, Sebastiano Andreana, Francesco E Intini, Robert J Buhite and Libuse A Bobek

    Citation: Journal of Translational Medicine 2007 5:13

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  37. Content type: Review

    Telomerase, a reverse transcriptase primarily devoted to the elongation of telomeres in mammalian cells, is also the first bona fide common tumor antigen. In fact, telomerase is over-expressed in > 85% of tumo...

    Authors: Xochtil Cortez-Gonzalez and Maurizio Zanetti

    Citation: Journal of Translational Medicine 2007 5:12

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  38. Content type: Research

    Although the sequence of events leading to wound repair has been described at the cellular and, to a limited extent, at the protein level this process has yet to be fully elucidated. Genome wide transcriptiona...

    Authors: Kavita Deonarine, Monica C Panelli, Mitchell E Stashower, Ping Jin, Kina Smith, Herbert B Slade, Christopher Norwood, Ena Wang, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2007 5:11

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  39. Content type: Research

    Toll-like receptor (TLR)3 ligands serve as natural inducers of pro-inflammatory cytokines capable of promoting Type-1 adaptive immunity, and TLR3 is abundantly expressed by cells within the central nervous sys...

    Authors: Xinmei Zhu, Fumihiko Nishimura, Kotaro Sasaki, Mitsugu Fujita, Jill E Dusak, Junichi Eguchi, Wendy Fellows-Mayle, Walter J Storkus, Paul R Walker, Andres M Salazar and Hideho Okada

    Citation: Journal of Translational Medicine 2007 5:10

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  40. Content type: Research

    As part of the Houston Vanguard study, a subset of 10 patients randomized to receive IL-2 therapy were compared to 4 patients randomized to not receive IL-2, for markers of T cell activation and death during t...

    Authors: Dorothy E Lewis, Kimber L Gross, Martine M Diez, Maria L Martinez, Helen N Lukefahr, Claudia A Kozinetz and Roberto C Arduino

    Citation: Journal of Translational Medicine 2007 5:9

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  41. Content type: Review

    Cord blood is currently used as an alternative to bone marrow as a source of stem cells for hematopoietic reconstitution after ablation. It is also under intense preclinical investigation for a variety of indi...

    Authors: Neil H Riordan, Kyle Chan, Annette M Marleau and Thomas E Ichim

    Citation: Journal of Translational Medicine 2007 5:8

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  42. Content type: Research

    The objective of this study was to identify the molecular processes responsible for the anti-lesional activity of imiquimod in subjects with actinic keratosis using global gene expression profiling.

    Authors: Abel Torres, Leslie Storey, Makala Anders, Richard L Miller, Barbara J Bulbulian, Jizhong Jin, Shalini Raghavan, James Lee, Herbert B Slade and Woubalem Birmachu

    Citation: Journal of Translational Medicine 2007 5:7

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  43. Content type: Research

    XIAP up-regulation is associated with chemotherapy resistance. Phenoxodiol causes XIAP degradation and chemotherapy sensitization in ovarian cancer. Here we assessed XIAP expression in melanomas, using tissue ...

    Authors: Harriet M Kluger, Mary M McCarthy, Ayesha B Alvero, Mario Sznol, Stephan Ariyan, Robert L Camp, David L Rimm and Gil Mor

    Citation: Journal of Translational Medicine 2007 5:6

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  44. Content type: Research

    Previously, we have successfully targeted the mannose receptor (MR) expressed on monocyte-derived dendritic cells (DCs) using a fully human MR-specific antibody, B11, as a vehicle to deliver whole protein tumo...

    Authors: Venky Ramakrishna, John P Vasilakos, Joseph D Tario Jr, Marc A Berger, Paul K Wallace and Tibor Keler

    Citation: Journal of Translational Medicine 2007 5:5

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  45. Content type: Review

    The potent clinical responses seen in patients with chronic myeloid leukemia (CML) after administration of donor-specific lymphocytes, as well as the correlation between the presence of antigen specific T cell...

    Authors: Annette M Marleau, Jeffrey H Lipton, Neil H Riordan and Thomas E Ichim

    Citation: Journal of Translational Medicine 2007 5:4

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  46. Content type: Review

    Despite advances in our cellular and molecular knowledge, hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. It is now known to be highly heterogeneous: it enc...

    Authors: Fabio Grizzi, Barbara Franceschini, Cody Hamrick, Eldo E Frezza, Everardo Cobos and Maurizio Chiriva-Internati

    Citation: Journal of Translational Medicine 2007 5:3

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  47. Content type: Research

    Overexpression of Neutral Endopeptidase (NEP) has been reported in metastatic carcinomas, implicating NEP in tumor progression and suggesting a role for NEP inhibitors in its treatment. We investigated the rol...

    Authors: Elsa F Velazquez, Molly Yancovitz, Anna Pavlick, Russell Berman, Richard Shapiro, Dusan Bogunovic, David O'Neill, Yi-Lo Yu, Joanna Spira, Paul J Christos, Xi Kathy Zhou, Madhu Mazumdar, David M Nanus, Leonard Liebes, Nina Bhardwaj, David Polsky…

    Citation: Journal of Translational Medicine 2007 5:2

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