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  1. Content type: Research

    Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblast...

    Authors: Andreina Baj, Alessia A Bettaccini, Rosario Casalone, Andrea Sala, Paolo Cherubino and Antonio Q Toniolo

    Citation: Journal of Translational Medicine 2005 3:21

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  2. Content type: Methodology

    The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell responses agai...

    Authors: Florian K Bihl, Elisabetta Loggi, John V Chisholm III, Hannah S Hewitt, Leah M Henry, Caitlyn Linde, Todd J Suscovich, Johnson T Wong, Nicole Frahm, Pietro Andreone and Christian Brander

    Citation: Journal of Translational Medicine 2005 3:20

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  3. Content type: Commentary

    Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2) and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, an...

    Authors: Craig L Slingluff Jr and Daniel E Speiser

    Citation: Journal of Translational Medicine 2005 3:18

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  4. Content type: Research

    In vitro stimulation of CD34+ cells with IL-2 induces NK cell differentiation. In order to define the stages of NK cell development, which influence their generation from CD34 cells, we cultured G-CSF mobilize...

    Authors: Giuseppe Sconocchia, Maurizio Provenzano, Katayoun Rezvani, Jongming Li, Jos Melenhorst, Nancy Hensel and A John Barrett

    Citation: Journal of Translational Medicine 2005 3:15

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  5. Content type: Research

    Although several genes and proteins have been implicated in the development of melanomas, the molecular mechanisms involved in the development of these tumors are not well understood. To gain a better understa...

    Authors: Suraiya Rasheed, Zisu Mao, Jane MC Chan and Linda S Chan

    Citation: Journal of Translational Medicine 2005 3:14

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  6. Content type: Research

    The aim of this study was to determine the basis for anti-tumor immune reactivity observed in patients with human epidermal growth factor receptor-2 (HER-2) (3+) breast carcinoma using an in vitro model in which ...

    Authors: Zorica D Juranic, Zora Neskovic-Konstantinovic, Tatjana P Stanojkovic, Zeljko Zizak, Tatjana Srdic, Nevenka Stanojevic-Bakic, Dusanka Milosevic and Danica Jovanovic

    Citation: Journal of Translational Medicine 2005 3:13

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  7. Content type: Research

    Sixty cancer cell lines have been extensively characterized and used by the National Cancer Institute's Developmental Therapeutics Program (NCI-60) since the early 90's as screening tools for anti-cancer drug ...

    Authors: Sharon Adams, Fu-Meei Robbins, Deborah Chen, Devika Wagage, Susan L Holbeck, Herbert C Morse III, David Stroncek and Francesco M Marincola

    Citation: Journal of Translational Medicine 2005 3:11

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  8. Content type: Protocol

    DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor rejection. Here we report the feasability and safety of the first Ph...

    Authors: Bernard Escudier, Thierry Dorval, Nathalie Chaput, Fabrice André, Marie-Pierre Caby, Sophie Novault, Caroline Flament, Christophe Leboulaire, Christophe Borg, Sebastian Amigorena, Catherine Boccaccio, Christian Bonnerot, Olivier Dhellin, Mojgan Movassagh, Sophie Piperno, Caroline Robert…

    Citation: Journal of Translational Medicine 2005 3:10

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  9. Content type: Research

    There is a continued need to develop more effective cancer immunotherapy strategies. Exosomes, cell-derived lipid vesicles that express high levels of a narrow spectrum of cell proteins represent a novel platf...

    Authors: Michael A Morse, Jennifer Garst, Takuya Osada, Shubi Khan, Amy Hobeika, Timothy M Clay, Nancy Valente, Revati Shreeniwas, Mary Ann Sutton, Alain Delcayre, Di-Hwei Hsu, Jean-Bernard Le Pecq and H Kim Lyerly

    Citation: Journal of Translational Medicine 2005 3:9

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  10. Content type: Research

    Nitric oxide-releasing nonsteroidal antiinflammatory drugs (NO-NSAIDs) are reported to be safer than NSAIDs because of their lower gastric toxicity. We compared the effect of a novel NO-releasing derivate, NCX...

    Authors: Anna Tesei, Paola Ulivi, Francesco Fabbri, Marco Rosetti, Carlo Leonetti, Marco Scarsella, Gabriella Zupi, Dino Amadori, Manlio Bolla and Wainer Zoli

    Citation: Journal of Translational Medicine 2005 3:7

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  11. Content type: Research

    Serologic tests for HIV infection in infants less than 18 months do not differentiate exposure and infection since maternally acquired IgG antibodies may be detected in infants. Thus, the gold standard for dia...

    Authors: Lynn S Zijenah, David A Katzenstein, Kusum J Nathoo, Simbarashe Rusakaniko, Ocean Tobaiwa, Christine Gwanzura, Arsene Bikoue, Margaret Nhembe, Petronella Matibe and George Janossy

    Citation: Journal of Translational Medicine 2005 3:6

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  12. Content type: Research

    Metastatic, chemotherapy-resistant melanoma is an intractable cancer with a very poor prognosis. As to immunotherapy targeting metastatic melanoma, HLA-A2+ patients were mainly enrolled in the study in Western co...

    Authors: Yasuto Akiyama, Ryuji Tanosaki, Naoki Inoue, Makiko Shimada, Yukie Hotate, Akifumi Yamamoto, Naoya Yamazaki, Ichiro Kawashima, Ikuei Nukaya, Kazutoh Takesako, Kouji Maruyama, Yoichi Takaue and Ken Yamaguchi

    Citation: Journal of Translational Medicine 2005 3:4

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  13. Content type: Research

    CD4+CD25+ regulatory T lymphocytes (TR) constitute 5–10% of peripheral CD4+ T cells in naive mice and humans, and play an important role in controlling immune responses. Accumulating evidences show that TR cells ...

    Authors: Ji-Yan Liu, Xiao-Shi Zhang, Ya Ding, Rui-Qing Peng, Xia Cheng, Nian-Hua Zhang, Jian-Chuan Xia and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2005 3:5

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  14. Content type: Research

    Spontaneous T cell responses against specific tumor-associated antigens (TAA) are frequently detected in peripheral blood of tumor patients of various histiotypes. However, little is known about whether these ...

    Authors: Dirk Nagorsen, Carmen Scheibenbogen, Anne Letsch, Christoph-Thomas Germer, Heinz-Johannes Buhr, Susanna Hegewisch-Becker, Licia Rivoltini, Eckhard Thiel and Ulrich Keilholz

    Citation: Journal of Translational Medicine 2005 3:3

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  15. Content type: Research

    Synovial sarcoma is a high-grade malignant tumor of soft tissue, characterized by the specific chromosomal translocation t(X;18), and its resultant SYT-SSX fusion gene. Despite intensive multimodality therapy,...

    Authors: Satoshi Kawaguchi, Takuro Wada, Kazunori Ida, Yuriko Sato, Satoshi Nagoya, Tomohide Tsukahara, Sigeharu Kimura, Hiroeki Sahara, Hideyuki Ikeda, Kumiko Shimozawa, Hiroko Asanuma, Toshihiko Torigoe, Hiroaki Hiraga, Takeshi Ishii, Shin-ichiro Tatezaki, Noriyuki Sato…

    Citation: Journal of Translational Medicine 2005 3:1

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  16. Content type: Research

    Forty to eighty percent of melanoma tumors have activating mutations in BRAF although the clinical importance of these mutations is not clear. We previously reported an analysis of BRAF mutations in metastatic me...

    Authors: David Z Chang, Katherine S Panageas, Iman Osman, David Polsky, Klaus Busam and Paul B Chapman

    Citation: Journal of Translational Medicine 2004 2:46

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  17. Content type: Research

    Immunosuppression is documented in several malignant diseases, including breast cancer. Subsequently, future therapeutic concepts might include immunological approaches. However, detailed knowledge about tumor...

    Authors: Jana M Schüle, Leif Bergkvist, Leif Håkansson, Bertil Gustafsson and Annika Håkansson

    Citation: Journal of Translational Medicine 2004 2:45

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  18. Content type: Research

    Walking along disease-associated protein sequences in the search for specific segments able to induce cellular immune response may direct clinical research towards effective peptide-based vaccines. To this aim...

    Authors: Alberta Lucchese, Abraham Mittelman, Mong-Shang Lin, Darja Kanduc and Animesh A Sinha

    Citation: Journal of Translational Medicine 2004 2:43

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  19. Content type: Research

    Tumors and viruses have developed many mechanisms to evade the immune system, including down-regulation of target antigens and MHC molecules. These immune escape mechanisms may be able to be circumvented by ad...

    Authors: Alexander Langerman, Glenda G Callender and Michael I Nishimura

    Citation: Journal of Translational Medicine 2004 2:42

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  20. Content type: Research

    T cell-mediated cancer immunotherapy is dose dependent and optimally requires participation of antigen-specific CD4+ and CD8+ T cells. Here, we isolated tumor-sensitized T cells and activated them in vitro using ...

    Authors: Li-Xin Wang, Wen-Xin Huang, Hallie Graor, Peter A Cohen, Julian A Kim, Suyu Shu and Gregory E Plautz

    Citation: Journal of Translational Medicine 2004 2:41

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  21. Content type: Research

    A novel tyrosine kinase receptor EphA2 is expressed at high levels in advanced and metastatic cancers. We examined whether vaccinations with synthetic mouse EphA2 (mEphA2)-derived peptides that serve as T cell...

    Authors: Manabu Hatano, Naruo Kuwashima, Tomohide Tatsumi, Jill E Dusak, Fumihiko Nishimura, Karlyne M Reilly, Walter J Storkus and Hideho Okada

    Citation: Journal of Translational Medicine 2004 2:40

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  22. Content type: Review

    Over the past decade RNA interference (RNAi) has emerged as a natural mechanism for silencing gene expression. This ancient cellular antiviral response can be exploited to allow specific inhibition of the func...

    Authors: Simone Mocellin and Maurizio Provenzano

    Citation: Journal of Translational Medicine 2004 2:39

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  23. Content type: Research

    D-dimer is considered a marker of hypercoagulable state and of endogenous fibrinolysis, so increased d-dimer is detectable in patients affected by thrombosis. Yet, several studies showed that also infertility,...

    Authors: Pierpaolo Di Micco, Maristella D'Uva, Ida Strina, Antonio Mollo, Valeria Amato, Alferio Niglio and Giuseppe De Placido

    Citation: Journal of Translational Medicine 2004 2:38

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  24. Content type: Commentary

    During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well wit...

    Authors: Nigel J Waterhouse, Karin A Sedelies and Chris JP Clarke

    Citation: Journal of Translational Medicine 2004 2:36

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  25. Content type: Research

    Human metastatic cutaneous melanoma has gained a well deserved reputation for its immune responsiveness. The reason(s) remain(s) unknown. We attempted previously to characterize several variables that may affe...

    Authors: Ena Wang, Monica C Panelli, Katia Zavaglia, Susanna Mandruzzato, Nan Hu, Phil R Taylor, Barbara Seliger, Paola Zanovello, Ralph S Freedman and Francesco M Marincola

    Citation: Journal of Translational Medicine 2004 2:34

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  26. Content type: Research

    Past studies suggested that tumor necrosis factor (TNF) assisted anti-tumor treatment and intensified the sensitivity of chemotherapy. However its clinical application has been curbed because of its low purity...

    Authors: Xing Liu, Xiang-fu Zhang, Zhi-weng Zheng, Huishan Lu, Xinyuan Wu, Changmin Huang, Chuan Wang and Guoxiang Guang

    Citation: Journal of Translational Medicine 2004 2:33

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  27. Content type: Research

    Recently BRCA1 has been implicated in the regulation of gene expression from the X chromosome. In this study the influence of BRCA1 on expression of X chromosome genes was investigated. Complementary DNA micro...

    Authors: Amir A Jazaeri, Gadisetti VR Chandramouli, Olga Aprelikova, Ulrike A Nuber, Christos Sotiriou, Edison T Liu, H Hilger Ropers, Cindy J Yee, Jeff Boyd and J Carl Barrett

    Citation: Journal of Translational Medicine 2004 2:32

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  28. Content type: Methodology

    This study assessed the Granzyme B (GrB) ELISPOT as a viable alternative to the 51Cr-release assay for measuring cytotoxic activity of innate immune effector cells. We strategically selected the GrB ELISPOT assay...

    Authors: Kimberly A Shafer-Weaver, Thomas Sayers, Douglas B Kuhns, Susan L Strobl, Mark W Burkett, Michael Baseler and Anatoli Malyguine

    Citation: Journal of Translational Medicine 2004 2:31

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  29. Content type: Research

    Sequence-based typing (SBT) is one of the most comprehensive methods utilized for HLA typing. However, one of the inherent problems with this typing method is the interpretation of ambiguous allele combination...

    Authors: Sharon D Adams, Kathleen C Barracchini, Deborah Chen, FuMeei Robbins, Lu Wang, Paula Larsen, Robert Luhm and David F Stroncek

    Citation: Journal of Translational Medicine 2004 2:30

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  30. Content type: Research

    Prostate-specific membrane antigen (PSMA) is a well characterized prostate-specific tumor associated antigen. Its expression is elevated in prostate carcinoma, particularly in metastatic and recurrent lesions....

    Authors: Jiaqiang Ren, Li Zheng, Qi Chen, Hua Li, Lin Zhang and Hongguang Zhu

    Citation: Journal of Translational Medicine 2004 2:29

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  31. Content type: Commentary

    Translational research requires a team approach to scientific inquiry and product development. Translational research teams consist of basic and clinical scientists who can be members of both academic and indu...

    Authors: Malcolm R Parks and Mary L Disis

    Citation: Journal of Translational Medicine 2004 2:28

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  32. Content type: Research

    Dendritic Cell (DC) vaccination is a very promising therapeutic strategy in cancer patients. The immunizing ability of DC is critically influenced by their migration activity to lymphatic tissues, where they h...

    Authors: Ruggero Ridolfi, Angela Riccobon, Riccardo Galassi, Gianluigi Giorgetti, Massimiliano Petrini, Laura Fiammenghi, Monica Stefanelli, Laura Ridolfi, Andrea Moretti, Giuseppe Migliori and Giuseppe Fiorentini

    Citation: Journal of Translational Medicine 2004 2:27

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  33. Content type: Commentary

    The hypothesis that human cancers express antigens that can be specifically targeted by cell mediated immunity has become a scientifically justifiable rationale for the design and clinical testing of novel tum...

    Authors: Maurizio Chiriva-Internati, Fabio Grizzi, Robert K Bright and W Martin Kast

    Citation: Journal of Translational Medicine 2004 2:26

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  34. Content type: Research

    The administration of granulocyte colony-stimulating factor (G-CSF) to peripheral blood progenitor cell (PBPC) donors causes spleen length to increase, but the duration of enlargement is not known. Eighteen he...

    Authors: David F Stroncek, Kristin Dittmar, Thomas Shawker, Angela Heatherman and Susan F Leitman

    Citation: Journal of Translational Medicine 2004 2:25

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  35. Content type: Research

    Nasopharyngeal carcinoma (NPC) is characterized by a high prevalence in Southern China, especially among Cantonese individuals of the Guangdong Province. Epidemiological studies have suggested that frequent ex...

    Authors: Ju-Hong Jiang, Wei-Hua Jia, Han-Kui Chen, Bing-Jian Feng, Hai-De Qin, Zhi-Gang Pan, Guo-Ping Shen, Li-Xi Huang, Qi-Sheng Feng, Li-Zhen Chen, Dong-Xin Lin and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2004 2:24

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  36. Content type: Review

    With the role of angiogenesis in tumor growth and progression firmly established, considerable effort has been directed to antiangiogenic therapy as a new modality to treat human cancers. Antiangiogenic agents...

    Authors: Anita Tandle, Dan G Blazer III and Steven K Libutti

    Citation: Journal of Translational Medicine 2004 2:22

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  37. Content type: Research

    Survivin is a member of the inhibitor of apoptosis protein (IAP) family containing a single baculovirus IAP repeat domain. It is expressed during fetal development but becomes undetectable in terminally differ...

    Authors: Tetsuhiro Tsuruma, Fumitake Hata, Toshihiko Torigoe, Tomohisa Furuhata, Satomi Idenoue, Takehiro Kurotaki, Masaaki Yamamoto, Atsuhito Yagihashi, Tosei Ohmura, Koji Yamaguchi, Tadashi Katsuramaki, Takahiro Yasoshima, Kazuaki Sasaki, Yasuhiro Mizushima, Hidetoshi Minamida, Hiromichi Kimura…

    Citation: Journal of Translational Medicine 2004 2:19

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