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  1. We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood. Here, we investigated the role ...

    Authors: Youguang Gao, Xingui Dai, Yunfeng Li, Guicheng Li, Xianzhong Lin, Chenmu Ai, Yuanyuan Cao, Tao Li and Bo Lin

    Citation: Journal of Translational Medicine 2020 18:114

    Content type: Research

    Published on:

  2. To detect the development, function and therapeutic potential of epicardial adipose tissue (EAT); analyze a related gene expression dataset, including data from neonates, infants, and children with congenital ...

    Authors: Li Ma, Wanting Shi, Xun Ma, Minghui Zou, Weidan Chen, Wenlei Li, Rongjun Zou and Xinxin Chen

    Citation: Journal of Translational Medicine 2020 18:111

    Content type: Research

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  3. Inflammatory damage following stroke aggravates brain damage, resulting in long-term neurological sequelae. The purpose of this study was to identify ways to reduce inflammatory reactions and to accelerate neu...

    Authors: Benping Zhang, Qian Li, Shuwei Jia, Feng Li, Qingsong Li and Jiebing Li

    Citation: Journal of Translational Medicine 2020 18:110

    Content type: Research

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  4. Myelin sheaths surrounding axons are critical for electrical signal transmission in the central nervous system (CNS). Diseases with myelin defects such as multiple sclerosis (MS) are devastating neurological c...

    Authors: Sujun Ding, Yun Gu, Yunyun Cai, Meijuan Cai, Tuo Yang, Shuangxi Bao, Weixing Shen, Xuejun Ni, Gang Chen and Lingyan Xing

    Citation: Journal of Translational Medicine 2020 18:109

    Content type: Research

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  5. Commonly used miRNA detection methods cannot be applied for high-throughput analyses. However, this study was aimed to performed a liquid bead array detection system (LBAS) to detect tissue 6 miRNAs in non-sma...

    Authors: Yuan-Yuan Zheng, Yun Fei, Zheng Wang, Yue Chen, Cheng Qiu and Fu-Rong Li

    Citation: Journal of Translational Medicine 2020 18:108

    Content type: Research

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  6. Human defensin-5 (HD-5) is a key antimicrobial peptide which plays an important role in host immune defense, while the short half-life greatly limits its clinical application. The purpose of this study was to ...

    Authors: Lishan Zeng, Jiasheng Tan, Meng Xue, Le Liu, Mingming Wang, Liping Liang, Jun Deng, Wei Chen and Ye Chen

    Citation: Journal of Translational Medicine 2020 18:107

    Content type: Research

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  7. Thiazide diuretics reduce the risk of recurrent kidney calculi in patients with kidney calculi or hypercalciuria. However, whether thiazide diuretics can definitely prevent recurrent kidney calculi remains unc...

    Authors: Dan-feng Li, Yu-lu Gao, Hong-chao Liu, Xiao-chen Huang, Rui-fang Zhu and Chang-tai Zhu

    Citation: Journal of Translational Medicine 2020 18:106

    Content type: Review

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  8. Following publication of the original article [1], the authors reported an error in one of the author names. In this Correction the incorrect and correct author names are listed.

    Authors: Yun-Wen Tao, Ying-Luo Gu, Xin-Qi Mao, Lei Zhang and Yu-Fang Pei

    Citation: Journal of Translational Medicine 2020 18:105

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2020 18:30

  9. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive age. It is characterised clinically by oligo-ovulation or anovulation, hyper-androgenism, and the presence of...

    Authors: Antonio Paoli, Laura Mancin, Maria Cristina Giacona, Antonino Bianco and Massimiliano Caprio

    Citation: Journal of Translational Medicine 2020 18:104

    Content type: Research

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  10. Salmonella enterica serovar Typhi (S. Typhi) is a highly invasive bacterium that infects the human intestinal mucosa and causes ~ 11.9–20.6 million infections and ~ 130,000–223,000 deaths annually worldwide. Oral...

    Authors: Jayaum S. Booth, Eric Goldberg, Robin S. Barnes, Bruce D. Greenwald and Marcelo B. Sztein

    Citation: Journal of Translational Medicine 2020 18:102

    Content type: Research

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  11. Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming. ABAT and ALDH6A1 are metabolic enzymes. In this study, we aim to investigate the associations of ABAT and ALDH6...

    Authors: Jun Lu, Zhan Chen, Hu Zhao, Huiyue Dong, Ling Zhu, Yi Zhang, Jie Wang, Hehuan Zhu, Qiang Cui, Chuang Qi, Shuiliang Wang, Shushang Chen and Jichun Shao

    Citation: Journal of Translational Medicine 2020 18:101

    Content type: Research

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  12. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has been emerging as a significant health issue worldwide. This study aimed to systemically assess the prevalence of CFS/ME in various aspects of analys...

    Authors: Eun-Jin Lim, Yo-Chan Ahn, Eun-Su Jang, Si-Woo Lee, Su-Hwa Lee and Chang-Gue Son

    Citation: Journal of Translational Medicine 2020 18:100

    Content type: Review

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  13. Disease progression in the absence of therapy varies significantly in mono-HIV and HCV infected individuals. Virus-specific CD8+ T cells play an important role in restricting lentiviral replication and determinin...

    Authors: Si-Yao Li, Zi-Ning Zhang, Yong‑Jun Jiang, Ya‑Jing Fu and Hong Shang

    Citation: Journal of Translational Medicine 2020 18:96

    Content type: Research

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  14. Despite the effective antiretroviral treatment (ART) of HIV-infected individuals, HIV persists in a small pool. Central memory CD4+ T cells (Tcm) make a major contribution to HIV persistence. We found that unlike...

    Authors: Cheng-Bo Song, Le-Le Zhang, Xian Wu, Ya-Jing Fu, Yong-Jun Jiang, Hong Shang and Zi-Ning Zhang

    Citation: Journal of Translational Medicine 2020 18:95

    Content type: Research

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  15. An increasing number of anti-cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absenc...

    Authors: Sinead Toomey, Aoife Carr, Mateusz Janusz Mezynski, Yasir Elamin, Shereen Rafee, Mattia Cremona, Clare Morgan, Stephen Madden, Khairun I. Abdul-Jalil, Kathy Gately, Angela Farrelly, Elaine W. Kay, Susan Kennedy, Kenneth O’Byrne, Liam Grogan, Oscar Breathnach…

    Citation: Journal of Translational Medicine 2020 18:99

    Content type: Research

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  16. The aim of this study was to investigate the expression of the nuclear receptor PPARγ, together with that of the cyclooxygenases Cox-1 and Cox-2, in breast cancer (BC) tissues and to correlate the data with se...

    Authors: Wanting Shao, Christina Kuhn, Doris Mayr, Nina Ditsch, Magdalena Kailuwait, Verena Wolf, Nadia Harbeck, Sven Mahner, Udo Jeschke, Vincent Cavaillès and Sophie Sixou

    Citation: Journal of Translational Medicine 2020 18:94

    Content type: Research

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  17. Metabolic reprogramming, immune evasion and tumor-promoting inflammation are three hallmarks of cancer that provide new perspectives for understanding the biology of cancer. We aimed to figure out the relation...

    Authors: Wenhui Li, Ming Xu, Yu Li, Ziwei Huang, Jun Zhou, Qiuyang Zhao, Kehao Le, Fang Dong, Cheng Wan and Pengfei Yi

    Citation: Journal of Translational Medicine 2020 18:92

    Content type: Research

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  18. The Editor-in-Chief and the publisher have retracted this article [1]. An investigation by the Lithuanian Bioethics Committee concluded that, contrary to the statements in the article, the study described was ...

    Authors: Adas Darinskas, Mindaugas Paskevicius, Gintaras Apanavicius, Gintaris Vilkevicius, Liutauras Labanauskas, Thomas E. Ichim and Rytis Rimdeika

    Citation: Journal of Translational Medicine 2020 18:90

    Content type: Retraction Note

    Published on:

    The original article was published in Journal of Translational Medicine 2017 15:143

  19. The Editor-in-Chief has retracted this article [1] because Figure 3a overlaps with Figure 2 in [2]. An investigation by Zhengzhou University has confirmed this. The data reported in this article are therefore ...

    Authors: Yuanyuan Wang, Wenqiao Zang, Yuwen Du, Yunyun Ma, Min Li, Ping Li, Xudong Chen, Tao Wang, Ziming Dong and Guoqiang Zhao

    Citation: Journal of Translational Medicine 2020 18:89

    Content type: Retraction Note

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    The original article was published in Journal of Translational Medicine 2013 11:301

  20. The present study compared the effects of training and detraining periods of high-intensity interval training (HIIT), moderate-intensity interval training (MIIT) and moderate-intensity continuous training (MIC...

    Authors: Victor Silveira Coswig, Matheus Barbalho, Rodolfo Raiol, Fabrício Boscolo Del Vecchio, Rodrigo Ramirez-Campillo and Paulo Gentil

    Citation: Journal of Translational Medicine 2020 18:88

    Content type: Research

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  21. NGS from plasma samples in non-squamous cell lung carcinoma (NSCC) can aid in the detection of actionable genomic alterations. However, the absolute clinical value of NGS in liquid biopsy (LB) made at baseline...

    Authors: Simon Heeke, Véronique Hofman, Marius Ilié, Maryline Allegra, Virginie Lespinet, Olivier Bordone, Jonathan Benzaquen, Jacques Boutros, Michel Poudenx, Salomé Lalvée, Virginie Tanga, Carole Salacroup, Christelle Bonnetaud, Charles-Hugo Marquette and Paul Hofman

    Citation: Journal of Translational Medicine 2020 18:87

    Content type: Research

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  22. The identity management is a central component in medical research. Patients are recruited from various sites, which requires an error tolerant record linkage method, to ensure that patients are registered onl...

    Authors: Christopher Hampf, Lars Geidel, Norman Zerbe, Martin Bialke, Dana Stahl, Arne Blumentritt, Thomas Bahls, Peter Hufnagl and Wolfgang Hoffmann

    Citation: Journal of Translational Medicine 2020 18:86

    Content type: Methodology

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  23. Rats with hyperandrogen-induced polycystic ovary syndrome (PCOS) have been shown to develop ovarian oxidative stress (OS) and fibrosis. The Sirt1 agonist, resveratrol, can reduce OS through inhibiting p66Shc i...

    Authors: Daojuan Wang, Tingyu Wang, Rong Wang, Xinlin Zhang, Lei Wang, Zou Xiang, Lingjia Zhuang, Shanmei Shen, Hongwei Wang, Qian Gao and Yong Wang

    Citation: Journal of Translational Medicine 2020 18:84

    Content type: Research

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  24. An impedance threshold device (ITD) was developed to increase venous return to the heart and therefore increase cardiac output and organ blood flow during cardiopulmonary rescue (CPR). Basic CPR aims to mainta...

    Authors: Benedict Kjaergaard, Hans O. Holdgaard, Sigridur O. Magnusdottir, Søren Lundbye-Christensen and Erika F. Christensen

    Citation: Journal of Translational Medicine 2020 18:83

    Content type: Research

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  25. To explore the modulatory effects and mechanism of secretory clusterin (sCLU) on cancer stem cell (CSC) properties in hepatocellular carcinoma (HCC).

    Authors: Wenjie Zheng, Min Yao, Mengna Wu, Junling Yang, Dengfu Yao and Li Wang

    Citation: Journal of Translational Medicine 2020 18:81

    Content type: Research

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  26. The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele. However, the impact of this variant on cl...

    Authors: Giulia Ciccarese, Bruna Dalmasso, William Bruno, Paola Queirolo, Lorenza Pastorino, Virginia Andreotti, Francesco Spagnolo, Enrica Tanda, Giovanni Ponti, Cesare Massone, Francesco Drago, Aurora Parodi, Giovanni Ghigliotti, Maria Antonietta Pizzichetta and Paola Ghiorzo

    Citation: Journal of Translational Medicine 2020 18:78

    Content type: Research

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  27. Pancreatic cancer is a major cause of cancer-related mortality. The identification of effective biomarkers is essential in order to improve management of the disease. Yes-associated protein 1 (YAP1) is a downs...

    Authors: Qimin Zhou, Monika Bauden, Roland Andersson, Dingyuan Hu, György Marko-Varga, Jianfeng Xu, Agata Sasor, Hua Dai, Krzysztof Pawłowski, Katarzyna Said Hilmersson, Xi Chen and Daniel Ansari

    Citation: Journal of Translational Medicine 2020 18:77

    Content type: Research

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  28. Tianzhi granule (TZ) is usually used for patients with vascular dementia (VaD) in China. The aim was to assess the effect of TZ by a randomized clinical trial (RCT).

    Authors: Jing Shi, Mingqing Wei, Jingnian Ni, Feng Sun, Li Sun, Junfu Wang, Tao Yu, Kai Wang, Peiyuan Lv, Yunfu Wang, Yulian Zhang, Xuguang Gao, Xuanzhao Gao, Benyan Luo, Shanping Mao, Baorong Zhang…

    Citation: Journal of Translational Medicine 2020 18:76

    Content type: Research

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  29. Venoarterial extracorporeal membrane oxygenation (VA ECMO) is widely used in the treatment of circulatory failure, but repeatedly, its negative effects on the left ventricle (LV) have been observed. The purpos...

    Authors: Pavel Hála, Mikuláš Mlček, Petr Ošťádal, Michaela Popková, David Janák, Tomáš Bouček, Stanislav Lacko, Jaroslav Kudlička, Petr Neužil and Otomar Kittnar

    Citation: Journal of Translational Medicine 2020 18:75

    Content type: Research

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  30. With the gradual unveiling of tumour heterogeneity, cancer stem cells (CSCs) are now being considered the initial component of tumour initiation. However, the mechanisms of the growth and maintenance of breast...

    Authors: Jianying Pei, Yanxia Wang and Yan Li

    Citation: Journal of Translational Medicine 2020 18:74

    Content type: Research

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  31. Retinitis Pigmentosa (RP) is a clinically and genetically heterogeneous disorder that results in inherited blindness. Despite the large number of genes identified, only ~ 60% of cases receive a genetic diagnos...

    Authors: María González-del Pozo, Elena Fernández-Suárez, Marta Martín-Sánchez, Nereida Bravo-Gil, Cristina Méndez-Vidal, Enrique Rodríguez-de la Rúa, Salud Borrego and Guillermo Antiñolo

    Citation: Journal of Translational Medicine 2020 18:73

    Content type: Research

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  32. Parkinson’s disease (PD) is a neurodegenerative disorder that results in the death of dopaminergic neurons within the substantia nigra pars compacta and the reduction in dopaminergic control over striatal output ...

    Authors: Inma Castilla-Cortázar, Gabriel A. Aguirre, Giovana Femat-Roldán, Irene Martín-Estal and Luis Espinosa

    Citation: Journal of Translational Medicine 2020 18:70

    Content type: Review

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  33. Clear cell renal cell carcinoma (ccRCC) is one of the most aggressive urological malignancies. MicroRNAs (miRNAs) are post-transcriptional gene regulators in tumor pathophysiology. As miRNAs exert cooperative ...

    Authors: Jiajia Chen, Yuqing Zhong and Liangzhi Li

    Citation: Journal of Translational Medicine 2020 18:69

    Content type: Research

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  34. Inflammation within the perivascular adipose tissue (PVAT) in obesity plays an important role in cardiovascular disorders. C-reactive protein (CRP) level in obesity patients is significantly increased and asso...

    Authors: Jia-Yuan Chen, Xiao-Lin Zhu, Wen-Hao Liu, Yong Xie, Hai-Feng Zhang, XiaoQiao Wang, Ru Ying, Zhi-Teng Chen, Mao-Xiong Wu, Qiong Qiu, Jing-Feng Wang and Yang-Xin Chen

    Citation: Journal of Translational Medicine 2020 18:68

    Content type: Research

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  35. Growing evidence has suggested that immune-related genes play crucial roles in the development and progression of hepatocellular carcinoma (HCC). Nevertheless, the utility of immune-related genes for evaluatin...

    Authors: Zheng Wang, Jie Zhu, Yongjuan Liu, Changhong Liu, Wenqi Wang, Fengzhe Chen and Lixian Ma

    Citation: Journal of Translational Medicine 2020 18:67

    Content type: Research

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  36. Translationally controlled tumor protein (TCTP) is linked to lung cancer. However, upon lung cancer carcinogens stimulation, there were no reports on the relationship between TCTP and lung cell carcinogenic ep...

    Authors: Li-Zhong Liu, Menghuan Wang, Qihang Xin, Bowen Wang, George G. Chen and Ming-Yue Li

    Citation: Journal of Translational Medicine 2020 18:66

    Content type: Research

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  37. Cancer recurrence is the important problem of cholangiocarcinoma (CCA) patients, lead to a very high mortality rate. Therefore, the identification of candidate markers to predict CCA recurrence is needed in or...

    Authors: Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun, Sakkarn Sungkhamanon, Hideyuki Saya and Watcharin Loilome

    Citation: Journal of Translational Medicine 2020 18:64

    Content type: Research

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  38. Direct cDNA preamplification protocols developed for single-cell RNA-seq have enabled transcriptome profiling of precious clinical samples and rare cell populations without the need for sample pooling or RNA e...

    Authors: Logan A. Walker, Michael G. Sovic, Chi-Ling Chiang, Eileen Hu, Jiyeon K. Denninger, Xi Chen, Elizabeth D. Kirby, John C. Byrd, Natarajan Muthusamy, Ralf Bundschuh and Pearlly Yan

    Citation: Journal of Translational Medicine 2020 18:63

    Content type: Research

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  39. There is a lack of well-established clinical tools for predicting dendritic cell (DC) vaccination response of pancreatic ductal adenocarcinoma (PDAC). DC vaccine treatment efficiency was demonstrated using his...

    Authors: Aydin Eresen, Jia Yang, Junjie Shangguan, Yu Li, Su Hu, Chong Sun, Yury Velichko, Vahid Yaghmai, Al B. Benson III and Zhuoli Zhang

    Citation: Journal of Translational Medicine 2020 18:61

    Content type: Research

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  40. Cell proliferation and death are key components of wound healing and tissue repair. Telocytes (TCs) represent a newly discovered cell type that can protect tissue from acute injury via cell–cell communication ...

    Authors: Lu Wang, Dongli Song, Chuanyuan Wei, Cheng Chen, Yanwen Yang, Xinyi Deng and Jianying Gu

    Citation: Journal of Translational Medicine 2020 18:60

    Content type: Research

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  41. Circulating tumor cells (CTCs) has been demonstrated as a promising liquid biopsy marker for breast cancer (BC). However, the intra-patient heterogeneity of CTCs remains a challenge to clinical application. We...

    Authors: Jing Chen, Changsheng Ye, Jianyu Dong, Shunwang Cao, Yanwei Hu, Bo Situ, Xiaoxue Xi, Sihua Qin, Jiasen Xu, Zhen Cai, Lei Zheng and Qian Wang

    Citation: Journal of Translational Medicine 2020 18:59

    Content type: Research

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  42. Macrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cel...

    Authors: Mohamed Hamed Abdelaziz, Sayed F. Abdelwahab, Jie Wan, Wei Cai, Wang Huixuan, Cheng Jianjun, Kesavan Dinesh Kumar, Aparna Vasudevan, Ahmed Sadek, Zhaoliang Su, Shengjun Wang and Huaxi Xu

    Citation: Journal of Translational Medicine 2020 18:58

    Content type: Review

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  43. Accumulating evidence suggests that plasminogen activator inhibitor-1 (PAI-1) plays an important role in bladder tumorigenesis by regulating cell cycle. However, it remains unclear whether and how inhibition o...

    Authors: Hideki Furuya, Kazukuni Hayashi, Yoshiko Shimizu, Nari Kim, Yutaro Tsukikawa, Runpu Chen, Yijun Sun, Owen T. M. Chan, Ian Pagano, Rafael Peres, Kanani Hokutan, Fumie Igari, Keith S. Chan and Charles J. Rosser

    Citation: Journal of Translational Medicine 2020 18:57

    Content type: Research

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  44. Interaction between malignant cells and immune cells that reside within the tumor microenvironment (TME) modulate different aspects of tumor development and progression. Recent works showed the importance of m...

    Authors: Natasha A. N. Jorge, Jéssica G. V. Cruz, Marco Antônio M. Pretti, Martín H. Bonamino, Patricia A. Possik and Mariana Boroni

    Citation: Journal of Translational Medicine 2020 18:56

    Content type: Research

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  45. Tumour cells interfere with normal immune functions by affecting the expression of some immune-related genes, which play roles in the prognosis of cancer patients. In recent years, immunotherapy for tumours ha...

    Authors: Xiaoshun Shi, Ruidong Li, Xiaoying Dong, Allen Menglin Chen, Xiguang Liu, Di Lu, Siyang Feng, He Wang and Kaican Cai

    Citation: Journal of Translational Medicine 2020 18:55

    Content type: Research

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  46. Few data are known regarding the molecular features and patterns of growth and presentation which characterize those lung neoplastic lesions presenting as non-solid nodules (NSN).

    Authors: Chandra Bortolotto, Claudio Maglia, Antonio Ciuffreda, Manuela Coretti, Roberta Catania, Filippo Antonacci, Sergio Carnevale, Ivana Sarotto, Roberto Dore, Andrea Riccardo Filippi, Gabriele Chiara, Daniele Regge, Lorenzo Preda, Patrizia Morbini and Giulia Maria Stella

    Citation: Journal of Translational Medicine 2020 18:54

    Content type: Research

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  47. Tissue-engineered skin (TES), as an analogue of native skin, is promising for wound repair and regeneration. However, a major drawback of TES products is a lack of skin appendages and nerves to enhance skin he...

    Authors: Tingting Weng, Pan Wu, Wei Zhang, Yurong Zheng, Qiong Li, Ronghua Jin, Haojiao Chen, Chuangang You, Songxue Guo, Chunmao Han and Xingang Wang

    Citation: Journal of Translational Medicine 2020 18:53

    Content type: Review

    Published on:

  48. The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metasta...

    Authors: Jennifer Pasquier, Pegah Ghiabi, Lotfi Chouchane, Kais Razzouk, Shahin Rafii and Arash Rafii

    Citation: Journal of Translational Medicine 2020 18:52

    Content type: Review

    Published on:

  49. Zinc finger E-box binding homeobox 1 (ZEB1, also termed TCF8 and δEF1) is a crucial member of the zinc finger-homeodomain transcription factor family, originally identified as a binding protein of the lens-spe...

    Authors: Hua-Tao Wu, Hui-Ting Zhong, Guan-Wu Li, Jia-Xin Shen, Qian-Qian Ye, Man-Li Zhang and Jing Liu

    Citation: Journal of Translational Medicine 2020 18:51

    Content type: Review

    Published on:

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