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  1. Lipid metabolites and cytokines, including chemokines and growth factors, are the key regulators of immune cell function and differentiation, and thus, dysregulation of these regulators is associated with vari...

    Authors: Hyun Ok Kim, Han-Soo Kim, Jong-Chan Youn, Eui-Cheol Shin and Sungha Park
    Citation: Journal of Translational Medicine 2011 9:113
  2. Hepatitis C virus is a major cause of chronic liver diseases which can lead to permanent liver damage, hepatocellular carcinoma and death. The presently available treatment with interferon plus ribavirin, has ...

    Authors: Usman A Ashfaq, Muhammad S Masoud, Zafar Nawaz and Sheikh Riazuddin
    Citation: Journal of Translational Medicine 2011 9:112
  3. Age related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role in AMD pat...

    Authors: Baoying Liu, Lai Wei, Catherine Meyerle, Jingsheng Tuo, H Nida Sen, Zhiyu Li, Sagarika Chakrabarty, Elvira Agron, Chi-Chao Chan, Michael L Klein, Emily Chew, Frederick Ferris and Robert B Nussenblatt
    Citation: Journal of Translational Medicine 2011 9:111
  4. Aurora kinases play critical roles in mitosis and are being evaluated as therapeutic targets in cancer. GSK1070916 is a potent, selective, ATP competitive inhibitor of Aurora kinase B and C. Translation of pre...

    Authors: Christopher Moy, Catherine A Oleykowski, Ramona Plant, Joel Greshock, Junping Jing, Kurtis Bachman, Mary Ann Hardwicke, Richard Wooster and Yan Degenhardt
    Citation: Journal of Translational Medicine 2011 9:110
  5. Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing specific cathepsin activity in complex tissue ext...

    Authors: Binbin Chen and Manu O Platt
    Citation: Journal of Translational Medicine 2011 9:109
  6. The introduction of antibody markers to identify undesired cell populations in flow-cytometry based assays, so called DUMP channel markers, has become a practice in an increasing number of labs performing HLA-...

    Authors: Sebastian Attig, Leah Price, Sylvia Janetzki, Michael Kalos, Michael Pride, Lisa McNeil, Tim Clay, Jianda Yuan, Kunle Odunsi, Axel Hoos, Pedro Romero and Cedrik M Britten
    Citation: Journal of Translational Medicine 2011 9:108
  7. The field of cellular therapy of cancer is moving quickly and the issues involved with its advancement are complex and wide ranging. The growing clinical applications and success of adoptive cellular therapy o...

    Authors: Cornelis JM Melief, John J O'Shea and David F Stroncek
    Citation: Journal of Translational Medicine 2011 9:107
  8. MHC class II transactivator CIITA inhibits the function of HTLV-2 Tax-2 viral transactivator and, consequently, the replication of the virus in infected cells. Moreover overexpression of the nuclear factor NF-...

    Authors: Chiara Orlandi, Greta Forlani, Giovanna Tosi and Roberto S Accolla
    Citation: Journal of Translational Medicine 2011 9:106
  9. This study was performed to determine whether injury induced by cerebral ischemia could be further improved by transplantation with bone marrow-derived mesenchymal stem cells (MSCs) modified by Survivin (SVV).

    Authors: Nan Liu, Yixian Zhang, Lin Fan, Mingzhou Yuan, Houwei Du, Ronghua Cheng, Deshan Liu and Feifei Lin
    Citation: Journal of Translational Medicine 2011 9:105
  10. Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1...

    Authors: Thomas K Kilvaer, Andrej Valkov, Sveinung W Sorbye, Eivind Smeland, Roy M Bremnes, Lill-Tove Busund and Tom Donnem
    Citation: Journal of Translational Medicine 2011 9:104
  11. GH and IGFs serum levels decline with age. Age-related changes appear to be associated to decreases in these anabolic hormones. We have previously demonstrated that IGF-I replacement therapy improves insulin r...

    Authors: Inma Castilla-Cortázar, María García-Fernández, Gloria Delgado, Juan E Puche, Inma Sierra, Rima Barhoum and Salvador González-Barón
    Citation: Journal of Translational Medicine 2011 9:103
  12. Bisphosphonate associated osteonecrosis of the jaw (BRONJ) implies an impairment in oral hard- and soft tissue repair. An understanding of the signal transduction alterations involved can inform therapeutic st...

    Authors: Falk Wehrhan, Peter Hyckel, Arndt Guentsch, Emeka Nkenke, Phillip Stockmann, Karl A Schlegel, Friedrich W Neukam and Kerstin Amann
    Citation: Journal of Translational Medicine 2011 9:102
  13. Non Obese Diabetic mice lacking B cells (NOD.Igμnull mice) do not develop diabetes despite their susceptible background. Upon reconstitution of B cells using a chimera approach, animals start developing diabetes ...

    Authors: Allen M Vong, Nazila Daneshjou, Patricia Y Norori, Huiming Sheng, Todd A Braciak, Eli E Sercarz and Claudia Raja Gabaglia
    Citation: Journal of Translational Medicine 2011 9:101
  14. Aurora kinase A (AURKA) is a member of serine/threonine kinase family. Several kinases belonging to this family are activated in the G2/M phase of the cell cycle being involved in mitotic chromosomal segregation....

    Authors: Marco Lo Iacono, Valentina Monica, Silvia Saviozzi, Paolo Ceppi, Enrico Bracco, Mauro Papotti and Giorgio V Scagliotti
    Citation: Journal of Translational Medicine 2011 9:100
  15. In our recent study, Periostin was up-regulated in prostate cancer(PCa) compared with benign prostate hyperplasia (BPH) by proteomics analysis of prostate biopsies. We investigated the effect of sliencing Peri...

    Authors: Chuanyu Sun, Xiaojun Zhao, Ke Xu, Jian Gong, Weiwei Liu, Weihong Ding, Yuancheng Gou, Guowei Xia and Qiang Ding
    Citation: Journal of Translational Medicine 2011 9:99
  16. The F11 Receptor (F11R; aka JAM-A, JAM-1) is a cell adhesion protein present constitutively on the membrane surface of circulating platelets and within tight junctions of endothelial cells (ECs). Previous repo...

    Authors: Bani M Azari, Jonathan D Marmur, Moro O Salifu, Yigal H Ehrlich, Elizabeth Kornecki and Anna Babinska
    Citation: Journal of Translational Medicine 2011 9:98
  17. Protein kinase CK2 is a highly conserved, ubiquitous protein serine/threonine kinase that phosphorylates many substrates and has a global role in numerous biological and pathological processes. Overexpression ...

    Authors: Jinjin Zou, Hesan Luo, Qin Zeng, Zhongyi Dong, Dehua Wu and Li Liu
    Citation: Journal of Translational Medicine 2011 9:97
  18. Hemoglobin E/β-thalassemia is particularly common in Southeast Asia and has variable symptoms ranging from mild to severe anemia. Previous investigations demonstrated the remarkable symptoms of β-thalassemia i...

    Authors: Saranyoo Ponnikorn, Tasanee Panichakul, Kitima Sresanga, Chokdee Wongborisuth, Sittiruk Roytrakul, Suradej Hongeng and Sumalee Tungpradabkul
    Citation: Journal of Translational Medicine 2011 9:96
  19. Metastasis suppressor-1 (MTSS1) has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of ...

    Authors: Fei Xie, Lin Ye, Jinfeng Chen, Nan Wu, Zhiqian Zhang, Yue Yang, Lijian Zhang and Wen G Jiang
    Citation: Journal of Translational Medicine 2011 9:95
  20. Platinum-based regimens are the treatments of choice in ovarian cancer, which remains the leading cause of death from gynecological malignancies in the Western world. The aim of the present study was to compar...

    Authors: Chiara Arienti, Anna Tesei, Giorgio Maria Verdecchia, Massimo Framarini, Salvatore Virzì, Antonio Grassi, Emanuela Scarpi, Livia Turci, Rosella Silvestrini, Dino Amadori and Wainer Zoli
    Citation: Journal of Translational Medicine 2011 9:94
  21. One of the most neglected areas of everyday clinical practice for HIV physicians is unexpectedly represented by CD4 T cell counts when used as an aid to clinical decisions. All who care for HIV patients believ...

    Authors: Andrea De Maria and Andrea Cossarizza
    Citation: Journal of Translational Medicine 2011 9:93
  22. Trauma is one of the leading causes of death in young adult patients. Many pre-clinical and clinical studies attempt to investigate the immunological pathways involved, however the true mediators remain to be ...

    Authors: Paul F Hwang, Nancy Porterfield, Dylan Pannell, Thomas A Davis and Eric A Elster
    Citation: Journal of Translational Medicine 2011 9:92
  23. Blood specimen collection at an early study visit is often included in observational studies or clinical trials for analysis of secondary outcome biomarkers. A common protocol is to store buffy coat specimens ...

    Authors: Josyf C Mychaleckyj, Emily A Farber, Jessica Chmielewski, Jamie Artale, Laney S Light, Donald W Bowden, Xuanlin Hou and Santica M Marcovina
    Citation: Journal of Translational Medicine 2011 9:91
  24. Tumor immune tolerance can derive from the recruitment of suppressor cell populations, including myeloid-derived suppressor cells (MDSC). In cancer patients, MDSC accumulation correlates with increased tumor b...

    Authors: Melissa G Lechner, Carolina Megiel, Sarah M Russell, Brigid Bingham, Nicholas Arger, Tammy Woo and Alan L Epstein
    Citation: Journal of Translational Medicine 2011 9:90
  25. The use of tolerogenic DCs is a promising therapeutic strategy for transplantation and autoimmune disorders. Immunomodulatory DCs are primarily generated from monocytes (MDDCs) for in vitro experiments following ...

    Authors: M Naranjo-Gómez, D Raïch-Regué, C Oñate, L Grau-López, C Ramo-Tello, R Pujol-Borrell, E Martínez-Cáceres and Francesc E Borràs
    Citation: Journal of Translational Medicine 2011 9:89
  26. Mast cells promote the progression of experimental tumors and might be a valuable therapeutic target. However, the relevant clinical evidence is still controversial. This study analyzed the relationship betwee...

    Authors: Qing Xia, Xiao-Jun Wu, Qiang Zhou, Jing-Zeng, Jing-Hui Hou, Zhi-Zhong Pan and Xiao-Shi Zhang
    Citation: Journal of Translational Medicine 2011 9:88
  27. Exosomes are small membrane vesicles with a size of 40-100 nm that are released by different cell types from a late endosomal cellular compartment. They can be found in various body fluids including plasma, ma...

    Authors: Sascha Keller, Johannes Ridinger, Anne-Kathleen Rupp, Johannes WG Janssen and Peter Altevogt
    Citation: Journal of Translational Medicine 2011 9:86
  28. Early detection of mixed aerobic-anaerobic infection has been a challenge in clinical practice due to the phenotypic changes in complex environments. Surface plasmon resonance (SPR) biosensor is widely used to...

    Authors: Jue Wang, Yang Luo, Bo Zhang, Ming Chen, Junfu Huang, Kejun Zhang, Weiyin Gao, Weiling Fu, Tianlun Jiang and Pu Liao
    Citation: Journal of Translational Medicine 2011 9:85
  29. The aim of this proteomic study was to look for changes taking place in plasma proteomes of patients with acute myocardial infarction (AMI), unstable angina pectoris (UAP), and stable angina pectoris (SAP).

    Authors: Pavel Májek, Zuzana Reicheltová, Jiří Suttnar, Martin Malý, Milan Oravec, Klára Pečánková and Jan E Dyr
    Citation: Journal of Translational Medicine 2011 9:84
  30. Preliminary experimental studies have suggested that the in situ destruction of tumor tissue by local laser ablation (LA) may also stimulate host immunity against cancer. We investigated local and systemic ind...

    Authors: Wen Xu Lin, Theodora Fifis, Caterina Malcontenti-Wilson, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Linh Nguyen and Christopher Christophi
    Citation: Journal of Translational Medicine 2011 9:83
  31. Colorectal cancer (CRC) is the predominant gastrointestinal malignancy and the leading cause of cancer death. The identification of genes related to CRC is important for the development of successful therapies...

    Authors: Chi-Jung Huang, Shung-Haur Yang, Shih-Ming Huang, Chih-Ming Lin, Chih-Cheng Chien, Yan-Chu Chen, Chia-Long Lee, Hao-Han Wu and Chun-Chao Chang
    Citation: Journal of Translational Medicine 2011 9:82
  32. Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is characterised by severe prolonged fatigue, and decreases in cognition and other physiological functions, resulting in severe loss of quality of li...

    Authors: Ekua W Brenu, Mieke L van Driel, Don R Staines, Kevin J Ashton, Sandra B Ramos, James Keane, Nancy G Klimas and Sonya M Marshall-Gradisnik
    Citation: Journal of Translational Medicine 2011 9:81
  33. Variability of plasma sample collection and of proteomics technology platforms has been detrimental to generation of large proteomic profile datasets from human biospecimens.

    Authors: Catherine P Riley, Xiang Zhang, Harikrishna Nakshatri, Bryan Schneider, Fred E Regnier, Jiri Adamec and Charles Buck
    Citation: Journal of Translational Medicine 2011 9:80
  34. Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, se...

    Authors: Thomas GP Grunewald, Saskia M Herbst, Jürgen Heinze and Stefan Burdach
    Citation: Journal of Translational Medicine 2011 9:79
  35. The prognosis of cutaneous melanoma (CM) differs for patients with identical clinico-pathological stage, and no molecular markers discriminating the prognosis of stage III individuals have been established. Ge...

    Authors: Luca Sigalotti, Elisabetta Fratta, Ettore Bidoli, Alessia Covre, Giulia Parisi, Francesca Colizzi, Sandra Coral, Samuele Massarut, John M Kirkwood and Michele Maio
    Citation: Journal of Translational Medicine 2011 9:78
  36. Time-dependent chemotherapeutic agents can selectively target tumor cells in susceptible phases of the cell cycle however a fraction of tumor cells in non-vulnerable cell cycle phases remain drug-resistant. Im...

    Authors: Ioannis Alagkiozidis, Andrea Facciabene, Marinos Tsiatas, Carmine Carpenito, Fabian Benencia, Sarah Adams, Zdenka Jonak, Carl H June, Daniel J Powell Jr and George Coukos
    Citation: Journal of Translational Medicine 2011 9:77
  37. A molecular linkage between the MAPK and the LKB1-AMPK energy sensor pathways suggests that combined MAPK oncogene inhibition and metabolic modulation of AMPK would be more effective than either manipulation a...

    Authors: Franziska Niehr, Erika von Euw, Narsis Attar, Deliang Guo, Doug Matsunaga, Hooman Sazegar, Charles Ng, John A Glaspy, Juan A Recio, Roger S Lo, Paul S Mischel, Begonya Comin-Anduix and Antoni Ribas
    Citation: Journal of Translational Medicine 2011 9:76
  38. Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Most GIST harbor a mutation affecting either the KIT or PDGFRA genes, whereas a small subgroup of tu...

    Authors: Alessandra Maleddu, Maria A Pantaleo, Margherita Nannini and Guido Biasco
    Citation: Journal of Translational Medicine 2011 9:75
  39. Aurora kinase ensures accurate chromosome segregation during cell cycle, maintaining genetic integrity in cell division. VX-680, a small-molecule Aurora kinase inhibitor, interferes with mitotic entry and form...

    Authors: Duo-Rong Xu, Shan Huang, Zi-Jie Long, Jia-Jie Chen, Zheng-Zhi Zou, Juan Li, Dong-Jun Lin and Quentin Liu
    Citation: Journal of Translational Medicine 2011 9:74
  40. Our previous studies indicate that either PEP-1-superoxide dismutase 1 (SOD1) or PEP-1-catalase (CAT) fusion proteins protects myocardium from ischemia-reperfusion-induced injury in rats. The aim of this study...

    Authors: Guang-Qing Huang, Jia-Ning Wang, Jun-Ming Tang, Lei Zhang, Fei Zheng, Jian-Ye Yang, Ling-Yun Guo, Xia Kong, Yong-Zhang Huang, Yong Liu and Shi-You Chen
    Citation: Journal of Translational Medicine 2011 9:73
  41. The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on cell surface. SULF1 and SULF2 are two endosulfatases able to cleave specific 6-O...

    Authors: Caroline Bret, Jérôme Moreaux, Jean-François Schved, Dirk Hose and Bernard Klein
    Citation: Journal of Translational Medicine 2011 9:72
  42. Acute myeloid leukemia (AML) is an immunophenotypically heterogenous malignant disease, in which CD34 positivity is associated with poor prognosis. CD34+ AML cells are 10-15-fold more resistant to daunorubicin (D...

    Authors: Jia Rao, Duo-Rong Xu, Fei-Meng Zheng, Zi-Jie Long, Sheng-Shan Huang, Xing Wu, Wei-Hua Zhou, Ren-Wei Huang and Quentin Liu
    Citation: Journal of Translational Medicine 2011 9:71
  43. A limitation of positive selection strategies to enrich for circulating tumor cells (CTCs) is that there might be CTCs with insufficient expression of the surface target marker which may be missed by the proce...

    Authors: Zhian Liu, Alberto Fusi, Eva Klopocki, Alexander Schmittel, Ingeborg Tinhofer, Anika Nonnenmacher and Ulrich Keilholz
    Citation: Journal of Translational Medicine 2011 9:70
  44. The HPV16 E7 protein is both a tumour-specific and a tumour-rejection antigen, the ideal target for developing therapeutic vaccines for the treatment of HPV16-associated cancer and its precursor lesions. E7, w...

    Authors: Linda Petrone, Maria G Ammendolia, Armando Cesolini, Stefano Caimi, Fabiana Superti, Colomba Giorgi and Paola Di Bonito
    Citation: Journal of Translational Medicine 2011 9:69
  45. Duchenne muscular dystrophy (DMD) is an inherited and progressive disease causing striated muscle deterioration. Patients in their twenties generally die from either respiratory or cardiac failure. In order to...

    Authors: Dawn A Delfín, Ying Xu, Jennifer M Peterson, Denis C Guttridge, Jill A Rafael-Fortney and Paul ML Janssen
    Citation: Journal of Translational Medicine 2011 9:68
  46. Interferons alpha (IFNα) are the cytokines most widely used in clinical medicine for the treatment of cancer and viral infections. Among the immunomodulatory activities possibly involved in their therapeutic e...

    Authors: Eleonora Aricò, Luciano Castiello, Francesca Urbani, Paola Rizza, Monica C Panelli, Ena Wang, Francesco M Marincola and Filippo Belardelli
    Citation: Journal of Translational Medicine 2011 9:67
  47. The differential diagnosis for hereditary ataxia encompasses a variety of diseases characterized by both autosomal dominant and recessive inheritance. There are no curative treatments available for these neuro...

    Authors: Wan-Zhang Yang, Yun Zhang, Fang Wu, Min Zhang, SC Cho, Chun-Zhen Li, Shao-Hui Li, Guo-Jian Shu, You-Xiang Sheng, Ning Zhao, Ying Tang, Shu Jiang, Shan Jiang, Matthew Gandjian, Thomas E Ichim and Xiang Hu
    Citation: Journal of Translational Medicine 2011 9:65
  48. Adoptive cell therapy (ACT) has emerged as an effective treatment for patients with metastatic melanoma. However, there are several logistical and safety concerns associated with large-scale ex vivo expansion of ...

    Authors: Thomas Zuliani, Julien David, Sylvain Bercegeay, Marie-Christine Pandolfino, Isabelle Rodde-Astier, Amir Khammari, Cécile Coissac, Bruno Delorme, Soraya Saïagh and Brigitte Dréno
    Citation: Journal of Translational Medicine 2011 9:63

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