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  1. The prognosis for malignant gliomas remains dismal. We addressed the safety, feasibility and preliminary clinical activity of the vaccinations using autologous glioma cells and interleukin (IL)-4 gene transfec...

    Authors: Hideho Okada, Frank S Lieberman, Kevin A Walter, L Dade Lunsford, Douglas S Kondziolka, Ghassan K Bejjani, Ronald L Hamilton, Alejandro Torres-Trejo, Pawel Kalinski, Quan Cai, Jennifer L Mabold, Howard D Edington, Lisa H Butterfield, Theresa L Whiteside, Douglas M Potter, S Clifford Schold Jr…
    Citation: Journal of Translational Medicine 2007 5:67
  2. Pharmacokinetic advantages of intraperitoneal (IP) rhIL-12, tumor response to IP delivery of other cytokines as well as its potential anti-angiogenic effect provided the rationale for further evaluation of IPr...

    Authors: Renato Lenzi, Robert Edwards, Carl June, Michael V Seiden, Michael E Garcia, Michael Rosenblum and Ralph S Freedman
    Citation: Journal of Translational Medicine 2007 5:66
  3. Interactions between mononuclear cells and activated pancreatic myofibroblasts (pancreatic stellate cells; PSC) may contribute to inflammation and fibrosis in chronic pancreatitis (CP).

    Authors: Christoph W Michalski, Andre Gorbachevski, Mert Erkan, Carolin Reiser, Stefanie Deucker, Frank Bergmann, Thomas Giese, Markus Weigand, Nathalia A Giese, Helmut Friess and Jörg Kleeff
    Citation: Journal of Translational Medicine 2007 5:63
  4. Although systemic T-cell responses against tumor antigens and tumor infiltration by T cells have been investigated in colorectal cancer (CRC), the initiation of spontaneous immune responses in situ is not well un...

    Authors: Dirk Nagorsen, Sabine Voigt, Erika Berg, Harald Stein, Eckhard Thiel and Christoph Loddenkemper
    Citation: Journal of Translational Medicine 2007 5:62
  5. Integrins are important adhesion molecules that regulate tumor and endothelial cell survival, proliferation and migration. The integrin α5β1 has been shown to play a critical role during angiogenesis. An inhib...

    Authors: Vinay Bhaskar, Dong Zhang, Melvin Fox, Pui Seto, Melanie HL Wong, Pauline E Wales, David Powers, Debra T Chao, Robert B DuBridge and Vanitha Ramakrishnan
    Citation: Journal of Translational Medicine 2007 5:61
  6. An open-label Phase 1 study of recombinant prime-boost poxviruses targeting CEA and MUC-1 in patients with advanced pancreatic cancer was conducted to determine safety, tolerability and obtain preliminary data...

    Authors: Howard L Kaufman, Seunghee Kim-Schulze, Kelledy Manson, Gail DeRaffele, Josephine Mitcham, Kang Seok Seo, Dae Won Kim and John Marshall
    Citation: Journal of Translational Medicine 2007 5:60
  7. A recent Keystone Symposium Meeting on "Immunological Intervention in Human Disease" was held in Big Sky, Montana on January, 6–11, 2007, organized by Jacques Banchereau, Federica Sallusto and Robert Coffman. ...

    Authors: Hideki Ueno, Catherine M Hawrylowicz and Jacques Banchereau
    Citation: Journal of Translational Medicine 2007 5:59
  8. Colon cancer is the second leading cause of cancer deaths in the western world. If detected early, colorectal cancer is one of the most treatable forms of cancer. Unfortunately, very few people are screened. N...

    Authors: Anuraag Shrivastav, Shailly Varma, Anurag Saxena, John DeCoteau and Rajendra K Sharma
    Citation: Journal of Translational Medicine 2007 5:58
  9. Angiogenesis is a critical component of the proliferative endometrial phase of the menstrual cycle. Thus, we hypothesized that a stem cell-like population exist and can be isolated from menstrual blood. Mononu...

    Authors: Xiaolong Meng, Thomas E Ichim, Jie Zhong, Andrea Rogers, Zhenglian Yin, James Jackson, Hao Wang, Wei Ge, Vladimir Bogin, Kyle W Chan, Bernard Thébaud and Neil H Riordan
    Citation: Journal of Translational Medicine 2007 5:57
  10. The mechanisms by which tumor-specific T cells induce regression of established metastases are not fully characterized. In using the poorly immunogenic B16BL6-D5 (D5) melanoma model we reported that T cell-med...

    Authors: Hauke Winter, Natasja K van den Engel, Dominik Rüttinger, Jürgen Schmidt, Matthias Schiller, Christian H Poehlein, Florian Löhe, Bernard A Fox, Karl-Walter Jauch, Rudolf A Hatz and Hong-Ming Hu
    Citation: Journal of Translational Medicine 2007 5:56
  11. The stromal vascular fraction (SVF) is a heterogeneous cell population derived from the adipose tissue. There is still a lack of information concerning the characterization of the cell subpopulations constitut...

    Authors: Giuseppe Astori, Francesca Vignati, Silvana Bardelli, Monica Tubio, Mauro Gola, Veronica Albertini, Franco Bambi, Giancarlo Scali, Damiano Castelli, Valeria Rasini, Gianni Soldati and Tiziano Moccetti
    Citation: Journal of Translational Medicine 2007 5:55
  12. Autologous mobilised peripheral blood stem cell (PBSC) transplantation is now a standard approach in the treatment of haematological diseases to reconstitute haematopoiesis following myeloablative chemotherapy...

    Authors: Olga Tura, G Robin Barclay, Huw Roddie, John Davies and Marc L Turner
    Citation: Journal of Translational Medicine 2007 5:53
  13. Despite numerous studies aimed at verifying the antitumor activity of nitric oxide-releasing nonsteroidal antiflammatory drugs (NO-NSAIDs), little is known about the molecular targets responsible for their ant...

    Authors: Anna Tesei, Marco Rosetti, Paola Ulivi, Francesco Fabbri, Laura Medri, Ivan Vannini, Manlio Bolla, Dino Amadori and Wainer Zoli
    Citation: Journal of Translational Medicine 2007 5:52
  14. Metastatic renal cell carcinoma (MRCC) has a poor prognosis with a median overall survival of about one year. Since only a minority of patients experienced therapeutic benefit to current treatments, several st...

    Authors: Michele Guida, Addolorata Casamassima, Giulia Monticelli, Michele Quaranta and Giuseppe Colucci
    Citation: Journal of Translational Medicine 2007 5:51
  15. Treatment options for patients with recurrent superficial bladder cancer are limited, necessitating aggressive exploration of new treatment strategies that effectively prevent recurrence and progression to inv...

    Authors: Michael T Buckley, Joanne Yoon, Herman Yee, Luis Chiriboga, Leonard Liebes, Gulshan Ara, Xiaozhong Qian, Dean F Bajorin, Tung-Tien Sun, Xue-Ru Wu and Iman Osman
    Citation: Journal of Translational Medicine 2007 5:49
  16. Electrochemotherapy (ECT) is a novel anticancer therapy that is currently being evaluated in human and pet cancer patients. ECT associates the administration of an anti-tumor agent to the delivery of trains of...

    Authors: Enrico P Spugnini, Feliciano Baldi, Pasquale Mellone, Florinda Feroce, Alfredo D'Avino, Francesco Bonetto, Bruno Vincenzi, Gennaro Citro and Alfonso Baldi
    Citation: Journal of Translational Medicine 2007 5:48
  17. Toxicogenomics can measure the expression of thousands of genes to identify changes associated with drug induced toxicities. It is expected that toxicogenomics can be an alternative or complementary approach i...

    Authors: Ying Jiang, David L Gerhold, Daniel J Holder, David J Figueroa, Wendy J Bailey, Ping Guan, Thomas R Skopek, Frank D Sistare and Joseph F Sina
    Citation: Journal of Translational Medicine 2007 5:47
  18. Dendritic cell (DC) vaccines can induce antitumor immune responses in patients with malignant diseases, while the most suitable DC culture conditions have not been established yet. In this study we compared mo...

    Authors: Mark Korthals, Nancy Safaian, Ralf Kronenwett, Dagmar Maihöfer, Matthias Schott, Claudia Papewalis, Elena Diaz Blanco, Meike Winter, Akos Czibere, Rainer Haas, Guido Kobbe and Roland Fenk
    Citation: Journal of Translational Medicine 2007 5:46
  19. Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder with monogenic mutations setting the stage for successful gene therapy treatment. We have completed a study that directly deals with the foll...

    Authors: Louise R Rodino-Klapac, Paul ML Janssen, Chrystal L Montgomery, Brian D Coley, Louis G Chicoine, K Reed Clark and Jerry R Mendell
    Citation: Journal of Translational Medicine 2007 5:45
  20. Portal hypertension is a clinical syndrome that is difficult to study in an isolated manner since it is always associated with a greater or lesser degree of liver functional impairment. The aim of this review ...

    Authors: María-Angeles Aller, Jorge-Luis Arias and Jaime Arias
    Citation: Journal of Translational Medicine 2007 5:44
  21. Given the considerable toxicity and modest benefit of adjuvant chemotherapy for non-small cell lung cancer (NSCLC), there is clearly a need for new treatment modalities in the adjuvant setting. Active specific...

    Authors: Dominik Rüttinger, Natasja K van den Engel, Hauke Winter, Marcus Schlemmer, Heike Pohla, Stefanie Grützner, Beate Wagner, Dolores J Schendel, Bernard A Fox, K-W Jauch and Rudolf A Hatz
    Citation: Journal of Translational Medicine 2007 5:43
  22. The HER2-inhibiting antibody trastuzumab, in combination with chemotherapy, significantly improves survival of women with resected, HER2-overexpressing breast cancers, but is associated with toxicities includi...

    Authors: Michael A Morse, Amy Hobeika, Takuya Osada, Donna Niedzwiecki, Paul Kelly Marcom, Kimberly L Blackwell, Carey Anders, Gayathri R Devi, H Kim Lyerly and Timothy M Clay
    Citation: Journal of Translational Medicine 2007 5:42
  23. Sub-clinical variant Creutzfeldt-Jakob disease (vCJD) infection and reports of vCJD transmission through blood transfusion emphasise the need for blood screening assays to ensure the safety of blood and transp...

    Authors: Timothy J Fagge, G Robin Barclay, G Colin Stove, Gordon Stove, Michael J Robinson, Mark W Head, James W Ironside and Marc L Turner
    Citation: Journal of Translational Medicine 2007 5:41
  24. In our endeavor to recognize outstanding contributions in the field of translational medicine, the Editorial Board of the Journal of Translational Medicine (JTM) in collaboration with Global Translational Medicin...

    Authors: Richard J Ablin and Yi-Xin Zeng
    Citation: Journal of Translational Medicine 2007 5:40
  25. Experimental results from studies with inbred mice and their syngeneic tumors indicated that the inoculation of semi-allogeneic cell hybrids (derived from the fusion between syngeneic tumor cells and an alloge...

    Authors: Jin Yu, Mark S Kindy and Sebastiano Gattoni-Celli
    Citation: Journal of Translational Medicine 2007 5:39
  26. Ocular melanoma is the leading intraocular malignancy. There is no effective treatment for metastatic ocular melanoma. We sought a treatment targeting the tumor microenvironment as well as the tumor cells.

    Authors: David P Mangiameli, Joseph A Blansfield, Stephan Kachala, Dominique Lorang, Peter H Schafer, George W Muller, David I Stirling and Steven K Libutti
    Citation: Journal of Translational Medicine 2007 5:38
  27. The discovery of adult endothelial progenitor cells (EPC) offers potential for vascular regenerative therapies. The expression of CD34 and VEGFR2 by EPC indicates a close relationship with haematopoietic proge...

    Authors: Olga Tura, G Robin Barclay, Huw Roddie, John Davies and Marc L Turner
    Citation: Journal of Translational Medicine 2007 5:37
  28. Bcl-3 as an oncoprotein is overexpressed in nasopharyngeal carcinoma (NPC). Nedd4 binding protein 2 (N4BP2), which is located in the NPC susceptibility locus, is a Bcl-3 binding protein. This study is aimed to...

    Authors: Mei-Zhen Zheng, Hai-De Qin, Xing-Juan Yu, Ru-Hua Zhang, Li-Zhen Chen, Qi-Sheng Feng and Yi-Xin Zeng
    Citation: Journal of Translational Medicine 2007 5:36
  29. Tumor cell contamination of the apheresis in multiple myeloma is likely to affect disease-free and overall survival after autografting.

    Authors: Sara Deola, Samantha Scaramuzza, Roberto Sciarretta Birolo, Massimiliano Cergnul, Francesca Ficara, Jonathan Dando, Claudia Voena, Sergio Vai, Marta Monari, Enrico Pogliani, Gianmarco Corneo, Jacopo Peccatori, Silvia Selleri, Claudio Bordignon, Maria Grazia Roncarolo, Alessandro Aiuti…
    Citation: Journal of Translational Medicine 2007 5:35
  30. High intensity focused ultrasound (HIFU) is an emerging non-invasive treatment modality for localized treatment of cancers. While current clinical strategies employ HIFU exclusively for thermal ablation of the...

    Authors: Zhenlin Hu, Xiao Yi Yang, Yunbo Liu, Georgy N Sankin, Eric C Pua, Michael A Morse, H Kim Lyerly, Timothy M Clay and Pei Zhong
    Citation: Journal of Translational Medicine 2007 5:34
  31. Despite its widespread use to assess fibrosis, liver biopsy has several important drawbacks, including that is it semi-quantitative, invasive, and limited by sampling and observer variability. Non-invasive ser...

    Authors: Ian R White, Keyur Patel, William T Symonds, Anouk Dev, Philip Griffin, Nikos Tsokanas, Mark Skehel, Chiang Liu, Amany Zekry, Paul Cutler, Mahanandeeshwar Gattu, Don C Rockey, Michelle M Berrey and John G McHutchison
    Citation: Journal of Translational Medicine 2007 5:33
  32. Sunitinib malate (SUTENT®) is an oral, multitargeted tyrosine kinase inhibitor, approved multinationally for the treatment of advanced RCC and of imatinib-resistant or – intolerant GIST. The purpose of this study...

    Authors: Samuel E DePrimo, Carlo L Bello, John Smeraglia, Charles M Baum, Dominic Spinella, Brian I Rini, M Dror Michaelson and Robert J Motzer
    Citation: Journal of Translational Medicine 2007 5:32
  33. Medical implants often fail as a result of so-called foreign body reactions during which inflammatory cells are recruited to implant surfaces. Despite the clinical importance of this phenomenon, the mechanisms...

    Authors: Johann Zdolsek, John W Eaton and Liping Tang
    Citation: Journal of Translational Medicine 2007 5:31
  34. Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions whose incidence is reaching epidemic proportions, afflicting approximately 1 in 166 children. Autistic disorder, or autism is the mo...

    Authors: Thomas E Ichim, Fabio Solano, Eduardo Glenn, Frank Morales, Leonard Smith, George Zabrecky and Neil H Riordan
    Citation: Journal of Translational Medicine 2007 5:30
  35. The anti-tumor efficacy of human immune effector cells, such as cytolytic T lymphocytes (CTLs), has been difficult to study in lung cancer patients in the clinical setting. Improved experimental models for the...

    Authors: Ezogelin Oflazoglu, Mark Elliott, Hiroshi Takita, Soldano Ferrone, Robert A Henderson and Elizabeth A Repasky
    Citation: Journal of Translational Medicine 2007 5:29
  36. Plant lectins such as Galanthus nivalis agglutinin (GNA) and Hippeastrum hybrid agglutinin (HHA) are natural proteins able to link mannose residues, and therefore inhibit HIV-target cell interactions. Plant lecti...

    Authors: Hela Saïdi, Nadine Nasreddine, Mohammad-Ali Jenabian, Maxime Lecerf, Dominique Schols, Corinne Krief, Jan Balzarini and Laurent Bélec
    Citation: Journal of Translational Medicine 2007 5:28
  37. Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease.

    Authors: Francesca Chamian, Shao-Lee Lin, Edmund Lee, Toyoko Kikuchi, Patricia Gilleaudeau, Mary Sullivan-Whalen, Irma Cardinale, Artemis Khatcherian, Inna Novitskaya, Knut M Wittkowski, James G Krueger and Michelle A Lowes
    Citation: Journal of Translational Medicine 2007 5:27
  38. The incidence of cancer increases significantly in later life, yet few pre-clinical studies of cancer immunotherapy use mice of advanced age. A novel vaccine delivery platform (VacciMax®,VM) is described that enc...

    Authors: Pirouz M Daftarian, Marc Mansour, Bill Pohajdak, Antar Fuentes-Ortega, Ella Korets-Smith, Lisa MacDonald, Genevieve Weir, Robert G Brown and W Martin Kast
    Citation: Journal of Translational Medicine 2007 5:26
  39. Although the risk of transfusion-transmitted infections today is lower than ever, the supply of safe blood products remains subject to contamination with known and yet to be identified human pathogens. Only co...

    Authors: Florian Bihl, Damiano Castelli, Francesco Marincola, Roger Y Dodd and Christian Brander
    Citation: Journal of Translational Medicine 2007 5:25
  40. Chronic lymphocytic leukemia (CLL) is characterized by accumulation of mature appearing lymphocytes and is rarely complicated by thrombosis. One possible explanation for the paucity of thrombotic events in the...

    Authors: Dianne Pulte, Kim E Olson, M Johan Broekman, Naziba Islam, Harold S Ballard, Richard R Furman, Ashley E Olson and Aaron J Marcus
    Citation: Journal of Translational Medicine 2007 5:23
  41. The high prevalence of nasopharyngeal cancer (NPC) in Southern Asia and Mediterranean Northern Africa suggests genetic predisposition among other factors. While Human Leukocyte Antigen (HLA) haplotypes have be...

    Authors: Xin Li, Nahla Ghandri, Daniela Piancatelli, Sharon Adams, Deborah Chen, Fu-Meei Robbins, Ena Wang, Alessandro Monaco, Silvia Selleri, Noureddine Bouaouina, David Stroncek, Domenico Adorno, Lotfi Chouchane and Francesco M Marincola
    Citation: Journal of Translational Medicine 2007 5:22
  42. Melanoma tumors are known to express antigens that usually induce weak immune responses of short duration. Expression of both tumor-associated antigens p53 and TRP2 by melanoma cells raises the possibility of ...

    Authors: Marc Mansour, Bill Pohajdak, W Martin Kast, Antar Fuentes-Ortega, Ella Korets-Smith, Genevieve M Weir, Robert G Brown and Pirouz Daftarian
    Citation: Journal of Translational Medicine 2007 5:20
  43. In the present study, we demonstrate, in rigorous fashion, that human monocyte-derived immature dendritic cells (DCs) can efficiently cross-present tumor-associated antigens when co-cultured with a mixture of ...

    Authors: Erika M von Euw, María M Barrio, David Furman, Michele Bianchini, Estrella M Levy, Cassian Yee, Yongqing Li, Rosa Wainstok and José Mordoh
    Citation: Journal of Translational Medicine 2007 5:19
  44. For optimal T cell activation it is desirable that dendritic cells (DCs) display peptides within MHC molecules as signal 1, costimulatory molecules as signal 2 and, in addition, produce IL-12p70 as signal 3. I...

    Authors: Anke Zobywalski, Miran Javorovic, Bernhard Frankenberger, Heike Pohla, Elisabeth Kremmer, Iris Bigalke and Dolores J Schendel
    Citation: Journal of Translational Medicine 2007 5:18

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