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  1. Endothelial dysfunction is associated with major causes of morbidity and mortality, as well as numerous age-related conditions. The possibility of preserving or even rejuvenating endothelial function offers a ...

    Authors: Nina A Mikirova, James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle WH Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Doru T Alexandrescu, Thomas E Ichim and Neil H Riordan
    Citation: Journal of Translational Medicine 2009 7:106
  2. Pancreatic cancer continues to prove difficult to clinically diagnose. Multiple simultaneous measurements of plasma biomarkers can increase sensitivity and selectivity of diagnosis. Proximity ligation assay (P...

    Authors: Stephanie T Chang, Jacob M Zahn, Joe Horecka, Pamela L Kunz, James M Ford, George A Fisher, Quynh T Le, Daniel T Chang, Hanlee Ji and Albert C Koong
    Citation: Journal of Translational Medicine 2009 7:105
  3. Liposomal doxorubicin (Doxil) is a cytotoxic chemotherapy drug with a favorable hematologic toxicity profile. Its active drug, doxorubicin, has interesting immunomodulatory properties. Here, the effects of Dox...

    Authors: Ioannis Alagkiozidis, Andrea Facciabene, Carmine Carpenito, Fabian Benencia, Zdenka Jonak, Sarah Adams, Richard G Carroll, Phyllis A Gimotty, Rachel Hammond, Gwen-äel Danet-Desnoyers, Carl H June, Daniel J Powell Jr and George Coukos
    Citation: Journal of Translational Medicine 2009 7:104
  4. Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. High expression levels of AMACR have been described ...

    Authors: Ichiya Honma, Toshihiko Torigoe, Yoshihiko Hirohashi, Hiroshi Kitamura, Eiji Sato, Naoya Masumori, Yasuaki Tamura, Taiji Tsukamoto and Noriyuki Sato
    Citation: Journal of Translational Medicine 2009 7:103
  5. The search for a suitable biomarker which indicates immune system responses in cancer patients has been long and arduous, but a widely known biomarker has emerged as a potential candidate for this purpose. C-R...

    Authors: Brendon J Coventry, Martin L Ashdown, Michael A Quinn, Svetomir N Markovic, Steven L Yatomi-Clarke and Andrew P Robinson
    Citation: Journal of Translational Medicine 2009 7:102
  6. HIV-1 exposure causes several dramatic unbalances in the immune system homeostasis. Here, we will focus on the paradox whereby CD4 specific autoimmune responses, which are expected to contribute to the catastr...

    Authors: Samuele E Burastero, Mariangela Figini, Barbara Frigerio, Paolo Lusso, Luca Mollica and Lucia Lopalco
    Citation: Journal of Translational Medicine 2009 7:101
  7. Macrophage migration inhibitory factor (MIF) plays an important regulatory role in sepsis. In the promoter region a C/G single nucleotide polymorphism (SNP) at position -173 (rs755622) and a CATT5-8 microsatellit...

    Authors: Lutz E Lehmann, Malte Book, Wolfgang Hartmann, Stefan U Weber, Jens-Christian Schewe, Sven Klaschik, Andreas Hoeft and Frank Stüber
    Citation: Journal of Translational Medicine 2009 7:100
  8. There are many diagnostic techniques and methods available for diagnosis of medically important microorganisms like bacteria, viruses, fungi and parasites. But, almost all these techniques and methods have som...

    Authors: Aamir Shahzad, Gottfried Köhler, Martin Knapp, Erwin Gaubitzer, Martin Puchinger and Michael Edetsberger
    Citation: Journal of Translational Medicine 2009 7:99
  9. MicroRNAs are ~22nt-long small non-coding RNAs that negatively regulate protein expression through mRNA degradation or translational repression in eukaryotic cells. Based upon their importance in regulating de...

    Authors: Seung-Jae Noh, Samuel H Miller, Y Terry Lee, Sung-Ho Goh, Francesco M Marincola, David F Stroncek, Christopher Reed, Ena Wang and Jeffery L Miller
    Citation: Journal of Translational Medicine 2009 7:98
  10. Acute ischemic stroke is the third leading cause of death in industrialized countries and the most frequent cause of permanent disability in adults worldwide. Despite advances in the understanding of the patho...

    Authors: Shaheen E Lakhan, Annette Kirchgessner and Magdalena Hofer
    Citation: Journal of Translational Medicine 2009 7:97
  11. Chronic Fatigue Syndrome (CFS) studies from our laboratory and others have described cytokine abnormalities. Other studies reported no difference between CFS and controls. However, methodologies varied widely ...

    Authors: Mary Ann Fletcher, Xiao Rong Zeng, Zachary Barnes, Silvina Levis and Nancy G Klimas
    Citation: Journal of Translational Medicine 2009 7:96
  12. Medical research to improve health care faces a major problem in the relatively limited availability of adequately annotated and collected biospecimens. This limitation is creating a growing gap between the pa...

    Authors: Peter H Watson, Janet E Wilson-McManus, Rebecca O Barnes, Sara C Giesz, Adrian Png, Richard G Hegele, Jacquelyn N Brinkman, Ian R Mackenzie, David G Huntsman, Anne Junker, Blake Gilks, Erik Skarsgard, Michael Burgess, Samuel Aparicio and Bruce M McManus
    Citation: Journal of Translational Medicine 2009 7:95
  13. Peri-tumoral inflammation is a common tumor response that plays a central role in tumor invasion and metastasis, and inflammatory cell recruitment is essential to this process. The purpose of this study was to...

    Authors: Akhilesh K Sista, Robert J Knebel, Sidhartha Tavri, Magnus Johansson, David G DeNardo, Sophie E Boddington, Sirish A Kishore, Celina Ansari, Verena Reinhart, Fergus V Coakley, Lisa M Coussens and Heike E Daldrup-Link
    Citation: Journal of Translational Medicine 2009 7:94
  14. CD40 activation of antigen presenting cells (APC) such as dendritic cells (DC) and B cells plays an important role in immunological licensing of T cell immunity. Agonist CD40 antibodies have been previously sh...

    Authors: Erica L Carpenter, Rosemarie Mick, Jens Rüter and Robert H Vonderheide
    Citation: Journal of Translational Medicine 2009 7:93
  15. The signal transducer and activator of transcription 3 (STAT-3) is frequently overexpressed in cancer cells, propagates tumorigenesis, and is a key regulator of immune suppression in cancer patients. The prese...

    Authors: William Humphries, Yongtao Wang, Wei Qiao, Chantal Reina-Ortiz, Mohamed K Abou-Ghazal, Lamonne M Crutcher, Jun Wei, Ling-Yuan Kong, Raymond Sawaya, Ganesh Rao, Jeffrey Weinberg, Sujit S Prabhu, Gregory N Fuller and Amy B Heimberger
    Citation: Journal of Translational Medicine 2009 7:92
  16. Our goal was to determine whether short-term intermittent hypoxia exposure, at a level well tolerated by healthy humans and previously shown by our group to increase EPO and erythropoiesis, could mobilize hema...

    Authors: Ginés Viscor, Casimiro Javierre, Teresa Pagès, Josep-Lluis Ventura, Antoni Ricart, Gregorio Martin-Henao, Carmen Azqueta and Ramon Segura
    Citation: Journal of Translational Medicine 2009 7:91
  17. The ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) gene involved in the regulation of cellular ubiquitin levels plays an important role in different cellular processes including cell growth and differentiatio...

    Authors: Barbara Seliger, Diana Handke, Elisabeth Schabel, Juergen Bukur, Rudolf Lichtenfels and Reinhard Dammann
    Citation: Journal of Translational Medicine 2009 7:90
  18. Foxp3 has been suggested to be a standard marker for murine Tregs whereas its role as marker for human Tregs is controversial. While some reports have shown that human Foxp3+ T cells had no regulatory function...

    Authors: Maciej Kmieciak, Madhu Gowda, Laura Graham, Kamar Godder, Harry D Bear, Francesco M Marincola and Masoud H Manjili
    Citation: Journal of Translational Medicine 2009 7:89
  19. Establishing a large rodent model of brain metastasis that can be monitored using clinically relevant magnetic resonance imaging (MRI) techniques is challenging. Non-invasive imaging of brain metastasis in mic...

    Authors: Ho-Taek Song, Elaine K Jordan, Bobbi K Lewis, Wei Liu, Justin Ganjei, Brenda Klaunberg, Daryl Despres, Diane Palmieri and Joseph A Frank
    Citation: Journal of Translational Medicine 2009 7:88
  20. This commentary discusses a study on measurements of matrix metalloproteinase 9 (MMP-9) in serum of pseudoxanthoma elasticum patients recently published in Journal of Molecular Medicine. This study can be cons...

    Authors: Klaus Jung, Ferdinando Mannello and Michael Lein
    Citation: Journal of Translational Medicine 2009 7:87
  21. The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underlying aggressiveness, clinical behavior, and respon...

    Authors: Giuseppe Palmieri, Mariaelena Capone, Maria Libera Ascierto, Giusy Gentilcore, David F Stroncek, Milena Casula, Maria Cristina Sini, Marco Palla, Nicola Mozzillo and Paolo A Ascierto
    Citation: Journal of Translational Medicine 2009 7:86
  22. Hepatitis C virus (HCV) infection is a major cause of hepatocellular carcinoma (HCC) worldwide. The molecular mechanisms of HCV-induced hepatocarcinogenesis are not yet fully elucidated. Besides indirect effec...

    Authors: Valeria De Giorgi, Alessandro Monaco, Andrea Worchech, MariaLina Tornesello, Francesco Izzo, Luigi Buonaguro, Francesco M Marincola, Ena Wang and Franco M Buonaguro
    Citation: Journal of Translational Medicine 2009 7:85
  23. Recent advances in animal models of glioma have facilitated a better understanding of biological mechanisms underlying gliomagenesis and glioma progression. The limitations of existing therapy, including surge...

    Authors: Michael E Sughrue, Isaac Yang, Ari J Kane, Martin J Rutkowski, Shanna Fang, C David James and Andrew T Parsa
    Citation: Journal of Translational Medicine 2009 7:84
  24. Sjögren's syndrome (SjS) is a relatively common autoimmune disease characterized by oral and ocular dryness. There is an increasing need for simple, sensitive and rapid technologies for the diagnosis of SjS an...

    Authors: Peter D Burbelo, Kathryn H Ching, Alexandra T Issa, Caroline M Loftus, Yi Li, Minoru Satoh, Westley H Reeves and Michael J Iadarola
    Citation: Journal of Translational Medicine 2009 7:83
  25. Adoptive cell therapy with allogenic NK cells constitutes a promising approach for the treatment of certain malignancies. Such strategies are currently limited by the requirement of an efficient protocol for N...

    Authors: Damien Portevin, Mary Poupot, Olivier Rolland, Cédric-Olivier Turrin, Jean-Jacques Fournié, Jean-Pierre Majoral, Anne-Marie Caminade and Remy Poupot
    Citation: Journal of Translational Medicine 2009 7:82
  26. In the studies of genomics, it is essential to select a small number of genes that are more significant than the others for the association studies of disease susceptibility. In this work, our goal was to comp...

    Authors: Lung-Cheng Huang, Sen-Yen Hsu and Eugene Lin
    Citation: Journal of Translational Medicine 2009 7:81
  27. Every year, 30,000 babies are born with congenital hearing impairment in China. The molecular etiology of hearing impairment in the Chinese population has not been investigated thoroughly. To provide appropria...

    Authors: Yongyi Yuan, Yiwen You, Deliang Huang, Jinghong Cui, Yong Wang, Qiang Wang, Fei Yu, Dongyang Kang, Huijun Yuan, Dongyi Han and Pu Dai
    Citation: Journal of Translational Medicine 2009 7:79
  28. Main scope of the EU and FDA regulations is to establish a classification criterion for advanced therapy medicinal products (ATMP). Regulations require that ATMPs must be prepared under good manufacturing prac...

    Authors: Sabrina Soncin, Viviana Lo Cicero, Giuseppe Astori, Gianni Soldati, Mauro Gola, Daniel Sürder and Tiziano Moccetti
    Citation: Journal of Translational Medicine 2009 7:78
  29. B-cell chronic lymphocytic leukemia (CLL), the most frequent leukemia in the Western world, is characterized by extremely variable clinical courses with survivals ranging from 1 to more than 15 years. The path...

    Authors: Michele Dal-Bo, Francesco Bertoni, Francesco Forconi, Antonella Zucchetto, Riccardo Bomben, Roberto Marasca, Silvia Deaglio, Luca Laurenti, Dimitar G Efremov, Gianluca Gaidano, Giovanni Del Poeta and Valter Gattei
    Citation: Journal of Translational Medicine 2009 7:76
  30. Kaposi's sarcoma (KS), hemangioma, and other angioproliferative diseases are highly prevalent in HIV-infected individuals. While KS is etiologically linked to the human herpesvirus-8 (HHV8) infection, HIV-pati...

    Authors: Suraiya Rasheed, Jasper S Yan, Adil Hussain and Bruce Lai
    Citation: Journal of Translational Medicine 2009 7:75
  31. apogossypolone (ApoG2) is a novel derivate of gossypol. We previously have reported that ApoG2 is a promising compound that kills nasopharyngeal carcinoma (NPC) cells by inhibiting the antiapoptotic function o...

    Authors: Zhe-Yu Hu, Jian Sun, Xiao-Feng Zhu, Dajun Yang and Yi-Xin Zeng
    Citation: Journal of Translational Medicine 2009 7:74
  32. Serological examination of Epstein-Barr virus (EBV) antibodies has been performed for screening nasopharyngeal carcinoma (NPC) and other EBV-associated diseases.

    Authors: Ai-Di Gu, Li-Xia Lu, Yan-Bo Xie, Li-Zhen Chen, Qi-Sheng Feng, Tiebang Kang, Wei-Hua Jia and Yi-Xin Zeng
    Citation: Journal of Translational Medicine 2009 7:73
  33. To identify novel HLA-A*2402-restricted human cytomegalovirus (HCMV) immediate early-1 (IE-1) epitopes for adoptive immunotherapy, we explored 120 overlapping 15-amino acid spanning IE-1.

    Authors: Jong-Baeck Lim, Hyun Ok Kim, Seok Hoon Jeong, Joo Eun Ha, Sunphil Jang, Sang-Guk Lee, Kyungwon Lee and David Stroncek
    Citation: Journal of Translational Medicine 2009 7:72
  34. One of the putative mechanisms of tumor immune escape is based on the hypothesis that carcinomas actively create an immunosuppressed state via the expression of indoleamine 2,3-dioxygenase (IDO), both in the c...

    Authors: Yan-Fang Gao, Rui-Qing Peng, Jiang Li, Ya Ding, Xing Zhang, Xiao-Jun Wu, Zhi-Zhong Pan, De-Sen Wan, Yi-Xin Zeng and Xiao-Shi Zhang
    Citation: Journal of Translational Medicine 2009 7:71
  35. To test the carcinostatic effects of ascorbic acid, we challenged the mice of seven experimental groups with 1.7 × 10-4 mol high dose concentration ascorbic acid after intraperitoneal administrating them with sar...

    Authors: Chang-Hwan Yeom, Gunsup Lee, Jin-Hee Park, Jaelim Yu, Seyeon Park, Sang-Yeop Yi, Hye Ree Lee, Young Seon Hong, Joosung Yang and Sukchan Lee
    Citation: Journal of Translational Medicine 2009 7:70
  36. Ovarian cancer ascites fluid (OCAF), contains malignant cells, is usually present in women with an advanced stage disease and currently has no effective therapy. Hence, we developed a new therapy strategy to t...

    Authors: Aya Mizrahi, Abraham Czerniak, Tally Levy, Smadar Amiur, Jennifer Gallula, Imad Matouk, Rasha Abu-lail, Vladimir Sorin, Tatiana Birman, Nathan de Groot, Abraham Hochberg and Patricia Ohana
    Citation: Journal of Translational Medicine 2009 7:69
  37. To explore the biological activity of EMD 273063 (hu14.18-IL2), a humanized anti-GD2 monoclonal antibody fused to interleukin-2 (IL2), in patients with unresectable, stage IV cutaneous melanoma as measured by ...

    Authors: Antoni Ribas, John M Kirkwood, Michael B Atkins, Theresa L Whiteside, William Gooding, Andreas Kovar, Stephen D Gillies, Oscar Kashala and Michael A Morse
    Citation: Journal of Translational Medicine 2009 7:68
  38. Inotropes are associated with adverse outcomes in heart failure (HF), raising concern they may accelerate myocardial injury. Whether biomarkers of myocardial necrosis, inflammation and apoptosis change in resp...

    Authors: David E Lanfear, Reema Hasan, Ramesh C Gupta, Celeste Williams, Barbara Czerska, Cristina Tita, Rasha Bazari and Hani N Sabbah
    Citation: Journal of Translational Medicine 2009 7:67
  39. The development of cell-based therapeutics for humans requires preclinical testing in animal models. The use of autologous animal products fails to address the efficacy of similar products derived from humans....

    Authors: Thomas J Kiernan, Barry A Boilson, Tyra A Witt, Allan B Dietz, Amir Lerman and Robert D Simari
    Citation: Journal of Translational Medicine 2009 7:66
  40. mRNA profiling has become an important tool for developing and validating prognostic assays predictive of disease treatment response and outcome. Archives of annotated formalin-fixed paraffin-embedded tissues ...

    Authors: Sven Duenwald, Mingjie Zhou, Yanqun Wang, Serguei Lejnine, Amit Kulkarni, Jaime Graves, Ryan Smith, John Castle, George Tokiwa, Bernard Fine, Hongyue Dai, Thomas Fare and Matthew Marton
    Citation: Journal of Translational Medicine 2009 7:65
  41. Mycophenolic acid (MPA) is widely used as part of immunosuppressive regimens following allograft transplantation. The large pharmacokinetic (PK) and pharmacodynamic (PD) variability and narrow therapeutic rang...

    Authors: Sara Bremer, Nils T Vethe, Helge Rootwelt, Pål F Jørgensen, Jean Stenstrøm, Hallvard Holdaas, Karsten Midtvedt and Stein Bergan
    Citation: Journal of Translational Medicine 2009 7:64
  42. We previously described a sub-population of epithelial ovarian cancer (EOC) cells with a functional TLR-4/MyD88/NF-κB pathway (Type I EOC cells), which confers the capacity to respond to Paclitaxel, a known TL...

    Authors: Ki Hyung Kim, Yanhua Xie, Ewan M Tytler, Richard Woessner, Gil Mor and Ayesha B Alvero
    Citation: Journal of Translational Medicine 2009 7:63
  43. While all anti-diabetic agents can decrease blood glucose level directly or indirectly, few are able to protect and preserve both pancreatic beta cell mass and their insulin-secreting functions. Thus, there is...

    Authors: Zaijun Zhang, Jie Jiang, Pei Yu, Xiangping Zeng, James W Larrick and Yuqiang Wang
    Citation: Journal of Translational Medicine 2009 7:62
  44. Sperm protein 17 (Sp17) is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine ...

    Authors: Maurizio Chiriva-Internati, Nicoletta Gagliano, Elena Donetti, Francesco Costa, Fabio Grizzi, Barbara Franceschini, Elena Albani, Paolo E Levi-Setti, Magda Gioia, Marjorie Jenkins, Everardo Cobos and W Martin Kast
    Citation: Journal of Translational Medicine 2009 7:61
  45. Mass spectrometric analysis of the blood proteome is an emerging method of clinical proteomics. The approach exploiting multi-protein/peptide sets (fingerprints) detected by mass spectrometry that reflect over...

    Authors: Monika Pietrowska, Lukasz Marczak, Joanna Polanska, Katarzyna Behrendt, Elzbieta Nowicka, Anna Walaszczyk, Aleksandra Chmura, Regina Deja, Maciej Stobiecki, Andrzej Polanski, Rafal Tarnawski and Piotr Widlak
    Citation: Journal of Translational Medicine 2009 7:60
  46. MHC class I expression by cancer cells enables specific antigen recognition by the immune system and protection of the host. However, in some cancer types MHC class I expression is associated with an unfavorab...

    Authors: Courtney Smith, Mariarita Santi, Bhargavi Rajan, Elisabeth J Rushing, Mi Rim Choi, Brian R Rood, Robert Cornelison, Tobey J MacDonald and Stanislav Vukmanovic
    Citation: Journal of Translational Medicine 2009 7:59
  47. The dose-delivery schedule of conventional chemotherapy, which determines its efficacy and toxicity, is based on the maximum tolerated dose. This strategy has lead to cure and disease control in a significant ...

    Authors: Ramon Kaneno, Galina V Shurin, Irina L Tourkova and Michael R Shurin
    Citation: Journal of Translational Medicine 2009 7:58

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