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  1. Results from large epidemiologic studies on the association between vitamin D and gastric cancer are controversial. Vitamin D significantly promotes apoptosis in the undifferentiated gastric cancer cell, but t...

    Authors: Chao Ren, Miao-zhen Qiu, De-shen Wang, Hui-yan Luo, Dong-sheng Zhang, Zhi-qiang Wang, Feng-hua Wang, Yu-hong Li, Zhi-wei Zhou and Rui-hua Xu
    Citation: Journal of Translational Medicine 2012 10:16
  2. Overcoming the notorious apoptotic resistance of melanoma cells remains a therapeutic challenge given dismal survival of patients with metastatic melanoma. However, recent clinical trials using a BRAF inhibito...

    Authors: Jianzhong Qin, Hong Xin and Brian J Nickoloff
    Citation: Journal of Translational Medicine 2012 10:15
  3. Intratumoral and circulating regulatory T cells (Tregs) have been shown to be critical in the pathogenesis of hepatocellular carcinoma (HCC). However there is limited knowledge on the alterations of regulatory...

    Authors: Tianxiang Chen, Dongli Song, Zhihui Min, Xiangdong Wang, Yu Gu, Bajin Wei, Jia Yao, Kangjie Chen, Zhijun Jiang, Haiyang Xie, Lin Zhou and Shusen Zheng
    Citation: Journal of Translational Medicine 2012 10:14
  4. It is widely accepted that systemic neoplastic spread is a late event in tumour progression. However, sometimes, rapidly invasive cancers are diagnosed because of appearance of metastatic lesions in absence of...

    Authors: Giulia Maria Stella, Rebecca Senetta, Adele Cassenti, Margherita Ronco and Paola Cassoni
    Citation: Journal of Translational Medicine 2012 10:12
  5. Osteoblast and adipocyte are derived from common mesenchymal progenitor cells. The bone loss of osteoporosis is associated with altered progenitor differentiation from an osteoblastic to an adipocytic lineage....

    Authors: Li You, Ling Pan, Lin Chen, Jin-Yu Chen, Xiaoping Zhang, Zhongwei Lv and Da Fu
    Citation: Journal of Translational Medicine 2012 10:11
  6. HER2 and TOP2A parameters (gene status, mRNA and protein expression) have individually been associated with the outcome of patients treated with anthracyclines. The aim of this study was to comprehensively eva...

    Authors: George Fountzilas, Christos Valavanis, Vassiliki Kotoula, Anastasia G Eleftheraki, Konstantine T Kalogeras, Olympia Tzaida, Anna Batistatou, Ralf Kronenwett, Ralph M Wirtz, Mattheos Bobos, Eleni Timotheadou, Nikolaos Soupos, George Pentheroudakis, Helen Gogas, Dimitrios Vlachodimitropoulos, Genovefa Polychronidou…
    Citation: Journal of Translational Medicine 2012 10:10
  7. Combination of oncolytic vaccinia virus therapy with conventional chemotherapy has shown promise for tumor therapy. However, side effects of chemotherapy including thrombocytopenia, still remain problematic.

    Authors: Julia B Sturm, Michael Hess, Stephanie Weibel, Nanhai G Chen, Yong A Yu, Qian Zhang, Ulrike Donat, Cora Reiss, Stepan Gambaryan, Georg Krohne, Jochen Stritzker and Aladar A Szalay
    Citation: Journal of Translational Medicine 2012 10:9
  8. Bcl-2 is believed to contribute to melanoma chemoresistance. However, expression of Bcl-2 proteins may be different among melanomas. Thus correlations among expression of Bcl-2-related proteins and in vivo melano...

    Authors: Salvador Mena, María L Rodriguez, Angel Ortega, Sonia Priego, Elena Obrador, Miguel Asensi, Ignacio Petschen, Miguel Cerdá, Bob D Brown and José M Estrela
    Citation: Journal of Translational Medicine 2012 10:8
  9. A large amount of information has been collected on the molecular tumorigenesis of thyroid cancer. A low expression of c-KIT gene has been reported during the transformation of normal thyroid epithelium to pap...

    Authors: Sara Tomei, Chiara Mazzanti, Ivo Marchetti, Leonardo Rossi, Katia Zavaglia, Francesca Lessi, Alessandro Apollo, Paolo Aretini, Giancarlo Di Coscio and Generoso Bevilacqua
    Citation: Journal of Translational Medicine 2012 10:7
  10. Currently, no data on the optimal time point after acute ischemic stroke (IS) at which high-sensitivity C-reactive protein (hs-CRP) level is most predictive of unfavorable outcome. We tested the hypothesis tha...

    Authors: Kuo-Ho Yeh, Tzu-Hsien Tsai, Han-Tan Chai, Steve Leu, Sheng-Ying Chung, Sarah Chua, Yung-Lung Chen, Hung-Sheng Lin, Chun-Man Yuen and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2012 10:6
  11. Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker discovery. They can transfer information between cells and ma...

    Authors: Jonathan M Street, Perdita E Barran, C Logan Mackay, Stefan Weidt, Craig Balmforth, Tim S Walsh, Rod TA Chalmers, David J Webb and James W Dear
    Citation: Journal of Translational Medicine 2012 10:5
  12. Virus-Like Particles (VLPs) represent an efficient strategy to present and deliver conformational antigens to the immune system, inducing both arms of the adaptive immune response. Moreover, their particulate ...

    Authors: Maria Luisa Visciano, Maria Tagliamonte, Maria Lina Tornesello, Franco M Buonaguro and Luigi Buonaguro
    Citation: Journal of Translational Medicine 2012 10:4
  13. Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed. Several oncolytic viruses including adenovirus st...

    Authors: Sandeep S Patil, Ivaylo Gentschev, Ingo Nolte, Gregory Ogilvie and Aladar A Szalay
    Citation: Journal of Translational Medicine 2012 10:3
  14. Proliferation and migration of vascular smooth muscle cells (VSMCs) play a key role in neointimal formation which leads to restenosis of vein graft in venous bypass. STAT-3 is a transcription factor associated...

    Authors: Jiangbin Sun, Jinhua Zheng, Kaitelynne H Ling, Keyan Zhao, Zhongshang Xie, Bo Li, Tiance Wang, Zhicheng Zhu, Amit N Patel, Weiping Min, Kexiang Liu and Xiufen Zheng
    Citation: Journal of Translational Medicine 2012 10:2
  15. The outcome prediction in cancer is usually achieved by evaluating tissue samples obtained during surgical removal of the primary tumor focusing on their histopathological characteristics. Tumor staging (AJCC/...

    Authors: Jérôme Galon, Franck Pagès, Francesco M Marincola, Magdalena Thurin, Giorgio Trinchieri, Bernard A Fox, Thomas F Gajewski and Paolo A Ascierto
    Citation: Journal of Translational Medicine 2012 10:1
  16. For clinical applications, dendritic cells (DCs) need to be generated using GMP-approved reagents. In this study, we tested the characteristics of DCs generated in two clinical grade culture media and activate...

    Authors: Jitka Fučíková, Daniela Rožková, Hana Ulčová, Vít Budinský, Klára Sochorová, Kateřina Pokorná, Jiřina Bartůňková and Radek Špíšek
    Citation: Journal of Translational Medicine 2011 9:223
  17. Human genome sequencing is the process by which the exact order of nucleic acid base pairs in the 24 human chromosomes is determined. Since the completion of the Human Genome Project in 2003, genomic sequencin...

    Authors: Karen K Mestan, Leonard Ilkhanoff, Samdeep Mouli and Simon Lin
    Citation: Journal of Translational Medicine 2011 9:222
  18. The treatment of human cancer has been seriously hampered for decades by resistance to chemotherapeutic drugs. Mechanisms underlying this resistance are far from being entirely known. A very efficient mechanis...

    Authors: Enrico P Spugnini, Alfonso Baldi, Sabrina Buglioni, Francesca Carocci, Giulia Milesi de Bazzichini, Gianluca Betti, Ilaria Pantaleo, Francesco Menicagli, Gennaro Citro and Stefano Fais
    Citation: Journal of Translational Medicine 2011 9:221
  19. Renal cell carcinoma (RCC) responds to agents that inhibit vascular endothelial growth factor (VEGF) pathway. Sorafenib, a multikinase inhibitor of VEGF receptor, is effective at producing tumor responses and ...

    Authors: Xiaoen Wang, Liang Zhang, S Nahum Goldberg, Manoj Bhasin, Victoria Brown, David C Alsop, Sabina Signoretti, James W Mier, Michael B Atkins and Rupal S Bhatt
    Citation: Journal of Translational Medicine 2011 9:220
  20. Degraded extracellular matrix can stimulate the innate immune system via the Toll-Like Receptor-4 (TLR4). In the pancreas, syndecan-anchored heparan sulphate (HS) on the ductal epithelium can be cleaved off it...

    Authors: Hamid Akbarshahi, Jakob BF Axelsson, Katarzyna Said, Anders Malmström, Hans Fischer and Roland Andersson
    Citation: Journal of Translational Medicine 2011 9:219
  21. In mid November the biopharma industry was shocked by the announcement from Geron that they were ending work on embryonic stem cell research and therapy. For more than 10 years the public image of all stem cel...

    Authors: Thomas Ichim, Neil H Riordan and David F Stroncek
    Citation: Journal of Translational Medicine 2011 9:218
  22. Th17 cells play a role in inflammation. Interleukin (IL)-10 is a potent anti-inflammatory cytokine. However, it is poorly understood whether and how endogenous IL-10 impacts the development of Th17 cells in hu...

    Authors: Cailin M Wilke, Lin Wang, Shuang Wei, Ilona Kryczek, Emina Huang, John Kao, Yanwei Lin, Jingyuan Fang and Weiping Zou
    Citation: Journal of Translational Medicine 2011 9:217
  23. The immune modulatory effect of granulocyte colony-stimulating factor (G-CSF) on T cells resulted in an unexpected low incidence of graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell tra...

    Authors: Li Xuan, Xiuli Wu, Yu Zhang, Zhiping Fan, Yiwen Ling, Fen Huang, Fuhua Zhang, Xiao Zhai and Qifa Liu
    Citation: Journal of Translational Medicine 2011 9:215
  24. Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a ...

    Authors: Bernard A Fox, Dolores J Schendel, Lisa H Butterfield, Steinar Aamdal, James P Allison, Paolo Antonio Ascierto, Michael B Atkins, Jirina Bartunkova, Lothar Bergmann, Neil Berinstein, Cristina C Bonorino, Ernest Borden, Jonathan L Bramson, Cedrik M Britten, Xuetao Cao, William E Carson…
    Citation: Journal of Translational Medicine 2011 9:214
  25. BORIS, or CTCFL, the so called Brother of the Regulator of Imprinted Sites because of the extensive homology in the central DNA binding region of the protein to the related regulator, CTCF, is expressed in ear...

    Authors: Rosalia de Necochea-Campion, Anahit Ghochikyan, Steven F Josephs, Shelly Zacharias, Erik Woods, Feridoun Karimi-Busheri, Doru T Alexandrescu, Chien-Shing Chen, Michael G Agadjanyan and Ewa Carrier
    Citation: Journal of Translational Medicine 2011 9:213
  26. HIV vaccine development must address the genetic diversity and plasticity of the virus that permits the presentation of diverse genetic forms to the immune system and subsequent escape from immune pressure. As...

    Authors: Jeffrey R Currier, Merlin L Robb, Nelson L Michael and Mary A Marovich
    Citation: Journal of Translational Medicine 2011 9:212
  27. Treatment failure for breast cancer is frequently due to lymph node metastasis and invasion to neighboring organs. The aim of the present study was to investigate invasion- and metastasis-related genes in brea...

    Authors: Jian Pan, Li-Chao Sun, Yan-Fang Tao, Zhuan Zhou, Xiao-Li Du, Liang Peng, Xing Feng, Jian Wang, Yi-Ping Li, Ling Liu, Shui-Yan Wu, Yan-Lan Zhang, Shao-Yan Hu, Wen-Li Zhao, Xue-Ming Zhu, Guo-Liang Lou…
    Citation: Journal of Translational Medicine 2011 9:211
  28. T cell receptor (TCR) reflects the status and function of T cells. We previously developed a gene melting spectral pattern (GMSP) assay, which rapidly detects clonal expansion of the T cell receptor β variable...

    Authors: Jiezuan Yang, Jianqin He, Haifeng Lu, Li Wei, Sujun Li, Baohong Wang, Hongyan Diao and Lanjuan Li
    Citation: Journal of Translational Medicine 2011 9:210
  29. Breast cancer stem cells (BCSCs) are the source of breast tumors. Compared with other cancer cells, cancer stem cells show high resistance to both chemotherapy and radiotherapy. Targeting of BCSCs is thus a po...

    Authors: Phuc V Pham, Nhan LC Phan, Nhung T Nguyen, Nhung H Truong, Thuy T Duong, Dong V Le, Kiet D Truong and Ngoc K Phan
    Citation: Journal of Translational Medicine 2011 9:209
  30. The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine des...

    Authors: Beatriz Mothe, Anuska Llano, Javier Ibarrondo, Marcus Daniels, Cristina Miranda, Jennifer Zamarreño, Vanessa Bach, Rosario Zuniga, Susana Pérez-Álvarez, Christoph T Berger, Maria C Puertas, Javier Martinez-Picado, Morgane Rolland, Marilu Farfan, James J Szinger, William H Hildebrand…
    Citation: Journal of Translational Medicine 2011 9:208
  31. The success rate of timely translation of genome-based technologies to commercially feasible products/services with applicability in health care systems is significantly low. We identified both industry and sc...

    Authors: Jonathan A Lal, Tobias Schulte in den Bäumen, Servaas A Morré and Angela Brand
    Citation: Journal of Translational Medicine 2011 9:207
  32. Astrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in diverse human cancers. The present study was aimed to investigate the clinical and prognostic significance of AEG-1 in sali...

    Authors: Wen-Ting Liao, Ling Guo, Yi Zhong, Yan-Heng Wu, Jun Li and Li-Bing Song
    Citation: Journal of Translational Medicine 2011 9:205
  33. Ipilimumab, a fully human monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4, has demonstrated an improvement in overall survival in two phase III trials of patients with advanced melanoma. The p...

    Authors: Omid Hamid, Henrik Schmidt, Aviram Nissan, Laura Ridolfi, Steinar Aamdal, Johan Hansson, Michele Guida, David M Hyams, Henry Gómez, Lars Bastholt, Scott D Chasalow and David Berman
    Citation: Journal of Translational Medicine 2011 9:204
  34. The detection of insulin autoantibodies (IAA) aids in the prediction of autoimmune diabetes development. However, the long-standing, gold standard 125I-insulin radiobinding assay (RBA) has low reproducibility bet...

    Authors: Bernice Lo, Austin DE Swafford, Kimberly A Shafer-Weaver, Lawrence F Jerome, Luba Rakhlin, Douglas R Mathern, Conor A Callahan, Ping Jiang, Lucy J Davison, Helen E Stevens, Carrie L Lucas, Jill White, Reid von Borstel, John A Todd and Michael J Lenardo
    Citation: Journal of Translational Medicine 2011 9:203
  35. Authors: Estíbaliz Ruiz-Ortiz de Arrizabaleta, Dolors Grados-Cánovas, Aina Teniente-Serra, Virginia García-López, Bibiana Quirant-Sánchez, Susana Holgado, Alejandro Olivé, Ricardo Pujol-Borrell and Eva Martínez-Cáceres
    Citation: Journal of Translational Medicine 2011 9(Suppl 2):P51

    This article is part of a Supplement: Volume 9 Supplement 2

  36. Authors: Rafael Fenutría, Vanesa G Martinez, Victor Gil, Jordi Sintes, Ines Simôes, Jesús Merino, Ramón Merino, Manel Ramos-Casals, Chander Raman, Pablo Engel and Francisco Lozano
    Citation: Journal of Translational Medicine 2011 9(Suppl 2):O6

    This article is part of a Supplement: Volume 9 Supplement 2

  37. Authors: Aina Teniente-Serra, Laia Grau-López, María Jesús Martínez-Arconada, Marco Fernández-Sanmartín, Cristina Ramo-Tello, Ricardo Pujol-Borrell and Eva Martínez-Cáceres
    Citation: Journal of Translational Medicine 2011 9(Suppl 2):O2

    This article is part of a Supplement: Volume 9 Supplement 2

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