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  1. High-dose IL-2 (HDIL2) is approved for the treatment of metastatic melanoma and renal cell carcinoma, but its use is limited in part by toxicity related to the development of vascular leak syndrome (VLS). Ther...

    Authors: Dae Won Kim, Andrew Zloza, Joseph Broucek, Jason M Schenkel, Carl Ruby, Georges Samaha and Howard L Kaufman
    Citation: Journal of Translational Medicine 2014 12:113
  2. Receptor-binding cancer antigen expressed on SiSo cell (RCAS1) is derived from uterine adenocarcinoma and can induce apoptosis in lymphocytes, allowing tumor cells to escape from immune surveillance. RCAS1 is ...

    Authors: Hideaki Tanaka, Takeshi Toyoshima, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto and Seiji Nakamura
    Citation: Journal of Translational Medicine 2014 12:112
  3. Authors: Yibing Yan, Grant McArthur, Omid Hamid, Igor Puzanov, Rene Gonzalez, Thomas Gajewski, Yulei Wang, Matthew Wongchenko, Nicholas Choong and Antoni Ribas
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):O12

    This article is part of a Supplement: Volume 12 Supplement 1

  4. Authors: Paolo Visca, Sheila Spada, Francesca Di Modugno, Emilio Bria, Isabella Sperduti, Barbara Antoniani, Gabriele Alessandrini, Belinda Palermo, Vienna Ludovini, Lucio Crinò, Francesco Facciolo, Michele Milella, Marcella Mottolese and Paola Nisticò
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):P12

    This article is part of a Supplement: Volume 12 Supplement 1

  5. Authors: Talib Hassan Ali, Simona Pisanti, Elena Ciaglia, Roberta Mortarini, Andrea Anichini, Mario Santinami, Elio Gulletta, Caterina Ietto, Mario Galgani, Cinzia Garofalo, Giuseppe Matarese, Maurizio Bifulco, Soldano Ferrone, Francesco Colucci, Alessandro Moretta, Klas Kärre…
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):P10

    This article is part of a Supplement: Volume 12 Supplement 1

  6. Authors: Giusy Gentilcore, Coaña Pico de Yago, Isabel Poschke, Yumeng Mao, Maria Nyström, Johan Hansson, Giuseppe V Masucci and Rolf Kiessling
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):O9

    This article is part of a Supplement: Volume 12 Supplement 1

  7. Authors: Igor Puzanov, Grant McArthur, Rene Gonzalez, Anna Pavlick, Omid Hamid, Thomas F Gajewski, Ming Yin, Jill Fredrickson, Nicholas Choong and Antoni Ribas
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):O7

    This article is part of a Supplement: Volume 12 Supplement 1

  8. Authors: Luca Vannucci, Elisabetta Falvo, Cristina Maria Failla, Miriam Carbo, Manuela Fornara, Rossella Canese, Serena Cecchetti, Lenka Rajsiglova, Dmitry Stakheev, Jiri Krizan, Alberto Boffi, Giulia Carpinelli, Veronica Morea and Pierpaolo Ceci
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):P6

    This article is part of a Supplement: Volume 12 Supplement 1

  9. Authors: Richard Kefford, Ryan J Sullivan, Wilson H Miller Jr, Elena M Elez, Daniel Tan, Kevin B Kim, Georgina V Long, Keith T Flaherty, David Tai, Simone Stutvoet, Heiko Maacke, Matt Whiley, Laure Moutouh-de Parseval and Josep Tabernero
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):P5

    This article is part of a Supplement: Volume 12 Supplement 1

  10. Authors: Maria Colombino, Maria Cristina Sini, Amelia Lissia, Antonio Cossu, Vincenzo De Giorgi, Daniela Massi, Ignazio Stanganelli, Corrado Rubino, Antonella Manca, Grazia Palomba, Gerardo Botti, Corrado Caracò, Nicola Mozzillo, Paolo Antonio Ascierto and Giuseppe Palmieri
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):O3

    This article is part of a Supplement: Volume 12 Supplement 1

  11. Authors: Nicola Mozzillo, Corrado Caracò, Ugo Marone, Ester Simeone, Stefano Mori, Lucia Benedetto, Gianluca Di Monta, Maria Luisa Di Cecilia, Massimiliano Di Marzo, Gerardo Botti and Paolo Antonio Ascierto
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):P1

    This article is part of a Supplement: Volume 12 Supplement 1

  12. Authors: Beatrix Kotlan, Gabriella Liszkay, Gyorgy Naszados, Judit Olasz, Szabolcs Horvath, Klara Eles, Miri Blank, Yehuda Shoenfeld, Laszlo Gobor, Laszlo Toth, Orsolya Csuka, Maria Godeny, Miklos Kasler and Francesco M Marincola
    Citation: Journal of Translational Medicine 2014 12(Suppl 1):O1

    This article is part of a Supplement: Volume 12 Supplement 1

  13. Contradictory evidence has been published on the effects of steroid treatments on the outcomes of kidney and liver transplantation from brain dead (BD) donors. Our study aimed to evaluate this disparity by inv...

    Authors: Rolando Rebolledo, Bo Liu, Mohammed Z Akhtar, Petra J Ottens, Jian-ning Zhang, Rutger J Ploeg and Henri GD Leuvenink
    Citation: Journal of Translational Medicine 2014 12:111
  14. Increasing evidence has revealed that microRNAs (miRNA) played a pivotal role in regulating cancer cell proliferation and metastasis. The deregulation of miR-182 has been identified in colorectal cancer (CRC)....

    Authors: Min-Hui Yang, Jiang Yu, Dong-Mei Jiang, Wen-Lu Li, Shuang Wang and Yan-Qing Ding
    Citation: Journal of Translational Medicine 2014 12:109
  15. We previously conducted a phase I trial for advanced colorectal cancer (CRC) using five HLA-A*2402-restricted peptides, three derived from oncoantigens and two from vascular endothelial growth factor (VEGF) re...

    Authors: Shoichi Hazama, Yusuke Nakamura, Hiroaki Tanaka, Kosei Hirakawa, Ko Tahara, Ryoichi Shimizu, Hiroaki Ozasa, Ryuichi Etoh, Fumiaki Sugiura, Kiyotaka Okuno, Takumi Furuya, Taku Nishimura, Koichiro Sakata, Kazuhiko Yoshimatsu, Hiroko Takenouchi, Ryouichi Tsunedomi…
    Citation: Journal of Translational Medicine 2014 12:108
  16. Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against...

    Authors: Taemin Oh, Shayan Fakurnejad, Eli T Sayegh, Aaron J Clark, Michael E Ivan, Matthew Z Sun, Michael Safaee, Orin Bloch, Charles D James and Andrew T Parsa
    Citation: Journal of Translational Medicine 2014 12:107
  17. The addition of an intra-aortic balloon pump (IABP) during peripheral venoarterial extracorporeal membrane oxygenation (VA ECMO) support has been shown to improve coronary bypass graft flows and cardiac functi...

    Authors: Feng Yang, Zai-shen Jia, Jia-lin Xing, Zheng Wang, Yuan Liu, Xing Hao, Chun-jing Jiang, Hong Wang, Ming Jia and Xiao-tong Hou
    Citation: Journal of Translational Medicine 2014 12:106
  18. Shaoyao decoction (SYD) is a traditional Chinese medicine prescription formulated by Liu Wan-Su, a master of traditional Chinese medicine in Jin-Yuan Dynasty. SYD is effective in treating ulcerative colitis. P...

    Authors: Xiaochang Lin, Zhiyong Yi, Jianxin Diao, Meng Shao, Liang Zhao, Hongbing Cai, Qin Fan, Xueqing Yao and Xuegang Sun
    Citation: Journal of Translational Medicine 2014 12:105
  19. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multi-system illness characterized, in part, by increased fatigue following minimal exertion, cognitive impairment, poor recovery to physical an...

    Authors: Betsy A Keller, John Luke Pryor and Ludovic Giloteaux
    Citation: Journal of Translational Medicine 2014 12:104
  20. Berberine (BBR), a natural plant extract, has been shown to improve lipid metabolism. However, its effects on PCSK9, a key factor involving in the lipid metabolism, have not yet been evaluated in vivo. The aim...

    Authors: Yan-Jun Jia, Rui-Xa Xu, Jing Sun, Yue Tang and Jian-Jun Li
    Citation: Journal of Translational Medicine 2014 12:103
  21. CD40-CD40 ligand (CD40L) interaction is considered to contribute to the promotion of prothrombotic responses and production of angiogenesis-associated factor in addition to adaptive immune responses. Recently,...

    Authors: Hye Won Chung and Jong-Baeck Lim
    Citation: Journal of Translational Medicine 2014 12:102
  22. We tested the hypothesis that clopidogrel and cilostazol combination therapy could effectively attenuate systemic inflammatory reaction, facilitate proliferation of circulating endothelial progenitor cell (EPC...

    Authors: Jiunn-Jye Sheu, Pao-Yuan Lin, Pei-Hsun Sung, Yi-Ching Chen, Steve Leu, Yung-Lung Chen, Tzu-Hsien Tsai, Han-Tan Chai, Sarah Chua, Hsueh-Wen Chang, Sheng-Ying Chung, Chih-Hung Chen, Sheung-Fat Ko and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2014 12:101
  23. Autophagy regulates innate and adaptive immune responses to pathogens and tumors. We have reported that autophagosomes derived from tumor cells after proteasome inhibition, DRibbles (Defective ribosomal produc...

    Authors: Wei Ye, Yun Xing, Christopher Paustian, Rieneke van de Ven, Tarsem Moudgil, Traci L Hilton, Bernard A Fox, Walter J Urba, Wei Zhao and Hong-Ming Hu
    Citation: Journal of Translational Medicine 2014 12:100
  24. Human diseases frequently cause complications such as obesity-induced diabetes and share numbers of pathological conditions, such as inflammation, by dysfunctions of common functional modules, such as protein–...

    Authors: Hyojung Paik, Hyoung-Sam Heo, Hyo-jeong Ban and Seong Beom Cho
    Citation: Journal of Translational Medicine 2014 12:99
  25. We studied whether thymidylate synthase (TS) genotype has an independent prognostic/predictive impact on a European population of advanced non-small cell lung cancer (NSCLC) patients receiving pemetrexed.

    Authors: Estefanía Arévalo, Eduardo Castañón, Inés López, Josefa Salgado, Víctor Collado, Marta Santisteban, María Rodríguez-Ruiz, Patricia Martín, Leire Zubiri, Ana Patiño-García, Christian Rolfo and Ignacio Gil-Bazo
    Citation: Journal of Translational Medicine 2014 12:98
  26. Immunotherapy offers a promising novel approach for the treatment of cancer and both adoptive T-cell transfer and immune modulation lead to regression of advanced melanoma. However, the potential synergy betwe...

    Authors: Emanuela Romano, Olivier Michielin, Verena Voelter, Julien Laurent, Hélène Bichat, Athina Stravodimou, Pedro Romero, Daniel E Speiser, Frédéric Triebel, Serge Leyvraz and Alexandre Harari
    Citation: Journal of Translational Medicine 2014 12:97
  27. Chikungunya fever (CHIKF) is a recently re-emerged mosquito transmitted viral disease caused by the chikungunya virus (CHIKV), an Alphavirus belonging to the family Togaviridae. Infection of humans with CHIKV can...

    Authors: Nitwara Wikan, Sarawut Khongwichit, Weerawat Phuklia, Sukathida Ubol, Tipparat Thonsakulprasert, Montri Thannagith, Duangrudee Tanramluk, Atchara Paemanee, Suthathip Kittisenachai, Sittiruk Roytrakul and Duncan R Smith
    Citation: Journal of Translational Medicine 2014 12:96
  28. In osteosarcoma (OS) and most Ewing sarcoma (EWS) patients, the primary tumor originates in the bone. Although tumor resection surgery is commonly used to treat these diseases, it frequently leaves massive bon...

    Authors: Enrico Lucarelli, Chiara Bellotti, Melissa Mantelli, Maria Antonietta Avanzini, Rita Maccario, Francesca Novara, Giulia Arrigo, Orsetta Zuffardi, Monia Zuntini, Martina Pandolfi, Luca Sangiorgi, Daniela Lisini, Davide Donati and Serena Duchi
    Citation: Journal of Translational Medicine 2014 12:95
  29. Transient episodes of ischemia in a remote organ or tissue (remote ischemic preconditioning, RIPC) can attenuate myocardial injury. Myocardial damage is associated with tissue remodeling and the matrix metallo...

    Authors: Karina Zitta, Patrick Meybohm, Berthold Bein, Matthias Gruenewald, Fabian Lauer, Markus Steinfath, Jochen Cremer, Kai Zacharowski and Martin Albrecht
    Citation: Journal of Translational Medicine 2014 12:94
  30. Understanding the pathogenic mechanism of pancreatic cancer associated diabetes (PCDM) might help yield biomarkers for the early diagnosis of pancreatic cancer (PC) from population with new-onset diabetes. In ...

    Authors: Langping Tan, Xiao Ye, Yu Zhou, Min Yu, Zhiqiang Fu, Ruiwan Chen, Baoxiong Zhuang, Bing Zeng, Huilin Ye, Wenchao Gao, Qing Lin, Zhihua Li, Quanbo Zhou and Rufu Chen
    Citation: Journal of Translational Medicine 2014 12:92
  31. Hepatitis C virus (HCV) shows a remarkable genetic diversity, contributing to its high persistence and varied susceptibilities to antiviral treatment. Previous studies have reported that the substitution of am...

    Authors: Fatimah S Alhamlan, Mohammed N Al-Ahdal, Nisreen Z Khalaf, Ayman A Abdo, Faisal M Sanai, Hamad I Al-Ashgar, Mahmoud ElHefnawi, Amina Zaid and Ahmed A Al-Qahtani
    Citation: Journal of Translational Medicine 2014 12:91
  32. The atrial fibrillation (AF) associated microRNAs (miRNAs) were found in the right atrium (RA) and left atrium (LA) from patients with rheumatic mitral valve disease (RMVD). However, most studies only focus on...

    Authors: Hai Liu, Han Qin, Guang-xian Chen, Meng-ya Liang, Jian Rong, Jian-ping Yao and Zhong-kai Wu
    Citation: Journal of Translational Medicine 2014 12:90
  33. Up-regulation of HO-1 by genetic manipulation or pharmacological pre-treatment has been reported to provide benefits in several animal models of myocardial infarction (MI). However, its efficacy following MI i...

    Authors: Claudia Kusmic, Cristina Barsanti, Marco Matteucci, Nicoletta Vesentini, Gualtiero Pelosi, Nader G Abraham and Antonio L’Abbate
    Citation: Journal of Translational Medicine 2014 12:89
  34. In the post-genomic era, it has become evident that genetic changes alone are not sufficient to understand most disease processes including pancreatic cancer. Genome sequencing has revealed a complex set of ge...

    Authors: Daniel Ansari, Linus Aronsson, Agata Sasor, Charlotte Welinder, Melinda Rezeli, György Marko-Varga and Roland Andersson
    Citation: Journal of Translational Medicine 2014 12:87
  35. Alpha fetoprotein (AFP) is an oncofetal antigen over-expressed by many hepatocellular cancers (HCC). We previously demonstrated that HLA-A2-restricted epitopes derived from AFP are immunogenic in vitro and in viv...

    Authors: Lisa H Butterfield, James S Economou, T Clark Gamblin and David A Geller
    Citation: Journal of Translational Medicine 2014 12:86
  36. Lipoid proteinosis (LP) is known to be resulted from mutations of the extracellular matrix protein 1 gene (ECM1). However, no effective or sustained therapeutic methods to alleviate LP symptoms have been reported...

    Authors: Rong Zhang, Yang Liu, Yang Xue, Yinan Wang, Xinwen Wang, Songtao Shi, Tao Cai and Qintao Wang
    Citation: Journal of Translational Medicine 2014 12:85
  37. Chemoradiation therapy (CRT) has been widely used for unresectable esophageal squamous cell carcinoma (ESCC) patients. However, many patients develop local recurrence after CRT. In this study, we hypothesized ...

    Authors: Hisae Iinuma, Ryoji Fukushima, Tsuyoshi Inaba, Junko Tamura, Taisuke Inoue, Etsushi Ogawa, Masahiro Horikawa, Yoshibumi Ikeda, Noriyuki Matsutani, Kazuyoshi Takeda, Koji Yoshida, Takuya Tsunoda, Tadashi Ikeda, Yusuke Nakamura and Kota Okinaga
    Citation: Journal of Translational Medicine 2014 12:84
  38. The polymeric immunoglobulin receptor (PIGR) has been proposed to be a candidate prognostic biomarker in a few cancer forms, and one previous study reported that reduced PIGR expression signifies more aggressi...

    Authors: Richard Fristedt, Alexander Gaber, Charlotta Hedner, Björn Nodin, Mathias Uhlén, Jakob Eberhard and Karin Jirström
    Citation: Journal of Translational Medicine 2014 12:83
  39. The risk of cardiovascular diseases (CVD) is increased tremendously among menopausal women, and there is an increasing demand for alternative therapies for managing factors like dyslipidemia that contribute to...

    Authors: Ramlah Mohamad Ibrahim, Nurul Syima Hamdan, Rozi Mahmud, Mustapha Umar Imam, Suraini Mohd Saini, Saiful Nizam Abd Rashid, Siti Aisyah Abd Ghafar, Latiffah Ab Latiff and Maznah Ismail
    Citation: Journal of Translational Medicine 2014 12:82
  40. Reliable prognostic markers based on biopsy specimens of colorectal cancer (CRC) are currently missing. We hypothesize that assessment of T-cell infiltration in biopsies of CRC may predict patient survival and...

    Authors: Viktor H Koelzer, Alessandro Lugli, Heather Dawson, Marion Hädrich, Martin D Berger, Markus Borner, Makhmudbek Mallaev, José A Galván, Jennifer Amsler, Beat Schnüriger, Inti Zlobec and Daniel Inderbitzin
    Citation: Journal of Translational Medicine 2014 12:81
  41. Yin Yang 1 (YY1) is a transcription factor that regulates diverse biological processes and increasing recognized to have important roles in carcinogenesis. The function and clinical significance of YY1 in gast...

    Authors: Wei Kang, Joanna HM Tong, Anthony WH Chan, Junhong Zhao, Yujuan Dong, Shiyan Wang, Weiqin Yang, Frankie MC Sin, Simon SM Ng, Jun Yu, Alfred SL Cheng and Ka Fai To
    Citation: Journal of Translational Medicine 2014 12:80
  42. It has been argued that circadian dysregulation is not only a critical inducer and promoter of adverse health effects, exacerbating symptom burden, but also hampers recovery. Therefore understanding the health...

    Authors: Jag Sunderram, Stavroula Sofou, Kubra Kamisoglu, Vassiliki Karantza and Ioannis P Androulakis
    Citation: Journal of Translational Medicine 2014 12:79

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