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Translational Signaling and System Biology

Section edited by Marcello Maggiolini

© © selvanegra / Getty Images / iStock

The Translational Signaling and System Biology section aims to uncover pivotal transduction signaling involved in pathophysiological processes toward a translational impact on the discovery of novel targets and therapeutics. 

The section welcomes research and review articles providing new mechanistic insights on a broad range of fields such as cancer, cardiovascular biology, neuroscience, metabolism, inflammation, immunology, microbiology, drug action also through new formulations and delivery methods, novel cellular and animal models, computational and systems biology, innovative laboratory concepts fostering translational research from the bench to the bedside.

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  1. Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liv...

    Authors: Xiangdong Li, Ziyi Wang, Chenyu Jiao, Yu Zhang, Nan Xia, Wenjie Yu, Xuejiao Chen, Likalamu Pascalia Wikana, Yue Liu, Linfeng Sun, Minhao Chen, Yuhao Xiao, Yuhua Shi, Sheng Han and Liyong Pu
    Citation: Journal of Translational Medicine 2023 21:121
    Content type: Research Published on:

  2. Gastric cancer (GC) is the third-leading cause of cancer-associated mortalities globally. The deregulation of circular RNAs (circRNAs) and microRNAs (miRNAs or miRs) is widely implicated in the pathogenesis an...

    Authors: Jun You, Yinan Chen, Donghan Chen, Yongwen Li, Tinghao Wang, Jingtao Zhu, Qingqi Hong and Qiyuan Li
    Citation: Journal of Translational Medicine 2023 21:83
    Content type: Research Published on:

  3. Our previous study showed that fucosyltransferase 2 (Fut2) deficiency is closely related to colitis. Colitis increases the risk for the development of colorectal cancer (CRC). This study aimed to investigate t...

    Authors: Weijun Wang, Xuelian Tang, Caihan Duan, Shuxin Tian, Chaoqun Han, Wei Qian, Xin Jiang, Xiaohua Hou and Rong Lin
    Citation: Journal of Translational Medicine 2023 21:82
    Content type: Research Published on:

  4. Chronic inflammation is a well-known risk factor for the development of gastric cancer (GC). Nevertheless, the molecular mechanisms underlying inflammation-related GC progression are incompletely defined.

    Authors: Tingting Xu, Mengyan Xie, Xinming Jing, Huning Jiang, Xi Wu, Xinzhu Wang and Yongqian Shu
    Citation: Journal of Translational Medicine 2023 21:77
    Content type: Research Published on:

  5. Pancreatic ductal adenocarcinoma (PDAC) and prostate cancer (PCa) are among the most prevalent malignant tumors worldwide. There is now a comprehensive understanding of metabolic reprogramming as a hallmark of...

    Authors: Ugo Chianese, Chiara Papulino, Ahmad Ali, Fortunato Ciardiello, Salvatore Cappabianca, Lucia Altucci, Vincenzo Carafa and Rosaria Benedetti
    Citation: Journal of Translational Medicine 2023 21:32
    Content type: Research Published on:

  6. Circular RNAs (circRNAs) have been shown to be essential for the emergence and growth of different cancers. However, further research is required to validate the function of circRNA in glioblastoma (GBM).

    Authors: Yuhang Wang, Binbin Wang, Fengqi Zhou, Kun Lv, Xiupeng Xu and Wenping Cao
    Citation: Journal of Translational Medicine 2023 21:22
    Content type: Research Published on:

  7. The actin filament-associated protein (AFAP) family genes include AFAP1/AFAP-110, AFAP1L1 and AFAP1L2/XB130. Increasing evidence indicates these three AFAP family members participate in tumor progression, but ...

    Authors: Bo Sun, Bai Ding, Yu Chen, Chuang Peng and Xu Chen
    Citation: Journal of Translational Medicine 2023 21:18
    Content type: Research Published on:

  9. Clear cell renal cell carcinoma (ccRCC), the most common urological malignancy, has an unfavorable prognosis and an unknown mechanism of progression. Through survival analyses screening of The Cancer Genome At...

    Authors: Wenliang Ma, Xin Li, Lei Yang, Jun Pan, Yi Chen, Yanwen Lu, Xiang Dong, Dongmei Li and Weidong Gan
    Citation: Journal of Translational Medicine 2022 20:554
    Content type: Research Published on:

  10. MICAL1 is involved in the malignant processes of several types of cancer; however, the role of MICAL1 in pancreatic cancer (PC) has not been well-characterized. This study aimed to investigate the expression a...

    Authors: Kun Cai, Lu Deng, Dijie Zheng, Lin Li, Zhiwei He and Chao Yu
    Citation: Journal of Translational Medicine 2022 20:528
    Content type: Research Published on:

  11. DNA ligases are crucial for DNA repair and cell replication since they catalyze the final steps in which DNA breaks are joined. DNA Ligase III (LIG3) exerts a pivotal role in Alternative-Non-Homologous End Joi...

    Authors: Daniele Caracciolo, Giada Juli, Caterina Riillo, Adriana Coricello, Francesca Vasile, Sara Pollastri, Roberta Rocca, Francesca Scionti, Nicoletta Polerà, Katia Grillone, Mariamena Arbitrio, Nicoletta Staropoli, Basilio Caparello, Domenico Britti, Giovanni Loprete, Giosuè Costa…
    Citation: Journal of Translational Medicine 2022 20:482
    Content type: Research Published on:

  12. Long non-coding RNAs (lncRNAs) are essential regulators of tumorigenesis and the development of colorectal cancer (CRC). Here, we aimed to investigate the role of lncRNA GAS6-AS1 in CRC and its potential mecha...

    Authors: Qing Chen, Lin Zhou, De Ma, Juan Hou, Yuxin Lin, Jie Wu and Min Tao
    Citation: Journal of Translational Medicine 2022 20:356
    Content type: Research Published on:

  13. NCAPG, non-SMC subunit in the concentrate I complex, might promote the proliferation of hepatocellular carcinoma (HCC), but the mechanism is unclear. The aim of this study was to explore how NCAPG affects PTEN...

    Authors: Rongguiyi Zhang, Jiyuan Ai, Jiakun Wang, Chi sun, Hongcheng Lu, Aoxiao He, Min Li, Yuting Liao, Jun Lei, Fan Zhou, Linquan Wu and Wenjun Liao
    Citation: Journal of Translational Medicine 2022 20:325
    Content type: Research Published on:

  14. Neuroendocrine neoplasms (NENs) represent a heterogeneous class of rare tumors with increasing incidence. They are characterized by the ability to secrete peptide hormones and biogenic amines but other reliabl...

    Authors: Viola Melone, Annamaria Salvati, Domenico Palumbo, Giorgio Giurato, Giovanni Nassa, Francesca Rizzo, Luigi Palo, Alessandro Giordano, Mariarosaria Incoronato, Mario Vitale, Caterina Mian, Immacolata Di Biase, Stefano Cristiano, Viviana Narciso, Monica Cantile, Annabella Di Mauro…
    Citation: Journal of Translational Medicine 2022 20:306
    Content type: Research Published on:

  15. As an important N6-methyladenosine (m6A) regulator, abnormal expression of methyltransferase-like protein 3 (METTL3) has been reported in certain human cancers. Although some data have shown that METTL3 plays an ...

    Authors: Dawei Zhu, Yingting Liu, Junjun Chen, Qi Wang, Yuan Li, Yulan Zhu, Jun Feng and Jingting Jiang
    Citation: Journal of Translational Medicine 2022 20:298
    Content type: Research Published on:

  16. Gastric cancer (GC), as one of the most common malignancies across the globe, is the fourth leading cause of cancer-related deaths. Though a large body of research has been conducted to develop the therapeutic...

    Authors: Guohua Jin, Jianguang Zhang, Tingting Cao, Bang Chen, Yu Tian and Yang Shi
    Citation: Journal of Translational Medicine 2022 20:284
    Content type: Research Published on:

  17. Metabolic disorders are associated with increased incidence, aggressive phenotype and poor outcome of breast cancer (BC) patients. For instance, hyperinsulinemia is an independent risk factor for BC and the in...

    Authors: Domenica Scordamaglia, Francesca Cirillo, Marianna Talia, Maria Francesca Santolla, Damiano Cosimo Rigiracciolo, Lucia Muglia, Azzurra Zicarelli, Salvatore De Rosis, Francesca Giordano, Anna Maria Miglietta, Ernestina Marianna De Francesco, Veronica Vella, Antonino Belfiore, Rosamaria Lappano and Marcello Maggiolini
    Citation: Journal of Translational Medicine 2022 20:263
    Content type: Research Published on:

  18. Lung adenocarcinoma (LUAD) is a heavy social burden worldwide. Because the mechanisms involved in LUAD remain unclear, the prognosis of LUAD remains poor. Consequently, it is urgent to investigate the potentia...

    Authors: Qian Wu, Rui Li, Qing-Xiang Wang, Meng-Yu Zhang, Ting-Ting Liu and Yi-Qing Qu
    Citation: Journal of Translational Medicine 2022 20:260
    Content type: Research Published on:

  19. Emerging evidence has highlighted the critical roles of long noncoding RNAs (lncRNAs) in tumor development and progression. However, the biological functions and underlying mechanisms of DLEU1 in esophageal sq...

    Authors: Qihang Li, Zhiyu Zhang, HongChao Jiang, Jun Hou, Yuhang Chai, Hongxing Nan, Feng Li and Lianghai Wang
    Citation: Journal of Translational Medicine 2022 20:245
    Content type: Research Published on:

  20. RNA adenosine modifications, which are primarily mediated by “writer” enzymes (RMWs), play a key role in epigenetic regulation in various biological processes, including tumorigenesis. However, the expression ...

    Authors: Shijie Chen, Jin Zeng, Liping Huang, Yi Peng, Zuyun Yan, Aiqian Zhang, Xingping Zhao, Jun Li, Ziting Zhou, Sidan Wang, Shengyu Jing, Minghua Hu, Yuezhan Li, Dong Wang, Weiguo Wang, Haiyang Yu…
    Citation: Journal of Translational Medicine 2022 20:228
    Content type: Research Published on:

  21. In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key player in regulating RNA metabolism and function through coding as well as non-coding RNAs. Accumulating evidence has shown that m5C m...

    Authors: Mingyang Li, Zijia Tao, Yiqiao Zhao, Lei Li, Jianyi Zheng, Zeyu Li and Xiaonan Chen
    Citation: Journal of Translational Medicine 2022 20:214
    Content type: Review Published on:

  22. Hepatocellular carcinoma (HCC) is the most common pathological type of liver cancer. Valosin-containing protein (VCP) is a member of the AAA-ATPase family associated with multiple molecular functions and invo...

    Authors: Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu and Xuegong Fan
    Citation: Journal of Translational Medicine 2022 20:212
    Content type: Research Published on:

  23. Tanimilast is a novel and selective inhaled inhibitor of phosphodiesterase-4 in advanced clinical development for chronic obstructive pulmonary disease (COPD). Tanimilast is known to exert prominent anti-infla...

    Authors: Hoang Oanh Nguyen, Valentina Salvi, Laura Tiberio, Fabrizio Facchinetti, Mirco Govoni, Gino Villetti, Maurizio Civelli, Ilaria Barbazza, Carolina Gaudenzi, Mauro Passari, Tiziana Schioppa, Francesca Sozio, Annalisa Del Prete, Silvano Sozzani and Daniela Bosisio
    Citation: Journal of Translational Medicine 2022 20:203
    Content type: Research Published on:

  24. Serine/arginine-rich splicing factor 9 (SRSF9) is a classical RNA-binding protein that is essential for regulating gene expression programs through its interaction with target RNA. Whether SRSF9 plays an essen...

    Authors: Xiaoyu Wang, Xiansheng Lu, Ping Wang, Qiaoyu Chen, Le Xiong, Minshan Tang, Chang Hong, Xiaowen Lin, Kaixi Shi, Li Liang and Jie Lin
    Citation: Journal of Translational Medicine 2022 20:198
    Content type: Research Published on:

  25. Hepatocellular carcinoma (HCC), as the most common type of liver cancer, is characterized by high recurrence and metastasis. Circular RNA (circRNA) circ_0036412 was selected for studying the underlying mechani...

    Authors: Liyan Wang, Bin Li, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng and Lei Ma
    Citation: Journal of Translational Medicine 2022 20:154
    Content type: Research Published on:

  26. Oral squamous cell carcinoma (OSCC), as one of the commonest malignancies showing poor prognosis, has been increasingly suggested to be modulated by circular RNAs (circRNAs). Through GEO (Gene Expression Omnib...

    Authors: Liang Rong, Bo Chen, Ke Liu, Bingyao Liu, Xinyao He, Juan Liu, Junxia Li, Maodian He, Lei Zhu, Ke Liu, Xiaolei Shi, Yi Shuai and Lei Jin
    Citation: Journal of Translational Medicine 2022 20:148
    Content type: Research Published on:

  27. Adiponectin is an adipocyte-secreted cytokine that enhances insulin sensitivity and attenuates inflammation. Although circulating adiponectin level is often inversely associated with several malignancies, its...

    Authors: Zongmeng Zhang, Jinlin Du, Hui Shi, Shuai Wang, Yunjing Yan, Qihua Xu, Sujin Zhou, Zhenggang Zhao, Yunping Mu, Chaonan Qian, Allan Zijian Zhao, Sumei Cao and Fanghong Li
    Citation: Journal of Translational Medicine 2022 20:89
    Content type: Research Published on:

  29. Colon cancer is a common malignant tumor of the digestive tract, and its incidence is ranked third among gastrointestinal tumors. The present study aims to investigate the role of a novel circular RNA (circCSP...

    Authors: Jin Wang, Lei Zhou, Bingxin Chen, Zhuwen Yu, Jianglei Zhang, Zhe Zhang, Chenrui Hu, Yanjin Bai, Xiaokang Ruan, Shengjia Wang, Jun Ouyang, Airong Wu and Xin Zhao
    Citation: Journal of Translational Medicine 2022 20:58
    Content type: Research Published on:

  30. Gastric cancer (GC) is the fifth leading cause of cancer-related death worldwide and is accompanied by low diagnosis and survival rates. The molecular mechanism of GC must be elucidated to improve treatment st...

    Authors: Zhijun Geng, Jing Li, Sandang Li, Yueyue Wang, Lele Zhang, Qiuzi Hu, Xinru Wang, Lugen Zuo, Xue Song, Xiaofeng Zhang, Sitang Ge and Jianguo Hu
    Citation: Journal of Translational Medicine 2022 20:50
    Content type: Research Published on:

  31. The aberrant expression of E3 ubiquitin ligase Pellino-1 (PELI1) contributes to several human cancer development and progression. However, its expression patterns and functional importance in papillary thyroid...

    Authors: Tingting Zheng, Youxing Zhou, Xiaowei Xu, Xin Qi, Jiameng Liu, Yanan Pu, Shan Zhang, Xuerong Gao, Xinkai Luo, Mei Li, Xuefeng Wang, Liyang Dong, Ying Wang and Chaoming Mao
    Citation: Journal of Translational Medicine 2022 20:20
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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