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Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Early life is a period of drastic epigenetic remodeling in which the epigenome is especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide dynamics of the DNA methylation changes ...

    Authors: Raúl F. Pérez, Pablo Santamarina, Juan Ramón Tejedor, Rocío G. Urdinguio, Julio Álvarez-Pitti, Pau Redon, Agustín F. Fernández, Mario F. Fraga and Empar Lurbe
    Citation: Journal of Translational Medicine 2019 17:15
  2. Intramuscular triglycerides (IMTGs) represent an important energy supply and a dynamic fat-storage depot that can expand during periods of elevated lipid availability and a fatty acid source. Ultrasonography (...

    Authors: Giovanni Tarantino, Susan Costantini, Vincenzo Citro, Paolo Conforti, Francesca Capone, Angela Sorice and Domenico Capone
    Citation: Journal of Translational Medicine 2019 17:8
  3. Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and effo...

    Authors: Yuan-Yuan Chen, Dan-Qian Chen, Lin Chen, Jing-Ru Liu, Nosratola D. Vaziri, Yan Guo and Ying-Yong Zhao
    Citation: Journal of Translational Medicine 2019 17:5
  4. This systematic review and meta-analysis summarized the most recent evidence on the efficacy of intermittent energy restriction (IER) versus continuous energy restriction on weight-loss, body composition, bloo...

    Authors: Iolanda Cioffi, Andrea Evangelista, Valentina Ponzo, Giovannino Ciccone, Laura Soldati, Lidia Santarpia, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo and Simona Bo
    Citation: Journal of Translational Medicine 2018 16:371
  5. l-Fucose (Fuc), a six-deoxy hexose monosaccharide, is present endogenously in humans and animals and has a wide range of biological functions. In the present study, we aimed to examine the effect of Fuc on obes.....

    Authors: Guangyan Wu, Mengwei Niu, Wenli Tang, Jingjuan Hu, Guoquan Wei, Zhanke He, Yangping Chen, Yong Jiang and Peng Chen
    Citation: Journal of Translational Medicine 2018 16:344

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:276

  6. Endoplasmic reticulum (ER) stress, which can promote lipid metabolism disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Calcium (Ca2+) homeo...

    Authors: Xiaobo Gao, Shun Guo, Song Zhang, An Liu, Lei Shi and Yan Zhang
    Citation: Journal of Translational Medicine 2018 16:319

    The Correction to this article has been published in Journal of Translational Medicine 2019 17:277

  7. The cytokine, interleukin-18 (IL-18), was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence suggesting that it has non-immunological effects on phy...

    Authors: Kyosuke Yamanishi, Seishi Maeda, Sachi Kuwahara-Otani, Takuya Hashimoto, Kaoru Ikubo, Keiichiro Mukai, Keiji Nakasho, Naomi Gamachi, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura and Hisato Matsunaga
    Citation: Journal of Translational Medicine 2018 16:314
  8. The Mediterranean diet (MeD) plays a key role in the prevention of obesity. Among the genes involved in obesity, the Fat mass and obesity-associated gene (FTO) is one of the most known, but its interaction wit...

    Authors: Laura Di Renzo, Giorgia Cioccoloni, Simone Falco, Ludovico Abenavoli, Alessandra Moia, Paola Sinibaldi Salimei and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2018 16:308
  9. Insulin resistance and beta cell dysfunction were reported to be responsible for gestational diabetes mellitus (GDM). However, little is known about the heterogeneity of these factors and its influences on per...

    Authors: Yingfeng Liu, Wolin Hou, Xiyan Meng, Weijing Zhao, Jiemin Pan, Junling Tang, Yajuan Huang, Minfang Tao and Fang Liu
    Citation: Journal of Translational Medicine 2018 16:289
  10. Microbiota and bile acids in the gastrointestinal tract profoundly alter systemic metabolic processes. In obese subjects, gradual weight loss ameliorates adipose tissue inflammation and related systemic change...

    Authors: José O. Alemán, Nicholas A. Bokulich, Jonathan R. Swann, Jeanne M. Walker, Joel Correa De Rosa, Thomas Battaglia, Adele Costabile, Alexandros Pechlivanis, Yupu Liang, Jan L. Breslow, Martin J. Blaser and Peter R. Holt
    Citation: Journal of Translational Medicine 2018 16:244
  11. The developmental origins of health and disease theory states that a disturbance in the early life environment can contribute to disease risk in later life. Leptin and insulin are anorectic hormones involved i...

    Authors: Annette Vriens, Michelle Plusquin, Willy Baeyens, Liesbeth Bruckers, Elly Den Hond, Ilse Loots, Vera Nelen, Greet Schoeters, Bram G. Janssen and Tim S. Nawrot
    Citation: Journal of Translational Medicine 2018 16:224
  12. A characteristic feature of malignant cells, such as colorectal cancer cells, is a profound decrease in the level of 5-hydroxymethylcytosine, a product of 5-methylcytosine oxidation by TET enzymes. Recent stud...

    Authors: Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Tomasz Dziaman, Anna Szpila, Kinga Linowiecka, Jolanta Guz, Justyna Szpotan, Maciej Gawronski, Anna Labejszo, Ariel Liebert, Zbigniew Banaszkiewicz, Maria Klopocka, Marek Foksinski, Daniel Gackowski and Ryszard Olinski
    Citation: Journal of Translational Medicine 2018 16:204
  13. Type 1 diabetes (DM1) is one of the most common chronic diseases in childhood and requires life-long insulin therapy and continuous health care support. An artificial pancreas (AP) or closed-loop system (CLS) ...

    Authors: Susanna Esposito, Elisa Santi, Giulia Mancini, Francesco Rogari, Giorgia Tascini, Giada Toni, Alberto Argentiero and Maria Giulia Berioli
    Citation: Journal of Translational Medicine 2018 16:176
  14. Lipid intermediates produced during triacylglycerols (TAGs) synthesis and lipolysis in adipocytes interfere with the intracellular insulin signaling pathway and development of insulin resistance. This study ai...

    Authors: Haya Al-Sulaiti, Ilhame Diboun, Sameem Banu, Mohamed Al-Emadi, Parvaneh Amani, Thomas M. Harvey, Alex S. Dömling, Aishah Latiff and Mohamed A. Elrayess
    Citation: Journal of Translational Medicine 2018 16:175
  15. DNA methylation has been evidenced as a potential epigenetic mechanism related to various candidate genes to development of obesity. Therefore, the objective of this study was to evaluate the DNA methylation l...

    Authors: Yohanna de Oliveira, Raquel Patrícia Ataíde Lima, Rafaella Cristhine Pordeus Luna, Mussara Gomes Cavalcanti Alves Monteiro, Cássia Surama Oliveira da Silva, Rayner Anderson Ferreira do Nascimento, Keylha Querino de Farias Lima, Ana Hermínia Andrade e Silva, Flávia Emília Leite de Lima Ferreira, Rodrigo Pinheiro de Toledo Vianna, Ronei Marcos de Moraes, Naila Francis Paulo de Oliveira, Aléssio Tony Cavalcanti de Almeida, Alexandre Sérgio Silva, Alcides da Silva Diniz, Maria José de Carvalho Costa…
    Citation: Journal of Translational Medicine 2018 16:152
  16. Chronic respiratory diseases, whose one of the hallmarks is oxidative stress, are still incurable and need novel therapeutic tools and pharmaceutical agents. The phenolic compounds contained in grape are endow...

    Authors: S. Castellani, A. Trapani, A. Spagnoletta, L. di Toma, T. Magrone, S. Di Gioia, D. Mandracchia, G. Trapani, E. Jirillo and M. Conese
    Citation: Journal of Translational Medicine 2018 16:140
  17. Immunotherapy has matured into standard treatment for several cancers, but much remains to be done to extend the reach of its effectiveness particularly to cancers that are resistant within each indication. Th...

    Authors: Laura Soldati, Laura Di Renzo, Emilio Jirillo, Paolo A. Ascierto, Francesco M. Marincola and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2018 16:75
  18. Extensive research within the last several decades has revealed that the major risk factors for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and diet. I...

    Authors: Ajaikumar B. Kunnumakkara, Bethsebie L. Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti and Bharat B. Aggarwal
    Citation: Journal of Translational Medicine 2018 16:14
  19. Numerous studies have investigated the role of the monounsaturated fatty acid and other dietary factors in the prevention of cognitive decline but the short-term effect of a low dose of extravirgin olive oil o...

    Authors: Elisa Mazza, Antonietta Fava, Yvelise Ferro, Stefania Rotundo, Stefano Romeo, Domenico Bosco, Arturo Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2018 16:10
  20. The present randomized clinical trial characterized the beneficial effects of a multi-strain probiotics supplementation on improving circulating endotoxin levels (primary endpoint) and other cardiometabolic bi...

    Authors: Shaun Sabico, Ayah Al-Mashharawi, Nasser M. Al-Daghri, Sobhy Yakout, Abdullah M. Alnaami, Majed S. Alokail and Philip G. McTernan
    Citation: Journal of Translational Medicine 2017 15:249
  21. Adipocytes derived from human mesenchymal stem cells (MSCs) are widely used to investigate adipogenesis. Taking into account both the novelty of these MSCs and the scarcity of studies focused on the effects of...

    Authors: Saioa Gómez-Zorita, Arrate Lasa, Naiara Abendaño, Alfredo Fernández-Quintela, Andrea Mosqueda-Solís, Maria Pilar Garcia-Sobreviela, Jose M. Arbonés-Mainar and Maria P. Portillo
    Citation: Journal of Translational Medicine 2017 15:237
  22. Chronic inflammation is a predisposing factor to numerous degenerative diseases including cancer, heart failure and Alzheimer’s disease. Infla-Kine is a natural supplement comprised of a proprietary blend of Lact...

    Authors: Nina A. Mikirova, Santosh Kesari, Thomas E. Ichim and Neil H. Riordan
    Citation: Journal of Translational Medicine 2017 15:213
  23. Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes–Weinstein monofilament (SWM) test is an efficient tool for evaluating diabeti...

    Authors: Sergio Martinez-Hervás, Mercedes Molina Mendez, José Folgado, Carmen Tormos, Pilar Ascaso, Marta Peiró, Jose T. Real and Juan F. Ascaso
    Citation: Journal of Translational Medicine 2017 15:187
  24. Evidence of probiotics effects on gut function, brain activity and emotional behaviour were provided. Probiotics can have dramatic effects on behaviour through the microbiome–gut–brain axis, through vagus nerv...

    Authors: Antonino De Lorenzo, Micaela Costacurta, Giuseppe Merra, Paola Gualtieri, Giorgia Cioccoloni, Massimiliano Marchetti, Dimitrios Varvaras, Raffaella Docimo and Laura Di Renzo
    Citation: Journal of Translational Medicine 2017 15:135
  25. Betaine (BET), a component of many foods, is an essential osmolyte and a source of methyl groups; it also shows an antioxidant activity. Moreover, BET stimulates muscle differentiation via insulin like growth ...

    Authors: Isabella Villa, Pamela Senesi, Anna Montesano, Anita Ferraretto, Fernanda Vacante, Alice Spinello, Michela Bottani, Simona Bolamperti, Alessandro Rubinacci, Livio Luzi and Ileana Terruzzi
    Citation: Journal of Translational Medicine 2017 15:132
  26. Standardized animal-free components are required for manufacturing cell-based medicinal products. Human platelet concentrates are sources of growth factors for cell expansion but such products are characterize...

    Authors: Francesco Agostini, Jerry Polesel, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Alessandro Da Ponte, Giuseppe Astori, Cristina Durante and Mario Mazzucato
    Citation: Journal of Translational Medicine 2017 15:107
  27. Nutrition is an environmental factor affecting bone health. Nutrition is considered essential to achieve and maintain optimal bone mass. Mediterranean diet (MD) has shown to prevent bone disease. Aim of this s...

    Authors: Maria Cristina Savanelli, Luigi Barrea, Paolo Emidio Macchia, Silvia Savastano, Andrea Falco, Andrea Renzullo, Elisabetta Scarano, Immacolata Cristina Nettore, Annamaria Colao and Carolina Di Somma
    Citation: Journal of Translational Medicine 2017 15:81
  28. Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascul...

    Authors: Rasnik K. Singh, Hsin-Wen Chang, Di Yan, Kristina M. Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani and Wilson Liao
    Citation: Journal of Translational Medicine 2017 15:73
  29. Replacing glucose with a better biocompatible osmotic agent in peritoneal dialysis (PD) solutions is needed in PD clinic. We previously demonstrated the potential of hyperbranched polyglycerol (HPG) as a repla...

    Authors: Caigan Du, Asher A. Mendelson, Qiunong Guan, Ghida Dairi, Irina Chafeeva, Gerald da Roza and Jayachandran N. Kizhakkedathu
    Citation: Journal of Translational Medicine 2016 14:338
  30. Intermittent fasting (IF) is an increasingly popular dietary approach used for weight loss and overall health. While there is an increasing body of evidence demonstrating beneficial effects of IF on blood lipi...

    Authors: Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri and Antonio Paoli
    Citation: Journal of Translational Medicine 2016 14:290
  31. Vitamin D (VitD) and thymoquinone (TQ) are nutraceutical agents with well-known immunomodulatory and hepatoprotective properties. This study measured whether VitD and TQ, individually or combined, could have d...

    Authors: Abdelghany Hassan Abdelghany, Mohammad A. BaSalamah, Shakir Idris, Jawwad Ahmad and Bassem Refaat
    Citation: Journal of Translational Medicine 2016 14:281
  32. Moniliformediquinone (MFD), a phenanthradiquinone in Dendrobium moniliforme, was synthesized in our laboratory. Beyond its in vitro inhibitory effects on cancer cells, other biological activity of MFD is unknown....

    Authors: Tsui-Hwa Tseng, Wea-Lung Lin, Zi-Hui Chen, Yean-Jang Lee, Ming-Shiun Shie, Kam-Fai Lee, Chien-Heng Shen and Hsing-Chun Kuo
    Citation: Journal of Translational Medicine 2016 14:263
  33. Body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI), triglyceride glucose index (TyG), TyG-BMI, and TyG-WC have been reported as markers of insulin resistance or type 2 diabetes mel...

    Authors: Shuang Zheng, Sheng Shi, Xingxing Ren, Tingting Han, Yangxue Li, Yawen Chen, Wei Liu, Peter C. Hou and Yaomin Hu
    Citation: Journal of Translational Medicine 2016 14:260
  34. Diabetes is the western world’s leading cause of end-stage renal disease. Glucose-dependent, oxidative stress is linked to the development of renal inflammation and sclerosis, which, in animal models of diabet...

    Authors: Kenneth A. Earle, Karima Zitouni, John Pepe, Maria Karaflou and James Godbold Jr
    Citation: Journal of Translational Medicine 2016 14:234
  35. Potentiation of glucose-induced insulin secretion is the main mechanism of exenatide (EXE) antidiabetic action, however, increased glucose utilization by peripheral tissues has been also reported. We here stud...

    Authors: Francesco Andreozzi, Gregory Alexander Raciti, Cecilia Nigro, Gaia Chiara Mannino, Teresa Procopio, Alberto M. Davalli, Francesco Beguinot, Giorgio Sesti, Claudia Miele and Franco Folli
    Citation: Journal of Translational Medicine 2016 14:229
  36. Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the intera...

    Authors: Federica Rizzi, Costanza Conti, Elena Dogliotti, Annalisa Terranegra, Erika Salvi, Daniele Braga, Flavia Ricca, Sara Lupoli, Alessandra Mingione, Francesca Pivari, Caterina Brasacchio, Matteo Barcella, Martina Chittani, Francesca D’Avila, Maurizio Turiel, Monica Lazzaroni…
    Citation: Journal of Translational Medicine 2016 14:186
  37. Obesity, metabolic syndrome (MetS), and psoriasis, largely driven by environmental factors, show multiple bidirectional associations, with important metabolic implications in psoriatic patients. Besides body m...

    Authors: Luigi Barrea, Paolo Emidio Macchia, Carolina Di Somma, Maddalena Napolitano, Anna Balato, Andrea Falco, Maria Cristina Savanelli, Nicola Balato, Annamaria Colao and Silvia Savastano
    Citation: Journal of Translational Medicine 2016 14:130
  38. Hericium erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration of H...

    Authors: Hsing-Chun Kuo, Chien-Chang Lu, Chien-Heng Shen, Shui-Yi Tung, Meng Chiao Hsieh, Ko-Chao Lee, Li-Ya Lee, Chin-Chu Chen, Chih-Chuan Teng, Wen-Shih Huang, Te-Chuan Chen and Kam-Fai Lee
    Citation: Journal of Translational Medicine 2016 14:78

    The Retraction Note to this article has been published in Journal of Translational Medicine 2021 19:67

  39. Fibroblast growth factor (FGF) 15/19 and FGF21 are two atypical members of FGF19 subfamily that function as hormones. Exogenous FGF15/19 and FGF21 have pharmacological effects, and endogenous FGF15/19 and FGF2...

    Authors: Dandan Guan, Lidan Zhao, Daiwen Chen, Bing Yu and Jie Yu
    Citation: Journal of Translational Medicine 2016 14:63
  40. The huge part of population in developed countries is overweight or obese. Obesity is often determined by body mass index (BMI) but new accurate methods and ratios have recently appeared to measure body fat or...

    Authors: Javier Martinez-Useros and Jesus Garcia-Foncillas
    Citation: Journal of Translational Medicine 2016 14:21
  41. Naturally occurring polyphenolic compounds from fruits, particularly from blueberries, have been reported to be significantly involved in cancer chemoprevention and chemotherapy. Biotransformation of blueberry...

    Authors: Tri Vuong, Jean-François Mallet, Maria Ouzounova, Sam Rahbar, Hector Hernandez-Vargas, Zdenko Herceg and Chantal Matar
    Citation: Journal of Translational Medicine 2016 14:13
  42. Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impai...

    Authors: G. A. Aguirre, J. Rodríguez De Ita, R. G. de la Garza and I. Castilla-Cortazar
    Citation: Journal of Translational Medicine 2016 14:3
  43. The beverage obtained by fermentation of milk with kefir grains, a complex matrix containing acid bacteria and yeasts, has been shown to have beneficial effects in various diseases. However, its effects on hyp...

    Authors: Andreia G. F. Friques, Clarisse M. Arpini, Ieda C. Kalil, Agata L. Gava, Marcos A. Leal, Marcella L. Porto, Breno V. Nogueira, Ananda T. Dias, Tadeu U. Andrade, Thiago Melo C. Pereira, Silvana S. Meyrelles, Bianca P. Campagnaro and Elisardo C. Vasquez
    Citation: Journal of Translational Medicine 2015 13:390
  44. There is limited information on the prevalence of vitamin D deficiency among patients diagnosed with hip fracture in the Chinese Han population. Therefore, the aim of this study was to assess the effects of ch...

    Authors: Xing-Mao Fu, Shao-Guang Fan, Shu-Liang Li, Yi-Sheng Chen, Hai Wu and Yan-Long Guo
    Citation: Journal of Translational Medicine 2015 13:388
  45. A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue.

    Authors: Eduardo García-Fuentes, Concepción Santiago-Fernández, Carolina Gutiérrez-Repiso, María D. Mayas, Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Juan Alcaide, Luis Ocaña-Wilhelmi, Joan Vendrell, Francisco J. Tinahones and Lourdes Garrido-Sánchez
    Citation: Journal of Translational Medicine 2015 13:373
  46. Human constitution, the fundamental basis of oriental medicine, is categorized into different patterns for a particular disease according to the physical, physiological, and clinical characteristics of the ind...

    Authors: Sun Woo Hong, Jae-Wook Yoo, Shambhunath Bose, Jung-Hyun Park, Kyungsun Han, Soyoun Kim, Chi-Yeon Lim, Hojun Kim and Dong-ki Lee
    Citation: Journal of Translational Medicine 2015 13:331
  47. Insulin growth factor 1 (IGF-1) has multiple effects on metabolism. Much evidence suggests that the deficiency of this hormone increases insulin resistance, impairs lipid metabolism, augments oxidative damage ...

    Authors: J. Rodríguez De Ita, I. Castilla-Cortázar, G. A. Aguirre, C. Sánchez-Yago, M. Olleros Santos-Ruiz, L. Guerra-Menéndez, I. Martín-Estal, M. García-Magariño, V. J. Lara-Díaz, J. E. Puche and U. Muñoz
    Citation: Journal of Translational Medicine 2015 13:326

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