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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Glutathione peroxidases (GPxs) belong to a family of enzymes that is important in organisms; these enzymes promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative d...

    Authors: Man-Li Zhang, Hua-Tao Wu, Wen-Jia Chen, Ya Xu, Qian-Qian Ye, Jia-Xin Shen and Jing Liu
    Citation: Journal of Translational Medicine 2020 18:247
    Content type: Review Published on:

  2. Variable resistance has been shown to induce greater total work and muscle activation when compared to constant resistance. However, little is known regarding the effects of chronic exposure to variable resist...

    Authors: Hamid Arazi, Lida Salek, Elham Nikfal, Mani Izadi, James J. Tufano, Bradley T. Elliott and Matt Brughelli
    Citation: Journal of Translational Medicine 2020 18:239
    Content type: Research Published on:

  3. On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans (COVID-19). On the 24th of April 2020, the number of COVID-19 deaths in...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Giulia Cinelli, Claudia Leggeri, Giovanna Caparello, Luigi Barrea, Francesco Scerbo, Ernesto Esposito and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2020 18:229
    Content type: Research Published on:

  4. Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-...

    Authors: Sheng Shi, Zhi Zhou, Jun-Jun Liao, Yue-Hua Yang, Jun-Song Wu, Shuang Zheng and Shi-Sheng He
    Citation: Journal of Translational Medicine 2020 18:211
    Content type: Research Published on:

  5. Green tea drinking has been proven to lower lipid and exert cardiovascular protection, while the potential mechanism has not been fully determined. This study was to investigate whether the beneficial impact o...

    Authors: Chuan-Jue Cui, Jing-Lu Jin, Lin-Na Guo, Jing Sun, Na-Qiong Wu, Yuan-Lin Guo, Geng Liu, Qian Dong and Jian-Jun Li
    Citation: Journal of Translational Medicine 2020 18:195
    Content type: Research Published on:

  6. The protective role of high HDL cholesterol levels against cardiovascular diseases has been recently questioned. Limited data are available on this specific topic in patients with type 2 diabetes mellitus (T2D...

    Authors: Giovanni Fanni, Rosalba Rosato, Luigi Gentile, Matteo Anselmino, Simone Frea, Valentina Ponzo, Marianna Pellegrini, Fabio Broglio, Francesca Pivari, Gaetano Maria De Ferrari, Ezio Ghigo and Simona Bo
    Citation: Journal of Translational Medicine 2020 18:189
    Content type: Research Published on:

  7. To observe the effect of rapid weight loss (RWL) methods over 3 days on muscle damage in judokas.

    Authors: Roberto Roklicer, Nemanja Lakicevic, Valdemar Stajer, Tatjana Trivic, Antonino Bianco, Diba Mani, Zoran Milosevic, Nebojsa Maksimovic, Antonio Paoli and Patrik Drid
    Citation: Journal of Translational Medicine 2020 18:142
    Content type: Research Published on:

  8. It is unclear the role of longitudinal trajectory of serum uric acid (SUA) on the development of non-alcoholic fatty liver disease (NAFLD). We aimed to determine whether longitudinal SUA trajectories are assoc...

    Authors: Zhimin Ma, Chaonan Xu, Xiaoping Kang, Shan Zhang, Haibin Li, Lixin Tao, Deqiang Zheng, Xiuhua Guo and Xinghua Yang
    Citation: Journal of Translational Medicine 2020 18:133
    Content type: Research Published on:

  9. Kidney stone disease (KSD) is more common in individuals with hypertension (HTN) than in individuals with normotension (NTN). Urinary dysbiosis is associated with urinary tract disease and systemic diseases. H...

    Authors: Fengping Liu, Nan Zhang, Peng Jiang, Qixiao Zhai, Chen Li, Deshui Yu, Yan Wu, Yuwei Zhang, Longxian Lv, Xinyu Xu and Ninghan Feng
    Citation: Journal of Translational Medicine 2020 18:130
    Content type: Research Published on:

  10. The role of the human microbiome in human health and disease has been studied in various body sites. However, compared to the gut microbiome, where most of the research focus is, the salivary microbiome still ...

    Authors: Selvasankar Murugesan, Sara Fahad Al Ahmad, Parul Singh, Marwa Saadaoui, Manoj Kumar and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2020 18:127
    Content type: Research Published on:

  11. Dietary restriction of methionine and cysteine is a well-described model that improves metabolic health in rodents. To investigate the translational potential in humans, we evaluated the effects of dietary met...

    Authors: Thomas Olsen, Bente Øvrebø, Nadia Haj-Yasein, Sindre Lee, Karianne Svendsen, Marit Hjorth, Nasser E. Bastani, Frode Norheim, Christian A. Drevon, Helga Refsum and Kathrine J. Vinknes
    Citation: Journal of Translational Medicine 2020 18:122
    Content type: Research Published on:

  12. Human defensin-5 (HD-5) is a key antimicrobial peptide which plays an important role in host immune defense, while the short half-life greatly limits its clinical application. The purpose of this study was to ...

    Authors: Lishan Zeng, Jiasheng Tan, Meng Xue, Le Liu, Mingming Wang, Liping Liang, Jun Deng, Wei Chen and Ye Chen
    Citation: Journal of Translational Medicine 2020 18:107
    Content type: Research Published on:

  13. Thiazide diuretics reduce the risk of recurrent kidney calculi in patients with kidney calculi or hypercalciuria. However, whether thiazide diuretics can definitely prevent recurrent kidney calculi remains unc...

    Authors: Dan-feng Li, Yu-lu Gao, Hong-chao Liu, Xiao-chen Huang, Rui-fang Zhu and Chang-tai Zhu
    Citation: Journal of Translational Medicine 2020 18:106
    Content type: Review Published on:

  14. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive age. It is characterised clinically by oligo-ovulation or anovulation, hyper-androgenism, and the presence of...

    Authors: Antonio Paoli, Laura Mancin, Maria Cristina Giacona, Antonino Bianco and Massimiliano Caprio
    Citation: Journal of Translational Medicine 2020 18:104
    Content type: Research Published on:

  15. The present study compared the effects of training and detraining periods of high-intensity interval training (HIIT), moderate-intensity interval training (MIIT) and moderate-intensity continuous training (MIC...

    Authors: Victor Silveira Coswig, Matheus Barbalho, Rodolfo Raiol, Fabrício Boscolo Del Vecchio, Rodrigo Ramirez-Campillo and Paulo Gentil
    Citation: Journal of Translational Medicine 2020 18:88
    Content type: Research Published on:

  16. Despite the efficacy of immune checkpoint inhibitors (ICIs) only the 20–30% of treated patients present long term benefits. The metabolic changes occurring in the gut microbiota metabolome are herein proposed ...

    Authors: Andrea Botticelli, Pamela Vernocchi, Federico Marini, Andrea Quagliariello, Bruna Cerbelli, Sofia Reddel, Federica Del Chierico, Francesca Di Pietro, Raffaele Giusti, Alberta Tomassini, Ottavia Giampaoli, Alfredo Miccheli, Ilaria Grazia Zizzari, Marianna Nuti, Lorenza Putignani and Paolo Marchetti
    Citation: Journal of Translational Medicine 2020 18:49
    Content type: Research Published on:

  17. There are several effective therapies for osteoporosis but these agents might cause serious adverse events. Lycopene intake could prevent bone loss, however studies on its effects on bone are scarce. Our aim w...

    Authors: Cristina Russo, Yvelise Ferro, Samantha Maurotti, Maria Antonietta Salvati, Elisa Mazza, Roberta Pujia, Rosa Terracciano, Giuseppina Maggisano, Rosario Mare, Sandro Giannini, Stefano Romeo, Arturo Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2020 18:43
    Content type: Research Published on:

  18. Circadian rhythms play a fundamental role in the progression of cardiovascular events. Almost all cardiovascular diseases have a circadian misalignment usually characterized by changes in metabolites. This stu...

    Authors: Huanjun Wang, Xiaoming Wang, Dongmei Qi, Mengjia Sun, Qingqing Hou, Yunlun Li and Haiqiang Jiang
    Citation: Journal of Translational Medicine 2020 18:38
    Content type: Research Published on:

  20. The manipulation of gut microbiota as a target has been suggested to reduce the risks for a number of diseases such as type 2 diabetes mellitus (T2DM). Conversely, T2DM is associated with complications such as...

    Authors: Mohammad Morshedi, Maryam Saghafi-Asl and Elaheh-Sadat Hosseinifard
    Citation: Journal of Translational Medicine 2020 18:18
    Content type: Research Published on:

  21. Epidemiologic studies show that cocaine- and amphetamine-regulated transcript prepropeptide (CARTPT) gene polymorphism modifies diet-obesity relationships. However, the interaction between CARTPT gene polymorp...

    Authors: Mahsa Mahmoudi-Nezhad, Mahdieh Abbasalizad Farhangi and Houman Kahroba
    Citation: Journal of Translational Medicine 2020 18:16
    Content type: Research Published on:

  22. The growth differentiation factor 11 (GDF11) was shown to reverse age-related hypertrophy on cardiomyocytes and considered as anti-aging rejuvenation factor. The role of GDF11 in regulating metabolic homeostas...

    Authors: Bingxin Lu, Jianing Zhong, Jianfei Pan, Xiaopeng Yuan, Mingzhi Ren, Liping Jiang, Yuqing Yang, Guisheng Zhang, Dexi Liu and Chunbo Zhang
    Citation: Journal of Translational Medicine 2019 17:422
    Content type: Research Published on:

  23. Tacrolimus (FK506)-induced diabetes mellitus is one of the most important factors of post-transplant diabetes mellitus (PTDM). However, the detailed mechanisms underlying PTDM are still unclear. Farnesoid X re...

    Authors: Ling Li, Huijia Zhao, Binyao Chen, Zhipeng Fan, Ning Li, Jiang Yue and Qifa Ye
    Citation: Journal of Translational Medicine 2019 17:418
    Content type: Research Published on:

  24. Currently, many clinical trials have shown that inulin-type fructans (ITF) supplementation is associated with glycemic control; nevertheless, the results are inconclusive. The aim of this meta-analysis of rand...

    Authors: Long Wang, Hong Yang, Hao Huang, Chao Zhang, Hong-Xia Zuo, Pan Xu, Yu-Ming Niu and Shi-Shi Wu
    Citation: Journal of Translational Medicine 2019 17:410
    Content type: Research Published on:

  25. The “nonclassic” apparent mineralocorticoid excess (NC-AME) has been identified in approximately 7% of general population. This phenotype is characterized by low plasma renin activity (PRA), high serum cortiso...

    Authors: Alejandra Tapia-Castillo, Dominic Guanzon, Carlos Palma, Andrew Lai, Eric Barros, Fidel Allende, Andrea Vecchiola, Carlos E. Fardella, Carlos Salomón and Cristian A. Carvajal
    Citation: Journal of Translational Medicine 2019 17:392
    Content type: Research Published on:

  26. Conflicting evidence exists on the relationship between body mass index (BMI) and serum uric acid (SUA). Therefore, we aimed to evaluate the SUA–BMI relationship in a large-scale epidemiological survey in coas...

    Authors: Hui Zhou, Zhen Liu, Zhong Chao, Yeqing Chao, Lidan Ma, Xiaoyu Cheng, Yangang Wang, Changgui Li and Ying Chen
    Citation: Journal of Translational Medicine 2019 17:389
    Content type: Research Published on:

  27. Cystic fibrosis (CF) is one of the most frequent genetic diseases and the median survival of these patients has improved in the last few decades, therefore it becomes necessary to evaluate the long-term compli...

    Authors: Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Enea Bonci, Paolo Giangreco Marotta, Francesco Pelligra, Manuel Murciano, Camilla Celani, Patrizia Troiani, Giuseppe Cimino and Paolo Palange
    Citation: Journal of Translational Medicine 2019 17:388
    Content type: Research Published on:

  28. Alcohol withdrawal syndrome (AWS) is routinely treated with B-vitamins. However, the relationship between thiamine status and outcome is rarely examined. The aim of the present study was to examine the relatio...

    Authors: Donogh Maguire, Dinesh Talwar, Alana Burns, Anthony Catchpole, Fiona Stefanowicz, Gordon Robson, David P. Ross, David Young, Alastair Ireland, Ewan Forrest, Peter Galloway, Michael Adamson, Eoghan Colgan, Hannah Bell, Lesley Orr, Joanna-Lee Kerr…
    Citation: Journal of Translational Medicine 2019 17:384
    Content type: Research Published on:

  29. Breastfeeding is the ideal source of infant nutrition. Human milk consists not only of nutrients but also biologically active components. Among these latter compounds, exosomes contain proteins, lipids, mRNAs ...

    Authors: Shimon Reif, Yaffa Elbaum Shiff and Regina Golan-Gerstl
    Citation: Journal of Translational Medicine 2019 17:325
    Content type: Research Published on:

  30. To investigate the association of serum levels of 25(OH)D and 1,25(OH)2D3 in healthy and non-healthy controls with Crohn’s disease (CD) and ulcerative colitis (UC).

    Authors: Xi-Xi Li, Yang Liu, Jie Luo, Zhen-Dong Huang, Chao Zhang and Yan Fu
    Citation: Journal of Translational Medicine 2019 17:323
    Content type: Research Published on:

  31. This study was conducted to investigate whether the daily consumption of haem, non-haem, total iron and red meat can affect the occurrence of metabolic syndrome (MetS) and its components.

    Authors: Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Parvin Mirmiran, Ali-Siamak Habibi-Moeini and Fereidoun Azizi
    Citation: Journal of Translational Medicine 2019 17:313
    Content type: Research Published on:

  32. Adipose tissue remodeling plays a significant role in obesity-induced insulin resistance. Published studies reported that level of trigger receptor expressed on myeloid cells 2 (TREM2) in adipose tissue is up-...

    Authors: Can Liu, Pinhao Li, Hui Li, Sicong Wang, Lifeng Ding, Hanbin Wang, Hui Ye, Yue Jin, Jinchao Hou, Xiangming Fang and Qiang Shu
    Citation: Journal of Translational Medicine 2019 17:300
    Content type: Research Published on:

  33. The effects of fasting on health in non-human models have been widely publicised for a long time and emerging evidence support the idea that these effects can be applicable to human practice.

    Authors: Iftikhar Alam, Rahmat Gul, Joni Chong, Crystal Tze Ying Tan, Hui Xian Chin, Glenn Wong, Radhouene Doggui and Anis Larbi
    Citation: Journal of Translational Medicine 2019 17:272
    Content type: Research Published on:

  34. Obesity is a chronic and systemic inflammatory disorder and an important risk factor for the onset of several chronic syndromes. Adipose tissue (AT) plays a crucial role in the development of obesity, promotin...

    Authors: Federica Tomay, Alessandra Marinelli, Valerio Leoni, Claudio Caccia, Andrea Matros, Hans-Peter Mock, Chiara Tonelli and Katia Petroni
    Citation: Journal of Translational Medicine 2019 17:237
    Content type: Research Published on:

  35. Diabetic nephropathy (DN) is associated with high risk of cardiovascular disease and mortality. Exosomal microRNAs (miRNAs) regulate gene expression in a variety of tissues and play important roles in the path...

    Authors: Hyoungnae Kim, Yun-Ui Bae, Jin Seok Jeon, Hyunjin Noh, Hyeong Kyu Park, Dong Won Byun, Dong Cheol Han, Seongho Ryu and Soon Hyo Kwon
    Citation: Journal of Translational Medicine 2019 17:236
    Content type: Research Published on:

  36. Lifestyle intervention may have a critical effect on the association between genetics and obesity. This study aimed to investigate changes in FTO and IRX3 gene expression in obese and overweight male adolescents ...

    Authors: Saeid Doaei, Naser Kalantari, Pantea Izadi, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Ghasem Azizi Tabesh, Ghazaleh Rahimzadeh, Maryam Gholamalizadeh and Mark O. Goodarzi
    Citation: Journal of Translational Medicine 2019 17:176
    Content type: Research Published on:

  37. Obesity must be considered a real pathology. In the world wide, obesity represent one of the major public health issue associated with increased morbidity and mortality. Overweight or obesity, in fact, signifi...

    Authors: Antonino De Lorenzo, Santo Gratteri, Paola Gualtieri, Andrea Cammarano, Pierfrancesco Bertucci and Laura Di Renzo
    Citation: Journal of Translational Medicine 2019 17:169
    Content type: Review Published on:

  38. Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in humans, and ranges from steatosis to non-alcoholic steatohepatitis (NASH), the latter with risk of progression to cirrhosis. The Gö...

    Authors: Camilla Schumacher-Petersen, Berit Østergaard Christoffersen, Rikke Kaae Kirk, Trine Pagh Ludvigsen, Nora Elisabeth Zois, Henrik Duelund Pedersen, Mogens Vyberg and Lisbeth Høier Olsen
    Citation: Journal of Translational Medicine 2019 17:110
    Content type: Research Published on:

  39. Human growth is a complex mechanism that depends on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each stage of development is growth hormone (GH) and its med...

    Authors: Susanna Esposito, Alberto Leonardi, Lucia Lanciotti, Marta Cofini, Giulia Muzi and Laura Penta
    Citation: Journal of Translational Medicine 2019 17:87
    Content type: Review Published on:

  40. Gastrointestinal microbiome has drawn an increasing amount of attention over the past decades. There is emerging evidence that the gut flora plays a major role in the pathogenesis of certain diseases. We aimed...

    Authors: Xiaoquan Huang, Xiaowen Fan, Jun Ying and Shiyao Chen
    Citation: Journal of Translational Medicine 2019 17:67
    Content type: Research Published on:

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2020 18:259

  41. Glycolysis is altered in various kidney diseases, but little is known about glycolysis in pre-eclampsia, a multi-system disorder with major pathological effects on the kidney. Urinary exosomes provide a non-in...

    Authors: R. Ellis, M. Katerelos, S. W. Choy, N. Cook, M. Lee, K. Paizis, G. Pell, S. Walker, D. A. Power and P. F. Mount
    Citation: Journal of Translational Medicine 2019 17:60
    Content type: Research Published on:

  42. Obesity is associated with impaired glucose tolerance which is a risk factor for cardiovascular risk. However, the oral glucose tolerance test (OGTT) is not usually performed in patients with normal fasting gl...

    Authors: Belén Pérez-Pevida, Jorge M. Núñez-Córdoba, Sonia Romero, Alexander Dimitri Miras, Patricia Ibañez, Neus Vila, María Ángeles Margall, Camilo Silva, Javier Salvador, Gema Frühbeck and Javier Escalada
    Citation: Journal of Translational Medicine 2019 17:48
    Content type: Research Published on:

  43. Ischemia–reperfusion injury is caused by a period of ischemia followed by massive blood flow into a tissue that had experienced restricted blood flow. The severity of the injury is dependent on the time the ti...

    Authors: Michael D. Wetzel and Joseph C. Wenke
    Citation: Journal of Translational Medicine 2019 17:33
    Content type: Review Published on:

  44. Early life is a period of drastic epigenetic remodeling in which the epigenome is especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide dynamics of the DNA methylation changes ...

    Authors: Raúl F. Pérez, Pablo Santamarina, Juan Ramón Tejedor, Rocío G. Urdinguio, Julio Álvarez-Pitti, Pau Redon, Agustín F. Fernández, Mario F. Fraga and Empar Lurbe
    Citation: Journal of Translational Medicine 2019 17:15
    Content type: Research Published on:

  45. Intramuscular triglycerides (IMTGs) represent an important energy supply and a dynamic fat-storage depot that can expand during periods of elevated lipid availability and a fatty acid source. Ultrasonography (...

    Authors: Giovanni Tarantino, Susan Costantini, Vincenzo Citro, Paolo Conforti, Francesca Capone, Angela Sorice and Domenico Capone
    Citation: Journal of Translational Medicine 2019 17:8
    Content type: Research Published on:

  46. Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and effo...

    Authors: Yuan-Yuan Chen, Dan-Qian Chen, Lin Chen, Jing-Ru Liu, Nosratola D. Vaziri, Yan Guo and Ying-Yong Zhao
    Citation: Journal of Translational Medicine 2019 17:5
    Content type: Review Published on:

  48. This systematic review and meta-analysis summarized the most recent evidence on the efficacy of intermittent energy restriction (IER) versus continuous energy restriction on weight-loss, body composition, bloo...

    Authors: Iolanda Cioffi, Andrea Evangelista, Valentina Ponzo, Giovannino Ciccone, Laura Soldati, Lidia Santarpia, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo and Simona Bo
    Citation: Journal of Translational Medicine 2018 16:371
    Content type: Review Published on:

  49. l-Fucose (Fuc), a six-deoxy hexose monosaccharide, is present endogenously in humans and animals and has a wide range of biological functions. In the present study, we aimed to examine the effect of Fuc on obes.....

    Authors: Guangyan Wu, Mengwei Niu, Wenli Tang, Jingjuan Hu, Guoquan Wei, Zhanke He, Yangping Chen, Yong Jiang and Peng Chen
    Citation: Journal of Translational Medicine 2018 16:344
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:276

  50. Endoplasmic reticulum (ER) stress, which can promote lipid metabolism disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Calcium (Ca2+) homeo...

    Authors: Xiaobo Gao, Shun Guo, Song Zhang, An Liu, Lei Shi and Yan Zhang
    Citation: Journal of Translational Medicine 2018 16:319
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2019 17:277

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