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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas

Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Coronavirus disease (COVID-19) pandemic has affected health and lifestyle behaviors of people globally. This project aims to identify the impact of COVID-19 on lifestyle behavior of individuals in the Middle E...

    Authors: Mohamed Abouzid, Dina M. El-Sherif, Nael Kamel Eltewacy, Nesrine Ben Hadj Dahman, Salah A. Okasha, Sherief Ghozy and Sheikh Mohammed Shariful Islam
    Citation: Journal of Translational Medicine 2021 19:129
  2. Omega-3 polyunsaturated fatty acids (n3-PUFAs) may exert beneficial effects on the immune system of patients with viral infections. This paper aimed to examine the effect of n3-PUFA supplementation on inflamma...

    Authors: Saeid Doaei, Somayeh Gholami, Samira Rastgoo, Maryam Gholamalizadeh, Fatemeh Bourbour, Seyedeh Elaheh Bagheri, Forough Samipoor, Mohammad Esmail Akbari, Mahdi Shadnoush, Fereshteh Ghorat, Seyed Alireza Mosavi Jarrahi, Narjes Ashouri Mirsadeghi, Azadeh Hajipour, Parvin Joola, Alireza Moslem and Mark O. Goodarzi
    Citation: Journal of Translational Medicine 2021 19:128

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2021 19:282

  3. Muscle wasting, low protein intake, hypoalbuminemia, low body mass, and chronic fatigue are prevalent in hemodialysis patients. Impaired creatine status may be an often overlooked, potential contributor to the...

    Authors: Adrian Post, Joëlle C. Schutten, Daan Kremer, Yvonne van der Veen, Dion Groothof, Camilo G. Sotomayor, Christa A. Koops, Pim de Blaauw, Ido P. Kema, Ralf Westerhuis, Theo Wallimann, M. Rebecca Heiner-Fokkema, Stephan J. L. Bakker and Casper F. M. Franssen
    Citation: Journal of Translational Medicine 2021 19:115
  4. Non-alcoholic steatohepatitis (NASH) is a key stage in leading development of non-alcoholic simple fatty liver (NAFL) into cirrhosis and even liver cancer. This study aimed at exploring the lncRNAs expression ...

    Authors: Liangying Ye, Dan Zhao, Yangzhi Xu, Jiaen Lin, Jiahui Xu, Kunyuan Wang, Zhanhui Ye, Yufeng Luo, Shiming Liu and Hui Yang
    Citation: Journal of Translational Medicine 2021 19:101
  5. To identify sex specific trajectories of waist circumference (WC),triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose (FPG) during adulthood and e...

    Authors: Noushin Sadat Ahanchi, Seyed Saeed Tamehri Zadeh, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh
    Citation: Journal of Translational Medicine 2021 19:84
  6. Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are highly prevalent comorbidities in patients with Type 2 diabetes. While many of these patients eventually will need treatme...

    Authors: Victoria Svop Jensen, Christian Fledelius, Christina Zachodnik, Jesper Damgaard, Helle Nygaard, Kristina Steinicke Tornqvist, Rikke Kaae Kirk, Birgitte Martine Viuff, Erik Max Wulff, Jens Lykkesfeldt and Henning Hvid
    Citation: Journal of Translational Medicine 2021 19:80
  7. The prevalence of metabolic syndrome (Mets) is closely related to an increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, h...

    Authors: Zhoujie Tong, Jie Peng, Hongtao Lan, Wenwen Sai, Yulin Li, Jiaying Xie, Yanmin Tan, Wei Zhang, Ming Zhong and Zhihao Wang
    Citation: Journal of Translational Medicine 2021 19:72
  8. Atherosclerosis is a chronic vascular disease posing a great threat to public health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities to inhibit lipid accumulation and polarization co...

    Authors: Xinxin Zhang, Yating Qin, Xiaoning Wan, Hao Liu, Chao Lv, Weibin Ruan, Lin He, Li Lu and Xiaomei Guo
    Citation: Journal of Translational Medicine 2021 19:62
  9. Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes ...

    Authors: Wei Pan, Pengfei Jiang, Jinxiu Zhao, Hongli Shi, Peng Zhang, Xiaoying Yang, Joanna Biazik, Minmin Hu, Hui Hua, Xing Ge, Xu-Feng Huang and Yinghua Yu
    Citation: Journal of Translational Medicine 2021 19:54
  10. Interleukin-33 (IL-33) plays a pivotal role in regulating innate immune response and metabolic homeostasis. However, whether its circulating level is correlated with obesity and metabolic disorders in humans r...

    Authors: Haoneng Tang, Ning Liu, Xiaojing Feng, Yanyi Yang, Yiyuan Fang, Siqi Zhuang, Yufeng Dai, Meilian Liu and Lingli Tang
    Citation: Journal of Translational Medicine 2021 19:52
  11. By binding to negatively charged polysaccharides called glycosaminoglycans, sodium can be stored in the body—particularly in the skin—without concurrent water retention. Concordantly, individuals with changed ...

    Authors: Eliane F. E. Wenstedt, Jetta J. Oppelaar, Stijn Besseling, Nienke M. G. Rorije, Rik H. G. Olde Engberink, Arie Oosterhof, Toin H. van Kuppevelt, Bert-Jan H. van den Born, Jan Aten and Liffert Vogt
    Citation: Journal of Translational Medicine 2021 19:38
  12. In 2013 American College of Cardiology and the American Heart Association released a guideline on the management of atherosclerotic cardiovascular disease (ASCVD) including a composite of death from CVD, non-f...

    Authors: Farzad Hadaegh, Samaneh Asgari, Fatemeh Moosaie, Meysam Orangi, Farzaneh Sarvghadi, Davood Khalili and Fereidoun Azizi
    Citation: Journal of Translational Medicine 2021 19:25
  13. Benign prostatic hyperplasia (BPH) is the most common urologic disease among elderly men. The diagnosis of BPH is usually driven by lower urinary tract symptoms (LUTS) that can significantly affect patients’ q...

    Authors: Luigi Cormio, Beppe Calò, Ugo Falagario, Manuela Iezzi, Alessia Lamolinara, Paola Vitaglione, Giovanni Silecchia, Giuseppe Carrieri, Vincenzo Fogliano, Stefano Iacobelli, Pier Giorgio Natali and Mauro Piantelli
    Citation: Journal of Translational Medicine 2021 19:24
  14. Most studies focused on the benefits of lycopene on serum lipids but no studies have been specifically designed to assess the role of a tomato sauce from vine-ripened tomatoes on patients affected by polygenic...

    Authors: Yvelise Ferro, Elisa Mazza, Elvira Angotti, Roberta Pujia, Angela Mirarchi, Maria Antonietta Salvati, Rosa Terracciano, Rocco Savino, Stefano Romeo, Antonio Scuteri, Rosario Mare, Francesco Saverio Costanzo, Arturo Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2021 19:19
  15. Cancer-associated fibroblasts (CAFs) play a pivotal role in regulating tumor progression by transferring exosomes to adjacent cells. Our aim was to clarify the role of LINC00659 encapsulated in CAFs-derived ex...

    Authors: Lin Zhou, Jian Li, Yaping Tang and Mei Yang
    Citation: Journal of Translational Medicine 2021 19:8
  16. Dyslipidaemia is a major risk factor for atherosclerosis and cardiovascular diseases. The molecular mechanisms that translate dyslipidaemia into atherogenesis and reliable markers of its progression are yet to...

    Authors: Mariola Olkowicz, Izabela Czyzynska-Cichon, Natalia Szupryczynska, Renata B. Kostogrys, Zdzislaw Kochan, Janusz Debski, Michal Dadlez, Stefan Chlopicki and Ryszard T. Smolenski
    Citation: Journal of Translational Medicine 2021 19:6
  17. The increasing prevalence of overweight and obesity among the worldwide population has been associated with a range of adverse health consequences such as Type 2 diabetes and cardiovascular diseases. The metab...

    Authors: Jéssica D. Schroder, Hugo Falqueto, Aline Mânica, Daniela Zanini, Tácio de Oliveira, Clodoaldo A. de Sá, Andréia Machado Cardoso and Leandro Henrique Manfredi
    Citation: Journal of Translational Medicine 2021 19:3
  18. In the past two decades, sphingolipids have become increasingly appreciated as bioactive molecules playing important roles in a wide array of pathophysiology mechanisms. Despite advances in the field, sphingol...

    Authors: Michele Dei Cas, Rita Paroni, Paola Signorelli, Alessandra Mirarchi, Laura Cerquiglini, Stefania Troiani, Samuela Cataldi, Michela Codini, Tommaso Beccari, Riccardo Ghidoni and Elisabetta Albi
    Citation: Journal of Translational Medicine 2020 18:481
  19. Childhood obesity persists as a serious public health problem. In the current meta-analysis, we summarized the results of controlled trials that evaluated the effect of obesity prevention policies in children ...

    Authors: Shahnaz Taghizadeh and Mahdieh Abbasalizad Farhangi
    Citation: Journal of Translational Medicine 2020 18:480
  20. In pre-clinical research, systematic reviews have the potential to mitigate translational challenges by facilitating understanding of how pre-clinical studies can inform future clinical research. Yet their con...

    Authors: Nicola L. Harman, Adrián Sanz-Moreno, Stamatia Papoutsopoulou, Katie A. Lloyd, Kamar E. Ameen-Ali, Malcolm Macleod and Paula R. Williamson
    Citation: Journal of Translational Medicine 2020 18:468
  21. Increasing evidence showed that carbamylated lipoprotein accelerated atherosclerosis. However, whether such modification of high-density lipoprotein (HDL) particles alters in type 2 diabetes mellitus (T2DM) pa...

    Authors: Zhongli Chen, Song Ding, Yan Ping Wang, Liang Chen, Jing Yan Mao, Ying Yang, Jia Teng Sun and Ke Yang
    Citation: Journal of Translational Medicine 2020 18:460
  22. Exosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant rs1799858] and environmental [elevated serum low...

    Authors: Cheng Liu, Yanxian Lai, Songsong Ying, Junfang Zhan and Yan Shen
    Citation: Journal of Translational Medicine 2020 18:459
  23. Magnesium is a fundamental cation that regulates neuronal transmission, protein synthesis, energy metabolism. Magnesium deficiency mostly affects nervous and cardiovascular systems determining weakness, tremor...

    Authors: Clementina Sitzia, Michele Sterlicchio, Calogero Crapanzano, Elena Dozio, Elena Vianello and Massimiliano Marco Corsi Romanelli
    Citation: Journal of Translational Medicine 2020 18:458
  24. The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives. Notably, obesity and its related com...

    Authors: Antonio Paoli, Stefania Gorini and Massimiliano Caprio
    Citation: Journal of Translational Medicine 2020 18:441
  25. Obesity is a chronic low-grade inflammatory disease that is generally characterized by enhanced inflammation in obese adipose tissue (AT). Here, we investigated alterations in gene expression between lean and ...

    Authors: Sang-Hyeop Lee, Nak-Hyeon Choi, In-Uk Koh, Bong-Jo Kim, Song Lee, Song-Cheol Kim and Sun Shim Choi
    Citation: Journal of Translational Medicine 2020 18:433
  26. Obesity is associated with impaired health and lower work ability. Increased physical activity is a cornerstone in the treatment of obesity and related risk factors. Recently, high-intensity interval training ...

    Authors: Dejan Reljic, Fabienne Frenk, Hans J. Herrmann, Markus F. Neurath and Yurdagül Zopf
    Citation: Journal of Translational Medicine 2020 18:419
  27. On December 12, 2019 a new coronavirus (SARS-CoV-2) emerged in Wuhan, China, triggering a pandemic of severe acute respiratory syndrome in humans (COVID-19). Today, the scientific community is investing all th...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Claudia Leggeri, Giulia Cinelli, Maria Grazia Tarsitano, Giovanna Caparello, Elena Carrano, Giuseppe Merra, Alberto Maria Pujia, Roberta Danieli and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2020 18:415
  28. Glycemic variability (GV) represents the amplitude of oscillations in glucose levels over time and is associated with higher mortality in critically ill patients. Our aim is to evaluate the impact of GV on acu...

    Authors: Blanca Fuentes, Silvia Pastor-Yborra, Raquel Gutiérrez-Zúñiga, Noemí González-Pérez de Villar, Elena de Celis, Jorge Rodríguez-Pardo, Mari Carmen Gómez-de Frutos, Fernando Laso-García, María Gutiérrez-Fernández, MÁngeles Ortega-Casarrubios, Alfonso Soto, María López-Fernández, María Santamaría, Noemí Díez-González, Mar M. Freijo, Beatriz Zandio…
    Citation: Journal of Translational Medicine 2020 18:414
  29. Hypertension and high triglyceride are two of the most important risk factors for hyperuricemia. Epidemiological records show that hypertension and dyslipidemia often coexist and may significantly increase the...

    Authors: Yuan Zhang, Miaomiao Zhang, Xiawen Yu, Fengjiang Wei, Chen Chen, Kai Zhang, Shuzhi Feng, Yaogang Wang and Wei-Dong Li
    Citation: Journal of Translational Medicine 2020 18:409
  30. Evidences support the view that central obesity is an independently cardiovascular risk. It is thought that leptin contributes to autonomic dysfunction and cardiovascular risks in type 1 and type 2 diabetes me...

    Authors: Yun-Ru Lai, Meng Hsiang Chen, Wei Che Lin, Wen-Chan Chiu, Ben-Chung Cheng, Jung-Fu Chen, Nai-Wen Tsai, Chih-Cheng Huang and Cheng-Hsien Lu
    Citation: Journal of Translational Medicine 2020 18:396
  31. Electronic cigarette use is on the rise despite a number of reports linking electronic cigarettes with adverse health outcomes. Recent studies have suggested that alterations in lipid signaling may be one mech...

    Authors: Holly R. Middlekauff, Kevin J. William, Baolong Su, Kacey Haptonstall, Jesus A. Araujo, Xiaohui Wu, Jason Kim and Tamer Sallam
    Citation: Journal of Translational Medicine 2020 18:379
  32. Pregnant women with gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) are at increased risks of pre-term labor, hypertension and preeclampsia. In this study, metabolic profiling of blood s...

    Authors: Ilhame Diboun, Manjunath Ramanjaneya, Yasser Majeed, Lina Ahmed, Mohammed Bashir, Alexandra E. Butler, Abdul Badi Abou-Samra, Stephen L. Atkin, Nayef A. Mazloum and Mohamed A. Elrayess
    Citation: Journal of Translational Medicine 2020 18:366
  33. Omega-3 fatty acids (Ω-3 PUFAs) may help to improve health status in polycystic ovarian syndrome (PCOS) by reducing numerous metabolic disorders (insulin sensitivity, hyperinsulinemia, lipid profile, obesity a...

    Authors: Fiza Komal, Muhammad Kamran Khan, Muhammad Imran, Muhammad Haseeb Ahmad, Haseeb Anwar, Usman Ali Ashfaq, Nazir Ahmad, Amna Masroor, Rabia Shabir Ahmad, Muhammad Nadeem and Mahr Un Nisa
    Citation: Journal of Translational Medicine 2020 18:349
  34. In the current systematic review and meta-analysis, we summarized the studies that evaluated the effects of sugar-sweetened beverages (SSBs) intake on blood pressure among children and adolescents.

    Authors: Mahdieh Abbasalizad Farhangi, Leila Nikniaz and Mahdieh Khodarahmi
    Citation: Journal of Translational Medicine 2020 18:344
  35. The coronavirus disease 2019 (COVID-19) pandemic has led to a declaration of a Public Health Emergency of International Concern by the World Health Organization. As of May 18, 2020, there have been more than 4...

    Authors: Yi Xu, David J. Baylink, Chien-Shing Chen, Mark E. Reeves, Jeffrey Xiao, Curtis Lacy, Eric Lau and Huynh Cao
    Citation: Journal of Translational Medicine 2020 18:322
  36. COVID 19-related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass ...

    Authors: Luigi Barrea, Gabriella Pugliese, Lydia Framondi, Rossana Di Matteo, Daniela Laudisio, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2020 18:318
  37. In the last twenty years, several studies have been conducted in the search for new therapeutic strategies in patients with food allergy; in particular, after the failure of injection immunotherapy, three diff...

    Authors: Francesco Marcucci, Chiara Isidori, Alberto Argentiero, Cosimo Neglia and Susanna Esposito
    Citation: Journal of Translational Medicine 2020 18:302
  38. Obesity and steatosis are associated with COVID-19 severe pneumonia. Elevated levels of pro-inflammatory cytokines and reduced immune response are typical of these patients. In particular, adipose tissue is th...

    Authors: Antonino De Lorenzo, Maria Grazia Tarsitano, Carmela Falcone, Laura Di Renzo, Lorenzo Romano, Sebastiano Macheda, Anna Ferrarelli, Demetrio Labate, Marco Tescione, Federico Bilotta and Paola Gualtieri
    Citation: Journal of Translational Medicine 2020 18:299
  39. Diabetic bladder disease is common complications of diabetes, its symptoms are diverse, can be due to different stages. In this study we investigate the mechanism of miR-128 targe...

    Authors: Xin Gou, Jing Wu, Mingqing Huang, Yuting Weng, Tongxin Yang, Tao Chen, Guiqing Li and Kewei Fang
    Citation: Journal of Translational Medicine 2020 18:284

    The Retraction Note to this article has been published in Journal of Translational Medicine 2021 19:59

  40. Worldwide, 70% of the adult population has limited expression of lactase enzyme with a wide variation among different regions and countries. Lactase deficiency may lead to lactose intolerance (LI). Depending b...

    Authors: Maria Sole Facioni, Benedetta Raspini, Francesca Pivari, Elena Dogliotti and Hellas Cena
    Citation: Journal of Translational Medicine 2020 18:260
  41. This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance imaging to evaluate the permeability of the blood–brain barrier...

    Authors: Ju Qiao, Christopher M. Lawson, Kilian F. G. Rentrup, Praveen Kulkarni and Craig F. Ferris
    Citation: Journal of Translational Medicine 2020 18:256
  42. The attraction and influx of monocytes into the retina has been considered a critical step in the development of diabetic retinopathy (DR). However, large population studies about the association between perip...

    Authors: Heng Wan, Yan Cai, Yuying Wang, Sijie Fang, Chi Chen, Yi Chen, Fangzhen Xia, Ningjian Wang, Minghao Guo and Yingli Lu
    Citation: Journal of Translational Medicine 2020 18:248
  43. Glutathione peroxidases (GPxs) belong to a family of enzymes that is important in organisms; these enzymes promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative d...

    Authors: Man-Li Zhang, Hua-Tao Wu, Wen-Jia Chen, Ya Xu, Qian-Qian Ye, Jia-Xin Shen and Jing Liu
    Citation: Journal of Translational Medicine 2020 18:247
  44. Variable resistance has been shown to induce greater total work and muscle activation when compared to constant resistance. However, little is known regarding the effects of chronic exposure to variable resist...

    Authors: Hamid Arazi, Lida Salek, Elham Nikfal, Mani Izadi, James J. Tufano, Bradley T. Elliott and Matt Brughelli
    Citation: Journal of Translational Medicine 2020 18:239
  45. On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans (COVID-19). On the 24th of April 2020, the number of COVID-19 deaths in...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Giulia Cinelli, Claudia Leggeri, Giovanna Caparello, Luigi Barrea, Francesco Scerbo, Ernesto Esposito and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2020 18:229
  46. Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-...

    Authors: Sheng Shi, Zhi Zhou, Jun-Jun Liao, Yue-Hua Yang, Jun-Song Wu, Shuang Zheng and Shi-Sheng He
    Citation: Journal of Translational Medicine 2020 18:211

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