Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

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  1. Review

    Obesity and colorectal cancer: molecular features of adipose tissue

    The huge part of population in developed countries is overweight or obese. Obesity is often determined by body mass index (BMI) but new accurate methods and ratios have recently appeared to measure body fat or...

    Javier Martinez-Useros and Jesus Garcia-Foncillas

    Journal of Translational Medicine 2016 14:21

    Published on: 22 January 2016

  2. Research

    Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation

    Naturally occurring polyphenolic compounds from fruits, particularly from blueberries, have been reported to be significantly involved in cancer chemoprevention and chemotherapy. Biotransformation of blueberry...

    Tri Vuong, Jean-François Mallet, Maria Ouzounova, Sam Rahbar, Hector Hernandez-Vargas, Zdenko Herceg and Chantal Matar

    Journal of Translational Medicine 2016 14:13

    Published on: 14 January 2016

  3. Review

    Insulin-like growth factor-1 deficiency and metabolic syndrome

    Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impai...

    G. A. Aguirre, J. Rodríguez De Ita, R. G. de la Garza and I. Castilla-Cortazar

    Journal of Translational Medicine 2016 14:3

    Published on: 6 January 2016

  4. Research

    Chronic administration of the probiotic kefir improves the endothelial function in spontaneously hypertensive rats

    The beverage obtained by fermentation of milk with kefir grains, a complex matrix containing acid bacteria and yeasts, has been shown to have beneficial effects in various diseases. However, its effects on hyp...

    Andreia G. F. Friques, Clarisse M. Arpini, Ieda C. Kalil, Agata L. Gava, Marcos A. Leal, Marcella L. Porto, Breno V. Nogueira, Ananda T. Dias, Tadeu U. Andrade, Thiago Melo C. Pereira, Silvana S. Meyrelles, Bianca P. Campagnaro and Elisardo C. Vasquez

    Journal of Translational Medicine 2015 13:390

    Published on: 30 December 2015

  5. Research

    Low 25(OH) D serum levels are related with hip fracture in postmenopausal women: a matched case–control study

    There is limited information on the prevalence of vitamin D deficiency among patients diagnosed with hip fracture in the Chinese Han population. Therefore, the aim of this study was to assess the effects of ch...

    Xing-Mao Fu, Shao-Guang Fan, Shu-Liang Li, Yi-Sheng Chen, Hai Wu and Yan-Long Guo

    Journal of Translational Medicine 2015 13:388

    Published on: 23 December 2015

  6. Research

    Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue

    A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue.

    Eduardo García-Fuentes, Concepción Santiago-Fernández, Carolina Gutiérrez-Repiso, María D. Mayas, Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Juan Alcaide, Luis Ocaña-Wilhelmi, Joan Vendrell, Francisco J. Tinahones and Lourdes Garrido-Sánchez

    Journal of Translational Medicine 2015 13:373

    Published on: 30 November 2015

  7. Research

    Understanding the molecular aspects of oriental obesity pattern differentiation using DNA microarray

    Human constitution, the fundamental basis of oriental medicine, is categorized into different patterns for a particular disease according to the physical, physiological, and clinical characteristics of the ind...

    Sun Woo Hong, Jae-Wook Yoo, Shambhunath Bose, Jung-Hyun Park, Kyungsun Han, Soyoun Kim, Chi-Yeon Lim, Hojun Kim and Dong-ki Lee

    Journal of Translational Medicine 2015 13:331

    Published on: 19 October 2015

  8. Research

    Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome

    Insulin growth factor 1 (IGF-1) has multiple effects on metabolism. Much evidence suggests that the deficiency of this hormone increases insulin resistance, impairs lipid metabolism, augments oxidative damage ...

    J. Rodríguez De Ita, I. Castilla-Cortázar, G. A. Aguirre, C. Sánchez-Yago, M. Olleros Santos-Ruiz, L. Guerra-Menéndez, I. Martín-Estal, M. García-Magariño, V. J. Lara-Díaz, J. E. Puche and U. Muñoz

    Journal of Translational Medicine 2015 13:326

    Published on: 14 October 2015

  9. Research

    Nutritional parameters predicting pressure ulcers and short-term mortality in patients with minimal conscious state as a result of traumatic and non-traumatic acquired brain injury

    The association between malnutrition and worse outcomes as pressure ulcers and mortality is well established in a variety of setting. Currently none investigation was conducted in patients with long-term conse...

    Tiziana Montalcini, Marta Moraca, Yvelise Ferro, Stefano Romeo, Sebastiano Serra, Maria Girolama Raso, Francesco Rossi, Walter G. Sannita, Giuliano Dolce and Arturo Pujia

    Journal of Translational Medicine 2015 13:305

    Published on: 17 September 2015

  10. Research

    Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day food-frequency questionnaire

    Western dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association be...

    Luigi Barrea, Paolo Emidio Macchia, Giovanni Tarantino, Carolina Di Somma, Elena Pane, Nicola Balato, Maddalena Napolitano, Annamaria Colao and Silvia Savastano

    Journal of Translational Medicine 2015 13:303

    Published on: 16 September 2015

  11. Research

    The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study

    Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interac...

    Maria L. Mansego, Griselda De Marco, Carmen Ivorra, Raúl Lopez-Izquierdo, Sonsoles Morcillo, Gemma Rojo-Martínez, Verónica González-Albert, Fernando Martinez, Federico Soriguer, Juan C. Martín-Escudero, Josep Redon and F. Javier Chaves

    Journal of Translational Medicine 2015 13:286

    Published on: 2 September 2015

  12. Research

    The effects of two common edible herbs, Ipomoea aquatica and Enhydra fluctuans, on cadmium-induced pathophysiology: a focus on oxidative defence and anti-apoptotic mechanism

    Ipomoea aquatica (Convolvulaceae) and Enhydra fluctuans (Asteraceae), two aquatic vegetables, are traditionally used against heavy metal toxicity in traditional medicines in India. The...

    Tarun K Dua, Saikat Dewanjee, Ritu Khanra, Niloy Bhattacharya, Bhuvan Bhaskar, Muhammad Zia-Ul-Haq and Vincenzo De Feo

    Journal of Translational Medicine 2015 13:245

    Published on: 28 July 2015

  13. Review

    Taurine: the appeal of a safe amino acid for skeletal muscle disorders

    Taurine is a natural amino acid present as free form in many mammalian tissues and in particular in skeletal muscle. Taurine exerts many physiological functions, including membrane stabilization, osmoregulatio...

    Annamaria De Luca, Sabata Pierno and Diana Conte Camerino

    Journal of Translational Medicine 2015 13:243

    Published on: 25 July 2015

  14. Research

    Dietary flavonoid intake and cardiovascular risk: a population-based cohort study

    The cardio-protective effects of flavonoids are still controversial; many studies referred to the benefits of specific foods, such as soy, cocoa, tea. A population-based cohort of middle-aged adults, coming fr...

    Valentina Ponzo, Ilaria Goitre, Maurizio Fadda, Roberto Gambino, Antonella De Francesco, Laura Soldati, Luigi Gentile, Paola Magistroni, Maurizio Cassader and Simona Bo

    Journal of Translational Medicine 2015 13:218

    Published on: 8 July 2015

  15. Research

    Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice

    Anthocyanins are major constituents of food colours and have been reported to possess anti-diabetic activities for potential medicinal use. The precise role of anthocyanins in diabetic nephropathy is poorly un...

    Eun Sil Koh, Ji Hee Lim, Min Young Kim, Sungjin Chung, Seok Joon Shin, Bum Soon Choi, Hye Won Kim, Seong Yeon Hwang, Sae Woong Kim, Cheol Whee Park and Yoon Sik Chang

    Journal of Translational Medicine 2015 13:203

    Published on: 27 June 2015

  16. Research

    Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice

    Non-alcoholic fatty liver disease (NAFLD) is becoming a pandemic. While multiple ‘hits’ have been reported to contribute to NAFLD progression to non-alcoholic steatohepatitis (NASH), fibrosis and liver cancer,...

    Michal Ganz, Terence N Bukong, Timea Csak, Banishree Saha, Jin-Kyu Park, Aditya Ambade, Karen Kodys and Gyongyi Szabo

    Journal of Translational Medicine 2015 13:193

    Published on: 16 June 2015

  17. Review

    Impact of heparanase on renal fibrosis

    Tubulo-interstitial fibrosis has been recognized as the hallmark of progression of chronic kidney disease, but, despite intensive research studies, there are currently no biomarkers or effective treatments for...

    Valentina Masola, Gianluigi Zaza, Maurizio Onisto, Antonio Lupo and Giovanni Gambaro

    Journal of Translational Medicine 2015 13:181

    Published on: 4 June 2015

  18. Research

    Bisphenol-A plasma levels are related to inflammatory markers, visceral obesity and insulin-resistance: a cross-sectional study on adult male population

    The current increase of obesity and metabolic syndrome (MS) focuses attention on bisphenol-A (BPA), “obesogen” endocrine disruptor, main plastic component. Aim was to verify the role of BPA in metabolic altera...

    Silvia Savastano, Giovanni Tarantino, Vittoria D’Esposito, Federica Passaretti, Serena Cabaro, Antonietta Liotti, Domenico Liguoro, Giuseppe Perruolo, Fabiana Ariemma, Carmine Finelli, Francesco Beguinot, Pietro Formisano and Rossella Valentino

    Journal of Translational Medicine 2015 13:169

    Published on: 29 May 2015

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