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Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas

Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Content type: Research

    Hericium erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration of H...

    Authors: Hsing-Chun Kuo, Chien-Chang Lu, Chien-Heng Shen, Shui-Yi Tung, Meng Chiao Hsieh, Ko-Chao Lee, Li-Ya Lee, Chin-Chu Chen, Chih-Chuan Teng, Wen-Shih Huang, Te-Chuan Chen and Kam-Fai Lee

    Citation: Journal of Translational Medicine 2016 14:78

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  2. Content type: Review

    Fibroblast growth factor (FGF) 15/19 and FGF21 are two atypical members of FGF19 subfamily that function as hormones. Exogenous FGF15/19 and FGF21 have pharmacological effects, and endogenous FGF15/19 and FGF2...

    Authors: Dandan Guan, Lidan Zhao, Daiwen Chen, Bing Yu and Jie Yu

    Citation: Journal of Translational Medicine 2016 14:63

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  3. Content type: Review

    The huge part of population in developed countries is overweight or obese. Obesity is often determined by body mass index (BMI) but new accurate methods and ratios have recently appeared to measure body fat or...

    Authors: Javier Martinez-Useros and Jesus Garcia-Foncillas

    Citation: Journal of Translational Medicine 2016 14:21

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  4. Content type: Research

    Naturally occurring polyphenolic compounds from fruits, particularly from blueberries, have been reported to be significantly involved in cancer chemoprevention and chemotherapy. Biotransformation of blueberry...

    Authors: Tri Vuong, Jean-François Mallet, Maria Ouzounova, Sam Rahbar, Hector Hernandez-Vargas, Zdenko Herceg and Chantal Matar

    Citation: Journal of Translational Medicine 2016 14:13

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  5. Content type: Review

    Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impai...

    Authors: G. A. Aguirre, J. Rodríguez De Ita, R. G. de la Garza and I. Castilla-Cortazar

    Citation: Journal of Translational Medicine 2016 14:3

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  6. Content type: Research

    The beverage obtained by fermentation of milk with kefir grains, a complex matrix containing acid bacteria and yeasts, has been shown to have beneficial effects in various diseases. However, its effects on hyp...

    Authors: Andreia G. F. Friques, Clarisse M. Arpini, Ieda C. Kalil, Agata L. Gava, Marcos A. Leal, Marcella L. Porto, Breno V. Nogueira, Ananda T. Dias, Tadeu U. Andrade, Thiago Melo C. Pereira, Silvana S. Meyrelles, Bianca P. Campagnaro and Elisardo C. Vasquez

    Citation: Journal of Translational Medicine 2015 13:390

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  7. Content type: Research

    There is limited information on the prevalence of vitamin D deficiency among patients diagnosed with hip fracture in the Chinese Han population. Therefore, the aim of this study was to assess the effects of ch...

    Authors: Xing-Mao Fu, Shao-Guang Fan, Shu-Liang Li, Yi-Sheng Chen, Hai Wu and Yan-Long Guo

    Citation: Journal of Translational Medicine 2015 13:388

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  8. Content type: Research

    A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue.

    Authors: Eduardo García-Fuentes, Concepción Santiago-Fernández, Carolina Gutiérrez-Repiso, María D. Mayas, Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Juan Alcaide, Luis Ocaña-Wilhelmi, Joan Vendrell, Francisco J. Tinahones and Lourdes Garrido-Sánchez

    Citation: Journal of Translational Medicine 2015 13:373

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  9. Content type: Research

    Human constitution, the fundamental basis of oriental medicine, is categorized into different patterns for a particular disease according to the physical, physiological, and clinical characteristics of the ind...

    Authors: Sun Woo Hong, Jae-Wook Yoo, Shambhunath Bose, Jung-Hyun Park, Kyungsun Han, Soyoun Kim, Chi-Yeon Lim, Hojun Kim and Dong-ki Lee

    Citation: Journal of Translational Medicine 2015 13:331

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  10. Content type: Research

    Insulin growth factor 1 (IGF-1) has multiple effects on metabolism. Much evidence suggests that the deficiency of this hormone increases insulin resistance, impairs lipid metabolism, augments oxidative damage ...

    Authors: J. Rodríguez De Ita, I. Castilla-Cortázar, G. A. Aguirre, C. Sánchez-Yago, M. Olleros Santos-Ruiz, L. Guerra-Menéndez, I. Martín-Estal, M. García-Magariño, V. J. Lara-Díaz, J. E. Puche and U. Muñoz

    Citation: Journal of Translational Medicine 2015 13:326

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  11. Content type: Research

    The association between malnutrition and worse outcomes as pressure ulcers and mortality is well established in a variety of setting. Currently none investigation was conducted in patients with long-term conse...

    Authors: Tiziana Montalcini, Marta Moraca, Yvelise Ferro, Stefano Romeo, Sebastiano Serra, Maria Girolama Raso, Francesco Rossi, Walter G. Sannita, Giuliano Dolce and Arturo Pujia

    Citation: Journal of Translational Medicine 2015 13:305

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  12. Content type: Research

    Western dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association be...

    Authors: Luigi Barrea, Paolo Emidio Macchia, Giovanni Tarantino, Carolina Di Somma, Elena Pane, Nicola Balato, Maddalena Napolitano, Annamaria Colao and Silvia Savastano

    Citation: Journal of Translational Medicine 2015 13:303

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  13. Content type: Research

    Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interac...

    Authors: Maria L. Mansego, Griselda De Marco, Carmen Ivorra, Raúl Lopez-Izquierdo, Sonsoles Morcillo, Gemma Rojo-Martínez, Verónica González-Albert, Fernando Martinez, Federico Soriguer, Juan C. Martín-Escudero, Josep Redon and F. Javier Chaves

    Citation: Journal of Translational Medicine 2015 13:286

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  14. Content type: Review

    Obesity is an epidemic chronic disease which is a risk factor for a number of serious medical conditions. Intragastric balloon, as an alternative, non-surgical treatment approach for the management of obesity,...

    Authors: Yiyuan Zheng, Miao Wang, Songhua He and Guang Ji

    Citation: Journal of Translational Medicine 2015 13:246

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  15. Content type: Research

    Ipomoea aquatica (Convolvulaceae) and Enhydra fluctuans (Asteraceae), two aquatic vegetables, are traditionally used against heavy metal toxicity in traditional medicines in India. The...

    Authors: Tarun K Dua, Saikat Dewanjee, Ritu Khanra, Niloy Bhattacharya, Bhuvan Bhaskar, Muhammad Zia-Ul-Haq and Vincenzo De Feo

    Citation: Journal of Translational Medicine 2015 13:245

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  16. Content type: Review

    Taurine is a natural amino acid present as free form in many mammalian tissues and in particular in skeletal muscle. Taurine exerts many physiological functions, including membrane stabilization, osmoregulatio...

    Authors: Annamaria De Luca, Sabata Pierno and Diana Conte Camerino

    Citation: Journal of Translational Medicine 2015 13:243

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  17. Content type: Research

    The cardio-protective effects of flavonoids are still controversial; many studies referred to the benefits of specific foods, such as soy, cocoa, tea. A population-based cohort of middle-aged adults, coming fr...

    Authors: Valentina Ponzo, Ilaria Goitre, Maurizio Fadda, Roberto Gambino, Antonella De Francesco, Laura Soldati, Luigi Gentile, Paola Magistroni, Maurizio Cassader and Simona Bo

    Citation: Journal of Translational Medicine 2015 13:218

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  18. Content type: Research

    Anthocyanins are major constituents of food colours and have been reported to possess anti-diabetic activities for potential medicinal use. The precise role of anthocyanins in diabetic nephropathy is poorly un...

    Authors: Eun Sil Koh, Ji Hee Lim, Min Young Kim, Sungjin Chung, Seok Joon Shin, Bum Soon Choi, Hye Won Kim, Seong Yeon Hwang, Sae Woong Kim, Cheol Whee Park and Yoon Sik Chang

    Citation: Journal of Translational Medicine 2015 13:203

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  19. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD) is becoming a pandemic. While multiple ‘hits’ have been reported to contribute to NAFLD progression to non-alcoholic steatohepatitis (NASH), fibrosis and liver cancer,...

    Authors: Michal Ganz, Terence N Bukong, Timea Csak, Banishree Saha, Jin-Kyu Park, Aditya Ambade, Karen Kodys and Gyongyi Szabo

    Citation: Journal of Translational Medicine 2015 13:193

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  20. Content type: Review

    Tubulo-interstitial fibrosis has been recognized as the hallmark of progression of chronic kidney disease, but, despite intensive research studies, there are currently no biomarkers or effective treatments for...

    Authors: Valentina Masola, Gianluigi Zaza, Maurizio Onisto, Antonio Lupo and Giovanni Gambaro

    Citation: Journal of Translational Medicine 2015 13:181

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  21. Content type: Research

    The current increase of obesity and metabolic syndrome (MS) focuses attention on bisphenol-A (BPA), “obesogen” endocrine disruptor, main plastic component. Aim was to verify the role of BPA in metabolic altera...

    Authors: Silvia Savastano, Giovanni Tarantino, Vittoria D’Esposito, Federica Passaretti, Serena Cabaro, Antonietta Liotti, Domenico Liguoro, Giuseppe Perruolo, Fabiana Ariemma, Carmine Finelli, Francesco Beguinot, Pietro Formisano and Rossella Valentino

    Citation: Journal of Translational Medicine 2015 13:169

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  22. Content type: Research

    Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms were found associated with body mass index (BMI)-defined obesity and lean mass.

    Authors: Laura Di Renzo, Luigi Tonino Marsella, Francesca Sarlo, Laura Soldati, Santo Gratteri, Ludovico Abenavoli and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2014 12:329

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  23. Content type: Research

    Cardiac hypertrophy is a compensatory stage of the heart in response to stress such as pressure overload (PO), which can develop into heart failure (HF) if left untreated. Resveratrol has been reported to prev...

    Authors: Qi Dong, Zhiye Wu, Xiaoyun Li, Jianyun Yan, Luning Zhao, Chuntao Yang, Junjiang Lu, Ju Deng and Minsheng Chen

    Citation: Journal of Translational Medicine 2014 12:323

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  24. Content type: Research

    There are no randomised controlled trials to demonstrate whether lifestyle modifications can improve pregnancy outcomes of gestational diabetes mellitus (GDM) diagnosed by the International Association of Diab...

    Authors: Xilin Yang, Huiguang Tian, Fuxia Zhang, Cuiping Zhang, Yi Li, Junhong Leng, Leishen Wang, Gongsu Liu, Ling Dong, Zhijie Yu, Gang Hu and Juliana CN Chan

    Citation: Journal of Translational Medicine 2014 12:290

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    The Erratum to this article has been published in Journal of Translational Medicine 2015 13:70

  25. Content type: Research

    The Y-75 (Ginsan) acidic polysaccharide from Korean Panax ginseng has been shown to function as an immunomodulatory molecule. However, the efficacy of Y-75 has not been evaluated in clinical trial.

    Authors: Young-Jin Cho, Hyeog-Jin Son and Kyung-Soo Kim

    Citation: Journal of Translational Medicine 2014 12:283

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  26. Content type: Research

    Breast cancer risk is partially determined by several hormone-related factors. Preclinical and clinical studies suggested that resveratrol may modulate these hormonal factors.

    Authors: H-H Sherry Chow, Linda L Garland, Brandy M Heckman-Stoddard, Chiu-Hsieh Hsu, Valerie D Butler, Catherine A Cordova, Wade M Chew and Terri L Cornelison

    Citation: Journal of Translational Medicine 2014 12:223

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  27. Content type: Research

    Orthorexia and muscle dysmorphia are disorders affecting above all young adults whose prevalence and social impact are still unclear. We aimed to evaluate the prevalence of the traits of orthorexia and muscle ...

    Authors: Simona Bo, Rossana Zoccali, Valentina Ponzo, Laura Soldati, Luca De Carli, Andrea Benso, Elisabetta Fea, Alberto Rainoldi, Marilena Durazzo, Secondo Fassino and Giovanni Abbate-Daga

    Citation: Journal of Translational Medicine 2014 12:221

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  28. Content type: Review

    The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol,...

    Authors: Stefania Bulotta, Marilena Celano, Saverio Massimo Lepore, Tiziana Montalcini, Arturo Pujia and Diego Russo

    Citation: Journal of Translational Medicine 2014 12:219

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  29. Content type: Research

    Tumor metabolism is a crucial factor for the carcinogenesis of oral squamous cell carcinoma (OSCC).

    Authors: Martin Grimm, Marcel Cetindis, Max Lehmann, Thorsten Biegner, Adelheid Munz, Peter Teriete, Wiebke Kraut and Siegmar Reinert

    Citation: Journal of Translational Medicine 2014 12:208

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  30. Content type: Research

    High-throughput screening techniques that analyze the metabolic endpoints of biological processes can identify the contributions of genetic predisposition and environmental factors to the development of common...

    Authors: Sweety Mathew, Susanne Krug, Thomas Skurk, Anna Halama, Antonia Stank, Anna Artati, Cornelia Prehn, Joel A Malek, Gabi Kastenmüller, Werner Römisch-Margl, Jerzy Adamski, Hans Hauner and Karsten Suhre

    Citation: Journal of Translational Medicine 2014 12:161

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  31. Content type: Editorial

    Resveratrol is a polyphenolic compound found in several plants. In the last decades, the interest in this compound has enormously increased after benefits on metabolism and increased lifespan of various organi...

    Authors: Valentina Ponzo, Laura Soldati and Simona Bo

    Citation: Journal of Translational Medicine 2014 12:158

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  32. Content type: Research

    Exposure to microgravity or immobilization results in alterations of renal function, fluid redistribution and bone loss, which couples to a rise of urinary calcium excretion. We recently demonstrated that high...

    Authors: Grazia Tamma, Annarita Di Mise, Marianna Ranieri, Maria Svelto, Rado Pisot, Giancarlo Bilancio, Pierpaolo Cavallo, Natale G De Santo, Massimo Cirillo and Giovanna Valenti

    Citation: Journal of Translational Medicine 2014 12:133

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  33. Content type: Research

    Increased sedentary lifestyle and prevalence of overweight/obesity are common in western countries. The purposes of this study were (i) to assess the main health-related anthropometric characteristics in a sam...

    Authors: Luciana Zaccagni, Davide Barbieri and Emanuela Gualdi-Russo

    Citation: Journal of Translational Medicine 2014 12:120

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  34. Content type: Research

    The risk of cardiovascular diseases (CVD) is increased tremendously among menopausal women, and there is an increasing demand for alternative therapies for managing factors like dyslipidemia that contribute to...

    Authors: Ramlah Mohamad Ibrahim, Nurul Syima Hamdan, Rozi Mahmud, Mustapha Umar Imam, Suraini Mohd Saini, Saiful Nizam Abd Rashid, Siti Aisyah Abd Ghafar, Latiffah Ab Latiff and Maznah Ismail

    Citation: Journal of Translational Medicine 2014 12:82

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  35. Content type: Review

    It has been argued that circadian dysregulation is not only a critical inducer and promoter of adverse health effects, exacerbating symptom burden, but also hampers recovery. Therefore understanding the health...

    Authors: Jag Sunderram, Stavroula Sofou, Kubra Kamisoglu, Vassiliki Karantza and Ioannis P Androulakis

    Citation: Journal of Translational Medicine 2014 12:79

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  36. Content type: Research

    To describe the preparation of nano emodin transfersome (NET) and investigate its effect on mRNA expression of adipose triglyceride lipase (ATGL) and G0/G1 switch gene 2 (G0S2) in adipose tissue of diet-induce...

    Authors: Kun Lu, Shuanshuan Xie, Shilong Han, Jidong Zhang, Xinwen Chang, Jin Chao, Qingqing Huang, Qing Yuan, Haiyan Lin, Lei Xu, Changxing Shen, Min Tan, Shen Qu, Changhui Wang and Xiaolian Song

    Citation: Journal of Translational Medicine 2014 12:72

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  37. Content type: Research

    Nuclear factor erythroid-2-related factor-2 (Nrf2) is known to protect against tissue injury by orchestrating antioxidant and detoxification responses to oxidative stress. This study investigated whether upreg...

    Authors: Yu Ah Hong, Ji Hee Lim, Min Young Kim, Eun Nim Kim, Eun Sil Koh, Seok Joon Shin, Bum Soon Choi, Cheol Whee Park, Yoon Sik Chang and Sungjin Chung

    Citation: Journal of Translational Medicine 2014 12:50

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  38. Content type: Research

    Insulin resistance plays an important role in the development of metabolic syndrome (MS). Fu Fang Zhen Zhu Tiao Zhi formula (FTZ), a Chinese medicinal decoction, has been used to relieve hyperlipidemia, athero...

    Authors: Xuguang Hu, Man Wang, Weijian Bei, Zongyu Han and Jiao Guo

    Citation: Journal of Translational Medicine 2014 12:47

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  39. Content type: Research

    A positive association between handgrip strength and bone mineral density was demonstrated, but not all the investigations confirmed these results. We conducted a screening programme for osteoporosis in a larg...

    Authors: Theodora Lamprinoudi, Elisa Mazza, Yvelise Ferro, Simona Brogneri, Daniela Foti, Elio Gulletta, Maurizio Iocco, Carmine Gazzaruso, Stefano Romeo, Arturo Pujia and Tiziana Montalcini

    Citation: Journal of Translational Medicine 2014 12:46

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  40. Content type: Research

    Body image perception depends on anthropometric and psychological factors. Body dissatisfaction is influenced by the socio-cultural environment and is associated with eating disorders and low self-esteem. This...

    Authors: Luciana Zaccagni, Sabrina Masotti, Roberta Donati, Gianni Mazzoni and Emanuela Gualdi-Russo

    Citation: Journal of Translational Medicine 2014 12:42

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  41. Content type: Research

    Nephrolithiasis is more frequent and severe in obese patients from different western nations. This may be supported by higher calcium, urate, oxalate excretion in obese stone formers. Except these parameters, ...

    Authors: Laura Soldati, Simona Bertoli, Annalisa Terranegra, Caterina Brasacchio, Alessandra Mingione, Elena Dogliotti, Benedetta Raspini, Alessandro Leone, Francesca Frau, Laila Vignati, Angela Spadafranca, Giuseppe Vezzoli, Daniele Cusi and Alberto Battezzati

    Citation: Journal of Translational Medicine 2014 12:34

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  42. Content type: Research

    Little is known about the involvement of matrix metalloproteinases (MMPs) in cardiac vascular remodelling induced by exercise. Our aim was to evaluate and localize MMP-2 and MMP-9’s activities in relation to c...

    Authors: Marianna Bellafiore, Giuseppe Battaglia, Antonino Bianco, Felicia Farina, Antonio Palma and Antonio Paoli

    Citation: Journal of Translational Medicine 2013 11:283

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  43. Content type: Research

    Bone is one of the major target tissues for Insulin-like Growth Factor I (IGF-I). Low doses of IGF-I were able to improve liver-associated osteopenia. In the present work, a model of partial IGF-I deficiency w...

    Authors: Lucia Guerra-Menéndez, Maria C Sádaba, Juan E Puche, Jose L Lavandera, Luis F de Castro, Arancha R de Gortázar and Inma Castilla-Cortázar

    Citation: Journal of Translational Medicine 2013 11:271

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  44. Content type: Research

    The role of body composition (lean mass and fat mass) on urine chemistries and bone quality is still debated. Our aim was therefore to determine the effect of lean mass and fat mass on urine composition and bo...

    Authors: Antonio Nouvenne, Andrea Ticinesi, Angela Guerra, Giuseppina Folesani, Franca Allegri, Silvana Pinelli, Paolo Baroni, Mario Pedrazzoni, Giuseppe Lippi, Annalisa Terranegra, Elena Dogliotti, Laura Soldati, Loris Borghi and Tiziana Meschi

    Citation: Journal of Translational Medicine 2013 11:248

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  45. Content type: Research

    The prevalence of vitamin D deficiency among patients with cancer has been previously reported. Because vitamin D is fat soluble, patients with pancreatic adenocarcinoma may have an especially high risk of vit...

    Authors: May Cho, Parvin F Peddi, Kevin Ding, Ling Chen, Denise Thomas, Jian Wang, Albert C Lockhart, Benjamin Tan and Andrea Wang-Gillam

    Citation: Journal of Translational Medicine 2013 11:206

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  46. Content type: Research

    High systemic estrogen levels contribute to breast cancer risk for postmenopausal women, whereas low levels contribute to osteoporosis risk. Except for obesity, determinants of non-ovarian systemic estrogen le...

    Authors: Roberto Flores, Jianxin Shi, Barbara Fuhrman, Xia Xu, Timothy D Veenstra, Mitchell H Gail, Pawel Gajer, Jacques Ravel and James J Goedert

    Citation: Journal of Translational Medicine 2012 10:253

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  47. Content type: Research

    Protein dynamics during non-steady state conditions as feeding are complex. Such studies usually demand combinations of methods to give conclusive information, particularly on myofibrillar proteins with slow t...

    Authors: Britt-Marie Iresjö and Kent Lundholm

    Citation: Journal of Translational Medicine 2012 10:238

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