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Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Type 1 diabetes (DM1) is one of the most common chronic diseases in childhood and requires life-long insulin therapy and continuous health care support. An artificial pancreas (AP) or closed-loop system (CLS) ...

    Authors: Susanna Esposito, Elisa Santi, Giulia Mancini, Francesco Rogari, Giorgia Tascini, Giada Toni, Alberto Argentiero and Maria Giulia Berioli

    Citation: Journal of Translational Medicine 2018 16:176

    Content type: Review

    Published on:

  2. Lipid intermediates produced during triacylglycerols (TAGs) synthesis and lipolysis in adipocytes interfere with the intracellular insulin signaling pathway and development of insulin resistance. This study ai...

    Authors: Haya Al-Sulaiti, Ilhame Diboun, Sameem Banu, Mohamed Al-Emadi, Parvaneh Amani, Thomas M. Harvey, Alex S. Dömling, Aishah Latiff and Mohamed A. Elrayess

    Citation: Journal of Translational Medicine 2018 16:175

    Content type: Research

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  3. DNA methylation has been evidenced as a potential epigenetic mechanism related to various candidate genes to development of obesity. Therefore, the objective of this study was to evaluate the DNA methylation l...

    Authors: Yohanna de Oliveira, Raquel Patrícia Ataíde Lima, Rafaella Cristhine Pordeus Luna, Mussara Gomes Cavalcanti Alves Monteiro, Cássia Surama Oliveira da Silva, Rayner Anderson Ferreira do Nascimento, Keylha Querino de Farias Lima, Ana Hermínia Andrade e Silva, Flávia Emília Leite de Lima Ferreira, Rodrigo Pinheiro de Toledo Vianna, Ronei Marcos de Moraes, Naila Francis Paulo de Oliveira, Aléssio Tony Cavalcanti de Almeida, Alexandre Sérgio Silva, Alcides da Silva Diniz, Maria José de Carvalho Costa…

    Citation: Journal of Translational Medicine 2018 16:152

    Content type: Research

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  4. Chronic respiratory diseases, whose one of the hallmarks is oxidative stress, are still incurable and need novel therapeutic tools and pharmaceutical agents. The phenolic compounds contained in grape are endow...

    Authors: S. Castellani, A. Trapani, A. Spagnoletta, L. di Toma, T. Magrone, S. Di Gioia, D. Mandracchia, G. Trapani, E. Jirillo and M. Conese

    Citation: Journal of Translational Medicine 2018 16:140

    Content type: Research

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  5. Immunotherapy has matured into standard treatment for several cancers, but much remains to be done to extend the reach of its effectiveness particularly to cancers that are resistant within each indication. Th...

    Authors: Laura Soldati, Laura Di Renzo, Emilio Jirillo, Paolo A. Ascierto, Francesco M. Marincola and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2018 16:75

    Content type: Review

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  6. Extensive research within the last several decades has revealed that the major risk factors for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and diet. I...

    Authors: Ajaikumar B. Kunnumakkara, Bethsebie L. Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti and Bharat B. Aggarwal

    Citation: Journal of Translational Medicine 2018 16:14

    Content type: Review

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  7. Numerous studies have investigated the role of the monounsaturated fatty acid and other dietary factors in the prevention of cognitive decline but the short-term effect of a low dose of extravirgin olive oil o...

    Authors: Elisa Mazza, Antonietta Fava, Yvelise Ferro, Stefania Rotundo, Stefano Romeo, Domenico Bosco, Arturo Pujia and Tiziana Montalcini

    Citation: Journal of Translational Medicine 2018 16:10

    Content type: Research

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  8. The present randomized clinical trial characterized the beneficial effects of a multi-strain probiotics supplementation on improving circulating endotoxin levels (primary endpoint) and other cardiometabolic bi...

    Authors: Shaun Sabico, Ayah Al-Mashharawi, Nasser M. Al-Daghri, Sobhy Yakout, Abdullah M. Alnaami, Majed S. Alokail and Philip G. McTernan

    Citation: Journal of Translational Medicine 2017 15:249

    Content type: Research

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  9. Adipocytes derived from human mesenchymal stem cells (MSCs) are widely used to investigate adipogenesis. Taking into account both the novelty of these MSCs and the scarcity of studies focused on the effects of...

    Authors: Saioa Gómez-Zorita, Arrate Lasa, Naiara Abendaño, Alfredo Fernández-Quintela, Andrea Mosqueda-Solís, Maria Pilar Garcia-Sobreviela, Jose M. Arbonés-Mainar and Maria P. Portillo

    Citation: Journal of Translational Medicine 2017 15:237

    Content type: Research

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  10. Chronic inflammation is a predisposing factor to numerous degenerative diseases including cancer, heart failure and Alzheimer’s disease. Infla-Kine is a natural supplement comprised of a proprietary blend of Lact...

    Authors: Nina A. Mikirova, Santosh Kesari, Thomas E. Ichim and Neil H. Riordan

    Citation: Journal of Translational Medicine 2017 15:213

    Content type: Research

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  11. Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes–Weinstein monofilament (SWM) test is an efficient tool for evaluating diabeti...

    Authors: Sergio Martinez-Hervás, Mercedes Molina Mendez, José Folgado, Carmen Tormos, Pilar Ascaso, Marta Peiró, Jose T. Real and Juan F. Ascaso

    Citation: Journal of Translational Medicine 2017 15:187

    Content type: Research

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  12. Evidence of probiotics effects on gut function, brain activity and emotional behaviour were provided. Probiotics can have dramatic effects on behaviour through the microbiome–gut–brain axis, through vagus nerv...

    Authors: Antonino De Lorenzo, Micaela Costacurta, Giuseppe Merra, Paola Gualtieri, Giorgia Cioccoloni, Massimiliano Marchetti, Dimitrios Varvaras, Raffaella Docimo and Laura Di Renzo

    Citation: Journal of Translational Medicine 2017 15:135

    Content type: Research

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  13. Betaine (BET), a component of many foods, is an essential osmolyte and a source of methyl groups; it also shows an antioxidant activity. Moreover, BET stimulates muscle differentiation via insulin like growth ...

    Authors: Isabella Villa, Pamela Senesi, Anna Montesano, Anita Ferraretto, Fernanda Vacante, Alice Spinello, Michela Bottani, Simona Bolamperti, Alessandro Rubinacci, Livio Luzi and Ileana Terruzzi

    Citation: Journal of Translational Medicine 2017 15:132

    Content type: Research

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  14. Standardized animal-free components are required for manufacturing cell-based medicinal products. Human platelet concentrates are sources of growth factors for cell expansion but such products are characterize...

    Authors: Francesco Agostini, Jerry Polesel, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Alessandro Da Ponte, Giuseppe Astori, Cristina Durante and Mario Mazzucato

    Citation: Journal of Translational Medicine 2017 15:107

    Content type: Research article

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  15. Nutrition is an environmental factor affecting bone health. Nutrition is considered essential to achieve and maintain optimal bone mass. Mediterranean diet (MD) has shown to prevent bone disease. Aim of this s...

    Authors: Maria Cristina Savanelli, Luigi Barrea, Paolo Emidio Macchia, Silvia Savastano, Andrea Falco, Andrea Renzullo, Elisabetta Scarano, Immacolata Cristina Nettore, Annamaria Colao and Carolina Di Somma

    Citation: Journal of Translational Medicine 2017 15:81

    Content type: Research

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  16. Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascul...

    Authors: Rasnik K. Singh, Hsin-Wen Chang, Di Yan, Kristina M. Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani and Wilson Liao

    Citation: Journal of Translational Medicine 2017 15:73

    Content type: Review

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  17. Replacing glucose with a better biocompatible osmotic agent in peritoneal dialysis (PD) solutions is needed in PD clinic. We previously demonstrated the potential of hyperbranched polyglycerol (HPG) as a repla...

    Authors: Caigan Du, Asher A. Mendelson, Qiunong Guan, Ghida Dairi, Irina Chafeeva, Gerald da Roza and Jayachandran N. Kizhakkedathu

    Citation: Journal of Translational Medicine 2016 14:338

    Content type: Research

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  18. Intermittent fasting (IF) is an increasingly popular dietary approach used for weight loss and overall health. While there is an increasing body of evidence demonstrating beneficial effects of IF on blood lipi...

    Authors: Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri and Antonio Paoli

    Citation: Journal of Translational Medicine 2016 14:290

    Content type: Research

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  19. Vitamin D (VitD) and thymoquinone (TQ) are nutraceutical agents with well-known immunomodulatory and hepatoprotective properties. This study measured whether VitD and TQ, individually or combined, could have d...

    Authors: Abdelghany Hassan Abdelghany, Mohammad A. BaSalamah, Shakir Idris, Jawwad Ahmad and Bassem Refaat

    Citation: Journal of Translational Medicine 2016 14:281

    Content type: Research

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  20. Moniliformediquinone (MFD), a phenanthradiquinone in Dendrobium moniliforme, was synthesized in our laboratory. Beyond its in vitro inhibitory effects on cancer cells, other biological activity of MFD is unknown....

    Authors: Tsui-Hwa Tseng, Wea-Lung Lin, Zi-Hui Chen, Yean-Jang Lee, Ming-Shiun Shie, Kam-Fai Lee, Chien-Heng Shen and Hsing-Chun Kuo

    Citation: Journal of Translational Medicine 2016 14:263

    Content type: Research

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  21. Body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI), triglyceride glucose index (TyG), TyG-BMI, and TyG-WC have been reported as markers of insulin resistance or type 2 diabetes mel...

    Authors: Shuang Zheng, Sheng Shi, Xingxing Ren, Tingting Han, Yangxue Li, Yawen Chen, Wei Liu, Peter C. Hou and Yaomin Hu

    Citation: Journal of Translational Medicine 2016 14:260

    Content type: Research

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  22. Diabetes is the western world’s leading cause of end-stage renal disease. Glucose-dependent, oxidative stress is linked to the development of renal inflammation and sclerosis, which, in animal models of diabet...

    Authors: Kenneth A. Earle, Karima Zitouni, John Pepe, Maria Karaflou and James Godbold Jr

    Citation: Journal of Translational Medicine 2016 14:234

    Content type: Protocol

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  23. Potentiation of glucose-induced insulin secretion is the main mechanism of exenatide (EXE) antidiabetic action, however, increased glucose utilization by peripheral tissues has been also reported. We here stud...

    Authors: Francesco Andreozzi, Gregory Alexander Raciti, Cecilia Nigro, Gaia Chiara Mannino, Teresa Procopio, Alberto M. Davalli, Francesco Beguinot, Giorgio Sesti, Claudia Miele and Franco Folli

    Citation: Journal of Translational Medicine 2016 14:229

    Content type: Research

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  24. Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the intera...

    Authors: Federica Rizzi, Costanza Conti, Elena Dogliotti, Annalisa Terranegra, Erika Salvi, Daniele Braga, Flavia Ricca, Sara Lupoli, Alessandra Mingione, Francesca Pivari, Caterina Brasacchio, Matteo Barcella, Martina Chittani, Francesca D’Avila, Maurizio Turiel, Monica Lazzaroni…

    Citation: Journal of Translational Medicine 2016 14:186

    Content type: Research

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  25. Obesity, metabolic syndrome (MetS), and psoriasis, largely driven by environmental factors, show multiple bidirectional associations, with important metabolic implications in psoriatic patients. Besides body m...

    Authors: Luigi Barrea, Paolo Emidio Macchia, Carolina Di Somma, Maddalena Napolitano, Anna Balato, Andrea Falco, Maria Cristina Savanelli, Nicola Balato, Annamaria Colao and Silvia Savastano

    Citation: Journal of Translational Medicine 2016 14:130

    Content type: Research

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  26. Hericium erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration of H...

    Authors: Hsing-Chun Kuo, Chien-Chang Lu, Chien-Heng Shen, Shui-Yi Tung, Meng Chiao Hsieh, Ko-Chao Lee, Li-Ya Lee, Chin-Chu Chen, Chih-Chuan Teng, Wen-Shih Huang, Te-Chuan Chen and Kam-Fai Lee

    Citation: Journal of Translational Medicine 2016 14:78

    Content type: Research

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  27. Fibroblast growth factor (FGF) 15/19 and FGF21 are two atypical members of FGF19 subfamily that function as hormones. Exogenous FGF15/19 and FGF21 have pharmacological effects, and endogenous FGF15/19 and FGF2...

    Authors: Dandan Guan, Lidan Zhao, Daiwen Chen, Bing Yu and Jie Yu

    Citation: Journal of Translational Medicine 2016 14:63

    Content type: Review

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  28. The huge part of population in developed countries is overweight or obese. Obesity is often determined by body mass index (BMI) but new accurate methods and ratios have recently appeared to measure body fat or...

    Authors: Javier Martinez-Useros and Jesus Garcia-Foncillas

    Citation: Journal of Translational Medicine 2016 14:21

    Content type: Review

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  29. Naturally occurring polyphenolic compounds from fruits, particularly from blueberries, have been reported to be significantly involved in cancer chemoprevention and chemotherapy. Biotransformation of blueberry...

    Authors: Tri Vuong, Jean-François Mallet, Maria Ouzounova, Sam Rahbar, Hector Hernandez-Vargas, Zdenko Herceg and Chantal Matar

    Citation: Journal of Translational Medicine 2016 14:13

    Content type: Research

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  30. Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impai...

    Authors: G. A. Aguirre, J. Rodríguez De Ita, R. G. de la Garza and I. Castilla-Cortazar

    Citation: Journal of Translational Medicine 2016 14:3

    Content type: Review

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  31. The beverage obtained by fermentation of milk with kefir grains, a complex matrix containing acid bacteria and yeasts, has been shown to have beneficial effects in various diseases. However, its effects on hyp...

    Authors: Andreia G. F. Friques, Clarisse M. Arpini, Ieda C. Kalil, Agata L. Gava, Marcos A. Leal, Marcella L. Porto, Breno V. Nogueira, Ananda T. Dias, Tadeu U. Andrade, Thiago Melo C. Pereira, Silvana S. Meyrelles, Bianca P. Campagnaro and Elisardo C. Vasquez

    Citation: Journal of Translational Medicine 2015 13:390

    Content type: Research

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  32. There is limited information on the prevalence of vitamin D deficiency among patients diagnosed with hip fracture in the Chinese Han population. Therefore, the aim of this study was to assess the effects of ch...

    Authors: Xing-Mao Fu, Shao-Guang Fan, Shu-Liang Li, Yi-Sheng Chen, Hai Wu and Yan-Long Guo

    Citation: Journal of Translational Medicine 2015 13:388

    Content type: Research

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  33. A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue.

    Authors: Eduardo García-Fuentes, Concepción Santiago-Fernández, Carolina Gutiérrez-Repiso, María D. Mayas, Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Juan Alcaide, Luis Ocaña-Wilhelmi, Joan Vendrell, Francisco J. Tinahones and Lourdes Garrido-Sánchez

    Citation: Journal of Translational Medicine 2015 13:373

    Content type: Research

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  34. Human constitution, the fundamental basis of oriental medicine, is categorized into different patterns for a particular disease according to the physical, physiological, and clinical characteristics of the ind...

    Authors: Sun Woo Hong, Jae-Wook Yoo, Shambhunath Bose, Jung-Hyun Park, Kyungsun Han, Soyoun Kim, Chi-Yeon Lim, Hojun Kim and Dong-ki Lee

    Citation: Journal of Translational Medicine 2015 13:331

    Content type: Research

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  35. Insulin growth factor 1 (IGF-1) has multiple effects on metabolism. Much evidence suggests that the deficiency of this hormone increases insulin resistance, impairs lipid metabolism, augments oxidative damage ...

    Authors: J. Rodríguez De Ita, I. Castilla-Cortázar, G. A. Aguirre, C. Sánchez-Yago, M. Olleros Santos-Ruiz, L. Guerra-Menéndez, I. Martín-Estal, M. García-Magariño, V. J. Lara-Díaz, J. E. Puche and U. Muñoz

    Citation: Journal of Translational Medicine 2015 13:326

    Content type: Research

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  36. The association between malnutrition and worse outcomes as pressure ulcers and mortality is well established in a variety of setting. Currently none investigation was conducted in patients with long-term conse...

    Authors: Tiziana Montalcini, Marta Moraca, Yvelise Ferro, Stefano Romeo, Sebastiano Serra, Maria Girolama Raso, Francesco Rossi, Walter G. Sannita, Giuliano Dolce and Arturo Pujia

    Citation: Journal of Translational Medicine 2015 13:305

    Content type: Research

    Published on:

  37. Western dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association be...

    Authors: Luigi Barrea, Paolo Emidio Macchia, Giovanni Tarantino, Carolina Di Somma, Elena Pane, Nicola Balato, Maddalena Napolitano, Annamaria Colao and Silvia Savastano

    Citation: Journal of Translational Medicine 2015 13:303

    Content type: Research

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  38. Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interac...

    Authors: Maria L. Mansego, Griselda De Marco, Carmen Ivorra, Raúl Lopez-Izquierdo, Sonsoles Morcillo, Gemma Rojo-Martínez, Verónica González-Albert, Fernando Martinez, Federico Soriguer, Juan C. Martín-Escudero, Josep Redon and F. Javier Chaves

    Citation: Journal of Translational Medicine 2015 13:286

    Content type: Research

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  39. Obesity is an epidemic chronic disease which is a risk factor for a number of serious medical conditions. Intragastric balloon, as an alternative, non-surgical treatment approach for the management of obesity,...

    Authors: Yiyuan Zheng, Miao Wang, Songhua He and Guang Ji

    Citation: Journal of Translational Medicine 2015 13:246

    Content type: Review

    Published on:

  40. Ipomoea aquatica (Convolvulaceae) and Enhydra fluctuans (Asteraceae), two aquatic vegetables, are traditionally used against heavy metal toxicity in traditional medicines in India. The...

    Authors: Tarun K Dua, Saikat Dewanjee, Ritu Khanra, Niloy Bhattacharya, Bhuvan Bhaskar, Muhammad Zia-Ul-Haq and Vincenzo De Feo

    Citation: Journal of Translational Medicine 2015 13:245

    Content type: Research

    Published on:

  41. Taurine is a natural amino acid present as free form in many mammalian tissues and in particular in skeletal muscle. Taurine exerts many physiological functions, including membrane stabilization, osmoregulatio...

    Authors: Annamaria De Luca, Sabata Pierno and Diana Conte Camerino

    Citation: Journal of Translational Medicine 2015 13:243

    Content type: Review

    Published on:

  42. The cardio-protective effects of flavonoids are still controversial; many studies referred to the benefits of specific foods, such as soy, cocoa, tea. A population-based cohort of middle-aged adults, coming fr...

    Authors: Valentina Ponzo, Ilaria Goitre, Maurizio Fadda, Roberto Gambino, Antonella De Francesco, Laura Soldati, Luigi Gentile, Paola Magistroni, Maurizio Cassader and Simona Bo

    Citation: Journal of Translational Medicine 2015 13:218

    Content type: Research

    Published on:

  43. Anthocyanins are major constituents of food colours and have been reported to possess anti-diabetic activities for potential medicinal use. The precise role of anthocyanins in diabetic nephropathy is poorly un...

    Authors: Eun Sil Koh, Ji Hee Lim, Min Young Kim, Sungjin Chung, Seok Joon Shin, Bum Soon Choi, Hye Won Kim, Seong Yeon Hwang, Sae Woong Kim, Cheol Whee Park and Yoon Sik Chang

    Citation: Journal of Translational Medicine 2015 13:203

    Content type: Research

    Published on:

  44. Non-alcoholic fatty liver disease (NAFLD) is becoming a pandemic. While multiple ‘hits’ have been reported to contribute to NAFLD progression to non-alcoholic steatohepatitis (NASH), fibrosis and liver cancer,...

    Authors: Michal Ganz, Terence N Bukong, Timea Csak, Banishree Saha, Jin-Kyu Park, Aditya Ambade, Karen Kodys and Gyongyi Szabo

    Citation: Journal of Translational Medicine 2015 13:193

    Content type: Research

    Published on:

  45. Tubulo-interstitial fibrosis has been recognized as the hallmark of progression of chronic kidney disease, but, despite intensive research studies, there are currently no biomarkers or effective treatments for...

    Authors: Valentina Masola, Gianluigi Zaza, Maurizio Onisto, Antonio Lupo and Giovanni Gambaro

    Citation: Journal of Translational Medicine 2015 13:181

    Content type: Review

    Published on:

  46. The current increase of obesity and metabolic syndrome (MS) focuses attention on bisphenol-A (BPA), “obesogen” endocrine disruptor, main plastic component. Aim was to verify the role of BPA in metabolic altera...

    Authors: Silvia Savastano, Giovanni Tarantino, Vittoria D’Esposito, Federica Passaretti, Serena Cabaro, Antonietta Liotti, Domenico Liguoro, Giuseppe Perruolo, Fabiana Ariemma, Carmine Finelli, Francesco Beguinot, Pietro Formisano and Rossella Valentino

    Citation: Journal of Translational Medicine 2015 13:169

    Content type: Research

    Published on:

  47. Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms were found associated with body mass index (BMI)-defined obesity and lean mass.

    Authors: Laura Di Renzo, Luigi Tonino Marsella, Francesca Sarlo, Laura Soldati, Santo Gratteri, Ludovico Abenavoli and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2014 12:329

    Content type: Research

    Published on:

  48. Cardiac hypertrophy is a compensatory stage of the heart in response to stress such as pressure overload (PO), which can develop into heart failure (HF) if left untreated. Resveratrol has been reported to prev...

    Authors: Qi Dong, Zhiye Wu, Xiaoyun Li, Jianyun Yan, Luning Zhao, Chuntao Yang, Junjiang Lu, Ju Deng and Minsheng Chen

    Citation: Journal of Translational Medicine 2014 12:323

    Content type: Research

    Published on:

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