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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. In 2013 American College of Cardiology and the American Heart Association released a guideline on the management of atherosclerotic cardiovascular disease (ASCVD) including a composite of death from CVD, non-f...

    Authors: Farzad Hadaegh, Samaneh Asgari, Fatemeh Moosaie, Meysam Orangi, Farzaneh Sarvghadi, Davood Khalili and Fereidoun Azizi
    Citation: Journal of Translational Medicine 2021 19:25
    Content type: Research Published on:

  2. Cancer-associated fibroblasts (CAFs) play a pivotal role in regulating tumor progression by transferring exosomes to adjacent cells. Our aim was to clarify the role of LINC00659 encapsulated in CAFs-derived ex...

    Authors: Lin Zhou, Jian Li, Yaping Tang and Mei Yang
    Citation: Journal of Translational Medicine 2021 19:8
    Content type: Research Published on:

  3. In the past two decades, sphingolipids have become increasingly appreciated as bioactive molecules playing important roles in a wide array of pathophysiology mechanisms. Despite advances in the field, sphingol...

    Authors: Michele Dei Cas, Rita Paroni, Paola Signorelli, Alessandra Mirarchi, Laura Cerquiglini, Stefania Troiani, Samuela Cataldi, Michela Codini, Tommaso Beccari, Riccardo Ghidoni and Elisabetta Albi
    Citation: Journal of Translational Medicine 2020 18:481
    Content type: Research Published on:

  4. Childhood obesity persists as a serious public health problem. In the current meta-analysis, we summarized the results of controlled trials that evaluated the effect of obesity prevention policies in children ...

    Authors: Shahnaz Taghizadeh and Mahdieh Abbasalizad Farhangi
    Citation: Journal of Translational Medicine 2020 18:480
    Content type: Review Published on:

  5. In pre-clinical research, systematic reviews have the potential to mitigate translational challenges by facilitating understanding of how pre-clinical studies can inform future clinical research. Yet their con...

    Authors: Nicola L. Harman, Adrián Sanz-Moreno, Stamatia Papoutsopoulou, Katie A. Lloyd, Kamar E. Ameen-Ali, Malcolm Macleod and Paula R. Williamson
    Citation: Journal of Translational Medicine 2020 18:468
    Content type: Research Published on:

  6. Increasing evidence showed that carbamylated lipoprotein accelerated atherosclerosis. However, whether such modification of high-density lipoprotein (HDL) particles alters in type 2 diabetes mellitus (T2DM) pa...

    Authors: Zhongli Chen, Song Ding, Yan Ping Wang, Liang Chen, Jing Yan Mao, Ying Yang, Jia Teng Sun and Ke Yang
    Citation: Journal of Translational Medicine 2020 18:460
    Content type: Research Published on:

  7. Exosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant rs1799858] and environmental [elevated serum low...

    Authors: Cheng Liu, Yanxian Lai, Songsong Ying, Junfang Zhan and Yan Shen
    Citation: Journal of Translational Medicine 2020 18:459
    Content type: Research Published on:

  8. Magnesium is a fundamental cation that regulates neuronal transmission, protein synthesis, energy metabolism. Magnesium deficiency mostly affects nervous and cardiovascular systems determining weakness, tremor...

    Authors: Clementina Sitzia, Michele Sterlicchio, Calogero Crapanzano, Elena Dozio, Elena Vianello and Massimiliano Marco Corsi Romanelli
    Citation: Journal of Translational Medicine 2020 18:458
    Content type: Research Published on:

  10. The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives. Notably, obesity and its related com...

    Authors: Antonio Paoli, Stefania Gorini and Massimiliano Caprio
    Citation: Journal of Translational Medicine 2020 18:441
    Content type: Review Published on:

  11. Obesity is a chronic low-grade inflammatory disease that is generally characterized by enhanced inflammation in obese adipose tissue (AT). Here, we investigated alterations in gene expression between lean and ...

    Authors: Sang-Hyeop Lee, Nak-Hyeon Choi, In-Uk Koh, Bong-Jo Kim, Song Lee, Song-Cheol Kim and Sun Shim Choi
    Citation: Journal of Translational Medicine 2020 18:433
    Content type: Research Published on:

  12. Obesity is associated with impaired health and lower work ability. Increased physical activity is a cornerstone in the treatment of obesity and related risk factors. Recently, high-intensity interval training ...

    Authors: Dejan Reljic, Fabienne Frenk, Hans J. Herrmann, Markus F. Neurath and Yurdagül Zopf
    Citation: Journal of Translational Medicine 2020 18:419
    Content type: Research Published on:

  13. On December 12, 2019 a new coronavirus (SARS-CoV-2) emerged in Wuhan, China, triggering a pandemic of severe acute respiratory syndrome in humans (COVID-19). Today, the scientific community is investing all th...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Claudia Leggeri, Giulia Cinelli, Maria Grazia Tarsitano, Giovanna Caparello, Elena Carrano, Giuseppe Merra, Alberto Maria Pujia, Roberta Danieli and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2020 18:415
    Content type: Review Published on:

  14. Glycemic variability (GV) represents the amplitude of oscillations in glucose levels over time and is associated with higher mortality in critically ill patients. Our aim is to evaluate the impact of GV on acu...

    Authors: Blanca Fuentes, Silvia Pastor-Yborra, Raquel Gutiérrez-Zúñiga, Noemí González-Pérez de Villar, Elena de Celis, Jorge Rodríguez-Pardo, Mari Carmen Gómez-de Frutos, Fernando Laso-García, María Gutiérrez-Fernández, MÁngeles Ortega-Casarrubios, Alfonso Soto, María López-Fernández, María Santamaría, Noemí Díez-González, Mar M. Freijo, Beatriz Zandio…
    Citation: Journal of Translational Medicine 2020 18:414
    Content type: Protocol Published on:

  16. Hypertension and high triglyceride are two of the most important risk factors for hyperuricemia. Epidemiological records show that hypertension and dyslipidemia often coexist and may significantly increase the...

    Authors: Yuan Zhang, Miaomiao Zhang, Xiawen Yu, Fengjiang Wei, Chen Chen, Kai Zhang, Shuzhi Feng, Yaogang Wang and Wei-Dong Li
    Citation: Journal of Translational Medicine 2020 18:409
    Content type: Research Published on:

  17. Evidences support the view that central obesity is an independently cardiovascular risk. It is thought that leptin contributes to autonomic dysfunction and cardiovascular risks in type 1 and type 2 diabetes me...

    Authors: Yun-Ru Lai, Meng Hsiang Chen, Wei Che Lin, Wen-Chan Chiu, Ben-Chung Cheng, Jung-Fu Chen, Nai-Wen Tsai, Chih-Cheng Huang and Cheng-Hsien Lu
    Citation: Journal of Translational Medicine 2020 18:396
    Content type: Research Published on:

  18. Electronic cigarette use is on the rise despite a number of reports linking electronic cigarettes with adverse health outcomes. Recent studies have suggested that alterations in lipid signaling may be one mech...

    Authors: Holly R. Middlekauff, Kevin J. William, Baolong Su, Kacey Haptonstall, Jesus A. Araujo, Xiaohui Wu, Jason Kim and Tamer Sallam
    Citation: Journal of Translational Medicine 2020 18:379
    Content type: Research Published on:

  19. Pregnant women with gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) are at increased risks of pre-term labor, hypertension and preeclampsia. In this study, metabolic profiling of blood s...

    Authors: Ilhame Diboun, Manjunath Ramanjaneya, Yasser Majeed, Lina Ahmed, Mohammed Bashir, Alexandra E. Butler, Abdul Badi Abou-Samra, Stephen L. Atkin, Nayef A. Mazloum and Mohamed A. Elrayess
    Citation: Journal of Translational Medicine 2020 18:366
    Content type: Research Published on:

  20. Omega-3 fatty acids (Ω-3 PUFAs) may help to improve health status in polycystic ovarian syndrome (PCOS) by reducing numerous metabolic disorders (insulin sensitivity, hyperinsulinemia, lipid profile, obesity a...

    Authors: Fiza Komal, Muhammad Kamran Khan, Muhammad Imran, Muhammad Haseeb Ahmad, Haseeb Anwar, Usman Ali Ashfaq, Nazir Ahmad, Amna Masroor, Rabia Shabir Ahmad, Muhammad Nadeem and Mahr Un Nisa
    Citation: Journal of Translational Medicine 2020 18:349
    Content type: Research Published on:

  21. In the current systematic review and meta-analysis, we summarized the studies that evaluated the effects of sugar-sweetened beverages (SSBs) intake on blood pressure among children and adolescents.

    Authors: Mahdieh Abbasalizad Farhangi, Leila Nikniaz and Mahdieh Khodarahmi
    Citation: Journal of Translational Medicine 2020 18:344
    Content type: Review Published on:

  22. The coronavirus disease 2019 (COVID-19) pandemic has led to a declaration of a Public Health Emergency of International Concern by the World Health Organization. As of May 18, 2020, there have been more than 4...

    Authors: Yi Xu, David J. Baylink, Chien-Shing Chen, Mark E. Reeves, Jeffrey Xiao, Curtis Lacy, Eric Lau and Huynh Cao
    Citation: Journal of Translational Medicine 2020 18:322
    Content type: Review Published on:

  23. COVID 19-related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass ...

    Authors: Luigi Barrea, Gabriella Pugliese, Lydia Framondi, Rossana Di Matteo, Daniela Laudisio, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2020 18:318
    Content type: Research Published on:

  24. In the last twenty years, several studies have been conducted in the search for new therapeutic strategies in patients with food allergy; in particular, after the failure of injection immunotherapy, three diff...

    Authors: Francesco Marcucci, Chiara Isidori, Alberto Argentiero, Cosimo Neglia and Susanna Esposito
    Citation: Journal of Translational Medicine 2020 18:302
    Content type: Review Published on:

  25. Obesity and steatosis are associated with COVID-19 severe pneumonia. Elevated levels of pro-inflammatory cytokines and reduced immune response are typical of these patients. In particular, adipose tissue is th...

    Authors: Antonino De Lorenzo, Maria Grazia Tarsitano, Carmela Falcone, Laura Di Renzo, Lorenzo Romano, Sebastiano Macheda, Anna Ferrarelli, Demetrio Labate, Marco Tescione, Federico Bilotta and Paola Gualtieri
    Citation: Journal of Translational Medicine 2020 18:299
    Content type: Research Published on:

  26. Diabetic bladder disease is common complications of diabetes, its symptoms are diverse, can be due to different stages. In this study we investigate the mechanism of miR-128 targe...

    Authors: Xin Gou, Jing Wu, Mingqing Huang, Yuting Weng, Tongxin Yang, Tao Chen, Guiqing Li and Kewei Fang
    Citation: Journal of Translational Medicine 2020 18:284
    Content type: Research Published on:

    The Retraction Note to this article has been published in Journal of Translational Medicine 2021 19:59

  27. Worldwide, 70% of the adult population has limited expression of lactase enzyme with a wide variation among different regions and countries. Lactase deficiency may lead to lactose intolerance (LI). Depending b...

    Authors: Maria Sole Facioni, Benedetta Raspini, Francesca Pivari, Elena Dogliotti and Hellas Cena
    Citation: Journal of Translational Medicine 2020 18:260
    Content type: Review Published on:

  29. This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance imaging to evaluate the permeability of the blood–brain barrier...

    Authors: Ju Qiao, Christopher M. Lawson, Kilian F. G. Rentrup, Praveen Kulkarni and Craig F. Ferris
    Citation: Journal of Translational Medicine 2020 18:256
    Content type: Methodology Published on:

  30. The attraction and influx of monocytes into the retina has been considered a critical step in the development of diabetic retinopathy (DR). However, large population studies about the association between perip...

    Authors: Heng Wan, Yan Cai, Yuying Wang, Sijie Fang, Chi Chen, Yi Chen, Fangzhen Xia, Ningjian Wang, Minghao Guo and Yingli Lu
    Citation: Journal of Translational Medicine 2020 18:248
    Content type: Research Published on:

  31. Glutathione peroxidases (GPxs) belong to a family of enzymes that is important in organisms; these enzymes promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative d...

    Authors: Man-Li Zhang, Hua-Tao Wu, Wen-Jia Chen, Ya Xu, Qian-Qian Ye, Jia-Xin Shen and Jing Liu
    Citation: Journal of Translational Medicine 2020 18:247
    Content type: Review Published on:

  32. Variable resistance has been shown to induce greater total work and muscle activation when compared to constant resistance. However, little is known regarding the effects of chronic exposure to variable resist...

    Authors: Hamid Arazi, Lida Salek, Elham Nikfal, Mani Izadi, James J. Tufano, Bradley T. Elliott and Matt Brughelli
    Citation: Journal of Translational Medicine 2020 18:239
    Content type: Research Published on:

  33. On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans (COVID-19). On the 24th of April 2020, the number of COVID-19 deaths in...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Giulia Cinelli, Claudia Leggeri, Giovanna Caparello, Luigi Barrea, Francesco Scerbo, Ernesto Esposito and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2020 18:229
    Content type: Research Published on:

  34. Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-...

    Authors: Sheng Shi, Zhi Zhou, Jun-Jun Liao, Yue-Hua Yang, Jun-Song Wu, Shuang Zheng and Shi-Sheng He
    Citation: Journal of Translational Medicine 2020 18:211
    Content type: Research Published on:

  35. Green tea drinking has been proven to lower lipid and exert cardiovascular protection, while the potential mechanism has not been fully determined. This study was to investigate whether the beneficial impact o...

    Authors: Chuan-Jue Cui, Jing-Lu Jin, Lin-Na Guo, Jing Sun, Na-Qiong Wu, Yuan-Lin Guo, Geng Liu, Qian Dong and Jian-Jun Li
    Citation: Journal of Translational Medicine 2020 18:195
    Content type: Research Published on:

  36. The protective role of high HDL cholesterol levels against cardiovascular diseases has been recently questioned. Limited data are available on this specific topic in patients with type 2 diabetes mellitus (T2D...

    Authors: Giovanni Fanni, Rosalba Rosato, Luigi Gentile, Matteo Anselmino, Simone Frea, Valentina Ponzo, Marianna Pellegrini, Fabio Broglio, Francesca Pivari, Gaetano Maria De Ferrari, Ezio Ghigo and Simona Bo
    Citation: Journal of Translational Medicine 2020 18:189
    Content type: Research Published on:

  37. To observe the effect of rapid weight loss (RWL) methods over 3 days on muscle damage in judokas.

    Authors: Roberto Roklicer, Nemanja Lakicevic, Valdemar Stajer, Tatjana Trivic, Antonino Bianco, Diba Mani, Zoran Milosevic, Nebojsa Maksimovic, Antonio Paoli and Patrik Drid
    Citation: Journal of Translational Medicine 2020 18:142
    Content type: Research Published on:

  38. It is unclear the role of longitudinal trajectory of serum uric acid (SUA) on the development of non-alcoholic fatty liver disease (NAFLD). We aimed to determine whether longitudinal SUA trajectories are assoc...

    Authors: Zhimin Ma, Chaonan Xu, Xiaoping Kang, Shan Zhang, Haibin Li, Lixin Tao, Deqiang Zheng, Xiuhua Guo and Xinghua Yang
    Citation: Journal of Translational Medicine 2020 18:133
    Content type: Research Published on:

  39. Kidney stone disease (KSD) is more common in individuals with hypertension (HTN) than in individuals with normotension (NTN). Urinary dysbiosis is associated with urinary tract disease and systemic diseases. H...

    Authors: Fengping Liu, Nan Zhang, Peng Jiang, Qixiao Zhai, Chen Li, Deshui Yu, Yan Wu, Yuwei Zhang, Longxian Lv, Xinyu Xu and Ninghan Feng
    Citation: Journal of Translational Medicine 2020 18:130
    Content type: Research Published on:

  40. The role of the human microbiome in human health and disease has been studied in various body sites. However, compared to the gut microbiome, where most of the research focus is, the salivary microbiome still ...

    Authors: Selvasankar Murugesan, Sara Fahad Al Ahmad, Parul Singh, Marwa Saadaoui, Manoj Kumar and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2020 18:127
    Content type: Research Published on:

  41. Dietary restriction of methionine and cysteine is a well-described model that improves metabolic health in rodents. To investigate the translational potential in humans, we evaluated the effects of dietary met...

    Authors: Thomas Olsen, Bente Øvrebø, Nadia Haj-Yasein, Sindre Lee, Karianne Svendsen, Marit Hjorth, Nasser E. Bastani, Frode Norheim, Christian A. Drevon, Helga Refsum and Kathrine J. Vinknes
    Citation: Journal of Translational Medicine 2020 18:122
    Content type: Research Published on:

  42. Human defensin-5 (HD-5) is a key antimicrobial peptide which plays an important role in host immune defense, while the short half-life greatly limits its clinical application. The purpose of this study was to ...

    Authors: Lishan Zeng, Jiasheng Tan, Meng Xue, Le Liu, Mingming Wang, Liping Liang, Jun Deng, Wei Chen and Ye Chen
    Citation: Journal of Translational Medicine 2020 18:107
    Content type: Research Published on:

  43. Thiazide diuretics reduce the risk of recurrent kidney calculi in patients with kidney calculi or hypercalciuria. However, whether thiazide diuretics can definitely prevent recurrent kidney calculi remains unc...

    Authors: Dan-feng Li, Yu-lu Gao, Hong-chao Liu, Xiao-chen Huang, Rui-fang Zhu and Chang-tai Zhu
    Citation: Journal of Translational Medicine 2020 18:106
    Content type: Review Published on:

  44. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive age. It is characterised clinically by oligo-ovulation or anovulation, hyper-androgenism, and the presence of...

    Authors: Antonio Paoli, Laura Mancin, Maria Cristina Giacona, Antonino Bianco and Massimiliano Caprio
    Citation: Journal of Translational Medicine 2020 18:104
    Content type: Research Published on:

  45. The present study compared the effects of training and detraining periods of high-intensity interval training (HIIT), moderate-intensity interval training (MIIT) and moderate-intensity continuous training (MIC...

    Authors: Victor Silveira Coswig, Matheus Barbalho, Rodolfo Raiol, Fabrício Boscolo Del Vecchio, Rodrigo Ramirez-Campillo and Paulo Gentil
    Citation: Journal of Translational Medicine 2020 18:88
    Content type: Research Published on:

  46. Despite the efficacy of immune checkpoint inhibitors (ICIs) only the 20–30% of treated patients present long term benefits. The metabolic changes occurring in the gut microbiota metabolome are herein proposed ...

    Authors: Andrea Botticelli, Pamela Vernocchi, Federico Marini, Andrea Quagliariello, Bruna Cerbelli, Sofia Reddel, Federica Del Chierico, Francesca Di Pietro, Raffaele Giusti, Alberta Tomassini, Ottavia Giampaoli, Alfredo Miccheli, Ilaria Grazia Zizzari, Marianna Nuti, Lorenza Putignani and Paolo Marchetti
    Citation: Journal of Translational Medicine 2020 18:49
    Content type: Research Published on:

  47. There are several effective therapies for osteoporosis but these agents might cause serious adverse events. Lycopene intake could prevent bone loss, however studies on its effects on bone are scarce. Our aim w...

    Authors: Cristina Russo, Yvelise Ferro, Samantha Maurotti, Maria Antonietta Salvati, Elisa Mazza, Roberta Pujia, Rosa Terracciano, Giuseppina Maggisano, Rosario Mare, Sandro Giannini, Stefano Romeo, Arturo Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2020 18:43
    Content type: Research Published on:

  48. Circadian rhythms play a fundamental role in the progression of cardiovascular events. Almost all cardiovascular diseases have a circadian misalignment usually characterized by changes in metabolites. This stu...

    Authors: Huanjun Wang, Xiaoming Wang, Dongmei Qi, Mengjia Sun, Qingqing Hou, Yunlun Li and Haiqiang Jiang
    Citation: Journal of Translational Medicine 2020 18:38
    Content type: Research Published on:

  50. The manipulation of gut microbiota as a target has been suggested to reduce the risks for a number of diseases such as type 2 diabetes mellitus (T2DM). Conversely, T2DM is associated with complications such as...

    Authors: Mohammad Morshedi, Maryam Saghafi-Asl and Elaheh-Sadat Hosseinifard
    Citation: Journal of Translational Medicine 2020 18:18
    Content type: Research Published on:
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