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Immunovirology

Section edited by Luigi Buonaguro

The Immunovirology section focuses on translational research related to virology and immunity to virus-based diseases, with a particular interest in human oncogenic viruses.

Studies focused on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections up to cancer, including vaccine and adjuvanting strategies, will be considered for publication. Classic immunology as well as more recent, less established "omics" approaches (genomics, proteomics, immunogenomics, pharmacogenomics) will also be considered.

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  1. Interferons alpha (IFNα) are the cytokines most widely used in clinical medicine for the treatment of cancer and viral infections. Among the immunomodulatory activities possibly involved in their therapeutic e...

    Authors: Eleonora Aricò, Luciano Castiello, Francesca Urbani, Paola Rizza, Monica C Panelli, Ena Wang, Francesco M Marincola and Filippo Belardelli

    Citation: Journal of Translational Medicine 2011 9:67

    Content type: Research

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  2. Hepatocyte growth factor (HGF) stimulates hepatocyte proliferation, and also acts as an anti-apoptotic factor. Therefore, HGF is a potential therapeutic agent for treatment of fatal liver diseases. We performe...

    Authors: Akio Ido, Akihiro Moriuchi, Masatsugu Numata, Toshinori Murayama, Satoshi Teramukai, Hiroyuki Marusawa, Naohisa Yamaji, Hitoshi Setoyama, Il-Deok Kim, Tsutomu Chiba, Shuji Higuchi, Masayuki Yokode, Masanori Fukushima, Akira Shimizu and Hirohito Tsubouchi

    Citation: Journal of Translational Medicine 2011 9:55

    Content type: Research

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  3. Novel, exciting intervention strategies to prevent infection with HIV have been tested in the past year, and the field is rapidly evolving. EUROPRISE is a network of excellence sponsored by the European Commis...

    Authors: Sarah Brinckmann, Kelly da Costa, Marit J van Gils, David Hallengärd, Katja Klein, Luisa Madeira, Lara Mainetti, Paolo Palma, Katharina Raue, David Reinhart, Marc Reudelsterz, Nicolas Ruffin, Janna Seifried, Katrein Schäfer, Enas Sheik-Khalil, Annette Sköld…

    Citation: Journal of Translational Medicine 2011 9:40

    Content type: Review

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  4. Replicative phenotypic HIV resistance testing (rPRT) uses recombinant infectious virus to measure viral replication in the presence of antiretroviral drugs. Due to its high sensitivity of detection of viral mi...

    Authors: Jan Fehr, Tracy R Glass, Séverine Louvel, François Hamy, Hans H Hirsch, Viktor von Wyl, Jürg Böni, Sabine Yerly, Philippe Bürgisser, Matthias Cavassini, Christoph A Fux, Bernard Hirschel, Pietro Vernazza, Gladys Martinetti, Enos Bernasconi, Huldrych F Günthard…

    Citation: Journal of Translational Medicine 2011 9:14

    Content type: Research

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  5. It has been suggested that p300 participates in the regulation of a wide range of cell biological processes and mutation of p300 has been identified in certain types of human cancers. However, the expression d...

    Authors: Mei Li, Rong-Zhen Luo, Jie-Wei Chen, Yun Cao, Jia-Bin Lu, Jie-Hua He, Qiu-Liang Wu and Mu-Yan Cai

    Citation: Journal of Translational Medicine 2011 9:5

    Content type: Research

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  6. Lung cancers consist of four major types that and for clinical-pathological reasons are often divided into two broad categories: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). All major ...

    Authors: Tonia Buonomo, Laura Carraresi, Mara Rossini and Rosanna Martinelli

    Citation: Journal of Translational Medicine 2011 9:2

    Content type: Research

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  7. Proteomic-based discovery of biomarkers for disease has recently come under scrutiny for a variety of issues; one prominent issue is the lack of orthogonal validation for biomarkers following discovery. Valida...

    Authors: Nicole Haverland, Gwënaël Pottiez, Jayme Wiederin and Pawel Ciborowski

    Citation: Journal of Translational Medicine 2010 8:137

    Content type: Research

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  8. Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and ...

    Authors: Giuseppe Castello, Susan Costantini and Stefania Scala

    Citation: Journal of Translational Medicine 2010 8:109

    Content type: Review

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  9. EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated r...

    Authors: Britta Wahren, Priscilla Biswas, Marie Borggren, Adam Coleman, Kelly Da Costa, Winni De Haes, Tessa Dieltjens, Stefania Dispinseri, Katrijn Grupping, David Hallengärd, Julia Hornig, Katja Klein, Lara Mainetti, Paolo Palma, Marc Reudelsterz, Janna Seifried…

    Citation: Journal of Translational Medicine 2010 8:72

    Content type: Review

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    The Erratum to this article has been published in Journal of Translational Medicine 2010 8:82

  10. Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and play a crucial role in the host's innate immune response. Genetic variations in TLR genes may influence host-viral interactions a...

    Authors: Elisabetta Ricci, Sandro Malacrida, Marisa Zanchetta, Ilaria Mosconi, Marco Montagna, Carlo Giaquinto and Anita De Rossi

    Citation: Journal of Translational Medicine 2010 8:49

    Content type: Research

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  11. Around half million new cases of cervical cancer arise each year, making the development of an effective therapeutic vaccine against HPV a high priority. As the E6 and E7 oncoproteins are expressed in all HPV-...

    Authors: Antonia Radaelli, Eleana Pozzi, Sole Pacchioni, Carlo Zanotto and Carlo De Giuli Morghen

    Citation: Journal of Translational Medicine 2010 8:40

    Content type: Research

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  12. Current vaccines against HPVs are constituted of L1 protein self-assembled into virus-like particles (VLPs) and they have been shown to protect against natural HPV16 and HPV18 infections and associated lesions...

    Authors: Nicolas Combelas, Emilie Saussereau, Maxime JJ Fleury, Tatiana Ribeiro, Julien Gaitan, Diego F Duarte-Forero, Pierre Coursaget and Antoine Touzé

    Citation: Journal of Translational Medicine 2010 8:28

    Content type: Research

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  13. Hepatitis C virus (HCV) is one of the major risk factors for chronic hepatitis, which may progress to cirrhosis and hepatocellular carcinoma, as well as for type II mixed cryoglobulinemia (MC), which may furth...

    Authors: Luigi Buonaguro, Annacarmen Petrizzo, Marialina Tornesello, Maria Napolitano, Debora Martorelli, Giuseppe Castello, Gerardo Beneduce, Amalia De Renzo, Oreste Perrella, Luca Romagnoli, Vitor Sousa, Valli De Re, Riccardo Dolcetti and Franco M Buonaguro

    Citation: Journal of Translational Medicine 2010 8:18

    Content type: Research

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  14. HIV and HPV can both cause chronic infections and are acquired during sexual contact. HIV infection results in a progressive loss of CD4+ T cells that is associated with an increased prevalence of HPV infectio...

    Authors: Sjoerd H van der Burg and Joel M Palefsky

    Citation: Journal of Translational Medicine 2009 7:108

    Content type: Review

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  15. HIV-1 exposure causes several dramatic unbalances in the immune system homeostasis. Here, we will focus on the paradox whereby CD4 specific autoimmune responses, which are expected to contribute to the catastr...

    Authors: Samuele E Burastero, Mariangela Figini, Barbara Frigerio, Paolo Lusso, Luca Mollica and Lucia Lopalco

    Citation: Journal of Translational Medicine 2009 7:101

    Content type: Review

    Published on:

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