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Immunovirology

Section edited by Luigi Buonaguro

The Immunovirology section focuses on translational research related to virology and immunity to virus-based diseases, with a particular interest in human oncogenic viruses.

Studies focused on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections up to cancer, including vaccine and adjuvanting strategies, will be considered for publication. Classic immunology as well as more recent, less established "omics" approaches (genomics, proteomics, immunogenomics, pharmacogenomics) will also be considered.

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  1. Hepatitis C Virus (HCV), a single stranded RNA virus, affects millions of people worldwide and leads to chronic infection characterized by chronic inflammation in the liver and in peripheral immune cells. Chro...

    Authors: Shashi Bala, Yaphet Tilahun, Odette Taha, Hawau Alao, Karen Kodys, Donna Catalano and Gyongyi Szabo

    Citation: Journal of Translational Medicine 2012 10:151

    Content type: Research

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  2. Europrise is a Network of Excellence supported by the European Commission within the 6th Framework programme from 2007 to 2012. The Network has involved over 50 institutions from 13 European countries together...

    Authors: Nicolas Ruffin, Marie Borggren, Zelda Euler, Fabio Fiorino, Katrijn Grupping, David Hallengärd, Aneele Javed, Kevin Mendonca, Charlotte Pollard, David Reinhart, Elisa Saba, Enas Sheik-Khalil, Annette Sköld, Serena Ziglio, Gabriella Scarlatti, Frances Gotch…

    Citation: Journal of Translational Medicine 2012 10:144

    Content type: Meeting report

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  3. Claspin is a nuclear protein involved in DNA replication and damage response and is a key mediator for the S-phase checkpoint. Claspin expression is significantly high in several human solid tumors. Furthermor...

    Authors: Maria Benevolo, Antonio Musio, Amina Vocaturo, Maria Gabriella Donà, Francesca Rollo, Irene Terrenato, Mariantonia Carosi, Edoardo Pescarmona, Giuseppe Vocaturo and Marcella Mottolese

    Citation: Journal of Translational Medicine 2012 10:132

    Content type: Research

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  4. The immune system reconstitution in HIV-1- infected patients undergoing combined antiretroviral therapy is routinely evaluated by T-cell phenotyping, even though the infection also impairs the B-cell mediated ...

    Authors: Eugenia Quiros-Roldan, Federico Serana, Marco Chiarini, Cinzia Zanotti, Alessandra Sottini, Daria Gotti, Carlo Torti, Luigi Caimi and Luisa Imberti

    Citation: Journal of Translational Medicine 2012 10:94

    Content type: Research

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  5. We have previously reported the induction of many interferon stimulated genes (ISGs) in PBMC collected from patients infected with HCV at various times after initiation of interferon-ribavirin treatment using ...

    Authors: Rahul Gupta, Sun Kim and Milton W Taylor

    Citation: Journal of Translational Medicine 2012 10:54

    Content type: Research

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  6. Recent studies of CH-C patients have demonstrated a strong association between IL28B CC genotype and sustained virologic response (SVR) after PEG-IFN/RBV treatment. We aimed to assess whether IL28B alleles rs1...

    Authors: Zobair M Younossi, Aybike Birerdinc, Mike Estep, Maria Stepanova, Arian Afendy and Ancha Baranova

    Citation: Journal of Translational Medicine 2012 10:25

    Content type: Research

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  7. A mobile health unit may be useful to follow up adult and pediatric patients on antiretroviral treatment and living in remote areas devoid of laboratory facilities. The study evaluated the use of the simplifie...

    Authors: François-Xavier Mbopi-Kéou, Bertrand Sagnia, Jeanne Ngogang, Fru F Angwafo III, Vittorio Colizzi, Luc Montagnier and Laurent Bélec

    Citation: Journal of Translational Medicine 2012 10:22

    Content type: Research

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  8. Transfusion transmitted infections create significant burden on health care system. Donor selection is of paramount importance because infected individuals serve as an asymptomatic reservoir and a potential so...

    Authors: Sobia Attaullah, Sanaullah Khan and Jabbar Khan

    Citation: Journal of Translational Medicine 2012 10:20

    Content type: Research

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  9. Currently, no data on the optimal time point after acute ischemic stroke (IS) at which high-sensitivity C-reactive protein (hs-CRP) level is most predictive of unfavorable outcome. We tested the hypothesis tha...

    Authors: Kuo-Ho Yeh, Tzu-Hsien Tsai, Han-Tan Chai, Steve Leu, Sheng-Ying Chung, Sarah Chua, Yung-Lung Chen, Hung-Sheng Lin, Chun-Man Yuen and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2012 10:6

    Content type: Research

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  10. Virus-Like Particles (VLPs) represent an efficient strategy to present and deliver conformational antigens to the immune system, inducing both arms of the adaptive immune response. Moreover, their particulate ...

    Authors: Maria Luisa Visciano, Maria Tagliamonte, Maria Lina Tornesello, Franco M Buonaguro and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2012 10:4

    Content type: Research

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  11. Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed. Several oncolytic viruses including adenovirus st...

    Authors: Sandeep S Patil, Ivaylo Gentschev, Ingo Nolte, Gregory Ogilvie and Aladar A Szalay

    Citation: Journal of Translational Medicine 2012 10:3

    Content type: Review

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  12. HIV vaccine development must address the genetic diversity and plasticity of the virus that permits the presentation of diverse genetic forms to the immune system and subsequent escape from immune pressure. As...

    Authors: Jeffrey R Currier, Merlin L Robb, Nelson L Michael and Mary A Marovich

    Citation: Journal of Translational Medicine 2011 9:212

    Content type: Research

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  13. The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine des...

    Authors: Beatriz Mothe, Anuska Llano, Javier Ibarrondo, Marcus Daniels, Cristina Miranda, Jennifer Zamarreño, Vanessa Bach, Rosario Zuniga, Susana Pérez-Álvarez, Christoph T Berger, Maria C Puertas, Javier Martinez-Picado, Morgane Rolland, Marilu Farfan, James J Szinger, William H Hildebrand…

    Citation: Journal of Translational Medicine 2011 9:208

    Content type: Research

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  14. HCV causes acute and chronic hepatitis which can eventually lead to permanent liver damage hepatocellular carcinoma and death. HCV glycoproteins play an important role in HCV entry by binding with CD81 recepto...

    Authors: Usman A Ashfaq, Muhammad Qasim, Muhammad Z Yousaf, Muhammad Tariq Awan and Shah Jahan

    Citation: Journal of Translational Medicine 2011 9:194

    Content type: Research

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  15. Human papilloma virus (HPV)-16 is the most prevalent high-risk mucosal genotype. Virus-like-particle (VLP)-based immunogens developed recently have proven to be successful as prophylactic HPV vaccines, but are...

    Authors: Carlo Zanotto, Eleana Pozzi, Sole Pacchioni, Massimiliano Bissa, Carlo De Giuli Morghen and Antonia Radaelli

    Citation: Journal of Translational Medicine 2011 9:190

    Content type: Research

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  16. Hepatitis C virus is a major cause of chronic liver diseases which can lead to permanent liver damage, hepatocellular carcinoma and death. The presently available treatment with interferon plus ribavirin, has ...

    Authors: Usman A Ashfaq, Muhammad S Masoud, Zafar Nawaz and Sheikh Riazuddin

    Citation: Journal of Translational Medicine 2011 9:112

    Content type: Research

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  17. MHC class II transactivator CIITA inhibits the function of HTLV-2 Tax-2 viral transactivator and, consequently, the replication of the virus in infected cells. Moreover overexpression of the nuclear factor NF-...

    Authors: Chiara Orlandi, Greta Forlani, Giovanna Tosi and Roberto S Accolla

    Citation: Journal of Translational Medicine 2011 9:106

    Content type: Research

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  18. One of the most neglected areas of everyday clinical practice for HIV physicians is unexpectedly represented by CD4 T cell counts when used as an aid to clinical decisions. All who care for HIV patients believ...

    Authors: Andrea De Maria and Andrea Cossarizza

    Citation: Journal of Translational Medicine 2011 9:93

    Content type: Commentary

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  19. The HPV16 E7 protein is both a tumour-specific and a tumour-rejection antigen, the ideal target for developing therapeutic vaccines for the treatment of HPV16-associated cancer and its precursor lesions. E7, w...

    Authors: Linda Petrone, Maria G Ammendolia, Armando Cesolini, Stefano Caimi, Fabiana Superti, Colomba Giorgi and Paola Di Bonito

    Citation: Journal of Translational Medicine 2011 9:69

    Content type: Research

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  20. Interferons alpha (IFNα) are the cytokines most widely used in clinical medicine for the treatment of cancer and viral infections. Among the immunomodulatory activities possibly involved in their therapeutic e...

    Authors: Eleonora Aricò, Luciano Castiello, Francesca Urbani, Paola Rizza, Monica C Panelli, Ena Wang, Francesco M Marincola and Filippo Belardelli

    Citation: Journal of Translational Medicine 2011 9:67

    Content type: Research

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  21. Hepatocyte growth factor (HGF) stimulates hepatocyte proliferation, and also acts as an anti-apoptotic factor. Therefore, HGF is a potential therapeutic agent for treatment of fatal liver diseases. We performe...

    Authors: Akio Ido, Akihiro Moriuchi, Masatsugu Numata, Toshinori Murayama, Satoshi Teramukai, Hiroyuki Marusawa, Naohisa Yamaji, Hitoshi Setoyama, Il-Deok Kim, Tsutomu Chiba, Shuji Higuchi, Masayuki Yokode, Masanori Fukushima, Akira Shimizu and Hirohito Tsubouchi

    Citation: Journal of Translational Medicine 2011 9:55

    Content type: Research

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  22. Novel, exciting intervention strategies to prevent infection with HIV have been tested in the past year, and the field is rapidly evolving. EUROPRISE is a network of excellence sponsored by the European Commis...

    Authors: Sarah Brinckmann, Kelly da Costa, Marit J van Gils, David Hallengärd, Katja Klein, Luisa Madeira, Lara Mainetti, Paolo Palma, Katharina Raue, David Reinhart, Marc Reudelsterz, Nicolas Ruffin, Janna Seifried, Katrein Schäfer, Enas Sheik-Khalil, Annette Sköld…

    Citation: Journal of Translational Medicine 2011 9:40

    Content type: Review

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  23. Replicative phenotypic HIV resistance testing (rPRT) uses recombinant infectious virus to measure viral replication in the presence of antiretroviral drugs. Due to its high sensitivity of detection of viral mi...

    Authors: Jan Fehr, Tracy R Glass, Séverine Louvel, François Hamy, Hans H Hirsch, Viktor von Wyl, Jürg Böni, Sabine Yerly, Philippe Bürgisser, Matthias Cavassini, Christoph A Fux, Bernard Hirschel, Pietro Vernazza, Gladys Martinetti, Enos Bernasconi, Huldrych F Günthard…

    Citation: Journal of Translational Medicine 2011 9:14

    Content type: Research

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  24. It has been suggested that p300 participates in the regulation of a wide range of cell biological processes and mutation of p300 has been identified in certain types of human cancers. However, the expression d...

    Authors: Mei Li, Rong-Zhen Luo, Jie-Wei Chen, Yun Cao, Jia-Bin Lu, Jie-Hua He, Qiu-Liang Wu and Mu-Yan Cai

    Citation: Journal of Translational Medicine 2011 9:5

    Content type: Research

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  25. Lung cancers consist of four major types that and for clinical-pathological reasons are often divided into two broad categories: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). All major ...

    Authors: Tonia Buonomo, Laura Carraresi, Mara Rossini and Rosanna Martinelli

    Citation: Journal of Translational Medicine 2011 9:2

    Content type: Research

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  26. Proteomic-based discovery of biomarkers for disease has recently come under scrutiny for a variety of issues; one prominent issue is the lack of orthogonal validation for biomarkers following discovery. Valida...

    Authors: Nicole Haverland, Gwënaël Pottiez, Jayme Wiederin and Pawel Ciborowski

    Citation: Journal of Translational Medicine 2010 8:137

    Content type: Research

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  27. Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and ...

    Authors: Giuseppe Castello, Susan Costantini and Stefania Scala

    Citation: Journal of Translational Medicine 2010 8:109

    Content type: Review

    Published on:

  28. EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated r...

    Authors: Britta Wahren, Priscilla Biswas, Marie Borggren, Adam Coleman, Kelly Da Costa, Winni De Haes, Tessa Dieltjens, Stefania Dispinseri, Katrijn Grupping, David Hallengärd, Julia Hornig, Katja Klein, Lara Mainetti, Paolo Palma, Marc Reudelsterz, Janna Seifried…

    Citation: Journal of Translational Medicine 2010 8:72

    Content type: Review

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    The Erratum to this article has been published in Journal of Translational Medicine 2010 8:82

  29. Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and play a crucial role in the host's innate immune response. Genetic variations in TLR genes may influence host-viral interactions a...

    Authors: Elisabetta Ricci, Sandro Malacrida, Marisa Zanchetta, Ilaria Mosconi, Marco Montagna, Carlo Giaquinto and Anita De Rossi

    Citation: Journal of Translational Medicine 2010 8:49

    Content type: Research

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  30. Around half million new cases of cervical cancer arise each year, making the development of an effective therapeutic vaccine against HPV a high priority. As the E6 and E7 oncoproteins are expressed in all HPV-...

    Authors: Antonia Radaelli, Eleana Pozzi, Sole Pacchioni, Carlo Zanotto and Carlo De Giuli Morghen

    Citation: Journal of Translational Medicine 2010 8:40

    Content type: Research

    Published on:

  31. Current vaccines against HPVs are constituted of L1 protein self-assembled into virus-like particles (VLPs) and they have been shown to protect against natural HPV16 and HPV18 infections and associated lesions...

    Authors: Nicolas Combelas, Emilie Saussereau, Maxime JJ Fleury, Tatiana Ribeiro, Julien Gaitan, Diego F Duarte-Forero, Pierre Coursaget and Antoine Touzé

    Citation: Journal of Translational Medicine 2010 8:28

    Content type: Research

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  32. Hepatitis C virus (HCV) is one of the major risk factors for chronic hepatitis, which may progress to cirrhosis and hepatocellular carcinoma, as well as for type II mixed cryoglobulinemia (MC), which may furth...

    Authors: Luigi Buonaguro, Annacarmen Petrizzo, Marialina Tornesello, Maria Napolitano, Debora Martorelli, Giuseppe Castello, Gerardo Beneduce, Amalia De Renzo, Oreste Perrella, Luca Romagnoli, Vitor Sousa, Valli De Re, Riccardo Dolcetti and Franco M Buonaguro

    Citation: Journal of Translational Medicine 2010 8:18

    Content type: Research

    Published on:

  33. HIV and HPV can both cause chronic infections and are acquired during sexual contact. HIV infection results in a progressive loss of CD4+ T cells that is associated with an increased prevalence of HPV infectio...

    Authors: Sjoerd H van der Burg and Joel M Palefsky

    Citation: Journal of Translational Medicine 2009 7:108

    Content type: Review

    Published on:

  34. HIV-1 exposure causes several dramatic unbalances in the immune system homeostasis. Here, we will focus on the paradox whereby CD4 specific autoimmune responses, which are expected to contribute to the catastr...

    Authors: Samuele E Burastero, Mariangela Figini, Barbara Frigerio, Paolo Lusso, Luca Mollica and Lucia Lopalco

    Citation: Journal of Translational Medicine 2009 7:101

    Content type: Review

    Published on:

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